LOCUS       NM_175922               3093 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens proline rich 18 (PRR18), mRNA.
ACCESSION   NM_175922
VERSION     NM_175922.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3093)
  AUTHORS   Huang,J.W., Acharya,A., Taglialatela,A., Nambiar,T.S.,
            Cuella-Martin,R., Leuzzi,G., Hayward,S.B., Joseph,S.A.,
            Brunette,G.J., Anand,R., Soni,R.K., Clark,N.L., Bernstein,K.A.,
            Cejka,P. and Ciccia,A.
  TITLE     MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and
            homologous recombination upon DNA damage
  JOURNAL   Nat Commun 11 (1), 2948 (2020)
   PUBMED   32528060
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3093)
  AUTHORS   Pandey,A.K., Lu,L., Wang,X., Homayouni,R. and Williams,R.W.
  TITLE     Functionally enigmatic genes: a case study of the brain ignorome
  JOURNAL   PLoS One 9 (2), e88889 (2014)
   PUBMED   24523945
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3093)
  AUTHORS   Yashin,A.I., Wu,D., Arbeev,K.G. and Ukraintseva,S.V.
  TITLE     Joint influence of small-effect genetic variants on human longevity
  JOURNAL   Aging (Albany NY) 2 (9), 612-620 (2010)
   PUBMED   20834067
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121956.21 and BC034775.1.
            
            On Nov 22, 2018 this sequence version replaced NM_175922.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC034775.1, ERR279845.1878.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322583.5/ ENSP00000319590.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL121956.21        31921-31929
            10-456              BC034775.1         1-447
            457-2713            AL121956.21        32377-34633
            2714-3093           AL121956.21        34634-35013
FEATURES             Location/Qualifiers
     source          1..3093
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..3093
                     /gene="PRR18"
                     /note="proline rich 18"
                     /db_xref="GeneID:285800"
                     /db_xref="HGNC:HGNC:28574"
     exon            1..3093
                     /gene="PRR18"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..1138
                     /gene="PRR18"
                     /note="proline rich region 18"
                     /codon_start=1
                     /product="proline-rich protein 18"
                     /protein_id="NP_787118.2"
                     /db_xref="CCDS:CCDS5291.1"
                     /db_xref="GeneID:285800"
                     /db_xref="HGNC:HGNC:28574"
                     /translation="MPFPPMPPPPAPAPGAQAARQLPRRPCAAGDKKKRPPQRPEGLL
                     SSSWPSATLKRPPARRGPGLDRTQPPAPPGVSPQALPSRARAPATCAPPRPAGSGHSP
                     ARTTYAATSAGTGTTAAGTSSGAGPCPDSAARFCLNLTPEAVLVIQKRHLEKQLLARP
                     RRPFPSPSAEPRRLLAPCLPARAAGPRRGGPASDPDAPPTAGQGRRAPPPGAQLLHGG
                     LQVPQLSPRPGALRPMLKVSLLNERHRYDDVEYEEEPEAVDEGLVRKCTEWLRGVESA
                     AAARGRAGALDSRRHLSTL"
     regulatory      2957..2962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR18"
                     /note="hexamer: AATAAA"
     polyA_site      2978
                     /gene="PRR18"
     regulatory      3073..3078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR18"
                     /note="hexamer: AATAAA"
     polyA_site      3093
                     /gene="PRR18"
                     /note="major polyA site"
ORIGIN      
        1 agtcggacgg cgggaggcgg ttcctgcagg gtccagtccc gggagcaccc ccaggaggag
       61 gggagggtgg gagcgcctct ctttgagtcc ccgggtttgg tcgctgggat gtgaggaagc
      121 cggagaggcc gcggctggac gcaggtgggt gtggaggggc cgcccggact gcggggaccc
      181 gctccgcgca cagtggctga gcgcccgcct ctctttccag gggctgagga tccggcggct
      241 cggctgcact atgcccttcc cgcccatgcc gccgccgccc gcccccgccc cgggggccca
      301 agccgcgcgc cagttacccc ggaggccctg cgccgcgggg gacaagaaga agaggccccc
      361 acagcggccc gaggggctcc tctccagctc ctggccctcc gccacgctca agaggccgcc
      421 ggcccggcgc ggccccggcc tggacaggac gcagccgccg gcccctccgg gcgtctcccc
      481 ccaggccttg cccagccgcg cgcgggcccc agccacgtgc gccccgcccc ggccggcagg
      541 ctccggccac agcccagcga ggaccaccta tgcggcgacc tcggcgggga cggggaccac
      601 cgccgcgggc acctcctcgg gggcggggcc ttgtccagac tccgctgcgc gcttctgcct
      661 gaatctcacc cccgaggccg tcctggtcat ccagaagcgt catctggaga agcagctgct
      721 ggcgcggccc cgcaggccct tcccctcacc ctcggccgaa cccaggcgcc tactcgcccc
      781 gtgtctcccg gctagggccg cgggcccgcg gaggggcggc cccgccagcg accccgacgc
      841 accccccacc gccggccagg gccgccgcgc gcctccgccc ggcgcccagc tgctgcacgg
      901 cggcctgcag gttccccagc tcagcccgcg gcccggggcc ctgcggccga tgctcaaggt
      961 gtcgctgctc aacgagcggc acaggtacga cgacgtggag tacgaggagg agccagaggc
     1021 ggtggacgag ggcctggtac gcaagtgcac ggagtggctg cgcggcgtgg agtccgcggc
     1081 tgccgcgcgg ggccgggcgg gggccctgga ctcacggcgg cacctgagca cgctgtgagc
     1141 ccagcgggcc tgcggggaca ggccaggcct gatcccacct cacttcctgc acgcgccact
     1201 ccgcctaggg gccctcgggg gagaccgcag gctcctctgg ccgccagcgc ccactttcgg
     1261 gacaccagtg cgcaagctgg cccacgtggg gcgcagccag actcgcccga cggccacggc
     1321 ccccctcctg ccctcgccag ccggcagccc gggcctttct cgttcacacc ggtggtatct
     1381 accccagatg cctgcctctg cccccactct ggcctcctct tggcatcgcc gagcatccat
     1441 gcagttcgtg gggaattaag caactgagaa aatgcctctt ggtgccccga cccccagggt
     1501 tcgtctaggt cccagagacc ctctgcctgg aggcgggcct tccccagggc tacatctgca
     1561 cgccccgtgg tgtcaccctc agccggcgcc gggcaccctg gacagtgcgg tgggcgatgg
     1621 cccaggtggg tggccgcgac ggtggcctcc tgcagagctg ggacccggtc ctacattcgt
     1681 gattttgttt tctcccaagt cagaaaaatg ttgagggtat tagacatccc tgaaactcag
     1741 ttaaccgaat ttccagtctc caaagcggaa gggtaggcat cgccaggcgc tggtgagccc
     1801 tggtcaatga gcgcttccat ggaaaccgct cggctgatta cattttttct gtgtattatt
     1861 tgaatagaga gtaaagctcc tccgctgttt cgtaaccata tcctttcccc cgctaactgg
     1921 aggctgattt ctacatattt cttccatgta tctgagaata tctaactaga aggatgagaa
     1981 ggaaataaaa tgttataatc agataaggct ggttataaaa gagtaatgta ttacctcaat
     2041 ttttgactga ctttgtaaaa gccaataact ggtttaatgt ttatcttgat agactttaaa
     2101 tgtatcaagt cttaattgta ttttaaattg aagccttaca tttttaaaac agattttgta
     2161 tttttcttgt ggaggtcttt gctctaataa cacacacaca ctgtctctct ctctctctct
     2221 ctctaattct aggcacacat ttagttagat gtgaagcatt taattcattg ggagctaggt
     2281 cagctgccag atgagttgca aaaacagaaa aaaacctacc cattgaataa cttctttgaa
     2341 tttggagata agttttcttt tacttaaaat gaatatatta attctagagg ggcaaaacta
     2401 gcaatgctta tgcaagtgac ggtgctgctc ttgttccacc cccacccaga tggtctctga
     2461 gtgcgccgtc ctgggcaggg cacacggtct ggagctgaga gggtggagca agagtgcact
     2521 gactccgagc cgagggcagg agtggctcaa cttggtctcg tcttgcactt agtgcaaata
     2581 ccaataatta agatgcctag acttctgccc ttggtcacag taacaacaac attttgaaga
     2641 cttttccctg gtggcatcct agagggaccg actttctgca gcctctgtct tccaagctga
     2701 gcttctgctg cagtgtggct gtcactgcac ctgtgtgtct ccctgacgtc cctgtcagct
     2761 gcttcatttt gatttccttt cttctcccgc cctttctgta ggctctgtcc cagcatctcc
     2821 tgttcttaac tggccacaat acaacactaa gcgcattttt agtaatttgt atttattaaa
     2881 tagagtttgt gggccttgtt ctctacttta aaagcagatg agtggaacat ttatgtttcc
     2941 ctggtcaatg agcttcaata aaaaacaaac agaaaaaagg ttttacacgt gacacatgat
     3001 atcttttcat tgctgttaag gacattttga gaaagttttc taagtcgcta tgctccaatt
     3061 tcttaatgct taaataaaag agaaattcag tga
//
