LOCUS       NM_002767               1958 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens phosphoribosyl pyrophosphate synthetase associated
            protein 2 (PRPSAP2), transcript variant 1, mRNA.
ACCESSION   NM_002767
VERSION     NM_002767.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Katashima,R., Iwahana,H., Fujimura,M., Yamaoka,T. and Itakura,M.
  TITLE     Assignment of the human phosphoribosylpyrophosphate
            synthetase-associated protein 41 gene (PRPSAP2) to 17p11.2-p12
  JOURNAL   Genomics 54 (1), 180-181 (1998)
   PUBMED   9806849
REFERENCE   6  (bases 1 to 1958)
  AUTHORS   Katashima,R., Iwahana,H., Fujimura,M., Yamaoka,T., Ishizuka,T.,
            Tatibana,M. and Itakura,M.
  TITLE     Molecular cloning of a human cDNA for the 41-kDa
            phosphoribosylpyrophosphate synthetase-associated protein
  JOURNAL   Biochim Biophys Acta 1396 (3), 245-250 (1998)
   PUBMED   9545573
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC424578.1, BC106050.1,
            AC107982.6, AI955172.1 and AI379788.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002767.3.
            
            Summary: This gene encodes a protein that associates with the
            enzyme phosphoribosylpyrophosphate synthetase (PRS). PRS catalyzes
            the formation of phosphoribosylpyrophosphate which is a substrate
            for synthesis of purine and pyrimidine nucleotides, histidine,
            tryptophan and NAD. PRS exists as a complex with two catalytic
            subunits and two associated subunits. This gene encodes a
            non-catalytic associated subunit of PRS. Alternate splicing results
            in multiple transcript variants. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.257405.1,
                                           SRR3476690.1117878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268835.7/ ENSP00000268835.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                DC424578.1         64-128
            66-435              BC106050.1         45-414
            436-436             AC107982.6         1082-1082           c
            437-1886            BC106050.1         416-1865
            1887-1954           AI955172.1         1-68                c
            1955-1958           AI379788.1         4-7                 c
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..1958
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /note="phosphoribosyl pyrophosphate synthetase associated
                     protein 2"
                     /db_xref="GeneID:5636"
                     /db_xref="HGNC:HGNC:9467"
                     /db_xref="MIM:603762"
     exon            1..131
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            132..227
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            228..378
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1369
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphoribosyl pyrophosphate synthase-associated protein
                     2; PRPP synthase-associated protein 2; 41 kDa
                     phosphoribosypyrophosphate synthetase-associated protein"
                     /codon_start=1
                     /product="phosphoribosyl pyrophosphate synthase-associated
                     protein 2 isoform 1"
                     /protein_id="NP_002758.1"
                     /db_xref="CCDS:CCDS11200.1"
                     /db_xref="GeneID:5636"
                     /db_xref="HGNC:HGNC:9467"
                     /db_xref="MIM:603762"
                     /translation="MFCVTPPELETKMNITKGGLVLFSANSNSSCMELSKKIAERLGV
                     EMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTSCAK
                     SIIGVIPYFPYSKQCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV
                     DNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAE
                     SDLVDGRHSPPMVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDDVD
                     SFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIPHEVQKLQCP
                     KIKTVDISMILSEAIRRIHNGESMSYLFRNIGLDD"
     exon            379..431
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            432..498
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            499..671
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            672..787
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            788..843
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            844..992
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1063
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1210
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1958
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1854..1859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /note="hexamer: AATAAA"
     polyA_site      1886
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /note="major polyA site"
     regulatory      1918..1923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /note="hexamer: AATAAA"
     regulatory      1923..1928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /note="hexamer: AATGAA"
     polyA_site      1939
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
                     /note="major polyA site"
     polyA_site      1958
                     /gene="PRPSAP2"
                     /gene_synonym="PAP41"
ORIGIN      
        1 gcagtcaccg cggacgccaa tcttgtgcat ggagtcgcca ttttgctcct agagaggccg
       61 ccaggagacc cggcgctttc ttccttctgc agctgaggct gcggcggggc cggggctggg
      121 gtcggggcca ggaggaattt tgttgtcaga gaataaaagg aggttgtcca taattgactt
      181 taagcagcaa tcagtaaaac attgagctct tcagctccgc ctttcttgct ctgaaaattg
      241 gaaaaccaag aaggttttga tgttttgtgt gacgccacct gaattagaaa ccaagatgaa
      301 cataaccaaa ggtggtctgg tgttgttttc agcaaactcg aattcatcat gtatggagct
      361 atcaaagaaa attgcagagc ggctaggggt ggagatgggc aaagtgcagg tttaccagga
      421 acctaacaga gaaacaagag tacaaattca agagtctgtg aggggaaaag atgttttcat
      481 catccaaact gtttcgaagg acgtgaacac caccatcatg gagctcctga tcatggtgta
      541 tgcatgtaag acctcttgtg ccaagagcat cattggcgtg ataccctact ttccttacag
      601 caagcagtgc aagatgagaa aaagaggctc cattgtctct aaattgctgg cttccatgat
      661 gtgcaaagct ggtctaactc atcttattac tatggattta caccagaagg aaattcaggg
      721 cttcttcaat attcctgttg acaatttaag agcatctccc ttcttattac agtatattca
      781 agaagagatc ccagattaca ggaatgcagt aatcgtggcc aagtctccag cctcggcgaa
      841 gagggcacag tcttttgctg agcgcctgcg cctgggaatt gcagtgattc atggagaggc
      901 gcaggatgcc gagtcggact tggtggatgg acggcattcc ccacccatgg tcagaagtgt
      961 ggctgccatc caccccagcc tggagatccc catgctgatt cctaaagaaa agcccccaat
     1021 cacggttgtg ggtgatgttg gaggaaggat tgccatcatc gtggatgaca tcattgatga
     1081 tgttgacagc tttcttgctg cagcagagac cctgaaggaa agaggtgcat ataagatctt
     1141 tgtgatggca actcatggct tgttgtcttc tgacgccccc cggcggattg aagagtctgc
     1201 cattgatgag gtggtggtca ccaatacaat tccacatgaa gtccagaagc tccagtgccc
     1261 caagattaaa actgtggata tcagcatgat cctttcagag gcgatccgtc ggatccacaa
     1321 tggggagtcc atgtcctacc ttttcagaaa cataggctta gatgactgag ttttccttta
     1381 ggaaaactcc cgagggccaa actggaaaca taagagtgac tgctcggtgg gatggatttc
     1441 acaggaaccg tcatgcttgt tcctccctct cccctgtaac ctcacttctt attgattcct
     1501 aagaagatag accaactttt tatgtcggtt tgggtgtttg tgagtttggg gagcaatttt
     1561 tataaaagaa aaactttatt ctcctctttt gaaaaggtaa gacctcgttt tagttgtaac
     1621 tgtttaaaaa ataacacttg gaataagatt tgtaagctca caaagccttc ttccaaagtt
     1681 gcttgagcca agtgcttaaa aagttaataa aataaaatga tctgtatgat acctgcaatt
     1741 gaaaagccga aaagattata ctgtcaagtc cagtaaatga catttttaga gatgcttttg
     1801 tagacaagca tatggaatat gtgattgtat ttattttctg caactaaaaa aggaataaaa
     1861 acttgtgttt gtgtgttttt ctaaaacttt gtgttttggc aatcgtttta taactaaaat
     1921 aaaatgaaag ctaaatctac acgctgtgaa tgttgaaa
//
