LOCUS       NM_018457               1105 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens proline rich 13 (PRR13), transcript variant 2, mRNA.
ACCESSION   NM_018457
VERSION     NM_018457.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1105)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1105)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1105)
  AUTHORS   Erdi,F., Kaya,B., Esen,H., Karatas,Y., Findik,S., Keskin,F.,
            Feyzioglu,B. and Kalkan,E.
  TITLE     New Clues in the Malignant Progression of Glioblastoma: Can the
            Thioredoxin System Play a Role?
  JOURNAL   Turk Neurosurg 28 (1), 7-12 (2018)
   PUBMED   28345125
  REMARK    GeneRIF: In primary glioblastoma samples there was a high
            expression of TXR1 in cerebral tissue compared to control tissue.
REFERENCE   4  (bases 1 to 1105)
  AUTHORS   Pontikakis,S., Papadaki,C., Tzardi,M., Trypaki,M., Sfakianaki,M.,
            Koinis,F., Lagoudaki,E., Giannikaki,L., Kalykaki,A., Kontopodis,E.,
            Saridaki,Z., Malamos,N., Georgoulias,V. and Souglakos,J.
  TITLE     Predictive value of ATP7b, BRCA1, BRCA2, PARP1, UIMC1 (RAP80),
            HOXA9, DAXX, TXN (TRX1), THBS1 (TSP1) and PRR13 (TXR1) genes in
            patients with epithelial ovarian cancer who received
            platinum-taxane first-line therapy
  JOURNAL   Pharmacogenomics J 17 (6), 506-514 (2017)
   PUBMED   27779244
  REMARK    GeneRIF: These findings indicate that PRR13/THBS1 and TXN
            expression could be used for the prediction of resistance to
            treatment of epithelial ovarian cancer patients.
REFERENCE   5  (bases 1 to 1105)
  AUTHORS   Bi,J., Bai,Z., Ma,X., Song,J., Guo,Y., Zhao,J., Yi,X., Han,S. and
            Zhang,Z.
  TITLE     Txr1: an important factor in oxaliplatin resistance in gastric
            cancer
  JOURNAL   Med Oncol 31 (2), 807 (2014)
   PUBMED   24362794
  REMARK    GeneRIF: High Txr1 expression is associated with oxaliplatin
            resistance in gastric cancer.
REFERENCE   6  (bases 1 to 1105)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 1105)
  AUTHORS   Papadaki,C., Tsaroucha,E., Kaklamanis,L., Lagoudaki,E., Trypaki,M.,
            Tryfonidis,K., Mavroudis,D., Stathopoulos,E., Georgoulias,V. and
            Souglakos,J.
  TITLE     Correlation of BRCA1, TXR1 and TSP1 mRNA expression with treatment
            outcome to docetaxel-based first-line chemotherapy in patients with
            advanced/metastatic non-small-cell lung cancer
  JOURNAL   Br J Cancer 104 (2), 316-323 (2011)
   PUBMED   21157449
  REMARK    GeneRIF: Low TXR1 mRNA levels were associated with higher response
            rate (RR), longer median progression-free survival (PFS) and median
            overall survival (mOS), whereas high TSP1 expression was correlated
            with higher RR, longer PFS and mOS
REFERENCE   8  (bases 1 to 1105)
  AUTHORS   Papadaki,C., Mavroudis,D., Trypaki,M., Koutsopoulos,A.,
            Stathopoulos,E., Hatzidaki,D., Tsakalaki,E., Georgoulias,V. and
            Souglakos,J.
  TITLE     Tumoral expression of TXR1 and TSP1 predicts overall survival of
            patients with lung adenocarcinoma treated with first-line
            docetaxel-gemcitabine regimen
  JOURNAL   Clin Cancer Res 15 (11), 3827-3833 (2009)
   PUBMED   19435835
  REMARK    GeneRIF: Multivariate analysis showed that high TXR1/low TSP1
            expression was an independent prognostic factor for decreased
            median time to tumor progression (TTP) and median overall survival
            (mOS).
REFERENCE   9  (bases 1 to 1105)
  AUTHORS   Lih,C.J., Wei,W. and Cohen,S.N.
  TITLE     Txr1: a transcriptional regulator of thrombospondin-1 that
            modulates cellular sensitivity to taxanes
  JOURNAL   Genes Dev 20 (15), 2082-2095 (2006)
   PUBMED   16847352
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN392914.1 and BC014257.2.
            
            On Nov 22, 2018 this sequence version replaced NM_018457.3.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014257.2, BK005847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429243.7/ ENSP00000412064.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CN392914.1         100-114
            16-1105             BC014257.2         1-1090
FEATURES             Location/Qualifiers
     source          1..1105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..1105
                     /gene="PRR13"
                     /gene_synonym="TXR1"
                     /note="proline rich 13"
                     /db_xref="GeneID:54458"
                     /db_xref="HGNC:HGNC:24528"
                     /db_xref="MIM:610459"
     exon            1..59
                     /gene="PRR13"
                     /gene_synonym="TXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            60..98
                     /gene="PRR13"
                     /gene_synonym="TXR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..526
                     /gene="PRR13"
                     /gene_synonym="TXR1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     proline-rich protein 13; taxane-resistance protein"
                     /codon_start=1
                     /product="proline-rich protein 13 isoform 1"
                     /protein_id="NP_060927.1"
                     /db_xref="CCDS:CCDS44899.1"
                     /db_xref="GeneID:54458"
                     /db_xref="HGNC:HGNC:24528"
                     /db_xref="MIM:610459"
                     /translation="MWNPNAGQPGPNPYPPNIGCPGGSNPAHPPPINPPFPPGPCPPP
                     PGAPHGNPAFPPGGPPHPVPQPGYPGCQPLGPYPPPYPPPAPGIPPVNPLAPGMVGPA
                     VIVDKKMQKKMKKAHKKMHKHQKHHKYHKHGKHSSSSSSSSSSDSD"
     exon            99..481
                     /gene="PRR13"
                     /gene_synonym="TXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..1105
                     /gene="PRR13"
                     /gene_synonym="TXR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1081..1086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR13"
                     /gene_synonym="TXR1"
                     /note="hexamer: AATAAA"
     polyA_site      1105
                     /gene="PRR13"
                     /gene_synonym="TXR1"
                     /note="major polyA site"
ORIGIN      
        1 gactaggaag agccgagact gcgaaggaga acgcagcaag cccaggcggc ggtggaaagg
       61 ctggaggaca cacctaaaca tgtggaatcc caatgccggg cagccagggc caaatccata
      121 tccccccaat attgggtgcc ctggaggttc caatcctgcc cacccaccac ctattaatcc
      181 accctttccc ccaggcccct gtcctcctcc cccaggagct ccccatggca atccagcttt
      241 ccccccaggt gggccccctc atcctgtgcc acagccaggg tatccaggat gccaaccgtt
      301 gggtccctac cctcctccat acccaccgcc tgcccctgga atccctcctg tgaatccctt
      361 ggctcctggc atggttggac cagcagtgat agtagacaag aagatgcaga agaaaatgaa
      421 gaaagctcat aaaaagatgc acaagcacca aaagcaccac aagtaccaca agcatggcaa
      481 gcattcctcc tcttcctcct cctcttccag cagtgattct gactgaatac aggccctgga
      541 cccttccctc aagtctcacc agttctgctc tcccatcaag cttcagatgc catgttgtac
      601 tgggggaatg tagcccttgt gctccccacc ccctacctcc acctgagcct caccctgctg
      661 ttgagccctg agtggctagg ggaaatggga agaggattgc catggcctgg ccatcttgtt
      721 gctgcttggt tagatcatat agctaatgaa ttaggcaggg gagctatttt ttgaagatga
      781 tgaactaaat gttgaagaca agtttgagat ctgtaaaatg tgatttttta cttccactta
      841 taatacttgt gattggggag gtttgtggaa attcaattat gatgaaaaac ctatcttttt
      901 tgtaatgttg gcatacttgg ggaatttagt ggcaaataca ttccccagca ggccttttgt
      961 tggttgcact aactgcaagg ttgctgggaa gtagagtcca tttggttgat gagctttgac
     1021 tgcggttttg gaaccttacc tctcctcctt agcccaatat gctgtcttgg gtcctattca
     1081 aataaagtta tttctcctgg tctca
//
