LOCUS       NM_001164257            3128 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens proline rich 29 (PRR29), transcript variant 2, mRNA.
ACCESSION   NM_001164257
VERSION     NM_001164257.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3128)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   2  (bases 1 to 3128)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat Genet 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK021786.1, BC030709.1, AC005803.1 and BC045676.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001164257.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            and includes an additional exon that causes a frameshift in the 3'
            coding region, compared to variant 1. The resulting isoform (2) has
            a distinct and shorter C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK021786.1, AU119233.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000412177.6/ ENSP00000400986.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-448               AK021786.1         1-448
            449-1577            BC030709.1         639-1767
            1578-2936           AC005803.1         83439-84797
            2937-3108           BC045676.1         2889-3060
            3109-3128           AC005803.1         84970-84989
FEATURES             Location/Qualifiers
     source          1..3128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     gene            1..3128
                     /gene="PRR29"
                     /gene_synonym="C17orf72"
                     /note="proline rich 29"
                     /db_xref="GeneID:92340"
                     /db_xref="HGNC:HGNC:25673"
     exon            1..74
                     /gene="PRR29"
                     /gene_synonym="C17orf72"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..584
                     /gene="PRR29"
                     /gene_synonym="C17orf72"
                     /EC_number="2.3.1.51"
                     /note="isoform 2 is encoded by transcript variant 2;
                     proline-rich protein 29"
                     /codon_start=1
                     /product="proline-rich protein 29 isoform 2"
                     /protein_id="NP_001157729.1"
                     /db_xref="CCDS:CCDS54158.1"
                     /db_xref="GeneID:92340"
                     /db_xref="HGNC:HGNC:25673"
                     /translation="MASGAGGSWGRSPPQSAVPTPWVTFLQPLSWAVPPAPPQPGRVK
                     EDLLELMMLQNAQMHQLLLSRLVAGALQPRPASPCPQVYLEVPQEEPEEEEEEMDVRE
                     KGPLVFHHHYLPYLMPSPGALLPWPAPFFPTPACQPYLQDVPRIQHCPASREREVRAV
                     PPPPPPSATGTVGADVPPASDYYDAESLL"
     exon            75..150
                     /gene="PRR29"
                     /gene_synonym="C17orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            151..257
                     /gene="PRR29"
                     /gene_synonym="C17orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            258..484
                     /gene="PRR29"
                     /gene_synonym="C17orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            485..555
                     /gene="PRR29"
                     /gene_synonym="C17orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            556..3128
                     /gene="PRR29"
                     /gene_synonym="C17orf72"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1913..1918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR29"
                     /gene_synonym="C17orf72"
                     /note="hexamer: ATTAAA"
     polyA_site      1936
                     /gene="PRR29"
                     /gene_synonym="C17orf72"
                     /note="major polyA site"
     regulatory      3089..3094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR29"
                     /gene_synonym="C17orf72"
                     /note="hexamer: TATAAA"
     regulatory      3103..3108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR29"
                     /gene_synonym="C17orf72"
                     /note="hexamer: ATTAAA"
     polyA_site      3108
                     /gene="PRR29"
                     /gene_synonym="C17orf72"
                     /note="major polyA site"
     polyA_site      3128
                     /gene="PRR29"
                     /gene_synonym="C17orf72"
                     /note="major polyA site"
ORIGIN      
        1 aaccggcgcc agccatggcc tctggggcgg gcggaagctg gggtcgctcc ccaccgcaga
       61 gcgcagtccc gacgccctgg gtcaccttcc tgcagcccct ctcgtgggcc gtcccacctg
      121 cgcccccgca gccaggccgc gtgaaggaag acctgctgga actgatgatg ctgcagaacg
      181 cgcagatgca ccagctgctg ctgagtcgcc tggtggctgg agcgctgcag ccccggcctg
      241 cctcgccctg ccctcaggtc tacctggagg ttccacagga agagcctgag gaggaggagg
      301 aggagatgga cgtgcgggag aaagggcctt tggtgtttca ccaccactac ttgccctatt
      361 tgatgccctc cccgggtgcc ctgctgccct ggccagcccc cttcttcccc acccctgctt
      421 gtcagcccta cttgcaggac gtgcccagga ttcagcactg tcctgcctcc agggaaaggg
      481 aggtgagagc tgtgccccca cccccacccc ccagtgccac agggactgtg ggtgctgatg
      541 tacccccggc ttcagactac tatgatgccg agagcctcct atgaggacag accccggccc
      601 tgggaactgc accagcttcc tgctctggat acagccccgg agccgcctcc tgcacctctc
      661 ttgtcgactc cccggtgccc atggctggca gtccttctca ctccctcaac ctcagccagg
      721 ccctcttctc ctggggaaat cagtccctgc cccacgccaa tgagttcctg gacgggccgg
      781 atctgtgctg ttgtgtaaga gctccctaga gcaccaccca ggcccttgaa gccacgtcag
      841 cccgcctctg ccccactgct tcctgcctgg agcaggggga ggcctgggaa cagagccccc
      901 accctctctc cctcacccct ctctctggga tgatgaggtc tccttccagc ctagtaatgg
      961 agcaagaggg gaggggggga ttccttctgc tttccacagc tttgaaggcc cctttgaggt
     1021 ggctggaggg gcccagagtg gtcggggaga gactttgctg ggcagcgccc ctgagcagag
     1081 tcagttcgct gggcccccca cccctcatcc caggaagcag ctctgttggc agaaaggaga
     1141 ggtcagagct ttgtcctgct gtggccagga gtggcctgag gtctcctggg gccaggtggg
     1201 aacagtgtgt cctctgcccc ctgggccagg gtgtgtttcc cccaccctcc ctcagtagca
     1261 atgagctact cgggccagat gggggcctgt tgcatgggct gggaggcccc tgtgaaggag
     1321 agggtgggga gggaggcatc tagggagagg ggtcccccat ggtggctccc ctccctggcc
     1381 attgttatcc caggaggaga cactgtgggc acagggctaa gtccaggtgt ttgtattcgg
     1441 gctagaaaag gcaatgtccc aagtctctgc tgcctgtcac agtccttcag ccagggctgg
     1501 acctcaaccc tgaggagtca cactgagttc cagtgaccac cgtggtggtg gccatgccac
     1561 tcatggttgc tatggccgga aggcctgggg cagcctcctc caagccgctc gcaccccgta
     1621 ggtgcccatc cgctgctggc gcaagtgctg gccgaagatg aagcagagca ggacagatgt
     1681 cacgaacagg gacagcaaca ccgacaccac cgtgactatg atgaccatct ggctgtccga
     1741 cacaggctct ggggagggag ggggcaaggg tcttagacgt cctgtgatcc cagttaccag
     1801 ggaccaaaag ggagtggaag tccaccccca acccagaccc ccagaccccg ccgcccgctc
     1861 atgcatccag cagtcacccc agttgcagag atgagtggtg aatggtgtct gcattaaaat
     1921 tattatctgg aaaaaaggtg gcccagggct caggctacca gctggacttc tgtgtggctg
     1981 tgagggcaga tgtccccttg tcagcagcca tgggaccagt gtgtagctgc tggacaccgt
     2041 ggcctggagg gtggcatggt cccagccaag ccccttcttg ggcagagctg agtgaacttc
     2101 atgccaggct ccctgtgtgc cggccgtcca gggtcaccaa gcagcagagc tctggggacc
     2161 tcagtggggg cagtcaggcc aaacttctca ttgtggaggg gagccaaggc cagggagagc
     2221 cgtcaaggtc atggggcttg atggtggccg aggaactagt tgacctctcc cgacctctgg
     2281 agcagttgag gtccaagctg gggacttgga aagaacttca gggaagaggg agagtaagag
     2341 ggaagcctca ggatgaaggg tgggctcctg ggtgtttgct tcccaagtgg gactcaagat
     2401 ttttcttccc ccgaggggct gaaagtgact tatcactccc aactccatcc acggatcccc
     2461 cctcaccata gatctccaac atcttcgggg ctgagtgttt gtgaaagatg ttgccaccgc
     2521 gagacatcaa gtccagcaca gccaggcagg agaagttgcg gtggccatcc tctctgtcag
     2581 ccgtgctgtt gaatgtggct gtggcctcct gcggagcagg ggctgccttc ccgaaggtct
     2641 catagtgcag agtctcattg ccacggaaca ggaagagggt gaggctgtcc aggggctcca
     2701 cggtgggcac cctgcactca atggtgaagg acttgcccac agccaccaaa gtgggttgca
     2761 gtgtcaggat gacctgcctt ggaggctctg caggggacaa aggagggagg tctggtcagg
     2821 atgggggtgc agtcccagca gcctccccct ggccagggcc atctcctgtc accatggtgt
     2881 tccacggttg gggaggaggt ggcctggccg gctccagtgc agagaggaag agggcagcag
     2941 ttgaggatgg aggctggact gtgtggtagt tttacagaca tgatggtttc cggtgaccag
     3001 gtgtctacaa ggacaaggtt cagaaattgt acagccaact ggaaagatat aaaagtttgg
     3061 gtctgtctcc tctccttcag aaatgaaata taaatttcaa acattaaaca gttgggtgat
     3121 cacgttga
//
