LOCUS       NM_001365597            7515 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens pre-mRNA processing factor 40 homolog A (PRPF40A),
            transcript variant 5, mRNA.
ACCESSION   NM_001365597 XM_005246676
VERSION     NM_001365597.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7515)
  AUTHORS   Martinez-Lumbreras,S., Trager,L.K., Mulorz,M.M., Payr,M.,
            Dikaya,V., Hipp,C., Konig,J. and Sattler,M.
  TITLE     Intramolecular autoinhibition regulates the selectivity of PRPF40A
            tandem WW domains for proline-rich motifs
  JOURNAL   Nat Commun 15 (1), 3888 (2024)
   PUBMED   38719828
  REMARK    GeneRIF: Intramolecular autoinhibition regulates the selectivity of
            PRPF40A tandem WW domains for proline-rich motifs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7515)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 7515)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7515)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 7515)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 7515)
  AUTHORS   Allen,M., Friedler,A., Schon,O. and Bycroft,M.
  TITLE     The structure of an FF domain from human HYPA/FBP11
  JOURNAL   J Mol Biol 323 (3), 411-416 (2002)
   PUBMED   12381297
  REMARK    GeneRIF: Data describe the structure of an FF domain from
            HYPA/FBP11, which differs from those of other
            phosphopeptide-binding domains and represents a novel
            phosphopeptide-binding fold.
REFERENCE   7  (bases 1 to 7515)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   8  (bases 1 to 7515)
  AUTHORS   Bedford,M.T., Reed,R. and Leder,P.
  TITLE     WW domain-mediated interactions reveal a spliceosome-associated
            protein that binds a third class of proline-rich motif: the proline
            glycine and methionine-rich motif
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10602-10607 (1998)
   PUBMED   9724750
REFERENCE   9  (bases 1 to 7515)
  AUTHORS   Faber,P.W., Barnes,G.T., Srinidhi,J., Chen,J., Gusella,J.F. and
            MacDonald,M.E.
  TITLE     Huntingtin interacts with a family of WW domain proteins
  JOURNAL   Hum Mol Genet 7 (9), 1463-1474 (1998)
   PUBMED   9700202
REFERENCE   10 (bases 1 to 7515)
  AUTHORS   Chan,D.C., Bedford,M.T. and Leder,P.
  TITLE     Formin binding proteins bear WWP/WW domains that bind proline-rich
            peptides and functionally resemble SH3 domains
  JOURNAL   EMBO J 15 (5), 1045-1054 (1996)
   PUBMED   8605874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079344.5 and AC012443.8.
            
            On Jul 8, 2021 this sequence version replaced NM_001365597.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14327317.482270.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000545856.8/ ENSP00000444656.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AC079344.5         40284-40515         c
            233-364             AC079344.5         39049-39180         c
            365-445             AC079344.5         17596-17676         c
            446-476             AC079344.5         16092-16122         c
            477-493             AC079344.5         14016-14032         c
            494-604             AC079344.5         4280-4390           c
            605-725             AC079344.5         2406-2526           c
            726-779             AC079344.5         2110-2163           c
            780-804             AC079344.5         505-529             c
            805-1179            AC012443.8         151069-151443       c
            1180-1288           AC012443.8         148262-148370       c
            1289-1353           AC012443.8         147642-147706       c
            1354-1518           AC012443.8         147123-147287       c
            1519-1627           AC012443.8         145937-146045       c
            1628-1778           AC012443.8         144895-145045       c
            1779-1912           AC012443.8         143801-143934       c
            1913-2027           AC012443.8         138802-138916       c
            2028-2119           AC012443.8         138540-138631       c
            2120-2236           AC012443.8         138319-138435       c
            2237-2374           AC012443.8         137699-137836       c
            2375-2470           AC012443.8         137267-137362       c
            2471-2557           AC012443.8         133934-134020       c
            2558-2654           AC012443.8         133757-133853       c
            2655-2716           AC012443.8         133612-133673       c
            2717-2848           AC012443.8         132553-132684       c
            2849-7515           AC012443.8         126396-131062       c
FEATURES             Location/Qualifiers
     source          1..7515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q23.3"
     gene            1..7515
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /note="pre-mRNA processing factor 40 homolog A"
                     /db_xref="GeneID:55660"
                     /db_xref="HGNC:HGNC:16463"
                     /db_xref="MIM:612941"
     exon            1..232
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..2941
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /note="isoform 5 is encoded by transcript variant 5;
                     formin binding protein 3; Huntingtin-interacting protein
                     A; NY-REN-6 antigen; Fas-ligand associated factor 1;
                     formin-binding protein 11; huntingtin yeast partner A; fas
                     ligand-associated factor 1; renal carcinoma antigen
                     NY-REN-6; huntingtin-interacting protein 10; PRP40
                     pre-mRNA processing factor 40 homolog A"
                     /codon_start=1
                     /product="pre-mRNA-processing factor 40 homolog A isoform
                     5"
                     /protein_id="NP_001352526.1"
                     /db_xref="CCDS:CCDS92876.1"
                     /db_xref="GeneID:55660"
                     /db_xref="HGNC:HGNC:16463"
                     /db_xref="MIM:612941"
                     /translation="MCSGSGRRRSSLSPTMRPGTGAERGGLMVSEMESHPPSQGPGDG
                     ERRLSGSSLCSGSWVSADGFLRRRPSMGHPGMHYAPMGMHPMGQRANMPPVPHGMMPQ
                     MMPPMGGPPMGQMPGMMSSVMPGMMMSHMSQASMQPALPPGVNSMDVAAGTASGAKSM
                     WTEHKSPDGRTYYYNTETKQSTWEKPDDLKTPAEQLLSKCPWKEYKSDSGKPYYYNSQ
                     TKESRWAKPKELEDLEGYQNTIVAGSLITKSNLHAMIKAEESSKQEECTTTSTAPVPT
                     TEIPTTMSTMAAAEAAAAVVAAAAAAAAAAAAANANASTSASNTVSGTVPVVPEPEVT
                     SIVATVVDNENTVTISTEEQAQLTSTPAIQDQSVEVSSNTGEETSKQETVADFTPKKE
                     EEESQPAKKTYTWNTKEEAKQAFKELLKEKRVPSNASWEQAMKMIINDPRYSALAKLS
                     EKKQAFNAYKVQTEKEEKEEARSKYKEAKESFQRFLENHEKMTSTTRYKKAEQMFGEM
                     EVWNAISERDRLEIYEDVLFFLSKKEKEQAKQLRKRNWEALKNILDNMANVTYSTTWS
                     EAQQYLMDNPTFAEDEELQNMDKEDALICFEEHIRALEKEEEEEKQKSLLRERRRQRK
                     NRESFQIFLDELHEHGQLHSMSSWMELYPTISSDIRFTNMLGQPGSTALDLFKFYVED
                     LKARYHDEKKIIKDILKDKGFVVEVNTTFEDFVAIISSTKRSTTLDAGNIKLAFNSLL
                     EKAEAREREREKEEARKMKRKESAFKSMLKQAAPPIELDAVWEDIRERFVKEPAFEDI
                     TLESERKRIFKDFMHVLEHECQHHHSKNKKHSKKSKKHHRKRSRSRSGSDSDDDDSHS
                     KKKRQRSESRSASEHSSSAESERSYKKSKKHKKKSKKRRHKSDSPESDAEREKDKKEK
                     DRESEKDRTRQRSESKHKSPKKKTGKDSGNWDTSGSELSEGELEKRRRTLLEQLDDDQ
                     "
     exon            233..364
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            365..445
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            446..476
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            477..493
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            494..604
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            605..725
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            726..779
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            780..804
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1179
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1288
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1353
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1518
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1627
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1778
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1912
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2027
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2119
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2236
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2374
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2470
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2557
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2654
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2716
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2848
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..7515
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2937..2942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /note="hexamer: AATAAA"
     polyA_site      2956
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /note="major polyA site"
     regulatory      3195..3200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /note="hexamer: ATTAAA"
     polyA_site      3219
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /note="major polyA site"
     regulatory      3898..3903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /note="hexamer: ATTAAA"
     polyA_site      3920
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /note="major polyA site"
     regulatory      6713..6718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /note="hexamer: AATAAA"
     polyA_site      6734
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
     regulatory      7495..7500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
                     /note="hexamer: AATATA"
     polyA_site      7515
                     /gene="PRPF40A"
                     /gene_synonym="FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10;
                     HYPA; NY-REN-6; Prp40"
ORIGIN      
        1 actcagatcg cttcttgttg gtatgtgtag cggcagtggc cgccggcgga gcagtctgag
       61 cccgacgatg aggccgggga cgggagctga gcgtggaggc ctcatggtga gtgaaatgga
      121 gagccatcct ccctcgcagg gtcctgggga cggggagcgg agattgtccg gctcaagcct
      181 ctgctccggc tcttgggtct ctgctgacgg cttcctgagg agacggccct cgatggggca
      241 ccctggcatg cattatgccc caatgggaat gcaccctatg ggtcagagag cgaatatgcc
      301 tcctgtacct catggaatga tgccgcagat gatgccccct atgggagggc caccaatggg
      361 acaaatgcct ggaatgatgt cgtcagtaat gcctggaatg atgatgtctc atatgtctca
      421 ggcttccatg cagcctgcct taccgccagg agtaaatagt atggatgtag cagcaggtac
      481 agcatctggt gcaaaatcaa tgtggactga acataaatca cctgatggaa ggacttacta
      541 ctacaacact gaaaccaaac agtctacctg ggagaaacca gatgatctta aaacacctgc
      601 tgagcaactc ttatctaaat gcccctggaa ggaatacaaa tcagattctg gaaagcctta
      661 ctattataat tctcaaacaa aagaatctcg ctgggccaaa cctaaagaac ttgaggatct
      721 tgaaggatac cagaatacca ttgttgctgg aagtcttatt acaaaatcaa acctgcatgc
      781 aatgatcaaa gctgaagaaa gcagtaagca agaagagtgc accacaacat caacagcccc
      841 agtccctaca acagaaattc cgaccacaat gagcaccatg gctgctgccg aagcagcagc
      901 tgctgttgtt gcagcagcag cagcggcagc agcagcagca gctgcagcca atgctaatgc
      961 ttccacttct gcttctaata ctgtcagtgg aactgttcca gttgttcctg agcctgaagt
     1021 tacttccatt gttgctactg ttgtagataa tgagaataca gtaactattt caactgagga
     1081 acaagcacaa cttactagta cccctgctat tcaggatcaa agtgtggaag tatccagtaa
     1141 tactggagaa gaaacatcta agcaagaaac tgtagctgat tttactccca aaaaagaaga
     1201 ggaggagagc caaccagcaa agaaaacata cacttggaat acaaaggaag aggcaaagca
     1261 agcttttaaa gaattattga aagaaaagcg ggtaccatcg aatgcttcat gggagcaggc
     1321 tatgaaaatg attattaatg atccacgata cagtgctttg gcaaagttaa gtgaaaaaaa
     1381 gcaagccttt aatgcctata aagtccagac agaaaaagaa gaaaaagaag aagcaagatc
     1441 aaagtacaaa gaggctaagg aatcctttca gcgttttctt gaaaatcatg agaaaatgac
     1501 ttctacaacc agatacaaaa aagcagagca aatgtttgga gagatggaag tttggaatgc
     1561 aatatcagaa cgtgatcgtc ttgaaatcta tgaagatgtt ttgttctttc tttcaaaaaa
     1621 agaaaaggaa caagcaaagc agttgcgaaa gagaaattgg gaagccttaa aaaacatact
     1681 tgacaacatg gctaatgtaa catactctac cacttggtct gaagcccagc agtatctgat
     1741 ggataatcca acttttgcag aagatgagga gttacaaaat atggacaaag aagatgcatt
     1801 aatttgcttt gaagaacaca ttcgggcttt agaaaaggag gaagaagaag aaaaacagaa
     1861 gagtttgctg agagaaagga gacgacagcg aaaaaatagg gaatctttcc agatattttt
     1921 agatgaatta catgaacatg gacaactgca ttctatgtca tcttggatgg aattgtatcc
     1981 aactattagt tctgatatta gattcactaa tatgcttggt cagcctggat caactgcact
     2041 tgatcttttc aagttttatg ttgaggatct taaagcacgt tatcatgacg agaagaagat
     2101 aataaaagac attctaaagg ataaaggatt tgtagttgaa gtaaacacta cttttgaaga
     2161 ttttgtggcg ataatcagtt caactaaaag atcaactaca ttagatgctg gaaatatcaa
     2221 attggctttc aatagtttac tagaaaaggc agaagcccgt gaacgtgaaa gagaaaaaga
     2281 agaggctcgg aagatgaaac gaaaagaatc tgcatttaag agtatgttaa aacaagctgc
     2341 tcctccgata gaattggatg ctgtctggga agatatccgt gagagatttg taaaagagcc
     2401 agcatttgag gacataactc tagaatctga aagaaaacga atatttaaag attttatgca
     2461 tgtgcttgag catgaatgtc agcatcatca ttcaaagaac aagaaacatt ctaagaaatc
     2521 taaaaaacat cataggaaac gttcccgctc tcgatcgggg tcagattcag atgatgatga
     2581 tagccattca aagaaaaaaa gacagcgatc agagtctcgt tctgcttcag aacattcttc
     2641 tagtgcagag tctgagagaa gttataaaaa gtcaaaaaag cataagaaga aaagtaagaa
     2701 gaggagacat aaatctgact ctccagaatc cgatgctgag cgagagaagg ataaaaaaga
     2761 aaaagatcgg gaaagtgaaa aagacagaac tagacaaaga tcagaatcaa aacacaaatc
     2821 gcctaagaaa aagactggaa aggattctgg taattgggat acttctggca gcgaactgag
     2881 tgaaggggaa ttggaaaagc gcagaagaac ccttttggag caactggatg atgatcaata
     2941 aattatacca aatatatgtt tacagtatga tttaaagtct gattcagacc agggactcta
     3001 ttttaagttc aactgaaata acactgggtt ttaattatat cacaggaaaa aaaaagtgca
     3061 tttaagtatt gttatcgtgg actttataaa agcaaaggaa attgaaagta acttttgatt
     3121 ctgtatcaag aatcatattt tcatacagtc ataactgtct ttctgtgacc ctttcacagg
     3181 gcactgtagg atggattaaa ggtggcaatt tactgataac tgcagatgtc tctactttgt
     3241 tctaaaatct aagtcatgag gtgatttgat ttactttata gaagctggat tttgaagatc
     3301 taatgaaaaa ttttttgata atatagtagt acaaaaaaag caccagcaac tgataaaaat
     3361 tgcttttttg tgcgctaccc aactggttaa agccaatgtg atcttttatg gtgaaactcc
     3421 taagaaacag gtggttttgc tggaaacttg gtagaccctt aattatagtg gtgctaatga
     3481 gcactactgt aatataaagc caccattatt ttttatcaaa catctgaata cattttacaa
     3541 aggctattgt gagggcatta ttttgagcat ctattttgag gtgatgttta aaaaaacttt
     3601 aacatcaaat caaattgtaa attaatttaa atatattgcc ttaaggacct actaaagaat
     3661 gtgccaccag actttaagtg atagttgcaa tatccttgtc taaaaaaaaa aaaaaagttg
     3721 acttaaacat tttctttaac agttgtcttt tttttctaaa ttcagtcttt ctcttgcttt
     3781 tttttccctg ctattgagga agtattttgc cttccctact cactgagaag tattgacttc
     3841 gtggtacaca ttctaaagca tttctgattt gaatattttt gtacattttt atcaattatt
     3901 aaaccttctc ttctagtgtg tactagtatt tatttctact taaactgctc agctctaaag
     3961 aaattgtatg atcactttaa aggtactaaa tccctgaaat tttgcttcat cttacccaca
     4021 ccgctagttt actttccttt tttaatattt aagaatatta taaatcagtg catttgaggt
     4081 ccctagattt gtttttcacc tatgaatttt ttacagacta ttttagagag gctgtggttt
     4141 gaagacagaa tactctttac atgctaactt ttgaaggttg gtaatgtaat ttatactatt
     4201 ttccttcagt gcaggagatt ttttaagtaa ataagtaaat tttagcacct attcttcggt
     4261 attatctgtg ttattctttt aatgtgtaca cttgaagaga tcctatttca aagttgggat
     4321 tttgaagaac aaaaagtttt tttcttaccc atcctagtga gttttgaaag tgggcctgac
     4381 cagaatgtct ctttcccatt ttgccccgtt tgaattaaat ataatgtcta ctctttaaag
     4441 gctgaagggg tgggtgaggg gattgtttct cattttgtct cccaagtcat ttttctgctg
     4501 tgaaatatga ccaggcttgt aggaagactc atcttggaga aaatgtgaag taatcaaatt
     4561 gcttgagatt agtctcctat tgtatattag agccaaaaca cataataact ttggcaacag
     4621 ggagttgtct agactcaatt ttcagaggtc ccattgtagt gagttaatat tgctaatcat
     4681 gtcaatcact tgacatggaa gtcagtggca aatctttaaa gtatgcattt gatactggca
     4741 aatatatact actgatgttt cacaaaagaa tcttagaatc tgtagaaaac attaattact
     4801 tccatgaatt atttctaaag tataacttta aagttttgat ttttctattt aaataaaaag
     4861 ctattgatgt gttttagcat gtcctcaaaa tagattcctg tatttcttac agagataatc
     4921 ttactataac cgcaaatccc tacaacacag tataaagttt ccctgtagtt cacccatgaa
     4981 aattatttga cttaaaaaca accatagtag taagccaatt gcaattcaaa atgcaacatc
     5041 cttgccataa aagatgtaac ttaagtgact gtgatccttt gtctaccttt caggatccca
     5101 tcaaatggga tttagttgct agaaagatac ttgacagtct gaaggcacag gtgataagat
     5161 tttgttctct gtgaatattt ttaaactaat aggttatgtt tttaaatctt caatttggta
     5221 aaaaactgaa acgtcttgga atattggttc tattagagtt aaatatggta aaacaggaaa
     5281 gcgtgtttat tttcagataa ggggaattta tacttttcat taaagtcttg gagtcttagg
     5341 aaaatgttga gggtttgtct tcccccagtg tcattaatac taatgaacta ttagatcaaa
     5401 ttcacttata catttaatat catagttatt caaaatcagg actttaaata tttttttctc
     5461 ccagttcata tttctttgtg cgaaaattga atttgtatga aaagttagat aattaagcta
     5521 atcaagtatg aagtatacac tcttcctaag tgaatttaaa taatgtaatg cttttaaata
     5581 aaagcagtgg tcccaccaca tttttttcag catagtagct ggcattttgt tatcattagc
     5641 cagagtagct tcagcatata agttattgat gttttccaac ttcaaaagtg cattttatgc
     5701 ctcccagtaa atttgataat gatttgtcac agctttgtca tcttttgact tttgcttatg
     5761 ggcctcactt cgtacaacta taacatgaaa aaggattgtc ctaaagtaag ggaatcagtt
     5821 aatggtagga tgaagaaact gtaaaaactc ctagaaaaaa acctgtgtgc atttttctgg
     5881 aaagttttca aactgtgtaa ttcagttttc attcaattat ataatttggt tatatgcttt
     5941 aaaaaacatt tgtctaaatg ttcccggttt tcttctggtc ttagagtcag ctgagtgctg
     6001 gctatgcagc cactcgtatt tttgcatcca gaaaggagta actcccttta tatgaagatt
     6061 ttttttttta agcttagatg ctatgtaaga gaaaactatt tgtaatcaca tagtacccag
     6121 ggaggagtga tgaatgcttt tttaaaaaag gatatttaag tatattatgt aatttaaata
     6181 taaattatca aactaaaaaa cttcagcttt taaaactttc taaacaaaat gaagcaaagt
     6241 acattaattc cttctatctt aaatctgaga ctttttattt tcccttgggt atatatttct
     6301 ctcagtgtta ggtagatgtt aattcaacca tcctacattc tctatataaa attacactca
     6361 ttttacatga aagcaaaata atgtcgttac tttcatggaa ctgtgttcta acaggcttat
     6421 aatctcattc tgtgcttctg gtaatggcgt ataccagtct gatgattctt accatcctta
     6481 ttcttacatt actcttccaa ttgttttgat tttaactggt ggtcatgtaa gttcctcggt
     6541 ggcagggatt tatctggttc atttactgtt atatatcctt gtggaatagg acagtgcctg
     6601 gcatataata ggcacttttg gaatgaatgt aaaatactag ttgaaatatg tattcatctg
     6661 gcatccatgg tacccatcat ctgtattaaa gggcttaaaa aagcatcatt gcaataaacc
     6721 atactaaccc accactaaag tcacagtcat aattgaagtg cacccaaaat aaggtccagt
     6781 gactgtacct tagcttttac ttcagacatg tccaaaactt gtgagaacat acaatttaaa
     6841 gttgaaaact catcattttg ggctattttt gaatagggct gaaatatggt gacatgtcag
     6901 gcactcagtt ttttggagct gtcttaaagg tgaggtggaa agtgagagat gattttgctc
     6961 taattaccca cacattctcc ctaaccctcc attttaagac acttagctat aatagcttaa
     7021 gactatcaaa actgcttttg tgattctcag taggatctag ttcaaagcca tctcagtgct
     7081 agtgattggt aattgttaat ttgatggtaa ttaccctact tgtaaagttg acattcatac
     7141 tggctaatcc tccctgcccc tagtcgtgga caatgaaaca gtgagtggct ggtgaattag
     7201 atcagattca aactaagcca ttccttgatg ctattcttca ctgctgttcc ttagggtatc
     7261 taaatgtgtt atttataaac atttttgggg gctcctgcct gcaaacttcg gtaggtgttg
     7321 gtcttcccca cctctacaac tgagccaagg acttgttctg aaaggtgagt aataaataag
     7381 ggaacaaggt ttctattttc tgtgtttgta attaccagat tttcacctct gtttatatat
     7441 tattctgatg taaaagaacc tcatagttat ataaaattag accttttgta aataaatata
     7501 atttattaga aaaaa
//
