LOCUS       NM_014502               2337 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens pre-mRNA processing factor 19 (PRPF19), mRNA.
ACCESSION   NM_014502
VERSION     NM_014502.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2337)
  AUTHORS   Shepelev,N.M., Kurochkina,A.O., Dontsova,O.A. and Rubtsova,M.P.
  TITLE     PRPF19 mRNA Encodes a Small Open Reading Frame That Is Important
            for Viability of Human Cells
  JOURNAL   Dokl Biochem Biophys 515 (1), 41-47 (2024)
   PUBMED   38472668
  REMARK    GeneRIF: PRPF19 mRNA Encodes a Small Open Reading Frame That Is
            Important for Viability of Human Cells.
REFERENCE   2  (bases 1 to 2337)
  AUTHORS   Wang,Y., Wang,J., He,J., Ji,B., Pang,Z., Wang,J., Liu,Y. and Ren,M.
  TITLE     Comprehensive analysis of PRPF19 immune infiltrates, DNA
            methylation, senescence-associated secretory phenotype and ceRNA
            network in bladder cancer
  JOURNAL   Front Immunol 14, 1289198 (2023)
   PUBMED   38022515
  REMARK    GeneRIF: Comprehensive analysis of PRPF19 immune infiltrates, DNA
            methylation, senescence-associated secretory phenotype and ceRNA
            network in bladder cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2337)
  AUTHORS   Zhang,G., Zhang,W., Dan,M., Zou,F., Qiu,C. and Sun,C.
  TITLE     PRPF19 promotes the proliferation, migration, and inhibits
            autophagy in prostate cancer by suppressing SLC40A1
  JOURNAL   Chin J Physiol 66 (5), 379-387 (2023)
   PUBMED   37929350
  REMARK    GeneRIF: PRPF19 promotes the proliferation, migration, and inhibits
            autophagy in prostate cancer by suppressing SLC40A1.
REFERENCE   4  (bases 1 to 2337)
  AUTHORS   Zhang,G.C., Yu,X.N., Guo,H.Y., Sun,J.L., Liu,Z.Y., Zhu,J.M.,
            Liu,T.T., Dong,L., Shen,X.Z. and Yin,J.
  TITLE     PRP19 Enhances Esophageal Squamous Cell Carcinoma Progression by
            Reprogramming SREBF1-Dependent Fatty Acid Metabolism
  JOURNAL   Cancer Res 83 (4), 521-537 (2023)
   PUBMED   36723974
  REMARK    GeneRIF: PRP19 Enhances Esophageal Squamous Cell Carcinoma
            Progression by Reprogramming SREBF1-Dependent Fatty Acid
            Metabolism.
REFERENCE   5  (bases 1 to 2337)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 2337)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   7  (bases 1 to 2337)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   8  (bases 1 to 2337)
  AUTHORS   Hatakeyama,S., Yada,M., Matsumoto,M., Ishida,N. and Nakayama,K.I.
  TITLE     U box proteins as a new family of ubiquitin-protein ligases
  JOURNAL   J Biol Chem 276 (35), 33111-33120 (2001)
   PUBMED   11435423
REFERENCE   9  (bases 1 to 2337)
  AUTHORS   Gotzmann,J., Gerner,C., Meissner,M., Holzmann,K., Grimm,R.,
            Mikulits,W. and Sauermann,G.
  TITLE     hNMP 200: a novel human common nuclear matrix protein combining
            structural and regulatory functions
  JOURNAL   Exp Cell Res 261 (1), 166-179 (2000)
   PUBMED   11082287
REFERENCE   10 (bases 1 to 2337)
  AUTHORS   Gerner,C., Holzmann,K., Meissner,M., Gotzmann,J., Grimm,R. and
            Sauermann,G.
  TITLE     Reassembling proteins and chaperones in human nuclear matrix
            protein fractions
  JOURNAL   J Cell Biochem 74 (2), 145-151 (1999)
   PUBMED   10404385
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL555169.3, AP003721.3, AP000777.4 and AW673738.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014502.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018698.2, AJ131186.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227524.9/ ENSP00000227524.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AL555169.3         16-60
            46-222              AP003721.3         12618-12794         c
            223-372             AP003721.3         9966-10115          c
            373-449             AP003721.3         9713-9789           c
            450-591             AP003721.3         8994-9135           c
            592-665             AP003721.3         8837-8910           c
            666-728             AP003721.3         8657-8719           c
            729-770             AP003721.3         7753-7794           c
            771-845             AP003721.3         7549-7623           c
            846-921             AP003721.3         7108-7183           c
            922-1031            AP003721.3         6836-6945           c
            1032-1187           AP003721.3         5403-5558           c
            1188-1257           AP003721.3         5116-5185           c
            1258-1343           AP003721.3         4795-4880           c
            1344-1514           AP003721.3         4355-4525           c
            1515-1620           AP003721.3         4100-4205           c
            1621-2126           AP000777.4         118429-118934       c
            2127-2337           AW673738.1         2-212               c
FEATURES             Location/Qualifiers
     source          1..2337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..2337
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /note="pre-mRNA processing factor 19"
                     /db_xref="GeneID:27339"
                     /db_xref="HGNC:HGNC:17896"
                     /db_xref="MIM:608330"
     exon            1..222
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1718
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /EC_number="2.3.2.27"
                     /note="nuclear matrix protein NMP200 related to splicing
                     factor PRP19; senescence evasion factor; nuclear matrix
                     protein 200; PRP19/PSO4 homolog; PRP19/PSO4 pre-mRNA
                     processing factor 19 homolog; psoralen 4; RING-type E3
                     ubiquitin transferase PRP19"
                     /codon_start=1
                     /product="pre-mRNA-processing factor 19"
                     /protein_id="NP_055317.1"
                     /db_xref="CCDS:CCDS7995.1"
                     /db_xref="GeneID:27339"
                     /db_xref="HGNC:HGNC:17896"
                     /db_xref="MIM:608330"
                     /translation="MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINN
                     QPLSEEQLIDIKVAHPIRPKPPSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQE
                     LSHALYQHDAACRVIARLTKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPM
                     DLGELVGMTPEIIQKLQDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHS
                     ASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQ
                     DLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSD
                     IQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHS
                     GPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYL
                     ALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL"
     exon            223..372
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     exon            373..449
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     exon            450..591
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     exon            592..665
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     exon            666..728
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     exon            729..770
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     exon            771..845
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     exon            846..921
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1031
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1187
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1257
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1343
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1514
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1620
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..2337
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2134..2139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /note="hexamer: ATTAAA"
     regulatory      2142..2147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /note="hexamer: AAGAAA"
     polyA_site      2154
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /note="major polyA site"
     polyA_site      2160
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /note="major polyA site"
     regulatory      2319..2324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
                     /note="hexamer: AACAAA"
     polyA_site      2337
                     /gene="PRPF19"
                     /gene_synonym="hPSO4; NMP200; PRP19; PSO4; SNEV; UBOX4"
ORIGIN      
        1 aatttccgtt aggtgctgaa ggctgtggcg cgcggctgtc cccattccca cgtgaagcgc
       61 tacgctagca tcgctcggct ggcggctccc agctcgccgc ggagcagtcc cggcagcagc
      121 gggggaccgg aagtggctcg cggaggctca gaagctagtc ccggagcccg gcgtgtggcg
      181 cctcggagca cggtgacggc gccatgtccc taatctgctc catctctaac gaagtgccgg
      241 agcacccatg tgtatcccct gtctctaatc atgtttatga gcggcggctc atcgagaagt
      301 acattgcgga gaatggtacc gaccccatca acaaccagcc tctctccgag gagcagctca
      361 tcgacatcaa agttgctcac ccaatccggc ccaagcctcc ctcagccacc agcatcccgg
      421 ccattctgaa agctttgcag gatgagtggg atgcagtcat gctgcacagc ttcactctgc
      481 gccagcagct gcagacaacc cgccaagagc tgtcacacgc tctgtaccag cacgatgccg
      541 cctgccgtgt cattgcccgt ctcaccaagg aagtcactgc tgcccgagaa gctctggcta
      601 ccctgaaacc acaggctggc ctcattgtgc cccaggctgt gccaagttcc caaccaagtg
      661 ttgtgggtgc gggtgagcca atggatttgg gtgagctggt gggaatgacc ccagagatta
      721 ttcagaagct tcaagacaaa gccactgtgc taaccacgga gcgcaagaag agagggaaga
      781 ctgtgcctga ggagctggtg aagccagaag agctcagcaa ataccggcag gtggcatccc
      841 acgtggggtt gcacagtgcc agcattcctg ggatcctggc cctggacctc tgcccgtccg
      901 acaccaacaa gatcctcact ggtggggcgg ataaaaatgt cgttgtgttt gacaaaagtt
      961 ctgaacaaat cctggctacc ctcaaaggcc ataccaagaa ggtcaccagc gtggtgtttc
     1021 acccttccca ggacctggtg ttttctgctt cccccgatgc cactatcagg atttggtcgg
     1081 tccccaatgc ctcttgtgta caggtggttc gggcccatga gagtgctgtg acaggcctca
     1141 gccttcatgc cactggcgac tatctcctga gctcctccga tgatcagtac tgggctttct
     1201 ctgacatcca gacagggcgt gtgctcacca aggtgacaga tgagacctcc ggctgctctc
     1261 tcacctgtgc acagttccac cctgacggac tcatctttgg aacaggaacc atggactctc
     1321 agatcaagat ctgggacttg aaggaacgta ctaatgtggc caacttccct ggccactcgg
     1381 gccccatcac tagcatcgcc ttctctgaga atggttacta cctggctaca gcggctgatg
     1441 actcctctgt caagctctgg gatctgcgca agcttaagaa ctttaagact ttgcagctgg
     1501 ataacaactt tgaggtaaag tcactgatct ttgaccagag tggtacctac ctggctcttg
     1561 ggggcacgga tgtccagatc tacatctgca aacaatggac ggagattctt cactttacag
     1621 agcatagcgg cctgaccaca ggggtggcct tcgggcatca cgccaagttc atcgcttcaa
     1681 caggcatgga cagaagcctc aagttctaca gcctgtaggc cctggccctt ctgatggaag
     1741 ctgggcctca tctcagtaga ggggtagaat tagggtttgg gggggggggt ggggggaatc
     1801 tatgggggga gggggctctg tggggtggga cattcacatc atttcactct ggtctgagtg
     1861 gtggcctgag aaccatggtg gcatggacca ccctcatcca tgcaactcca ggccccatgg
     1921 gaacggatgt ggaaggaaga actgtcaccc tcttaaggcc cagggtcgga gcccagggcc
     1981 tctcccttcc tgtcgttcaa tggacgtggt ggtggctgtt ccacacccat tttgttgcag
     2041 ttcctgtgag acaggagagg ctgagccaag ggaactgtga aggggatggg caggagggct
     2101 tgtgcagggt tttgtaagca gtgatctagt ttcattaaaa aaagaaaaca ataaccataa
     2161 ccacctcccc gtgtctgtct gcaccaggag cacctgggac tgggaaggtc aaggggaggg
     2221 agcacacact gggacactgg cttccgggaa gcccatcttc ctttcctttc acagctctta
     2281 cccttttttt ttttttttaa ttgcacagca gaaataaaaa caaatctgca gatgaaa
//
