LOCUS       NM_020719               7416 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens proline rich 12 (PRR12), mRNA.
ACCESSION   NM_020719 XM_935121 XM_946218
VERSION     NM_020719.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7416)
  AUTHORS   Reis,L.M., Costakos,D., Wheeler,P.G., Bardakjian,T., Schneider,A.,
            Fung,S.S.M. and Semina,E.V.
  CONSRTM   University of Washington Center for Mendelian Genomics
  TITLE     Dominant variants in PRR12 result in unilateral or bilateral
            complex microphthalmia
  JOURNAL   Clin Genet 99 (3), 437-442 (2021)
   PUBMED   33314030
  REMARK    GeneRIF: Dominant variants in PRR12 result in unilateral or
            bilateral complex microphthalmia.
REFERENCE   2  (bases 1 to 7416)
  AUTHORS   Leduc,M.S., Mcguire,M., Madan-Khetarpal,S., Ortiz,D., Hayflick,S.,
            Keller,K., Eng,C.M., Yang,Y. and Bi,W.
  TITLE     De novo apparent loss-of-function mutations in PRR12 in three
            patients with intellectual disability and iris abnormalities
  JOURNAL   Hum Genet 137 (3), 257-264 (2018)
   PUBMED   29556724
  REMARK    GeneRIF: Here we report on three unrelated patients with
            heterozygous de novo apparent loss-of-function mutations in PRR12
            detected by clinical whole exome sequencing: c.1918G>T (p.Glu640*),
            c.4502_4505delTGCC (p.Leu1501Argfs*146) and c.903_909dup
            (p.Pro304Thrfs*46). All three patients had global developmental
            delay, intellectual disability, eye and vision abnormalities,
            dysmorphic features, and neuropsychiatric problems
REFERENCE   3  (bases 1 to 7416)
  AUTHORS   Cordova-Fletes,C., Dominguez,M.G., Delint-Ramirez,I.,
            Martinez-Rodriguez,H.G., Rivas-Estilla,A.M., Barros-Nunez,P.,
            Ortiz-Lopez,R. and Neira,V.A.
  TITLE     A de novo t(10;19)(q22.3;q13.33) leads to ZMIZ1/PRR12 reciprocal
            fusion transcripts in a girl with intellectual disability and
            neuropsychiatric alterations
  JOURNAL   Neurogenetics 16 (4), 287-298 (2015)
   PUBMED   26163108
  REMARK    GeneRIF: This case represents the first constitutional balanced
            translocation disrupting and fusing both MIZ-type containing and
            proline-rich 12 and provides clues for the potential function and
            effects of these in the central nervous system.
REFERENCE   4  (bases 1 to 7416)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010619.7, BF805116.1,
            BF933932.1, AC011495.8, AB033031.1, BM723432.1 and BM684867.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_020719.2.
            
            Summary: This gene encodes a proline-rich protein that contains two
            A-T hook DNA binding domains. A chromosomal translocation and gene
            fusion between this gene and zinc finger, MIZ-type containing 1
            (Gene ID: 57178) may underlie intellectual disability and
            neuropsychiatric problems in a human patient. Enriched expression
            of this gene in embryonic mouse brain suggests that this gene may
            play a role in nervous system development. [provided by RefSeq, Jul
            2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000418929.7/ ENSP00000394510.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-498               AC010619.7         178353-178850
            499-592             BF805116.1         52-145
            593-594             BF933932.1         107-108
            595-852             BF805116.1         148-405
            853-2983            AC011495.8         20525-22655
            2984-6750           AB033031.1         54-3820
            6751-7010           BM723432.1         213-472
            7011-7416           BM684867.1         18-423              c
FEATURES             Location/Qualifiers
     source          1..7416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..7416
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /note="proline rich 12"
                     /db_xref="GeneID:57479"
                     /db_xref="HGNC:HGNC:29217"
                     /db_xref="MIM:616633"
     exon            1..559
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /inference="alignment:Splign:2.1.0"
     CDS             474..6584
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /codon_start=1
                     /product="proline-rich protein 12"
                     /protein_id="NP_065770.1"
                     /db_xref="CCDS:CCDS46143.1"
                     /db_xref="GeneID:57479"
                     /db_xref="HGNC:HGNC:29217"
                     /db_xref="MIM:616633"
                     /translation="MDRNYPSAGFGDPLGAGAGWSYERSAKASLVYGSSRTSHPETDI
                     LHRQAYAAPHPLQSYATNHHPAGLSGLFDTGLHHAGSAGPDASVMNLISALESRGPQP
                     GPSASSLLSQFRSPSWQTAMHTPGPTELFISGALPGSSTFPSSSALSAYQHPASFGSR
                     PFPVPSSLSLQDPPFSPPANGLLSPHDVLHLKPSQAPTVPSSLGFERLAGGGVLGPAG
                     LGPAQTPPYRPGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPP
                     PPERALPRQDTVIKHYQRPASAQPPPPPPPAHALQHYLSCGGSYPSMGHRANLACSPL
                     GGGEPSPGAGEPSKAGPSGATAGASGRATGPEAAGGGGAGGGGGGYRPIIQSPGYKTG
                     KGGYGAAAGGATRPPPPRSTATPKCQSLGGPAAAYATGKASGAGGAGGQAYSPGQPQG
                     LLGPQAYGQGFGGGQAQDLSKAPSYSGGPPQPPSGPPPPGLATCQSYSPDQLQGQLYG
                     VQGEPYPGPAAHSQGLPTASPSLSYSTGHSPALSGHGGGWGPSSLGGGGEASPSHIIR
                     PLQSPPATGRPPGVGSPGAPGKYLSSVLASAPFLAPPGAGSYAAGAGGYKGKGDGSEL
                     LAGPGGPPAERTEDEEFLIQHLLQAPSPPRTSGADGLVGEDGAADASKGLGGSGGAGG
                     PPGTPYELAKEDPQRYHLQSVIRTSASLDEGATAALELGLGRLKEKKKGPERGGETPE
                     GLATSVVHYGAGAKELGAFLQKSPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPP
                     PQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPPPPPPMPLQLEAHLRS
                     HGLEPAAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAYR
                     SPSPQGTKAPRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAADDYGKAGPPEDEG
                     DPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEPLGLI
                     QSGPHQAAPPPPPPPPPPPAPASEPKGGLTSPIFCSTKPKKLLKTSSFHLLRRRDPPF
                     QTPKKLYAQEYEFEADEDKADVPADIRLNPRRLPDLVSSCRSRPALSPLGDIDFCPPN
                     PGPDGPRRRGRKPTKAKRDGPPRPRGRPRIRPLEVPTTAGPASASTPTDGAKKPRGRG
                     RGRGRKAEEAGGTRLEPLKPLKIKLSVPKAGEGLGTSSGDAISGTDHNSLDSSLTREK
                     IEAKIKEVEEKQPEMKSGFMASFLDFLKSGKRHPPLYQAGLTPPLSPPKSVPPSVPAR
                     GLQPQPPATPAVPHPPPSGAFGLGGALEAAESEGLGLGCPSPCKRLDEELKRNLETLP
                     SFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPAAAVPGPPPL
                     PGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPSPPPLVAPTPS
                     SPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPELPDTRPLHLAKKQ
                     ETAAVCGETDEEAGESGGEGIFRERDEFVIRAEDIPSLKLALQTGREPPPIWRVQKAL
                     LQKFTPEIKDGQRQFCATSNYLGYFGDAKNRYQRLYVKFLENVNKKDYVRVCARKPWH
                     RPPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEP
                     PAPEKPSLLRPVEKEKEKEKVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKA
                     RPTKVKAEPPPKKRKKWLKEAGGNATAGGGPPGSSSDSESSPGAPSEDERAVPGRLLK
                     TRAMREMYRSYVEMLVSTALDPDMIQALEDTHDELYLPPMRKIDGLLNEHKKKVLKRL
                     SLSPALQDALHTFPQLQVEQSGEGSPEEGAVRLRPAGEPYNRKTLSKLKRSVVRAQEF
                     KVELEKSGYYTLYHSLHHYKYHTFLRCRDQTLAIEGGAEDLGQEEVVQQCMRNQPWLE
                     QLFDSFSDLLAQAQAHSRCG"
     exon            560..672
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /inference="alignment:Splign:2.1.0"
     exon            673..834
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /inference="alignment:Splign:2.1.0"
     exon            835..4151
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /inference="alignment:Splign:2.1.0"
     exon            4152..4818
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /inference="alignment:Splign:2.1.0"
     exon            4819..5246
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /inference="alignment:Splign:2.1.0"
     exon            5247..5363
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /inference="alignment:Splign:2.1.0"
     exon            5364..5497
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /inference="alignment:Splign:2.1.0"
     exon            5498..5970
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /inference="alignment:Splign:2.1.0"
     exon            5971..6096
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /inference="alignment:Splign:2.1.0"
     exon            6097..6194
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /inference="alignment:Splign:2.1.0"
     exon            6195..6341
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /inference="alignment:Splign:2.1.0"
     exon            6342..6437
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /inference="alignment:Splign:2.1.0"
     exon            6438..7416
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      7416
                     /gene="PRR12"
                     /gene_synonym="KIAA1205; NOC"
                     /note="major polyA site"
ORIGIN      
        1 ccccctcccc cagccgcctt gtgcaaagat ggctgcaccg tgagcgcaga ggaggaggag
       61 gcggcggcgg cggcggcgag agagcgagca cccagcgcct gcacccaccc cggggccgcc
      121 cgggacgccc cctcccgagc gcgcgccccc ccttttctct cgcaagcgcc ggggcaaagg
      181 cggagacagc ggggtccctc ctcccccctt ccctcctcta gggggaaccc cccttccccc
      241 ttccttggct cagcgactgc accccctccc ttgcccgccc ctccgcccct gccccctccc
      301 tcccccgccc ggggccttcc cgggccttcg gcggctgcaa agaaaaaaag agagagagaa
      361 aaggggggaa aaaaaagcag cagcggaggg agcggcggcg gaggagagcg cgcgcgcgcc
      421 ccctccctcc ctccctccct ccccctcccc ccaatttcca ccgcggccaa ttcatggaca
      481 ggaactaccc cagcgccggc ttcggggacc cgctcggcgc cggggcggga tggagttacg
      541 agaggtcagc gaaagctagc ttggtttatg gcagctccag gacctcgcac cccgagacgg
      601 acatcttaca ccgccaggcc tatgcggccc cccacccact gcaaagctat gccaccaacc
      661 accacccggc aggcctctct ggactcttcg acactggcct ccaccacgcg ggctcagcag
      721 ggcccgacgc ctccgtcatg aaccttatct cggccctgga atcccggggc ccccagcctg
      781 gcccctccgc ctcctctctc ctctcccagt tccgcagtcc ttcctggcaa acagccatgc
      841 acacgccagg ccccacggag ctcttcatct cgggtgccct gccgggttcc agcacctttc
      901 cgtcctcatc tgccctgtcg gcttaccaac acccggcttc cttcggcagc cgccccttcc
      961 cagtgccctc gtccctcagc ctccaggacc ccccattcag ccctccagct aacgggctcc
     1021 tgtcccctca tgacgtgctg cacctgaagc cctcgcaggc acccacggtg ccctcttcac
     1081 tgggcttcga gcgcctggca gggggcggtg tcttggggcc agctggtctc ggtccagccc
     1141 agaccccccc ttaccgccct ggccccccag acccaccacc acctcctcgc cacctcccaa
     1201 ctcagttcaa cctgctggct tcctcttccg ctgccgccgc cgctgccgag cagtcctccc
     1261 cacagctcta taacttctcg ggtgctgccc cgggcccacc gccgcctgag cgggccctgc
     1321 cacgccagga cacggtcatc aagcactacc agcggccagc cagtgcccag cccccaccac
     1381 ccccgccacc agcccatgcg ctccagcact atctgagctg tggaggcagc tacccctcca
     1441 tgggccaccg ggccaacctg gcctgcagcc ccctgggtgg tggggagccc tccccgggtg
     1501 ctggggagcc tagcaaggct ggtcccagcg gagccacggc tggggcatct ggccgggcca
     1561 cgggccctga ggcagcaggg ggcggtgggg ctgggggtgg tggtggaggt taccgcccca
     1621 tcattcagtc gcctgggtac aagacgggca aaggtggtta tggagcagct gccgggggtg
     1681 ccaccaggcc ccccccaccc cgttcgaccg ccacccccaa atgtcagagc ctgggtgggc
     1741 cagcagccgc ctatgccact gggaaggcct ctggggctgg aggggcaggg ggccaggctt
     1801 attcccccgg tcagcctcaa gggcttctgg gaccccaggc ctacgggcaa gggtttggag
     1861 gggggcaggc acaggacttg agcaaagccc ccagctactc agggggcccc ccacagcccc
     1921 ccagcggccc ccctcctcct ggcctggcca catgtcagag ctactccccg gaccagctgc
     1981 aggggcagct gtatggggtg cagggcgagc catacccagg gccagccgcc cactcccagg
     2041 ggctgcccac agccagcccc tcgctcagct acagtaccgg ccattcccca gcgctctcgg
     2101 gccatggggg tggctgggga cccagctccc tgggaggcgg cggtgaggcc agcccatctc
     2161 acatcattcg tccgctccag tcaccgcctg ccaccggccg tccacctgga gtcggctctc
     2221 caggagcccc tggcaaatac ctgagctcag tcttggcctc agcgcctttc ctggcacctc
     2281 cgggagctgg cagctatgca gccggagcag gtggctacaa gggcaagggg gatggctcgg
     2341 agctgctggc gggcccaggt gggcctcctg cggagcgcac agaggatgag gagttcctta
     2401 tccagcacct cttgcaggcg cccagccctc ctcggacctc aggggcggac ggcttggtgg
     2461 gcgaggacgg ggcagcagat gcctctaagg gacttggggg gagtggcggg gccgggggac
     2521 caccgggtac accctacgag ttggccaagg aagaccccca gaggtaccac ctgcagagtg
     2581 tcatccgcac cagtgccagc ctggatgagg gtgccactgc ggcactggag ctgggcctgg
     2641 ggaggctgaa ggagaagaag aaagggccag agcggggtgg cgagaccccc gaggggctgg
     2701 ccacctctgt tgtccactac ggggcaggcg ccaaggagct gggggccttc ttgcaaaaga
     2761 gccctccgcc cccacctccc acggcccagt ctacccagcc cactccccat ggcctccttc
     2821 tggaggccgg gggccctgac ctcccactgg tgctgcctcc gcctcccccc cagctgctcc
     2881 cctcggtcct cagccatgcc cccagtccct ctcccagcgc ctccaaagtc ggcgtccacc
     2941 tccttgagcc agccacccgc gatggggcac cccagccacc tccaccgcca cccccgcctc
     3001 caccacccat gcccctgcag ctcgaggccc acctccgcag ccatggcctg gagcccgcgg
     3061 cccccagccc ccgcctgcga cccgaggaga gcctggatcc gccaggcgcc atgcaggaat
     3121 tgctcggggc tctggagccg ctgcccccgg cgcctgggga tactggcgta ggcccaccaa
     3181 actcggaggg caaggatccc gcaggcgcct accgcagccc cagcccgcaa ggcaccaagg
     3241 cgccgcgttt cgtgccgctc acctccatct gcttccctga ctccttgctc caagacgagg
     3301 agcgcagctt cttccccacc atggaggaga tgttcggtgg aggggccgcg gacgactacg
     3361 gcaaggccgg gccacctgag gacgaggggg accccaaggc tggcgctggg ccaccccccg
     3421 gcccccctgc ttatgatccc tatgggccct actgtcctgg ccgggcgtcg ggagccgggc
     3481 ccgagacacc gggcctgggc ctggacccca acaaaccgcc tgaactgccc tccacggtca
     3541 acgccgagcc gctgggcctg atccagagtg gcccccacca ggcggcgcca ccacccccgc
     3601 ctccgccacc gccgcctccc gcgccggcct ccgaacccaa gggtggcctc acctcgccca
     3661 tcttctgctc taccaagcca aagaagctgc tcaagacatc ctccttccac ctgctgcggc
     3721 gccgcgaccc acccttccag acccccaaga agctgtacgc ccaggagtac gagttcgagg
     3781 cggacgagga caaggccgat gttcccgccg acatccgcct caacccccgg cgcttgcctg
     3841 acctggtctc cagctgccgc tcccgtccgg ccctctcgcc actgggggac atcgacttct
     3901 gcccacccaa cccaggaccc gatggccccc ggcgccgtgg ccgcaagccc acgaaggcga
     3961 aacgtgatgg gccaccccgg ccacggggga ggccccggat ccgccccctg gaggtcccga
     4021 ccactgcggg gcccgcctcg gcctccacgc ccaccgatgg cgccaagaaa ccccggggcc
     4081 ggggccgagg ccggggtcga aaggctgagg aggcaggggg cacccggttg gagcccctga
     4141 agccacttaa gatcaagctg tctgtgccca aggctggcga gggtctggga acctcatcgg
     4201 gtgatgccat atcaggcact gaccacaaca gcctggactc gagcctgact cgggagaaga
     4261 tcgaggccaa gattaaggag gtggaggaga agcagccgga gatgaagtcg ggtttcatgg
     4321 cctccttctt ggacttcctc aagtcaggca agcgccaccc accactctac caggcgggcc
     4381 tgacgcctcc gctcagccct cccaagagtg tgccaccctc tgtgccagcc cgaggcctgc
     4441 agccccagcc ccctgccacc cctgctgtgc cacatccccc accttccgga gcctttgggc
     4501 ttgggggcgc cctggaggct gcagagagtg agggtctggg gcttggctgc ccttcaccct
     4561 gcaagcggct tgatgaggag ctgaagcgga acctcgagac gctgccctcc ttctcctcgg
     4621 atgaggaaga ctctgtcgcc aagaaccgag acctgcagga gagcatctcc tccgccatct
     4681 ctgccctcga tgacccaccc cttgctgggc caaaagacac ttccacccca gatgggccgc
     4741 ccttggcccc cgcggctgca gttccagggc caccccctct tccggggctc cccagtgcca
     4801 acagcaatgg cactcccgag cccccgctgc tggaggagaa acccccaccc actccacctc
     4861 ctgccccgac tcctcagcct cagcctccgc caccccctcc gccgccacag ccagccctgc
     4921 cctcgccacc cccgctggtg gcccccacgc ccagctcacc accgccaccg ccgctgccgc
     4981 cgccacctcc accagccatg ccctcgcctc caccaccacc cccaccagcc gctgccccac
     5041 tggctgctcc tcctgaggag cccgccgccc cgtctcccga agaccccgag ctgccggaca
     5101 cccggcccct gcatctggcc aaaaagcagg agacggcggc agtgtgtggg gagacggacg
     5161 aggaggccgg cgagagtggc ggagagggca tcttccggga acgggacgag ttcgtcatcc
     5221 gtgctgagga catcccttcc ctcaagctgg cgttgcagac ggggcgtgaa cccccaccca
     5281 tctggcgagt ccagaaggcc cttctgcaga aattcactcc ggagatcaag gacggccaga
     5341 ggcagttttg tgccaccagt aattatttgg ggtattttgg ggatgcaaaa aatcggtacc
     5401 agcgcctcta tgtaaagttc ctggaaaatg tcaataagaa ggactacgtg agggtctgtg
     5461 ctcggaaacc ctggcatcgg cccccagtgc cagtcagacg ctctgggcag gccaagaacc
     5521 ccgtatctgc tgggggtagc tctgcacctc cccctaaggc cccagcacca cctcccaagc
     5581 ctgagacccc tgaaaagacg acatctgaga agcccccaga gcagactcct gagacggcca
     5641 tgcctgagcc ccctgccccc gagaagccct ccctcctgcg gcctgttgag aaggaaaagg
     5701 agaaggagaa ggtgacacgt ggagagcggc cattgcgggg tgagcgggcc accagcggac
     5761 ggcagacacg gccagagcgg agtctcgcca cgggacaacc tgccacatcc cggctgccca
     5821 aagcccggcc taccaaggtg aaggctgaac cgccccctaa gaagaggaag aaatggctga
     5881 aggaggcagg cggcaacgct acagcaggcg ggggcccacc aggcagctcc tcggactcgg
     5941 agtcctcccc tggagccccc agcgaggacg agcgggcagt acctgggcgt ctgctcaaaa
     6001 ccagggcgat gcgggagatg taccggagct acgtggagat gttggtgagc acagcacttg
     6061 acccagacat gatccaggcc ctggaggaca cgcatgacga gctgtacctg ccccccatgc
     6121 ggaagataga cggcctgctg aatgagcaca agaagaaagt cctgaagcgg ctgtcgctaa
     6181 gcccagccct gcaggatgct ctgcacacgt tcccacagct gcaagtggag cagagtgggg
     6241 agggctctcc ggaagagggg gctgtgcggc tgcggcctgc tggggaaccc tacaaccgca
     6301 agacgctcag caagctcaag aggagcgtgg tcagagccca ggagttcaag gttgagctgg
     6361 aaaagtcggg atactataca ctctaccatt cgctccacca ctataaatac cacaccttcc
     6421 tgcgctgccg ggaccagacc ctggccatcg agggcggcgc cgaggacctg ggccaggagg
     6481 aggtggtcca gcagtgcatg cggaaccagc cgtggctgga acagctcttt gactccttca
     6541 gtgacctgct ggcccaagca caggcccaca gccgctgcgg gtgaccccgc cccagcttgt
     6601 gaggggggcg cctcctccat gaaccgagaa ttgggacaga accgtgtcct caggagctaa
     6661 cacctgggct ccatcgccgg ggaaaggggg tcatgggtca gggtgtgtct gtgctgcccc
     6721 ctccagggca gggttcaaag tccgactccc cccctctccc aagccccctc cactccctcc
     6781 ccattcctcc cactgttcgg tgtacagaga aattatttat atatatgtat aaatgtctat
     6841 ttagtaacgg tttccctctc cccttgcccc gaccccccct ccacagccac agcccccgcc
     6901 ccctccacct tgtacataat gtataggaaa agtctatgta tggctggggg gggtggggtg
     6961 gcttcagaga gctgggggac cccttccccc caagtccccc ctgcaggcca agatctttgc
     7021 taaaggccat tccctccgca gggcatttgg cgtcgggtgg gaggggaaaa cgcatcttgt
     7081 taattatttt taatcttatt tattgtacat acctggggca ggggcttggg gaggtggagg
     7141 ggggagaagg gtcccctctc tctgcccctc ccactccttt tctacggcga tttgtctgtg
     7201 tctggccccc acccactgcc catcccccat tgttgtctgg atgtggttct attttttatc
     7261 ggtctccttt cccctcctcc ccgttctcgc ccccgcccca ccccctgctc ccactaccct
     7321 ttgtctcttg ctctttcttg ggcttctgta caactcaact tgtatacact gtgtacacac
     7381 aaccagccaa acgaaaaccc aacggcaaac acttta
//
