LOCUS       NM_175887               1652 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens proline rich 15 (PRR15), transcript variant 1, mRNA.
ACCESSION   NM_175887
VERSION     NM_175887.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1652)
  AUTHORS   Guo,F., Ma,J., Li,C., Liu,S., Wu,W., Li,C., Wang,J., Wang,J.,
            Li,Z., Zhai,J., Sun,F., Zhou,Y., Guo,C., Qian,H. and Xu,B.
  TITLE     PRR15 deficiency facilitates malignant progression by mediating
            PI3K/Akt signaling and predicts clinical prognosis in
            triple-negative rather than non-triple-negative breast cancer
  JOURNAL   Cell Death Dis 14 (4), 272 (2023)
   PUBMED   37072408
  REMARK    GeneRIF: PRR15 deficiency facilitates malignant progression by
            mediating PI3K/Akt signaling and predicts clinical prognosis in
            triple-negative rather than non-triple-negative breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1652)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1652)
  AUTHORS   Gates,K.C., Goetzmann,L.N., Cantlon,J.D., Jeckel,K.M. and
            Anthony,R.V.
  TITLE     Effect of proline rich 15-deficiency on trophoblast viability and
            survival
  JOURNAL   PLoS One 12 (4), e0174976 (2017)
   PUBMED   28380025
  REMARK    GeneRIF: enhances trophoblast viability and survival during early
            implantation and placentation
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1652)
  AUTHORS   Meunier,D., Patra,K., Smits,R., Hagebarth,A., Luttges,A.,
            Jaussi,R., Wieduwilt,M.J., Quintanilla-Fend,L., Himmelbauer,H.,
            Fodde,R. and Fundele,R.H.
  TITLE     Expression analysis of proline rich 15 (Prr15) in mouse and human
            gastrointestinal tumors
  JOURNAL   Mol Carcinog 50 (1), 8-15 (2011)
   PUBMED   21061267
REFERENCE   5  (bases 1 to 1652)
  AUTHORS   Purcell,S.H., Cantlon,J.D., Wright,C.D., Henkes,L.E., Seidel,G.E.
            Jr. and Anthony,R.V.
  TITLE     The involvement of proline-rich 15 in early conceptus development
            in sheep
  JOURNAL   Biol Reprod 81 (6), 1112-1121 (2009)
   PUBMED   19605793
  REMARK    GeneRIF: Proline-rich 15 is required for conceptus elongation and
            survival during early ovine pregnancy.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC029131.1.
            
            On Nov 23, 2018 this sequence version replaced NM_175887.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All three variants encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018144.1, BC029131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319694.3/ ENSP00000317836.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1652              BC029131.1         25-1676
FEATURES             Location/Qualifiers
     source          1..1652
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..1652
                     /gene="PRR15"
                     /note="proline rich 15"
                     /db_xref="GeneID:222171"
                     /db_xref="HGNC:HGNC:22310"
                     /db_xref="MIM:618344"
     exon            1..543
                     /gene="PRR15"
                     /inference="alignment:Splign:2.1.0"
     exon            544..1652
                     /gene="PRR15"
                     /inference="alignment:Splign:2.1.0"
     CDS             689..1078
                     /gene="PRR15"
                     /codon_start=1
                     /product="proline-rich protein 15"
                     /protein_id="NP_787083.1"
                     /db_xref="CCDS:CCDS5421.1"
                     /db_xref="GeneID:222171"
                     /db_xref="HGNC:HGNC:22310"
                     /db_xref="MIM:618344"
                     /translation="MADSGDAGSSGPWWKSLTNSRKKSKEAAVGVPPPAQPAPGEPTP
                     PAPPSPDWTSSSRENQHPNLLGGAGEPPKPDKLYGDKSGSSRRNLKISRSGRFKEKRK
                     VRATLLPEAGRSPEEAGFPGDPHEDKQ"
     regulatory      1632..1637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR15"
                     /note="hexamer: ATTAAA"
     polyA_site      1652
                     /gene="PRR15"
                     /note="major polyA site"
ORIGIN      
        1 gttattttct tttctccccc agctgcccca gggttctggt ttcccgaatc acttggcaaa
       61 taaccagcag gtgggcagat gtcttttttg cgttcctacg gacgcgtagg caagttcgat
      121 gcgccggagt gaacagccag ggtcccatct ctcagccggc tcccgggcgg tgctagcagg
      181 gaagagggac gcgccggcga atgaaacact actagcccgg aaagccgccc tggaccttcc
      241 acccgggcag cgagtctggc ggcccctcgc cgccgccccc tccgaccaga acagactgcg
      301 ctgcgagccc cgggcttccg ccgcagcgcg cagcaattgg aggtgccaga ggagaccagc
      361 agcagcactt gatttagctg ggctgcggga attccgacct gtacactttc cagaagcctg
      421 atctctccaa gtccgcgccc agggactcga gccccggctt ccaggttgac ccgagcgcgc
      481 ccccttcgtg ctctcggccg cgttcaccgc gcgaggcctc cgggtcctgt taagcccgag
      541 cagcacaggc cgctgcctca gcatccaccc cgcagcccac gtgtggcaag ccggggaagg
      601 ggtggagtga acggccggag accacgtgga gaaaggggcc gctttggccc ttccatctgg
      661 gtgccgggag cccctaggcc ctccggccat ggccgacagc ggcgatgctg gcagctccgg
      721 cccctggtgg aaatcgctca ccaacagcag aaagaaaagc aaggaagccg cagtgggggt
      781 gccgcctccc gcccagcccg ctcccgggga gcccacgcca cctgcgccgc ccagcccgga
      841 ctggaccagc agctcccggg agaaccagca ccccaatctc ctcgggggcg ccggcgagcc
      901 ccccaaacca gacaagttat acggggacaa atccggcagc agccgccgca atttgaagat
      961 ctcgcgctcc ggccgcttta aggagaagag gaaagtgcgc gccacgctgc tcccggaggc
     1021 gggcaggtcc ccggaggagg caggctttcc tggtgacccc cacgaggaca agcagtagcc
     1081 ccaatagcct gcgcgctcca ggactgccta cccagcacta ccccaaaccc ccagttccaa
     1141 acccgagact tcaggcccgc ccccttacgc gttgtctcat tccaccaaat tcagaatatt
     1201 tacacaatgc cttcatgatt ttatttttct ggaaattgaa gtgtcaattg ggttctcaat
     1261 atttcatgac tccaaggatg cattaaatat ttatttgtgg taagagaaga tacctgccgc
     1321 ggaggagggt ggcataatta tttttttttc aaaaagctat tctggggccc tggccccctg
     1381 gctcctgtca cagctcagct tgaactctgt agcctctcaa atgaagaagg tggctgttat
     1441 ttaggactct gtggaaagca aatcacagtg ctgtttttaa tgcctgagaa atgcacttta
     1501 ggggtagact tataccttaa gtgaaggagt gggggaggaa gaagcattct taagtagaag
     1561 cattttaaaa taaggcagga ttgcttttaa tgttaaacta caaaactgta cagcctattt
     1621 tagtgtggac tattaaaacc cttgcactgt aa
//
