LOCUS       NM_012469               3047 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens pre-mRNA processing factor 6 (PRPF6), mRNA.
ACCESSION   NM_012469
VERSION     NM_012469.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3047)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3047)
  AUTHORS   Fritze,J.S., Stiehler,F.F. and Wolfrum,U.
  TITLE     Pathogenic Variants in USH1G/SANS Alter Protein Interaction with
            Pre-RNA Processing Factors PRPF6 and PRPF31 of the Spliceosome
  JOURNAL   Int J Mol Sci 24 (24), 17608 (2023)
   PUBMED   38139438
  REMARK    GeneRIF: Pathogenic Variants in USH1G/SANS Alter Protein
            Interaction with Pre-RNA Processing Factors PRPF6 and PRPF31 of the
            Spliceosome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3047)
  AUTHORS   Wang,H., Zhou,Y., Zhang,S., Qi,Y.A. and Wang,M.
  TITLE     PRPF6 promotes metastasis and paclitaxel resistance of ovarian
            cancer via SNHG16/CEBPB/GATA3 axis
  JOURNAL   Oncol Res 29 (4), 275-289 (2022)
   PUBMED   37303939
  REMARK    GeneRIF: PRPF6 promotes metastasis and paclitaxel resistance of
            ovarian cancer via SNHG16/CEBPB/GATA3 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3047)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   5  (bases 1 to 3047)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 3047)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   7  (bases 1 to 3047)
  AUTHORS   Yuryev,A., Ono,M., Goff,S.A., Macaluso,F. and Wennogle,L.P.
  TITLE     Isoform-specific localization of A-RAF in mitochondria
  JOURNAL   Mol Cell Biol 20 (13), 4870-4878 (2000)
   PUBMED   10848612
REFERENCE   8  (bases 1 to 3047)
  AUTHORS   Makarov,E.M., Makarova,O.V., Achsel,T. and Luhrmann,R.
  TITLE     The human homologue of the yeast splicing factor prp6p contains
            multiple TPR elements and is stably associated with the U5 snRNP
            via protein-protein interactions
  JOURNAL   J Mol Biol 298 (4), 567-575 (2000)
   PUBMED   10788320
REFERENCE   9  (bases 1 to 3047)
  AUTHORS   Nishikimi,A., Mukai,J., Kioka,N. and Yamada,M.
  TITLE     A novel mammalian nuclear protein similar to Schizosaccharomyces
            pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA
            splicing factors
  JOURNAL   Biochim Biophys Acta 1435 (1-2), 147-152 (1999)
   PUBMED   10561546
REFERENCE   10 (bases 1 to 3047)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP366197.1 and AF221842.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_012469.3.
            
            Summary: The protein encoded by this gene appears to be involved in
            pre-mRNA splicing, possibly acting as a bridging factor between U5
            and U4/U6 snRNPs in formation of the spliceosome. The encoded
            protein also can bind androgen receptor, providing a link between
            transcriptional activation and splicing. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF221842.1, SRR1660803.50856.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266079.5/ ENSP00000266079.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BP366197.1         55-63
            10-3047             AF221842.1         1-3038
FEATURES             Location/Qualifiers
     source          1..3047
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..3047
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /note="pre-mRNA processing factor 6"
                     /db_xref="GeneID:24148"
                     /db_xref="HGNC:HGNC:15860"
                     /db_xref="MIM:613979"
     exon            1..185
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..2940
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /note="androgen receptor N-terminal domain transactivating
                     protein-1; p102 U5 small nuclear ribonucleoprotein
                     particle-binding protein; putative mitochondrial outer
                     membrane protein import receptor; U5 snRNP-associated 102
                     kDa protein; PRP6 homolog; U5-102 kDa protein; PRP6
                     pre-mRNA processing factor 6 homolog"
                     /codon_start=1
                     /product="pre-mRNA-processing factor 6"
                     /protein_id="NP_036601.2"
                     /db_xref="CCDS:CCDS13550.1"
                     /db_xref="GeneID:24148"
                     /db_xref="HGNC:HGNC:15860"
                     /db_xref="MIM:613979"
                     /translation="MNKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPV
                     DDRHAPPGKRTVGDQMKKNQAADDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEAD
                     AIYAALDKRMDERRKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSI
                     PEVGDARNKRQRNPRYEKLTPVPDSFFAKHLQTGENHTSVDPRQTQFGGLNTPYPGGL
                     NTPYPGGMTPGLMTPGTGELDMRKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTD
                     LNSMIPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMK
                     GTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDIRAKKRV
                     LRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYENAR
                     KVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQ
                     DAEECDRAGSVATCQAVMRAVIGIGIEEEDRKHTWMEDADSCVAHNALECARAIYAYA
                     LQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAGDV
                     PAARSILALAFQANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAPTARVFMKSV
                     KLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCP
                     HSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLWLESVRLEYRAGLKNIANT
                     LMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKCEHDPHVLLAVAKLFWSQRK
                     ITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCESAEPRHGELWCA
                     VSKDIANWQKKIGDILRLVAGRIKNTF"
     exon            186..354
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            355..473
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            474..552
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            553..729
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            730..885
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            886..980
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1137
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1300
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1419
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1638
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1761
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1883
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2022
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2142
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2319
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2453
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2545
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2660
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2787
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..3047
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3019..3024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /note="hexamer: ATTAAA"
     polyA_site      3047
                     /gene="PRPF6"
                     /gene_synonym="ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60;
                     SNRNP102; TOM; U5-102K"
                     /note="major polyA site"
ORIGIN      
        1 gacggcgaca ctttgctacg gagtgcatcg gacgtcgaag cctagagtct ctgcgtcttt
       61 ccctcttccg ctgcctcatt cctttccttc ctagccttgg tcgtcgccgc caccatgaac
      121 aagaagaaga aaccgttcct agggatgccc gcgcccctcg gctacgtgcc ggggctgggc
      181 cggggcgcca ctggcttcac cacgcggtca gacattgggc ccgcccgtga tgcaaatgac
      241 cctgtggatg atcgccatgc acccccaggc aagagaaccg ttggggacca gatgaagaaa
      301 aatcaggctg ctgacgatga cgacgaggat ctaaatgaca ccaattacga tgagtttaat
      361 ggctatgctg ggagcctctt ctcaagtgga ccctacgaga aagatgatga ggaagcagat
      421 gctatctatg cagccctgga taaaaggatg gatgaaagaa gaaaagaaag acgggagcaa
      481 agggagaaag aagaaataga gaaatatcgt atggaacgcc ccaaaatcca acagcagttc
      541 tcagacctca agaggaagtt ggcagaagtc acagaagaag agtggctgag catccccgag
      601 gttggcgatg ccagaaataa acgtcagcgg aacccacgct atgagaagct gacccctgtt
      661 cctgacagtt tctttgccaa acatttacag accggagaga accatacctc agtggatccc
      721 cgacaaactc aatttggagg tcttaacaca ccctatccag gtggactaaa cactccatac
      781 ccaggtggaa tgacgccagg actgatgaca cctggcacag gtgagctgga catgaggaag
      841 attggccaag cgaggaacac tctgatggac atgaggctga gccaggtgtc tgactccgtg
      901 agtggacaga ccgtcgttga ccccaaaggc tacctgacgg atttaaattc catgatcccg
      961 acacacggag gagacatcaa tgatatcaag aaggcgcgac tgctcctcaa gtctgttcgg
     1021 gagacgaacc ctcatcaccc gccagcctgg attgcatcag cccgcctgga agaagtcact
     1081 gggaagctac aagtagctcg gaaccttatc atgaagggga cggagatgtg ccccaagagt
     1141 gaagatgtct ggctggaagc agccaggttg cagcctgggg acacagccaa ggccgtggta
     1201 gcccaagctg tccgtcatct cccacagtct gtcaggattt acatcagagc cgcagagctg
     1261 gaaacggaca ttcgtgcaaa gaagcgggtt cttcggaaag ccctcgagca tgttccaaac
     1321 tcggttcgct tgtggaaagc agccgttgag ctggaagaac ctgaagatgc tagaatcatg
     1381 ctgagccgag ctgtggagtg ctgccccacc agcgtggagc tctggcttgc tctggcaagg
     1441 ctggagacct atgaaaatgc ccgcaaggtc ttgaacaagg cgcgggagaa cattcctaca
     1501 gaccgacata tctggatcac ggctgctaag ctggaggaag ccaatgggaa cacgcagatg
     1561 gtggagaaga tcatcgaccg agccatcacc tcgctgcggg ccaacggtgt ggagatcaac
     1621 cgtgagcagt ggatccagga tgccgaggaa tgtgacaggg ctgggagtgt ggccacctgc
     1681 caggccgtca tgcgtgccgt gattgggatt gggattgagg aggaagatcg gaagcatacc
     1741 tggatggagg atgctgacag ttgtgtagcc cacaatgccc tggagtgtgc acgagccatc
     1801 tacgcctacg ccctgcaggt gttccccagc aagaagagtg tgtggctgcg cgccgcgtac
     1861 ttcgagaaga accatggcac tcgggagtcc ctggaagcac tcctgcagag ggctgtggcc
     1921 cactgcccca aagcagaggt gctgtggctc atgggcgcca agtccaagtg gctggcaggg
     1981 gatgtgcctg cagcaaggag catcctggcc ctggccttcc aggccaaccc caacagtgag
     2041 gagatctggc tggcagccgt gaagctggag tccgagaatg atgagtacga gcgggcccgg
     2101 aggctgctgg ccaaggcgcg gagcagtgcc cccaccgccc gggtgttcat gaagtctgtg
     2161 aagctggagt gggtgcaaga caacatcagg gcagcccaag atctgtgcga ggaggccctg
     2221 cggcactatg aggacttccc caagctgtgg atgatgaagg ggcagatcga ggagcagaag
     2281 gagatgatgg agaaggcgcg ggaagcctat aaccaggggt tgaagaagtg tccccactcc
     2341 acacccctgt ggcttttgct ctctcggctg gaggagaaga ttgggcagct tactcgagca
     2401 cgggccattt tggaaaagtc tcgtctgaag aacccaaaga accctgggct gtggttggag
     2461 tccgtgcggc tggagtaccg tgcggggctg aagaacatcg caaatacact catggccaag
     2521 gcgctgcagg agtgccccaa ctccggtatc ctgtggtctg aggccatctt cctcgaggca
     2581 aggccccaga ggaggaccaa gagcgtggat gccctgaaga agtgtgagca tgacccccat
     2641 gtgctcctgg ccgtggccaa gctgttttgg agtcagcgga agatcaccaa ggccagggag
     2701 tggttccacc gcactgtgaa gattgactcg gacctggggg atgcctgggc cttcttctac
     2761 aagtttgagc tgcagcatgg cactgaggag cagcaggagg aggtgaggaa gcgctgtgag
     2821 agtgcagagc ctcggcatgg ggagctgtgg tgcgccgtgt ccaaggacat cgccaactgg
     2881 cagaagaaga tcggggacat ccttaggctg gtggccggcc gcatcaagaa caccttctga
     2941 ttgagcggtt gccatggccg gtctccgtgg ggcagggttg ggccgcatgt ggaagggctc
     3001 tgagctgtgt cctccttcat taaaagtttt tatgtctcgt gtcagaa
//
