LOCUS       NM_178553               2008 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens proline rich 30 (PRR30), mRNA.
ACCESSION   NM_178553
VERSION     NM_178553.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2008)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB052016.1, DB022743.1, BC045671.1, BX118458.1, DB336367.1 and
            AA812952.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178553.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045671.1, BM560143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335524.7/ ENSP00000335017.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               DB052016.1         55-359
            306-306             DB022743.1         358-358
            307-1105            BC045671.1         307-1105
            1106-1424           BX118458.1         183-501
            1425-1771           BC045671.1         1425-1771
            1772-2005           DB336367.1         1-234               c
            2006-2008           AA812952.1         4-6                 c
FEATURES             Location/Qualifiers
     source          1..2008
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..2008
                     /gene="PRR30"
                     /gene_synonym="C2orf53"
                     /note="proline rich 30"
                     /db_xref="GeneID:339779"
                     /db_xref="HGNC:HGNC:28677"
     exon            1..108
                     /gene="PRR30"
                     /gene_synonym="C2orf53"
                     /inference="alignment:Splign:2.1.0"
     exon            109..161
                     /gene="PRR30"
                     /gene_synonym="C2orf53"
                     /inference="alignment:Splign:2.1.0"
     exon            162..2008
                     /gene="PRR30"
                     /gene_synonym="C2orf53"
                     /inference="alignment:Splign:2.1.0"
     CDS             527..1765
                     /gene="PRR30"
                     /gene_synonym="C2orf53"
                     /codon_start=1
                     /product="proline-rich protein 30"
                     /protein_id="NP_848648.2"
                     /db_xref="CCDS:CCDS1739.1"
                     /db_xref="GeneID:339779"
                     /db_xref="HGNC:HGNC:28677"
                     /translation="MLPQNKDQVLPQTSVLPGRPTWGFSQLVDSSPHNLQPLSPHQGL
                     PPSQPPFSSTQSRRPSSPPPASPSPGFQFGSCDSNSDFAPHPYSPSLPSSPTFFHQNY
                     LSLPRPRASSPSNHWLYPSPPLTPSFSPSQPQNSSLPHSPCQSPSHPEELHSSTLTSP
                     GPSPPSHRLHSNRQTWRWHQYRDTGSGSPGVVERCVPSEKDPAQFRDPGALAQALVVQ
                     LGHRRIAHDLRLLLLQHLWLGRTGQAPVVEYPICLVCLRPRSPSCPLPRYRTGPRLLA
                     FPQLLPCVQGQESGPLRIGIGFGLRLPQGQARALHLLPEKRPKEAGPQGKATQACGHQ
                     LPASQPPAAQARADPVPGTPSQTRSFRSAGLQSPNSPRCFSGPPPRAPKQVTTSLKPR
                     PCPGPKRPVSLELILQKSSV"
     regulatory      1987..1992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR30"
                     /gene_synonym="C2orf53"
                     /note="hexamer: AATAAA"
     polyA_site      2008
                     /gene="PRR30"
                     /gene_synonym="C2orf53"
                     /note="major polyA site"
ORIGIN      
        1 agctcccatt ggggtcggcg aacctggtgc caccccttag acaaagtccc agtctcccag
       61 aggcttttac cagctggccc cattccttct gctgctgggt ataataaggt cctctcaacg
      121 ctgaagtgcc tgtgaaacac agcccagagg agttctcatt ggtcctatgg gctttgtctt
      181 cctctctgcc ccacccagat aatcgctgct gcccctccac tcccaagatg cagctgtgat
      241 tctccatccc cacacatccc tcatcaatgg ttgactgcaa agaagtgaga agccaagctt
      301 agattcatgc tcatgcctga acaccctgag agcctggtgc tggagggctg ggtatcccct
      361 tggcctgcca ccagcacctg cacccacacc aggctggagc cacgctctgc gcacagaagg
      421 tggccttgat ttctcaggca cagctgacct cagagatact ggtcctgact ctgccaggtc
      481 tcttatccct agtcttgttg ccccagttcc ttctggattc aaggcgatgt tgcctcaaaa
      541 caaggaccag gtgctgccac agacctcagt gctccctggg cgccccactt ggggcttctc
      601 acaacttgtg gactcctctc ctcacaacct acagcctctc tctccccatc agggcctccc
      661 tccctctcaa ccaccgttct cttccactca gtcccgtcgt ccctcctccc ctccaccagc
      721 atccccctct cctggcttcc aattcggctc ttgtgactca aattctgact ttgctccaca
      781 tccctattct ccctctctcc caagttcccc tactttcttt caccagaact acctctctct
      841 cccccgtcca cgtgcatcct ctccctccaa ccactggctg tacccctctc cccctctgac
      901 cccttccttt tctccctccc agcctcagaa ctcctccctt ccccactcac cttgccagtc
      961 cccttcccac cccgaggaac tgcatagctc cacactcact tccccaggcc ccagcccacc
     1021 ttctcatagg ctccactcta acaggcagac atggcgctgg catcagtaca gggacactgg
     1081 gtccgggtcc cctggagtgg tggagagatg cgtgccaagc gagaaggatc ctgcacagtt
     1141 cagggaccca ggggccctgg cccaggccct ggtggtccag ctggggcacc gccgcatcgc
     1201 acacgacctg cggctactgc ttttgcagca cctgtggcta ggcagaaccg gccaggcccc
     1261 agtcgtggag tatcctatat gcctggtgtg cctccggccc cgcagcccct cctgccccct
     1321 ccccaggtac aggactggac cccggctgct tgctttccct caactactgc cctgtgtgca
     1381 gggccaggaa tctgggccac tccggatagg catcggcttc ggcctccgcc tgcctcaggg
     1441 ccaggccagg gccttgcatc tgctgcccga gaaaaggccg aaggaagcag ggcctcaggg
     1501 caaggctact caggcctgtg ggcatcaatt gccagcatct cagcctccag cagctcaggc
     1561 ccgggccgac ccagtcccag gcacaccctc ccagaccagg agcttcaggt ctgcaggcct
     1621 tcaatcacca aactccccac gatgtttctc cgggcctcca cctcgggcac caaaacaggt
     1681 cactacctcc ctgaagccca ggccttgccc tggcccaaag aggccagttt ctctggagct
     1741 cattctccaa aagtcatcag tctagttcca gagccacgga ggccccctgg aacaccccct
     1801 ccaaacccaa ccctcccaac caggccccag atctcgggga gtccccgaga caccctgaag
     1861 ggctggctgg ccggaggtca ggtgtgttct cctgctctga accctgggag ccccttgtgg
     1921 agtctgctgt ctccaggctg aagaggacca agggcaccaa ggccccattc agccctccgt
     1981 gtatctaata aagtctgacc ctgtgaaa
//
