LOCUS       NM_024320               1524 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens proline rich 15 like (PRR15L), mRNA.
ACCESSION   NM_024320
VERSION     NM_024320.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1524)
  AUTHORS   Steffens,M., Leu,C., Ruppert,A.K., Zara,F., Striano,P.,
            Robbiano,A., Capovilla,G., Tinuper,P., Gambardella,A., Bianchi,A.,
            La Neve,A., Crichiutti,G., de Kovel,C.G., Kasteleijn-Nolst
            Trenite,D., de Haan,G.J., Lindhout,D., Gaus,V., Schmitz,B.,
            Janz,D., Weber,Y.G., Becker,F., Lerche,H., Steinhoff,B.J.,
            Kleefuss-Lie,A.A., Kunz,W.S., Surges,R., Elger,C.E., Muhle,H., von
            Spiczak,S., Ostertag,P., Helbig,I., Stephani,U., Moller,R.S.,
            Hjalgrim,H., Dibbens,L.M., Bellows,S., Oliver,K., Mullen,S.,
            Scheffer,I.E., Berkovic,S.F., Everett,K.V., Gardiner,M.R.,
            Marini,C., Guerrini,R., Lehesjoki,A.E., Siren,A., Guipponi,M.,
            Malafosse,A., Thomas,P., Nabbout,R., Baulac,S., Leguern,E.,
            Guerrero,R., Serratosa,J.M., Reif,P.S., Rosenow,F., Morzinger,M.,
            Feucht,M., Zimprich,F., Kapser,C., Schankin,C.J., Suls,A.,
            Smets,K., De Jonghe,P., Jordanova,A., Caglayan,H., Yapici,Z.,
            Yalcin,D.A., Baykan,B., Bebek,N., Ozbek,U., Gieger,C.,
            Wichmann,H.E., Balschun,T., Ellinghaus,D., Franke,A., Meesters,C.,
            Becker,T., Wienker,T.F., Hempelmann,A., Schulz,H., Ruschendorf,F.,
            Leber,M., Pauck,S.M., Trucks,H., Toliat,M.R., Nurnberg,P.,
            Avanzini,G., Koeleman,B.P. and Sander,T.
  CONSRTM   EPICURE Consortium; EMINet Consortium
  TITLE     Genome-wide association analysis of genetic generalized epilepsies
            implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
  JOURNAL   Hum Mol Genet 21 (24), 5359-5372 (2012)
   PUBMED   22949513
REFERENCE   2  (bases 1 to 1524)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018521.8, BM829856.1, BM831136.1, AA707319.1 and AA916635.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024320.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002865.2, ERR279830.1252.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300557.3/ ENSP00000300557.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC018521.8         39335-39340
            7-611               BM829856.1         1-605
            612-888             BM831136.1         268-544
            889-1424            AA707319.1         3-538               c
            1425-1524           AA916635.1         13-112              c
FEATURES             Location/Qualifiers
     source          1..1524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..1524
                     /gene="PRR15L"
                     /gene_synonym="ATAD4"
                     /note="proline rich 15 like"
                     /db_xref="GeneID:79170"
                     /db_xref="HGNC:HGNC:28149"
     exon            1..227
                     /gene="PRR15L"
                     /gene_synonym="ATAD4"
                     /inference="alignment:Splign:2.1.0"
     exon            228..1524
                     /gene="PRR15L"
                     /gene_synonym="ATAD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..568
                     /gene="PRR15L"
                     /gene_synonym="ATAD4"
                     /note="ATPase family, AAA domain containing 4; testicular
                     tissue protein Li 157"
                     /codon_start=1
                     /product="proline-rich protein 15-like protein"
                     /protein_id="NP_077296.1"
                     /db_xref="CCDS:CCDS11523.1"
                     /db_xref="GeneID:79170"
                     /db_xref="HGNC:HGNC:28149"
                     /translation="MTTEIGWWKLTFLRKKKSTPKVLYEIPDTYAQTEGDAEPPRPDA
                     GGPNSDFNTRLEKIVDKSTKGKHVKVSNSGRFKEKKKVRATLAENPNLFDDHEEGRSS
                     K"
     regulatory      1500..1505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR15L"
                     /gene_synonym="ATAD4"
                     /note="hexamer: AGTAAA"
     polyA_site      1524
                     /gene="PRR15L"
                     /gene_synonym="ATAD4"
                     /note="major polyA site"
ORIGIN      
        1 accttgactc caggagctgc agcagagcag gtaacagctc ttgcacctgt ttctcttgca
       61 cctgacgtgc agctgctcct acccacctct cctggctgag ccttgcctga tacagcagcc
      121 cggaggcacc acttgcttcc cgagtctcac cctcccaggc agctcctaca ctcaactgct
      181 tctctaggaa aggtctcacc tccagcctgg agcagtcggg attacagaaa gccccatcct
      241 tggcttaggg agcgccatga cgactgaaat tggttggtgg aagctgactt tcctccggaa
      301 aaagaaatcc actcccaaag tgctgtatga gatccctgac acctatgccc aaacagaggg
      361 agatgcagaa cccccgaggc ctgacgctgg aggccccaac agcgacttta acacccgcct
      421 ggagaagatt gtggacaaga gcacaaaggg caagcacgtc aaggtctcca actcaggacg
      481 cttcaaggag aagaagaaag tgagagccac gctggcagag aaccctaacc tctttgatga
      541 tcacgaggaa ggacggtcat caaagtgaag ggctgaggag ggtgctagca cctcttggct
      601 ccctgccatc agccagatct gagacaggac cttgccacgc tggcctcttt ggccatagct
      661 gaagctgtgg ggccagttga tacctgctgg caggaaatgg ctgtttttta ggtttgtatt
      721 tatgtgccgc cacttttgta aggcctggga gatcccaggg tcctccaccc tccccctgac
      781 cacatacaaa ggcactctag ttcaagagtg aaaagtctca cccaggagga acagccctcc
      841 ttgaagcaat ggcagggcca gcagggaggt gggcatggca gggaatggag agagtgagcc
      901 agacagactt cacctcctta ctggacacag ggtcaagggc gagtttcaat tgctgctccc
      961 tttactttct ctacctgtga ctactccctg gaccaatcct gaggagggca cattttccag
     1021 aagccacgtg ataggggctg gtttctgtgg agccagaggc agagacactg aacttgagct
     1081 cacctcctaa caccggcagt aaacttcctg gaactttgcc ctcaggtgcg gaggggacag
     1141 aggaccctgg cactctgtta gggtgctgta gaagactaga ttgatggtag tttggcctgt
     1201 tagttcctgt tttggccatg acttttgcag atggcaagtc acacaccctc aaagggaagc
     1261 tacacgggcc aaatcggggg agtgggtggg gaattttctc ctctcccttt cctactataa
     1321 tagtatttaa gacatatcag ctccagagat gagtcctgga gccttgaatt ttgtttaaca
     1381 aaataattgt aggtttctct ctgtaataac aacgctggaa aggcagagaa cctcttttat
     1441 gctcatgtct tgcatttatt gagatgactg tttctcatgc ctttatgttc cttcatgtaa
     1501 gtaaagtgga cctttgtgct caaa
//
