LOCUS       NM_025263               1845 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens proline rich 3 (PRR3), transcript variant 1, mRNA.
ACCESSION   NM_025263
VERSION     NM_025263.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1845)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1845)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1845)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1845)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1845)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 1845)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 1845)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 1845)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet 5 (10), e1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1845)
  AUTHORS   Paladini,F., Belfiore,F., Cocco,E., Carcassi,C., Cauli,A.,
            Vacca,A., Fiorillo,M.T., Mathieu,A., Cascino,I. and Sorrentino,R.
  TITLE     HLA-E gene polymorphism associates with ankylosing spondylitis in
            Sardinia
  JOURNAL   Arthritis Res Ther 11 (6), R171 (2009)
   PUBMED   19912639
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 1845)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662800.4.
            
            On Jul 25, 2019 this sequence version replaced NM_025263.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U63336.1, AK298621.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376560.8/ ENSP00000365744.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AL662800.4         57470-57625
            157-219             AL662800.4         58325-58387
            220-510             AL662800.4         62009-62299
            511-1845            AL662800.4         62564-63898
FEATURES             Location/Qualifiers
     source          1..1845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1845
                     /gene="PRR3"
                     /gene_synonym="CAT56"
                     /note="proline rich 3"
                     /db_xref="GeneID:80742"
                     /db_xref="HGNC:HGNC:21149"
     exon            1..156
                     /gene="PRR3"
                     /gene_synonym="CAT56"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..617
                     /gene="PRR3"
                     /gene_synonym="CAT56"
                     /note="isoform a is encoded by transcript variant 1;
                     proline-rich polypeptide 3; proline-rich protein 3; MHC
                     class I region proline-rich protein CAT56"
                     /codon_start=1
                     /product="proline-rich protein 3 isoform a"
                     /protein_id="NP_079539.2"
                     /db_xref="CCDS:CCDS43440.1"
                     /db_xref="GeneID:80742"
                     /db_xref="HGNC:HGNC:21149"
                     /translation="MPKRKKQNHHQPPTQQQPPLPEREETGDEEDGSPIGPPSLLGPP
                     PMANGKPGDPKSALHRGPPGSRGPLIPPLLSLPPPPWGRGPIRRGLGPRSSPYGRGWW
                     GVNAEPPFPGPGHGGPTRGSFHKEQRNPRRLKSWSLIKNTCPPKDDPQVMEDKSDRPV
                     CRHFAKKGHCRYEDLCAFYHPGVNGPPL"
     exon            157..219
                     /gene="PRR3"
                     /gene_synonym="CAT56"
                     /inference="alignment:Splign:2.1.0"
     exon            220..510
                     /gene="PRR3"
                     /gene_synonym="CAT56"
                     /inference="alignment:Splign:2.1.0"
     exon            511..1845
                     /gene="PRR3"
                     /gene_synonym="CAT56"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1813..1818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR3"
                     /gene_synonym="CAT56"
                     /note="hexamer: AATAAA"
     polyA_site      1845
                     /gene="PRR3"
                     /gene_synonym="CAT56"
                     /note="major polyA site"
ORIGIN      
        1 cccttcctca ctaccctcca aatcccgctg cagccattgc cgcagacacg atgccgaaac
       61 gaaagaagca gaatcatcac cagccaccga cacagcagca gcccccgctg cccgagcggg
      121 aagagactgg agatgaggag gatgggagtc ccatcggacc acccagcctt ctgggccctc
      181 cccccatggc caatggaaaa cctggcgacc ctaagtcagc tcttcacaga ggtcctccag
      241 gatcaagggg accactgatt ccaccactgc tgagtctccc acctcctcct tggggtagag
      301 gcccaattcg gagagggctt ggccccaggt ctagcccata tggtcgtggt tggtggggag
      361 tcaatgcaga acctcctttt ccggggccag gccatggggg tcccaccagg ggaagctttc
      421 acaaggaaca gagaaaccct cgaaggctca aaagctggtc tcttatcaag aatacctgcc
      481 cgcccaagga tgacccccag gttatggaag acaaatccga ccgccctgtc tgccgacatt
      541 ttgccaaaaa gggccactgt cgatatgagg acctctgtgc cttctaccat ccaggcgtca
      601 atggacctcc tctgtgagac tgtgccttcc catccaggct ggaaggagct ctctgtgacc
      661 tagcggccat ttatttctct gtagccctat gatggctact gtgaggctct tctaacaccc
      721 tcagtcagtg acacacccat cccatccacc acttcccccg tgtggggtcc agagtggtgt
      781 tgcatcactg gtgcgcggca tacgcgcttt cttctgatcc agcctgtaga gactcgcctt
      841 tgggacccat ctttgcttcc tttcagttgc ctcctggatc ttctttcccg tcatcaaatg
      901 actgctgaac aggaaacctc tttggtgctg tttcttgtgc atctgtccac ctgttcccca
      961 gtattgccct caattcctga gagccctgga gcggtttcct accattccct tcttttagct
     1021 gcttgtttta agtccttttt atgtgacatt ccctaccccc aatgttgtca gctgcttgtg
     1081 aaactcagcc aggttgtcta acctggggtc aagtttgggt gactggtgca gagttacttc
     1141 ctaaaaggcc actctccctg cctttggatt tcatagtttc tctgtcagta gcatgatccc
     1201 caccgctatg gtctatctat gatcaccgtg ctttgtgaaa ctgtgcatcc ccttgtagcc
     1261 tttctcagtg tccgtggcat ttttgtgact tcccagcact agaataagtt ttcctgccaa
     1321 aatgagtgag gcgcttggtg ccctctggac tttcccactt cccaacatgg gagaattgtg
     1381 aactttccat cagactgcct ccctggccct ccccattctt ctcctgttgg ttattctgag
     1441 tctgacacag acccatgaca tgtcttataa agcctccaat ggctttatcc tacctagatc
     1501 ccttccagcc cattttaatt agactatgtc attgtgaggc caccagtcca ttcatttgaa
     1561 ttctgtgaat ctccaccttg cctatctttg ggtagaagct ggacagtact gttgccctct
     1621 tccaatcctc ttcccctaca tccctggcac tggttgtttt ctgtgaaaac agcagtgaac
     1681 aggttcagtt ttgaactggc cctgaggaaa tgggtcagga gttgtattgg caagagggag
     1741 gggtgagagc tgttggagaa ctgagaatga ggtttttttt ttttttttct ttttaacttt
     1801 ttttatatta gtaataaatg cagtggaaac cagcatttta tttaa
//
