LOCUS       NM_018304               6226 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens proline rich 11 (PRR11), mRNA.
ACCESSION   NM_018304
VERSION     NM_018304.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6226)
  AUTHORS   Wen,J., Wan,L. and Dong,X.
  TITLE     Prognostic value of PRR11 and immune cell infiltration in Ewing
            sarcoma
  JOURNAL   PLoS One 19 (3), e0299720 (2024)
   PUBMED   38427643
  REMARK    GeneRIF: Prognostic value of PRR11 and immune cell infiltration in
            Ewing sarcoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6226)
  AUTHORS   Zhu,P., Dou,C., Song,Z., Bi,X., Wu,X. and Miao,Y.
  TITLE     ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and
            motility in early pregnancy
  JOURNAL   Am J Reprod Immunol 90 (3), e13758 (2023)
   PUBMED   37641376
  REMARK    GeneRIF: ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation
            and motility in early pregnancy.
REFERENCE   3  (bases 1 to 6226)
  AUTHORS   Han,W. and Chen,L.
  TITLE     Predictive significance of PRR11 in prognosis and immune
            infiltration of glioma patients
  JOURNAL   Mol Carcinog 62 (7), 975-990 (2023)
   PUBMED   37036189
  REMARK    GeneRIF: Predictive significance of PRR11 in prognosis and immune
            infiltration of glioma patients.
REFERENCE   4  (bases 1 to 6226)
  AUTHORS   Ni,W., Yi,L., Dong,X., Cao,M., Zheng,J., Wei,Q. and Yuan,C.
  TITLE     PRR11 is a prognostic biomarker and correlates with immune
            infiltrates in bladder urothelial carcinoma
  JOURNAL   Sci Rep 13 (1), 2051 (2023)
   PUBMED   36739300
  REMARK    GeneRIF: PRR11 is a prognostic biomarker and correlates with immune
            infiltrates in bladder urothelial carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6226)
  AUTHORS   Tan,R., Zhao,C., Lu,Y. and Chen,L.
  TITLE     Clinical significance and effect of PRR 11 up-regulation on the
            malignancy of osteosarcoma
  JOURNAL   Pol J Pathol 73 (3), 264-276 (2022)
   PUBMED   36734441
  REMARK    GeneRIF: Clinical significance and effect of PRR 11 up-regulation
            on the malignancy of osteosarcoma.
REFERENCE   6  (bases 1 to 6226)
  AUTHORS   Zhang,C., Zhang,Y., Li,Y., Zhu,H., Wang,Y., Cai,W., Zhu,J.,
            Ozaki,T. and Bu,Y.
  TITLE     PRR11 regulates late-S to G2/M phase progression and induces
            premature chromatin condensation (PCC)
  JOURNAL   Biochem Biophys Res Commun 458 (3), 501-508 (2015)
   PUBMED   25666944
  REMARK    GeneRIF: Overexpression of PRR11 inhibits cell proliferation and
            induces premature chromatin condensation.
REFERENCE   7  (bases 1 to 6226)
  AUTHORS   Ji,Y., Xie,M., Lan,H., Zhang,Y., Long,Y., Weng,H., Li,D., Cai,W.,
            Zhu,H., Niu,Y., Yang,Z., Zhang,C., Song,F. and Bu,Y.
  TITLE     PRR11 is a novel gene implicated in cell cycle progression and lung
            cancer
  JOURNAL   Int J Biochem Cell Biol 45 (3), 645-656 (2013)
   PUBMED   23246489
  REMARK    GeneRIF: our results strongly demonstrated that this newly
            identified gene, PRR11, had a critical role in both cell cycle
            progression and tumorigenesis, and might serve as a novel potential
            target in the diagnosis and/or treatment of human lung cancer.
REFERENCE   8  (bases 1 to 6226)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 6226)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: the apparent occurrence of an unusual TG 3' splice site in
            intron 10 is discussed
REFERENCE   10 (bases 1 to 6226)
  AUTHORS   Weinmann,A.S., Yan,P.S., Oberley,M.J., Huang,T.H. and Farnham,P.J.
  TITLE     Isolating human transcription factor targets by coupling chromatin
            immunoprecipitation and CpG island microarray analysis
  JOURNAL   Genes Dev 16 (2), 235-244 (2002)
   PUBMED   11799066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB106349.1, AK225377.1, AC099850.7 and AW957315.1.
            
            On Jun 2, 2019 this sequence version replaced NM_018304.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.49420.1, AK225377.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262293.9/ ENSP00000262293.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-565               DB106349.1         15-579
            566-1303            AK225377.1         566-1303
            1304-5734           AC099850.7         58009-62439         c
            5735-6226           AW957315.1         1-492
FEATURES             Location/Qualifiers
     source          1..6226
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..6226
                     /gene="PRR11"
                     /note="proline rich 11"
                     /db_xref="GeneID:55771"
                     /db_xref="HGNC:HGNC:25619"
                     /db_xref="MIM:615920"
     exon            1..60
                     /gene="PRR11"
                     /inference="alignment:Splign:2.1.0"
     exon            61..193
                     /gene="PRR11"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1148
                     /gene="PRR11"
                     /note="transcription repressor of MHCII"
                     /codon_start=1
                     /product="proline-rich protein 11"
                     /protein_id="NP_060774.2"
                     /db_xref="CCDS:CCDS11614.1"
                     /db_xref="GeneID:55771"
                     /db_xref="HGNC:HGNC:25619"
                     /db_xref="MIM:615920"
                     /translation="MPKFKQRRRKLKAKAERLFKKKEASHFQSKLITPPPPPPSPERV
                     GISSIDISQSRSWLTSSWNFNFPNIRDAIKLWTNRVWSIYSWCQNCITQSLEVLKDTI
                     FPSRICHRELYSVKQQFCILESKLCKLQEALKTISESSSCPSCGQTCHMSGKLTNVPA
                     CVLITPGDSKAVLPPTLPQPASHFPPPPPPPPLPPPPPPLAPVLLRKPSLAKALQAGP
                     LKKDGPMQITVKDLLTVKLKKTQSLDEKRKLIPSPKARNPLVTVSDLQHVTLKPNSKV
                     LSTRVTNVLITPGKSQMDLRKLLRKVDVERSPGGTPLTNKENMETGTGLTPVMTQALR
                     RKFQLAHPRSPTPTLPLSTSSFDEQN"
     exon            194..344
                     /gene="PRR11"
                     /inference="alignment:Splign:2.1.0"
     exon            345..467
                     /gene="PRR11"
                     /inference="alignment:Splign:2.1.0"
     exon            468..710
                     /gene="PRR11"
                     /inference="alignment:Splign:2.1.0"
     exon            711..809
                     /gene="PRR11"
                     /inference="alignment:Splign:2.1.0"
     exon            810..922
                     /gene="PRR11"
                     /inference="alignment:Splign:2.1.0"
     exon            923..982
                     /gene="PRR11"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1079
                     /gene="PRR11"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..6226
                     /gene="PRR11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3460..3465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR11"
                     /note="hexamer: AATAAA"
     regulatory      3469..3474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR11"
                     /note="hexamer: AATAAT"
     regulatory      3482..3487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR11"
                     /note="hexamer: AATAAA"
     polyA_site      3483
                     /gene="PRR11"
                     /note="major polyA site"
     polyA_site      3487
                     /gene="PRR11"
     polyA_site      3511
                     /gene="PRR11"
     regulatory      3613..3618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRR11"
                     /note="hexamer: ATTAAA"
     polyA_site      3637
                     /gene="PRR11"
ORIGIN      
        1 ctttatggcg tgggagaggc cacagcccgg actccatcga ctcccccggc tcttagacta
       61 aaatcatgcc caagttcaaa caacgaagac gaaagctaaa agccaaagcc gaaagattat
      121 tcaaaaaaaa agaagcctct cactttcagt ccaagctaat tacacctcct cctccaccac
      181 cctcaccaga aagagtcggt atttcttcaa tagatatatc tcaaagcaga agctggctaa
      241 catcatcctg gaacttcaat tttcctaaca tcagagatgc aataaaactt tggacaaata
      301 gagtatggtc tatatacagc tggtgccaga actgcataac ccagagttta gaagtattga
      361 aagacaccat ctttccatct cgtatctgcc accgagaact ttacagtgta aaacaacagt
      421 tttgcatttt ggaaagtaaa ttatgcaagc tccaggaagc actgaagacc atctcagaaa
      481 gttcttcctg tccaagctgt ggtcaaacat gtcacatgag tggtaaactt acaaatgtgc
      541 ctgcctgcgt tctgatcacc cctggagact ccaaagctgt gcttcctccc acactgccac
      601 agccagccag ccattttcct cctcctcctc cacctccacc tctgccacct cctccaccac
      661 cactagcacc tgtgttgctc agaaaaccca gtctcgctaa agcacttcag gctggaccat
      721 taaaaaaaga tggacccatg cagataacag ttaaagatct gctgactgta aaattaaaga
      781 agacacagag tttagatgaa aagaggaagc ttataccatc gccgaaagca cggaatccac
      841 tagttaccgt ctctgacttg cagcatgtta ccctgaaacc taactccaaa gtgttatcga
      901 ctcgagttac aaacgtctta atcactcctg gaaaaagtca gatggatctg cggaaactgc
      961 ttagaaaagt cgatgtagag aggagcccag gtggaacccc tcttaccaat aaggaaaata
     1021 tggaaacagg aacaggactg actccagtga tgacgcaggc cttaaggaga aagtttcagc
     1081 tggctcaccc tagaagccca actccaactc tgccactttc tacaagcagc tttgatgaac
     1141 aaaactgatg ccaactctgc ctcactccat gagatgatcc ataacaaata cagataaaaa
     1201 cacccagctg ggtgcagtgg ctcacacctg taatcccagc actttgggag gctgaggcag
     1261 gtggatcacc tgaggtcagg agtttgagac cagcctggcc aacatggtga aactccttcc
     1321 ccactaaaaa tacagaaatt agctgggcat agtggcgggt gcctgtaatc ccagctatgc
     1381 gggaggctaa ggcaggagaa ttgcttgaac ccaagaggca gaggttgcag tgagccaaga
     1441 tcgcgtcatt gcactccagc ctgagcaaca agagcaaaac aaaaacaaac aaacaaacaa
     1501 aaaaaaccca cccaaatcct tttttttaat gtagtagggt ttatatagat atactaatat
     1561 aattgcattt ggagaattag agtatgtatg gagcccacac atactgtgat ataaagtgta
     1621 tatacagata tttggatatt ttctagtttg catgatgatt aagagaacca gatgggaaaa
     1681 tacaatctcc aaagtgatgt ttatcctgga attacccaat ttagattaga gaggttgttc
     1741 aaatttaact agataactct agtttgtact gtataggtgc agttatgaca gtaaaaaaat
     1801 agcctcttgg ctcatacctg taatcccacc actttgggag gccaaggtgg gaggattgct
     1861 tgagcccagg aattcaagac tagcctgggc aacataatac agggagaccc cgtttctatt
     1921 aaaaatacaa aaatcagcca gctgtggtga cacatgccta tagtcccagc tacttaggaa
     1981 gctgagaagg gaggatcact tgaggctgta gtgcactata attatgcctg tgaatagcca
     2041 ctctactcca gcctgggcaa catagcaaga ccccatctct aaaaattaaa aaaaaaattt
     2101 aaattagaat atcatttcta gcatcttagg taggtactta tatctggctt acagaagtct
     2161 aaggtattcc ttatttttat atctgctgtc cacatttata cagctacata aaaattttat
     2221 gacaacttca acatgaacct tatattttcg acaatgcctt gccaaggaat ctctgaagtc
     2281 catagcaggt cactgtgaga cctagttccc tgttgtcact gacctatgta atcaaagaca
     2341 gtaatacagc ctgggaaaca tagcgagacc ctgtctctat caaaaattta aaattaccca
     2401 ggcatggtga cgcacacctg tagtctaagt gtccaagtta cttgtgaagc tgaggtggga
     2461 ggatcacttg agcccaagag tttgaagcta tggtgagcta tgattgttcc actatactcc
     2521 agcattggca acagagcaag aactcatctc taaaaagtaa aaagcaactc cccagaaaga
     2581 ctgtatttct acagataaat attgcattga gatgccaaat agagtgttgt tgtaaagtca
     2641 tcagactaga aagcagacct ggggacagtg tttaccacct aagaggcagt cctgtttttg
     2701 agacccacat ctatatatag agatttttgt ttgtttgttt gtttgttttg ttttgttttg
     2761 agatgaagtc tcactctgtc acccaggctg gagtgcagtg gcgcaatctt ggctcactgc
     2821 aacctccacc tcccaggttc aagcaattct cctgcctcag cctcctgagt agctgggatt
     2881 acaggtgcgc actgccacgc ctgactaatt tttgtatttc tagtaaagat ggggtttcac
     2941 tatgttggcc aggctggtct tgaactcctc acctcaggtg atccacccat ctcagcctcc
     3001 caaagtgctg agattacagg cgtgagccac cacgcccggc cagagatcca catctatatt
     3061 tataacacat ttatggatga aaattaaaca ggtgtccggg tgcggttact catgcctgta
     3121 atccgagcac ttgtggaggc cgaggcaggc ggattacttg aggtcaggac ttcgaaacca
     3181 gcctggccaa catggtgaaa tcccatctct actaaaaata caaaattagc caggtgtggt
     3241 gtcacgcacc tgtagtccca gttacttgaa cctgggaggc agaggttgca gtgagccgag
     3301 attgcaacac tgccactcca gcctgggtga cagagcaaga gaccctgtct caaaaaaaaa
     3361 aaaaaaaaat taaatgggta gtgacgttaa gagatatata tcagcttcta gtaaaagttt
     3421 ttttttttaa acctgctagc tacatttaca ttatgtaaaa ataaagggaa taatcactga
     3481 gaataaagca gttgagtatt tataacaata atattttatg gggcgcttat aatgtttata
     3541 atattgtaaa ccactgtgta ctctattcat ttaatgctaa atgacttgac cattcttgtg
     3601 ggataagaga tcattaaaaa aatgctaggg ccgggcacca tggctcacgc ctgtaatccc
     3661 aggactttag gaggccaagg caggtggatg acttgagctc aggagtttga gaccagcctg
     3721 ggcaacatga tgaaaactcc gtctctacca aaaatcaaaa aaattagcca ggtgtgatgt
     3781 tgtgtgcctg tagtcccagc tacttgtgag gctgaggtgg gaggatggtt tgggccccgg
     3841 aggtagaggt tgcagtgagc tgagattgtg ccactgtatt ccatcctggg caacagagcc
     3901 agaccctgcc tcaaaaaaaa aaaaaaaaaa aaaaaaggcc tggcacagtg gctcacgcct
     3961 gtaatcccag cactttggga ggctgaggcg ggcaaaacac ttgaggtcag acgtttgaga
     4021 ccagcctggc caacatggtg aaaccccgtc tctaccaaaa ataaaaataa aaattatcca
     4081 ggcgtggtgg catgtgccta tagccccagc tactcaggaa gctaaagcac gagaattatg
     4141 tgcatcctgg aggtgaaggt tgcagtgagc caagatcaca ccactccact ccagtctgga
     4201 caacagagtg agaccctgtg tcaaaaaaaa aaaaaagaaa gaaagaaaga aaaaatgctt
     4261 tatggcccag tgcagtggct cacacctata atcctagcac tttgggaggc taaggcagga
     4321 ggattgcttg aggccaagag ttcaaaacaa gcctgggcaa cattgcaaga ccccaactct
     4381 acaaaaaacg aaaaattagc cgggagcggt gatgtgtgcc tgtagtccca gctactcagg
     4441 agactgaggt gggagaatca cttgagcctg ggaggttgag gctgcagtga gctgtgttta
     4501 taccactgca ctccagcctg ctgggtaaca gagcaagact ccatctcaaa aagaaaagaa
     4561 aaaatgcttt gctacataat gaggccaggc aaaaaaaaaa aagtcctgtg gaaatcatat
     4621 agacaaacat ttgcaaagct gctactgcca ttgtaccagt gttaaactgt gttctacctt
     4681 gcatctttta ctgattttta tgacagattt tatattgtaa ccattcgaga actctgtaag
     4741 tgctatggct tccttaaact acgatttatc atatgctccc ggtgtttact ttgagactga
     4801 atggcaacca gagaatgtaa acaaccaagg tgcatctggt tatgttttaa aataaagatt
     4861 aataaaagtt ttggtttttc tctttctaac cttcttttta aactagaaat ataataccta
     4921 tagaaaagta aatgttggcc gggtgcggtg gctcatgcct ataatcccag cactttggga
     4981 ggccgaggca ggcagatcac ctgaggtcaa gagttcgaga ccagtctggc caacatggtg
     5041 aaaccctgtc tctactaaaa atacaaaaat tagccgggca tagtggcaga cacctgtaat
     5101 cccagctact gggaaggctg agccagaatg gcttgaacct gggaggcaga ggttgcagtg
     5161 agccgagatc gccccattgc actccagctt gagcaacaag agcgaaactg tctcaaaaaa
     5221 aaaaaaaaag tatatgttaa gtatagaaaa atatataaat taaaaaatta taggcttggg
     5281 ggccaggcac agtggctcac acctgtaatc ccagcacttt gggaggccga ggtgggtgta
     5341 tcacttgagg tcaggagttt gagaccagcc tggccaacat ggtgaaaccc cgtctctacc
     5401 aaaaaaaata tataaaaatt atctgggtgt ggtggcatgt gcctatagtc tcagcttctc
     5461 agaagactga ggcgtgagaa tcacttgaac gatggaagtg gaggttgcag tgagctgaga
     5521 tcacactact gcactacagt ctgggcaaca gagtgagacc ttgtctcaaa aaaaaaagaa
     5581 agaaaaagaa aaatgcttta tggcccagtg cagtggctca cacctataat cctagcactt
     5641 tgggaggcta aggcaggagg ttcgcttgag gccaagagtt caaaacaagc ctgggcaaca
     5701 ctgcaagacc ccaactctac aaaaaacgaa aaattagccg ggagcggtga tgtgtgcctg
     5761 tagtcccagc tactcaggag actgaggtgg aagaatcact tgagcccggg aggttgaggc
     5821 tgcagtgagc tgtgtttata ccactgcact ccagcctgct gggtaacaga gcaagactcc
     5881 atctcaaaaa gaaaagaaaa aatgctttgc tacataatga ggccaggcaa aaaaaaaaag
     5941 tcctgtggaa atcatataga caaacatttg caaagctgct actgccattg taccagtgtt
     6001 aaaatgtgtt ctaccttgca tcttttactg atttttatga cagattttat attgtaacca
     6061 tttgagaact ctgtaagtgc tatggcttcc ttaaactacg atttatcata tgctcccagt
     6121 gtttactttg agactgaatg gcaaccagag aatgtaaaca accaaggtgc atctggttat
     6181 gttttaaaat aaagattaat aaaagttttg gtttttctct ttctaa
//
