LOCUS       NM_002766               3435 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens phosphoribosyl pyrophosphate synthetase associated
            protein 1 (PRPSAP1), transcript variant 1, mRNA.
ACCESSION   NM_002766
VERSION     NM_002766.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3435)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3435)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3435)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3435)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3435)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 3435)
  AUTHORS   Ishijima,S., Asai,T., Kita,K., Sonoda,T. and Tatibana,M.
  TITLE     Partial reconstitution of mammalian phosphoribosylpyrophosphate
            synthetase in Escherichia coli cells. Coexpression of catalytic
            subunits with the 39-kDa associated protein leads to formation of
            soluble multimeric complexes of various compositions
  JOURNAL   Biochim Biophys Acta 1342 (1), 28-36 (1997)
   PUBMED   9366267
REFERENCE   7  (bases 1 to 3435)
  AUTHORS   Ishizuka,T., Ahmad,I., Kita,K., Sonoda,T., Ishijima,S., Sawa,K.,
            Suzuki,N. and Tatibana,M.
  TITLE     The human phosphoribosylpyrophosphate synthetase-associated protein
            39 gene (PRPSAP1) is located in the chromosome region 17q24-q25
  JOURNAL   Genomics 33 (2), 332-334 (1996)
   PUBMED   8660991
REFERENCE   8  (bases 1 to 3435)
  AUTHORS   Ishizuka,T., Kita,K., Sonoda,T., Ishijima,S., Sawa,K., Suzuki,N.
            and Tatibana,M.
  TITLE     Cloning and sequencing of human complementary DNA for the
            phosphoribosylpyrophosphate synthetase-associated protein 39
  JOURNAL   Biochim Biophys Acta 1306 (1), 27-30 (1996)
   PUBMED   8611620
REFERENCE   9  (bases 1 to 3435)
  AUTHORS   Tatibana,M., Kita,K., Taira,M., Ishijima,S., Sonoda,T.,
            Ishizuka,T., Iizasa,T. and Ahmad,I.
  TITLE     Mammalian phosphoribosyl-pyrophosphate synthetase
  JOURNAL   Adv Enzyme Regul 35, 229-249 (1995)
   PUBMED   7572345
  REMARK    Review article
REFERENCE   10 (bases 1 to 3435)
  AUTHORS   Kita,K., Ishizuka,T., Ishijima,S., Sonoda,T. and Tatibana,M.
  TITLE     A novel 39-kDa phosphoribosylpyrophosphate synthetase-associated
            protein of rat liver. Cloning, high sequence similarity to the
            catalytic subunits, and a negative regulatory role
  JOURNAL   J Biol Chem 269 (11), 8334-8340 (1994)
   PUBMED   8132556
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB031565.1, AK312637.1, BC009012.1, AI289298.1 and AC090699.10.
            
            On May 17, 2019 this sequence version replaced NM_002766.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1296947.1,
                                           SRR3476690.1132965.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000446526.8/ ENSP00000414624.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                DB031565.1         235-290
            57-1371             AK312637.1         1-1315
            1372-1980           BC009012.1         1084-1692
            1981-2126           AI289298.1         1-146               c
            2127-3435           AC090699.10        21504-22812         c
FEATURES             Location/Qualifiers
     source          1..3435
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..3435
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
                     /note="phosphoribosyl pyrophosphate synthetase associated
                     protein 1"
                     /db_xref="GeneID:5635"
                     /db_xref="HGNC:HGNC:9466"
                     /db_xref="MIM:601249"
     exon            1..383
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1371
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
                     /EC_number="2.7.6.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphoribosyl pyrophosphate synthase-associated protein
                     1; PRPP synthase-associated protein 1; 39 kDa
                     phosphoribosypyrophosphate synthase-associated protein"
                     /codon_start=1
                     /product="phosphoribosyl pyrophosphate synthase-associated
                     protein 1 isoform 1"
                     /protein_id="NP_002757.2"
                     /db_xref="CCDS:CCDS11743.2"
                     /db_xref="GeneID:5635"
                     /db_xref="HGNC:HGNC:9466"
                     /db_xref="MIM:601249"
                     /translation="MPKKLLLLPPPSASSAFRVPRARPVPPPAMNAARTGYRVFSANS
                     TAACTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTA
                     VMELLIMAYALKTACARNIIGVIPYFPYSKQSKMRKRGSIVCKLLASMLAKAGLTHII
                     TMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIPNYRNAVIVAKSPDAAKRAQSYAE
                     RLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNATVHPGLELPLMMAKEKPPITVVGDV
                     GGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEV
                     VVTNTVPHEVQKLQCPKIKTVDISLILSEAIRRIHNGESMAYLFRNITVDD"
     exon            384..436
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
                     /inference="alignment:Splign:2.1.0"
     exon            437..503
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
                     /inference="alignment:Splign:2.1.0"
     exon            504..676
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
                     /inference="alignment:Splign:2.1.0"
     exon            677..792
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
                     /inference="alignment:Splign:2.1.0"
     exon            793..848
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
                     /inference="alignment:Splign:2.1.0"
     exon            849..994
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1065
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1212
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..3435
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1962..1967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
                     /note="hexamer: AATAAA"
     polyA_site      1980
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
                     /note="major polyA site"
     polyA_site      2024
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
     regulatory      3016..3021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
                     /note="hexamer: AATAAA"
     polyA_site      3048
                     /gene="PRPSAP1"
                     /gene_synonym="PAP39"
ORIGIN      
        1 gcctctggct ctgaggcggc ggcgccgggc gctgcgaagg ctcggccgct gtagtcagtg
       61 gtgtggggtg cgcaagggca cggacctcgg agctctcccc gcttgcgccg agtttctcag
      121 cgccttcccc acccaaaccg gggtctcgca gtcggaagca ctcagagtgc agccccgcgc
      181 ggggccggtc gtaaccgcgc cgcgggccgg acgatgccca agaagctgct gctgttgccc
      241 ccgccctccg cgtcctcggc tttccgcgtc ccgcgcgccc gccccgttcc cccgccggcc
      301 atgaacgccg ctcgcaccgg ctaccgagtc ttctcggcca actccacggc cgcctgcacg
      361 gagctggcca agcgcatcac agagcgcctt ggtgctgaat tggggaagtc tgttgtatat
      421 caagagacca atggagaaac aagagttgaa ataaaagaat ctgttcgtgg ccaagatatt
      481 ttcattatac agacaatacc cagagatgtg aatacagctg tgatggagtt gctcatcatg
      541 gcttacgcac tgaagactgc ctgtgccagg aacattattg gggtcatccc ctacttcccc
      601 tacagcaagc agagcaagat gaggaagagg ggttccattg tgtgcaagct gctagcatcc
      661 atgctggcga aagcaggttt aactcacatt atcactatgg atcttcatca aaaggaaata
      721 caaggctttt tcagctttcc tgtggacaac cttagagcct cacctttcct gcttcagtat
      781 atccaggaag aaattccaaa ttacagaaat gcagtcattg tagctaagtc tcctgatgct
      841 gcaaagaggg cccagtccta tgcggagaga ctgcgtctgg gtttggccgt cattcacggg
      901 gaagctcagt gcacggaact ggacatggac gatggtcgtc actccccgcc tatggtcaaa
      961 aatgctactg tgcacccagg cctggagttg ccattgatga tggccaaaga gaagccaccg
     1021 ataactgtag ttggagatgt tggaggccgc atcgcaatca tcgtggatga cattattgac
     1081 gatgtggaga gttttgttgc tgccgcggag atcctgaaag agagaggcgc ctataagatc
     1141 tatgttatgg ccacccacgg catcctgtct gcagaggccc ctcgcctgat tgaggagtcc
     1201 tccgtagacg aggtggtggt gacgaatact gtccctcatg aggttcagaa gctgcaatgt
     1261 cccaagataa agactgtgga tatcagtttg attctttctg aagccattcg gagaatccac
     1321 aatggagagt ccatggccta ccttttccga aacatcactg tggatgacta gctttcacga
     1381 gggtctcgac cctggacctc ctgagggaaa catggaaaaa gcagtgccat gagtgataca
     1441 gtgtttcctt gcaagggagg actcgaaaca gcctggagtt agatatcttc ttttgcccgg
     1501 attgatgggg aggagggatt aaaagagtca ggaagaagac agagctaatg gataaatatc
     1561 ataacatggc cttacatgtc tgctgtcatc agccctgttc cttaaaagtt ctagctgctt
     1621 tcttaaaaat aatctgaaaa tcttattgat actaaagagg agttaaaggc acataaagtc
     1681 ttaactctat aatgttcatt tagttgtttc agctccaggg aaatggaggt attgatgttg
     1741 aacctggtta gggaagctga gcgcctgtgg ccctattact atccagttgg cctctcccaa
     1801 atcaacttca agtcttttat agagaatcgt atttttcttt cagaaattgt tatgcctaca
     1861 gccattgaaa aatgaagcat tcatgttgtt acatcttcca aggatgtcag attagaaaat
     1921 agcatcccac ctctgggtat ctgagtggct ctgaagttgc aaataaaata atttgttgtc
     1981 ttgctagtct tttcattaga cagcagaaga ccatggatac agaacagcag tcaggtctgt
     2041 ggctggacac aaacactttc ccaggttcca ccctcttcct aagtgttgaa gctaaatcct
     2101 tgttgaatac tgtattttaa atctttaaaa aaaaaaaaaa aaagtctagg tgtggtggct
     2161 cacacctata atctgagtac tttgggaggc tgaggcaagg aggattgctt gagcccagga
     2221 gtttcagacc agcctgggaa acatggcgaa acccccatgt ctacaaaaaa tacaaaaatt
     2281 agccaggcat tggtagcatg tgcctgtagt tccagctacc ttgggaggct gaggtgggag
     2341 gattgcctga gccaaggagg ttgaagctgc agtgaactat gattgtacca ctgccatcca
     2401 tcctgggtga cagagcaaca ccctgtctca aaaaaaaaaa acaggccagg gatcgtgtct
     2461 tatgcctgta atccctgcac tttgggaggc cgaggcaggt agatcacctg aggtcaggag
     2521 tttgagacca gcctggccaa catggcaaaa ccccgtctct actaaaaata caaaaattag
     2581 cctagctaag ttaaaagcat aaaaagacta caaagaggcc aggcatcatg gctcacgcct
     2641 gtaatcccag cactttggga ggccgaggtg ggcagatcac ttgaggtcag gagtttgaga
     2701 ccagcctggc caatatggtg aaaccctgtc cctactaaaa atacaaaaat tagccgggtg
     2761 ttgggggagg gggtgcacgc ctgtaatccc agctactcgg gaggctgagg caggagaatt
     2821 aattggttga acccaagagg cagagattgc agtgagctga gattgtgcca ctgcactcca
     2881 gcccaagtga cagagcaaga ttccatctca aaaaaaaaaa aagactgcaa agaactagtt
     2941 attttgataa ccccttaaag gcctactgtg tcccaagtta ttggaatata atgatgatcg
     3001 aaaatccttc aattaaataa acagtacctc tcaggctgaa gtgaaaaatc tgaacttgaa
     3061 cagtagttaa aatagtacag ttattcctta caatccatgg gtgattggtt ccaggactca
     3121 acctcctgcc catggatgtg caagtccctg atagaaaatg gtgtagtatc tgcatataag
     3181 ctatgcacat cctggatgac ttgtaatacc tactgcaata tcctgtgtag atggtggtca
     3241 tgctgtatta tttagagaat catgacagga atctgtacgt gttcagtcgt ggttggttaa
     3301 atctgcagat gcagagctca cggaggaggc tggccatgca tggcacacat tcataggttc
     3361 tctttaagta gccttgctgt gcttctgtta ggaagtttta tttatacgtt tttgggaaga
     3421 atcttgtatg gggaa
//
