LOCUS       NM_024031               2078 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens proline rich 14 (PRR14), transcript variant 1, mRNA.
ACCESSION   NM_024031
VERSION     NM_024031.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2078)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2078)
  AUTHORS   Dunlevy,K.L., Medvedeva,V., Wilson,J.E., Hoque,M., Pellegrin,T.,
            Maynard,A., Kremp,M.M., Wasserman,J.S., Poleshko,A. and Katz,R.A.
  TITLE     The PRR14 heterochromatin tether encodes modular domains that
            mediate and regulate nuclear lamina targeting
  JOURNAL   J Cell Sci 133 (10) (2020)
   PUBMED   32317397
  REMARK    GeneRIF: The PRR14 heterochromatin tether encodes modular domains
            that mediate and regulate nuclear lamina targeting.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2078)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2078)
  AUTHORS   Li,F., Zhang,C. and Fu,L.
  TITLE     PRR14 overexpression promotes cell growth, epithelial to
            mesenchymal transition and metastasis of colon cancer via the AKT
            pathway
  JOURNAL   PLoS One 14 (10), e0218839 (2019)
   PUBMED   31596887
  REMARK    GeneRIF: PRR14 may promote the progression and metastasis of colon
            cancer, and may be a novel prognostic and therapeutic marker for
            the disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2078)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2078)
  AUTHORS   Yang,M., Lewinska,M., Fan,X., Zhu,J. and Yuan,Z.M.
  TITLE     PRR14 is a novel activator of the PI3K pathway promoting lung
            carcinogenesis
  JOURNAL   Oncogene 35 (42), 5527-5538 (2016)
   PUBMED   27041574
  REMARK    GeneRIF: We show that increased PRR14 expression promoted and
            reduced PRR14 expression impeded lung cancer cell proliferation.
            Interestingly, PRR14 cells were markedly enlarged in size and
            exhibited an elevated activity of the PI3-kinase/Akt/mTOR pathway
REFERENCE   7  (bases 1 to 2078)
  AUTHORS   Yang,M. and Yuan,Z.M.
  TITLE     A novel role of PRR14 in the regulation of skeletal myogenesis
  JOURNAL   Cell Death Dis 6 (4), e1734 (2015)
   PUBMED   25906157
  REMARK    GeneRIF: The results altogether support a model in which PRR14
            promotes skeletal myogenesis via supporting nuclear lamina
            structure and enhancing the activity of MyoD.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2078)
  AUTHORS   Poleshko,A. and Katz,R.A.
  TITLE     Specifying peripheral heterochromatin during nuclear lamina
            reassembly
  JOURNAL   Nucleus 5 (1), 32-39 (2014)
   PUBMED   24637393
  REMARK    Review article
REFERENCE   9  (bases 1 to 2078)
  AUTHORS   Poleshko,A., Mansfield,K.M., Burlingame,C.C., Andrake,M.D.,
            Shah,N.R. and Katz,R.A.
  TITLE     The human protein PRR14 tethers heterochromatin to the nuclear
            lamina during interphase and mitotic exit
  JOURNAL   Cell Rep 5 (2), 292-301 (2013)
   PUBMED   24209742
  REMARK    GeneRIF: The stepwise reassembly of PRR14 suggests a function in
            the selection of heterochromatin protein 1-bound heterochromatin
            for reattachment to the nuclear lamina as cells exit mitosis.
REFERENCE   10 (bases 1 to 2078)
  AUTHORS   Nozawa,R.S., Nagao,K., Masuda,H.T., Iwasaki,O., Hirota,T.,
            Nozaki,N., Kimura,H. and Obuse,C.
  TITLE     Human POGZ modulates dissociation of HP1alpha from mitotic
            chromosome arms through Aurora B activation
  JOURNAL   Nat Cell Biol 12 (7), 719-727 (2010)
   PUBMED   20562864
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC050677.1.
            
            On Feb 27, 2020 this sequence version replaced NM_024031.4.
            
            Summary: The protein encoded by this gene tethers heterochromatin
            to the nuclear laminar scaffold by binding heterochromatin protein
            1 (HP1) and the nuclear lamina. The tether is broken during mitosis
            and reforms quickly after mitosis, with the encoded protein first
            binding HP1 and then attaching to the nuclear lamina. This protein
            also has been shown to promote MyoD activity and skeletal
            myogenesis. Two transcript variants encoding the same protein have
            been found for this gene. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050677.1, AK074783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300835.9/ ENSP00000300835.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2078              BC050677.1         41-2118
FEATURES             Location/Qualifiers
     source          1..2078
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2078
                     /gene="PRR14"
                     /note="proline rich 14"
                     /db_xref="GeneID:78994"
                     /db_xref="HGNC:HGNC:28458"
                     /db_xref="MIM:617423"
     exon            1..168
                     /gene="PRR14"
                     /inference="alignment:Splign:2.1.0"
     exon            169..241
                     /gene="PRR14"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1976
                     /gene="PRR14"
                     /codon_start=1
                     /product="proline-rich protein 14"
                     /protein_id="NP_076936.1"
                     /db_xref="CCDS:CCDS10687.1"
                     /db_xref="GeneID:78994"
                     /db_xref="HGNC:HGNC:28458"
                     /db_xref="MIM:617423"
                     /translation="MDLPGDSSPPGQPRLCRQPLTRALWGARSPKRPRLQLPGAPSPL
                     EKASRRVLAVVLEDVMAVHMVPVVPSKQTSIPQHHSYHQDPVHRQPPASPPRQAGWSS
                     QARPPDPLCLCREPLSRIHRTSSTLRRRSRTTPGPEEGPSQKVDRAPQPTLVVMLEDI
                     ASPRPPAEGFIDETPNFIIPAQRAEPMRIVRQPTPPPGDLEPPFQPSALPADPLESPP
                     TAPDPALELPSTPPPSSLLRPRLSPWGLAPLFRSVRSKLESFADIFLTPNKTPQPPPP
                     SPPMKLELKIAISEAEQSGAAEGTASVSPRPPIRQWRTQDHNTPALLPKPSLGRSYSC
                     PDLGPPGPGTCTWPPAPPQPSRPRPRRHTVGGGEMARAPPPPRPCLRKEVFPLGGVGA
                     SPSLTTSCSSTASTSFSEPAEPRLGSTKGKEPRASKDQVLSEPETKTMGKVSRFRIRR
                     TPARPQLNLTPMGLPRPIRLNKKEFSLEEIYTNKNYQSPTTRRTFETIFEEPRERNGT
                     LIFTSSRKLRRAVEFRDSSLPRSRRPSRGVRAAGGRTVPPNVAPSPDVGPLLQQRLEE
                     LDALLLEEETVDREQPHWT"
     exon            242..410
                     /gene="PRR14"
                     /inference="alignment:Splign:2.1.0"
     exon            411..532
                     /gene="PRR14"
                     /inference="alignment:Splign:2.1.0"
     exon            533..722
                     /gene="PRR14"
                     /inference="alignment:Splign:2.1.0"
     exon            723..766
                     /gene="PRR14"
                     /inference="alignment:Splign:2.1.0"
     exon            767..876
                     /gene="PRR14"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1462
                     /gene="PRR14"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1532
                     /gene="PRR14"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1624
                     /gene="PRR14"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1696
                     /gene="PRR14"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..2078
                     /gene="PRR14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2054..2059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR14"
                     /note="hexamer: AGTAAA"
     polyA_site      2078
                     /gene="PRR14"
                     /note="major polyA site"
ORIGIN      
        1 gggattggag tgaagagggt atctgcttga cagtggatcc ctggggatct acgctgagtt
       61 cggagatgct ccagctcggg ccgcccctgt ctgagcggag ctttgcggcg ctgaagctta
      121 caggggaagg aaaagcctcg cccggcgtct gattggcgga accgcgctgc cgcagcctgg
      181 gattccccag ggaccccccc ggagccgccg cgtctcccat ggacttgccc ggggactcca
      241 gcccgcctgg ccagccgcgt ctgtgccgcc agcctctgac tcgagcatta tggggagcca
      301 ggagcccgaa acggccgagg ctgcagctcc cgggggcccc ttctcccctg gaaaaggcct
      361 ctcggcgggt cctggccgtg gtgctagaag atgtcatggc tgttcacatg gtccccgtgg
      421 tgccctcaaa gcagacctcc ataccacagc accacagcta ccatcaggat cctgtccaca
      481 ggcagccgcc tgcctcgcca ccccggcagg ccgggtggtc ctcgcaggcc aggcctcccg
      541 accctctgtg tttgtgtcgc gagcccttga gccgcatcca ccggacctct tccaccctga
      601 ggcggcgatc aaggacaacc cctggcccag aggagggccc ttcacaaaag gtggaccggg
      661 ccccccagcc caccctggtg gtgatgctgg aagacatcgc cagtcctaga ccccccgctg
      721 agggcttcat tgatgagacc cccaacttca tcatcccagc acaaagagct gagcccatga
      781 ggatagttcg ccagccaacg cctccacctg gggacctaga acccccattc cagccatctg
      841 ctctgcctgc agaccctctg gagagcccac caacagcccc agatcctgct ctggagctcc
      901 catccacccc accaccgtcc agccttttac gcccccgcct cagtccctgg ggcttggccc
      961 cgctcttccg ttccgtccgc tccaagctgg agagctttgc tgacatcttc ctcacgccca
     1021 acaaaacccc acagccccca cccccgtccc ccccaatgaa gctggagttg aagatcgcca
     1081 tctcagaggc cgagcagtct ggggctgctg agggcactgc gtctgtcagc ccccggcccc
     1141 caatccgcca gtggcgaact caggaccaca ataccccagc acttctccct aagccctctc
     1201 tgggccgaag ctactcctgc cctgatctgg ggccccctgg cccaggtacc tgcacctggc
     1261 cacctgctcc accccaacca agccgaccac ggccgcggcg gcacactgtg ggtggtgggg
     1321 aaatggcccg agccccgcca ccccctcggc cctgtctccg gaaagaggtc ttccctctcg
     1381 gaggagtggg agcctcccct tctctcacca catcttgctc gtccacggca tccacttcct
     1441 tctccgaacc agcagaaccc aggttgggtt caaccaaagg gaaggagcca agagcctcaa
     1501 aggaccaggt gctttcagaa cctgagacca agaccatggg aaaggtttct cgattcagaa
     1561 tacgcagaac accagcccgt cctcagctaa accttacacc aatgggactg cctcgaccaa
     1621 tcaggttgaa caagaaggag ttcagcttgg aagaaattta caccaacaag aattaccaat
     1681 cacccacaac caggaggacc tttgagacca tctttgagga accccgggag cgcaatggga
     1741 ctctgatttt caccagctca aggaagctcc ggcgggctgt ggaatttcgg gacagcagcc
     1801 ttcctcgatc acgaagaccg tcccgtgggg tccgggctgc agggggcagg actgttcctc
     1861 ccaatgtggc ccccagccct gatgtgggcc ccctgctcca gcagcggctg gaggagctag
     1921 atgccttgct cctggaggaa gaaacagtag atcgggagca gccccactgg acctaggtgc
     1981 cccatctgtt ggtcatccat cctgaaggga caggaaacct cccaggcagt tatttttttt
     2041 tctctatatt tctagtaaag ttttcgatat gtttctga
//
