LOCUS       NP_060774                360 aa            linear   PRI 29-APR-2025
DEFINITION  proline-rich protein 11 [Homo sapiens].
ACCESSION   NP_060774
VERSION     NP_060774.2
DBSOURCE    REFSEQ: accession NM_018304.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 360)
  AUTHORS   Wen,J., Wan,L. and Dong,X.
  TITLE     Prognostic value of PRR11 and immune cell infiltration in Ewing
            sarcoma
  JOURNAL   PLoS One 19 (3), e0299720 (2024)
   PUBMED   38427643
  REMARK    GeneRIF: Prognostic value of PRR11 and immune cell infiltration in
            Ewing sarcoma.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 360)
  AUTHORS   Zhu,P., Dou,C., Song,Z., Bi,X., Wu,X. and Miao,Y.
  TITLE     ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and
            motility in early pregnancy
  JOURNAL   Am J Reprod Immunol 90 (3), e13758 (2023)
   PUBMED   37641376
  REMARK    GeneRIF: ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation
            and motility in early pregnancy.
REFERENCE   3  (residues 1 to 360)
  AUTHORS   Han,W. and Chen,L.
  TITLE     Predictive significance of PRR11 in prognosis and immune
            infiltration of glioma patients
  JOURNAL   Mol Carcinog 62 (7), 975-990 (2023)
   PUBMED   37036189
  REMARK    GeneRIF: Predictive significance of PRR11 in prognosis and immune
            infiltration of glioma patients.
REFERENCE   4  (residues 1 to 360)
  AUTHORS   Ni,W., Yi,L., Dong,X., Cao,M., Zheng,J., Wei,Q. and Yuan,C.
  TITLE     PRR11 is a prognostic biomarker and correlates with immune
            infiltrates in bladder urothelial carcinoma
  JOURNAL   Sci Rep 13 (1), 2051 (2023)
   PUBMED   36739300
  REMARK    GeneRIF: PRR11 is a prognostic biomarker and correlates with immune
            infiltrates in bladder urothelial carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 360)
  AUTHORS   Tan,R., Zhao,C., Lu,Y. and Chen,L.
  TITLE     Clinical significance and effect of PRR 11 up-regulation on the
            malignancy of osteosarcoma
  JOURNAL   Pol J Pathol 73 (3), 264-276 (2022)
   PUBMED   36734441
  REMARK    GeneRIF: Clinical significance and effect of PRR 11 up-regulation
            on the malignancy of osteosarcoma.
REFERENCE   6  (residues 1 to 360)
  AUTHORS   Zhang,C., Zhang,Y., Li,Y., Zhu,H., Wang,Y., Cai,W., Zhu,J.,
            Ozaki,T. and Bu,Y.
  TITLE     PRR11 regulates late-S to G2/M phase progression and induces
            premature chromatin condensation (PCC)
  JOURNAL   Biochem Biophys Res Commun 458 (3), 501-508 (2015)
   PUBMED   25666944
  REMARK    GeneRIF: Overexpression of PRR11 inhibits cell proliferation and
            induces premature chromatin condensation.
REFERENCE   7  (residues 1 to 360)
  AUTHORS   Ji,Y., Xie,M., Lan,H., Zhang,Y., Long,Y., Weng,H., Li,D., Cai,W.,
            Zhu,H., Niu,Y., Yang,Z., Zhang,C., Song,F. and Bu,Y.
  TITLE     PRR11 is a novel gene implicated in cell cycle progression and lung
            cancer
  JOURNAL   Int J Biochem Cell Biol 45 (3), 645-656 (2013)
   PUBMED   23246489
  REMARK    GeneRIF: our results strongly demonstrated that this newly
            identified gene, PRR11, had a critical role in both cell cycle
            progression and tumorigenesis, and might serve as a novel potential
            target in the diagnosis and/or treatment of human lung cancer.
REFERENCE   8  (residues 1 to 360)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (residues 1 to 360)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: the apparent occurrence of an unusual TG 3' splice site in
            intron 10 is discussed
REFERENCE   10 (residues 1 to 360)
  AUTHORS   Weinmann,A.S., Yan,P.S., Oberley,M.J., Huang,T.H. and Farnham,P.J.
  TITLE     Isolating human transcription factor targets by coupling chromatin
            immunoprecipitation and CpG island microarray analysis
  JOURNAL   Genes Dev 16 (2), 235-244 (2002)
   PUBMED   11799066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB106349.1, AK225377.1, AC099850.7 and AW957315.1.
            
            On Feb 23, 2006 this sequence version replaced NP_060774.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.49420.1, AK225377.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262293.9/ ENSP00000262293.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     Protein         1..360
                     /product="proline-rich protein 11"
                     /note="transcription repressor of MHCII"
                     /calculated_mol_wt=39954
     Region          20..43
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96HE9.1)"
     Site            33
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q96HE9.1)"
     Site            40
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17081983,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q96HE9.1)"
     Region          174..201
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96HE9.1)"
     Region          285..291
                     /region_name="Phosphodegron"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96HE9.1)"
     Site            287
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q96HE9.1)"
     Site            291
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q96HE9.1)"
     Region          296..304
                     /region_name="D-box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96HE9.1)"
     Region          316..318
                     /region_name="KEN box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96HE9.1)"
     Region          325..330
                     /region_name="Phosphodegron"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96HE9.1)"
     Region          340..360
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96HE9.1)"
     Site            344
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q96HE9.1)"
     Site            346
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q96HE9.1)"
     Site            348
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q96HE9.1)"
     CDS             1..360
                     /gene="PRR11"
                     /coded_by="NM_018304.4:66..1148"
                     /db_xref="CCDS:CCDS11614.1"
                     /db_xref="GeneID:55771"
                     /db_xref="HGNC:HGNC:25619"
                     /db_xref="MIM:615920"
ORIGIN      
        1 mpkfkqrrrk lkakaerlfk kkeashfqsk litpppppps pervgissid isqsrswlts
       61 swnfnfpnir daiklwtnrv wsiyswcqnc itqslevlkd tifpsrichr elysvkqqfc
      121 ilesklcklq ealktisess scpscgqtch msgkltnvpa cvlitpgdsk avlpptlpqp
      181 ashfpppppp pplppppppl apvllrkpsl akalqagplk kdgpmqitvk dlltvklkkt
      241 qsldekrkli pspkarnplv tvsdlqhvtl kpnskvlstr vtnvlitpgk sqmdlrkllr
      301 kvdverspgg tpltnkenme tgtgltpvmt qalrrkfqla hprsptptlp lstssfdeqn
//
