LOCUS       NM_214711               4747 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens proline rich 27 (PRR27), mRNA.
ACCESSION   NM_214711
VERSION     NM_214711.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4747)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX485867.1, BX640892.1, BX647183.1, BX648872.1, BX647185.1,
            BX648896.1 and AC104811.4.
            
            On May 17, 2019 this sequence version replaced NM_214711.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648895.1, BX648724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344526.10/ ENSP00000343172.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BX485867.1         48-84
            38-1178             BX640892.1         1-1141
            1179-1467           BX647183.1         1053-1341
            1468-2035           BX648872.1         1391-1958
            2036-2430           BX647185.1         2015-2409
            2431-2769           BX648896.1         2365-2703
            2770-3466           BX647183.1         2639-3335
            3467-3467           AC104811.4         67884-67884
            3468-4747           BX647183.1         3337-4616
FEATURES             Location/Qualifiers
     source          1..4747
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..4747
                     /gene="PRR27"
                     /gene_synonym="C4orf40"
                     /note="proline rich 27"
                     /db_xref="GeneID:401137"
                     /db_xref="HGNC:HGNC:33193"
     exon            1..190
                     /gene="PRR27"
                     /gene_synonym="C4orf40"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..799
                     /gene="PRR27"
                     /gene_synonym="C4orf40"
                     /note="proline-rich protein 27"
                     /codon_start=1
                     /product="proline-rich protein 27 precursor"
                     /protein_id="NP_999876.2"
                     /db_xref="CCDS:CCDS3535.1"
                     /db_xref="GeneID:401137"
                     /db_xref="HGNC:HGNC:33193"
                     /translation="MKLLLWACIVCVAFARKRRFPFIGEDDNDDGHPLHPSLNIPYGI
                     RNLPPPLYYRPVNTVPSYPGNTYTDTGLPSYPWILTSPGFPYVYHIRGFPLATQLNVP
                     PLPPRGFPFVPPSRFFSAAAAPAAPPIAAEPAAAAPLTATPVAAEPAAGAPVAAEPAA
                     EAPVGAEPAAEAPVAAEPAAEAPVGVEPAAEEPSPAEPATAKPAAPEPHPSPSLEQAN
                     Q"
     exon            191..214
                     /gene="PRR27"
                     /gene_synonym="C4orf40"
                     /inference="alignment:Splign:2.1.0"
     exon            215..787
                     /gene="PRR27"
                     /gene_synonym="C4orf40"
                     /inference="alignment:Splign:2.1.0"
     exon            788..832
                     /gene="PRR27"
                     /gene_synonym="C4orf40"
                     /inference="alignment:Splign:2.1.0"
     exon            833..4747
                     /gene="PRR27"
                     /gene_synonym="C4orf40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      994..999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR27"
                     /gene_synonym="C4orf40"
                     /note="hexamer: AATAAA"
     polyA_site      1013
                     /gene="PRR27"
                     /gene_synonym="C4orf40"
                     /note="major polyA site"
ORIGIN      
        1 aagggtcttc ctagacagac taaaaaagcc atgtattctt tcgtttctct ctaaaagaag
       61 aaaaatataa tttaaaaata cattgcgtat tttctaaaac aataaattta tagtgttaat
      121 attcataggg tcaatcaaaa tgaagcttct cctttgggcc tgcattgtat gtgttgcttt
      181 tgcaaggaag agacggttcc ccttcattgg tgaggatgac aatgacgatg gtcacccact
      241 tcatccatct ctgaatattc cttatggcat acggaattta ccacctcctc tttattatcg
      301 cccagtgaat acagtcccca gttaccctgg gaatacttac actgacacag ggttaccttc
      361 gtatccctgg attctaactt ctcctggatt cccctatgtc tatcacatcc gtggttttcc
      421 cttagctact cagttgaatg ttcctcctct ccctcctagg ggtttcccgt ttgtccctcc
      481 ttcaaggttt ttttcagcag ctgcagcacc cgctgcccca cctattgcag ctgagcctgc
      541 tgcagctgca cctcttacag ccacacctgt agcagctgag cctgctgcag gggcccctgt
      601 tgcagctgag cctgctgcag aggcacctgt tggagctgag cctgctgcag aggcacctgt
      661 tgcagctgag cctgctgcag aggcacctgt tggagtggag ccagctgcag aggaaccttc
      721 accagctgag cctgctacag ccaagcctgc tgccccagaa cctcaccctt ctccctctct
      781 tgaacaggca aatcagtgaa attctctaga agagtaccat gggttcattt ctatactgat
      841 gcagaaataa gtgaaatcta caaaagtttt ctttcttttc caaagactat ttcattctgt
      901 tgtattcaga gtattcatct cactacattg atttgtttgt ggtagttttt ccttggactt
      961 aatttatatt gaaaaaacat tgataattaa ataaataaaa tagataattt agaccaatgg
     1021 tgataaggtc tggatgaaaa ctacgctatg gaggactgaa atggcaatca ttcagcctag
     1081 cctggagtct gattatacag ctactatagg atgatgttag tattggtttt gagtgcaata
     1141 ggttttttcc taaacaaaca tattttgtag tcaatgaact ttttgtcaca aaacagtaaa
     1201 acatctgtgt ttaacctatg gtaaacaaca tgttaatgaa ctatgctatc catgacttaa
     1261 tggacagttc aaatgtgaca tctacagttt ttcatttctc ttttatgcca gcacacaatc
     1321 aattcatcac caattgtcat ttgatttact tcaaaaaata tacccccaaa tcctaatact
     1381 tctaaccttc tccactgcat ctagccaact ctagctattg tcatccctaa cagaaatgga
     1441 ggaatagcct cttttttttt tttttttttt gagacgaagt ctcacactgt tgcacggctg
     1501 tagtgcaatg gtgccaactc agctcactgc aacttccacc tcccgggttc aagtgattct
     1561 cctgcctcag cctcctgagt agccgggatt acaggtgtgt gccaccacgc ctggctaatt
     1621 ttttgtaatt tagtacagac aggggttccc tatgttggcc aggatggtct tgatctcctg
     1681 acctcatgat ctgtccgcct cggcctccca aagtgctggg aatacaggcg tgagccaccg
     1741 tgccctgcca gaatagccta ttaaccagtc tacctgcttc cacttttcct ccaccctgat
     1801 cacatacaca catgcattat ccactgagca gtcacaatca gatgttaaac caaacattat
     1861 tcagataaga tctctgaaaa gcctctgata ctttctcttt taaaatggaa tatattctaa
     1921 acacctctcc aaggacacaa gacttacctt gtctaactaa tgacttttct aacttcattc
     1981 cctatcattc tccatcttgc cccatgctcc tcatgcagca gctttttttt ttttttcctt
     2041 tttcaaatat gttggttttg atcttatcca agaacctttg ccctgatgta tgaatgacta
     2101 actgcttttc tacttcgggg gtctcatata gaaatcctgc ttcagaatac tcttccctga
     2161 gcactctatc taaataaatc cctcttctgc aacccagtgc tttttgttct attactgact
     2221 tcttttcctt gtagaagtta ctattactgc tttttacctt tttatttatt tgtgtattgt
     2281 ctttgttgtt gccctcatct tatctccaca aaaatatatg ctccataaaa acaggcattt
     2341 ctgtgtctta ttcagcactt tatcagggcc tataacaatg cctgggacat attcagtgac
     2401 cagtgaatat ttttggaagg aaagaaaaga agaaagaatg aagtaacaaa caaagaatga
     2461 aggaagaaaa aatttttaca aacattcaac atatttttat tttgaaataa ttttgtattt
     2521 ttccctatat cctacattgg atcagaatat tactgttatg tatagccatg aggacatggt
     2581 ctcaaaaaat gagaaacttt cttagacagt aaaattgtta acttgagatg tttgcttcca
     2641 tcttctagag ccaagtagga tctaacttta atttgactta gccaataatc tgaaactatt
     2701 atagtatctg tctttcacag atacatgcaa tattcacttc taaatattta atgataaatt
     2761 tgtaatcata catgatagtc aattttaatg attatgttgt caaaattcag gctttttgtg
     2821 tgaattgaag acttaaagaa gaatttgtaa atatgactgt ataagaaaca acagaaagat
     2881 gaagatgaac cgaaatagaa atatcaagag gctacaaagt cttagcaaat tataattgct
     2941 aatggtacat tatgtggtgt ttagtatcac atttagaatg tagtcatttg ttaagttttt
     3001 catggggtaa aagaaagaat ttattccaag aaaattttgg aattttaaaa ataaacatga
     3061 catcttatca tgagaaacat ttacagtttt tgcttttact acaagatact gtgaaatgtt
     3121 ctgctctgtc agttgtgaaa gtatgaaatt taagtctatc actacaataa tattttgttt
     3181 ttagtgttca tttttttcct cctgactaca ttgagatgag ttagattgag tgaaaggtaa
     3241 acactaacat ttgaattgag gtaatttcca ctgtggaaaa caaactgttg ttagtaaaca
     3301 ggcatcagct ttgagacaca gaaaagtcat ccaaaccaga agattgggaa cttcctcaat
     3361 tactttgtct tccatttatt gcattcaatt agtcaaaaat gttgttaatt atacatttta
     3421 aagactattt ttggtaaggt ctatgacaca ttcaaaatac tacatacaag tttgtattat
     3481 cataaataat ccaaaagaaa acatacatgt aaccaccacc atctggaaat ttcacactaa
     3541 attataaaac atttccatca ctgcatgtat tgtttaatgt cgctttatga atccaccttc
     3601 ttccttatct gtagagttaa aaactactta gtggattagg gtaattcatt ctacttttaa
     3661 aaatgatttt tccacctcta atgtattcta taaaataata ttgttcactt ttgcctattt
     3721 ttgagctttt tatagaaaaa tgctactgcg aaattatttt gagtcatatc ttttgatcga
     3781 tattaagata catttgcaga gttttgtatg tgtgtttata tccatcttac ataattcttt
     3841 actgtatagc gttcccttta gccactggaa aatgatataa tgtcattgct tacagaaggt
     3901 gactgattct tattcagtgc tactttctac agacaggtaa ctattcgcat ttacgattaa
     3961 gaaatgttca caccttcaca ctggtatcaa ctgcaacaac cactatactt ctccagtgat
     4021 tgccagatgg cccactatac atcctttctt ctatttcttt cttttgtggc cagaaagtca
     4081 ggacctcaaa gaggtataag tttgtgtgta taattccctg gcttttttct aaaattttag
     4141 tatgcattta tgtggcactt aatatataaa agagttttat gagttttaaa aatgtatata
     4201 aacaagacat ataataaatg gtatgtcatt tcacaattta ctatttttac tcaacattta
     4261 tatttctgag acttttcaca tttttgaatg tattcatagt ttcactttaa ttgatgtttg
     4321 ccatgaaaga tcaaatatat cacattttat ttgactaaaa agtaaactat atttcctaca
     4381 ttatgctata gaacttatag actaatttaa gttaattata ggccttatct cagacctttg
     4441 caagtagcct gaataaaact tttcattatt tatattatca catgcatata tgtgtgtatg
     4501 tatatatgtg tgcatgtgca tgcatagtaa aaatcttaac ccaaaactga aataaaaaat
     4561 tataagagaa aatactattt tccaccaata tcacaatgga taatcttttt taaatgacta
     4621 catatgtcga taagttacaa aatccatata tgagtatgac accaataaga acattttctc
     4681 taaccatttt gaatacgaat aaccatggat tctaatagca aacattatta aaatattatt
     4741 gaaataa
//
