LOCUS       NM_001134316            1373 bp    mRNA    linear   PRI 07-SEP-2020
DEFINITION  Homo sapiens proline rich 22 (PRR22), mRNA.
ACCESSION   NM_001134316
VERSION     NM_001134316.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1373)
  AUTHORS   Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu
            C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J and Stanton
            LW.
  TITLE     Transcriptome characterization elucidates signaling networks that
            control human ES cell growth and differentiation
  JOURNAL   Nat. Biotechnol. 22 (6), 707-716 (2004)
   PUBMED   15146197
REFERENCE   2  (bases 1 to 1373)
  AUTHORS   Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD,
            Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg
            B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T,
            Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin
            GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL,
            Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P,
            Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy
            SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH,
            Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW,
            Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J,
            Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M,
            Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW,
            Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J,
            Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U,
            Smailus DE, Schnerch A, Schein JE, Jones SJ and Marra MA.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN370733.1 and BC008985.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001134316.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279874.1984.1, CN370733.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000419421.3/ ENSP00000407653.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-546               CN370733.1         20-565
            547-1373            BC008985.1         814-1640
FEATURES             Location/Qualifiers
     source          1..1373
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1373
                     /gene="PRR22"
                     /note="proline rich 22"
                     /db_xref="GeneID:163154"
                     /db_xref="HGNC:HGNC:28354"
     exon            1..216
                     /gene="PRR22"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1355
                     /gene="PRR22"
                     /codon_start=1
                     /product="proline-rich protein 22"
                     /protein_id="NP_001127788.1"
                     /db_xref="CCDS:CCDS45933.1"
                     /db_xref="GeneID:163154"
                     /db_xref="HGNC:HGNC:28354"
                     /translation="MQHPKPFCAPAAPQEGFSPQSLEGAEVLGNQPAPTCAEPPPAMG
                     SLNLYHPPDPEKEVFPAPPAGFQMAPCGCFFDPRIYRIEWTTPDLGQSALYKLAASSG
                     GPAGVPSAPGSYLLEPQPYLKAPGLPPYPHYQQAPGGPQFLLPYFPPEGPGPEALGFV
                     GDAGPAAFVELPLPPLEEGPAPLPPPPPKENKPPPVLITLPAEPTLPPDAYSHLQGHL
                     GHFPGPEPLAFPVKELQGSGARPGVPLYPPGLSELKVAEVKEGALLGAGKAKAPKTAR
                     ALALPDKVLLEDAMKLFDCLPGASEPEGTLCEVPGPALPDSSGGNSADDIRSLCLPEE
                     LLSFDYSVPEILDTVSNVDYFFNFKALDEEQPPHPGPPATNTPAPILSGKRKASTAKK
                     GKPGRKARQPAGPASATPPGPREDLGATPH"
     exon            217..279
                     /gene="PRR22"
                     /inference="alignment:Splign:2.1.0"
     exon            280..1373
                     /gene="PRR22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1351..1356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR22"
                     /note="hexamer: ATTAAA"
     polyA_site      1373
                     /gene="PRR22"
                     /note="major polyA site"
ORIGIN      
        1 aggttctcag cctgttctcc ggttgggcca cttgcactcc cactgccgcc ctcctggcct
       61 gtctggaccg ggccccccgc tgccccatgc agcaccccaa accgttctgt gcccctgcag
      121 ctccccagga aggtttcagc ccgcagagtc tggagggggc tgaggtgctg ggcaaccagc
      181 ctgctcccac ctgtgccgag cctcctcccg ctatgggctc cttgaacctg tatcatcccc
      241 cagacccaga gaaagaggtg tttccagccc caccagcagg tttccagatg gccccatgcg
      301 ggtgcttctt cgacccccgc atctatcgga tcgagtggac cacccccgac ctgggccagt
      361 cagccctgta taagctggca gcaagcagcg gggggccagc gggggtcccc tccgccccag
      421 gcagctacct cctggagcct cagccctacc tcaaggcccc ggggctgcct ccataccccc
      481 actaccagca ggcacccggg gggccccagt ttctcttgcc ctacttcccg cctgagggcc
      541 ccgggccaga ggctctgggt tttgtggggg acgcagggcc cgccgccttc gtggagctgc
      601 ccctaccgcc cctagaggaa ggcccggccc cgctgccacc cccacccccc aaggagaaca
      661 agccgccccc tgtactcatc acgctgcctg cagagcccac actgccccca gacgcctaca
      721 gccacctcca gggtcacctc ggccacttcc ctgggcccga acccctggcc ttccccgtca
      781 aggagctgca gggcagtggg gcccgacctg gggtgcccct gtacccaccg ggcctcagcg
      841 agctcaaggt ggccgaggtc aaggaggggg ccctgctggg agcaggcaag gccaaggccc
      901 ccaagacggc cagagctttg gcactgcctg acaaggttct gctggaggac gccatgaagc
      961 tcttcgactg cctgccaggc gcctctgagc ctgagggtac cctgtgcgag gtccctgggc
     1021 cggccctgcc tgacagcagt ggtgggaact cagccgatga catccgctcg ctgtgcctgc
     1081 ccgaggagct gctgtccttt gactacagcg tgcctgagat cctggacacc gtgtccaacg
     1141 ttgactactt cttcaacttc aaggcgctcg acgaggagca gccgccccac ccggggcccc
     1201 ctgccaccaa caccccggcc cccattctgt ctggcaagag aaaggcctcg acggccaaga
     1261 agggaaagcc gggaaggaag gccaggcagc cggcaggccc agccagcgcc actcccccgg
     1321 ggcccaggga ggacctggga gccaccccgc attaaagcac atttgacctt tca
//
