LOCUS       NM_003891               1497 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens protein Z, vitamin K dependent plasma glycoprotein
            (PROZ), transcript variant 2, mRNA.
ACCESSION   NM_003891
VERSION     NM_003891.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1497)
  AUTHORS   Bianchini,E.P., Razanakolona,M., Helms,J., Zouiti,F.,
            Couteau-Chardon,A., Marin-Esteban,V., Chaisemartin,L.,
            De-Carvalho,A., Bironien,R., Chollet-Martin,S., Denis,C.V.,
            Diehl,J.L., Vasse,M., Meziani,F. and Borgel,D.
  TITLE     The Proteolytic Inactivation of Protein Z-Dependent Protease
            Inhibitor by Neutrophil Elastase Might Promote the Procoagulant
            Activity of Neutrophil Extracellular Traps in Sepsis
  JOURNAL   Thromb Haemost 122 (4), 506-516 (2022)
   PUBMED   34134169
  REMARK    GeneRIF: The Proteolytic Inactivation of Protein Z-Dependent
            Protease Inhibitor by Neutrophil Elastase Might Promote the
            Procoagulant Activity of Neutrophil Extracellular Traps in Sepsis.
REFERENCE   2  (bases 1 to 1497)
  AUTHORS   Pan,C., Huang,Y., Guo,X., Gu,C., Guo,J. and Luo,X.
  TITLE     Expression and diagnostic value of plasma protein Z and protein
            Z-dependent protease inhibitor in fetal growth restriction
  JOURNAL   Ginekol Pol 93 (12), 987-992 (2022)
   PUBMED   35072242
  REMARK    GeneRIF: Expression and diagnostic value of plasma protein Z and
            protein Z-dependent protease inhibitor in fetal growth restriction.
REFERENCE   3  (bases 1 to 1497)
  AUTHORS   Bae,Y.U., You,J.H., Cho,N.H., Kim,L.E., Shim,H.M., Park,J.H. and
            Cho,H.C.
  TITLE     Association of Protein Z with Prediabetes and Type 2 Diabetes
  JOURNAL   Endocrinol Metab (Seoul) 36 (3), 637-646 (2021)
   PUBMED   34074095
  REMARK    GeneRIF: Association of Protein Z with Prediabetes and Type 2
            Diabetes.
REFERENCE   4  (bases 1 to 1497)
  AUTHORS   Yakut,K., Atalay,C.R., Ocal,D.F., Sari,M.E. and Turhan,T.
  TITLE     The Relationship between Z-Protein Level and other Parameters in
            Pregnant Women with Intrauterine Growth Retardation in Third
            Trimester
  JOURNAL   Clin Lab 65 (10) (2019)
   PUBMED   31625376
  REMARK    GeneRIF: Data show that women with intrauterine growth restriction
            (IUGR) had significantly higher mean plasma concentrations of
            protein Z compared to women with normal pregnancies.
REFERENCE   5  (bases 1 to 1497)
  AUTHORS   Fujimaki,K., Yamazaki,T., Taniwaki,M. and Ichinose,A.
  TITLE     The gene for human protein Z is localized to chromosome 13 at band
            q34 and is coded by eight regular exons and one alternative exon
  JOURNAL   Biochemistry 37 (19), 6838-6846 (1998)
   PUBMED   9578570
REFERENCE   6  (bases 1 to 1497)
  AUTHORS   Hogg,P.J. and Stenflo,J.
  TITLE     Interaction of human protein Z with thrombin: evaluation of the
            species difference in the interaction between bovine and human
            protein Z and thrombin
  JOURNAL   Biochem Biophys Res Commun 178 (3), 801-807 (1991)
   PUBMED   1872862
REFERENCE   7  (bases 1 to 1497)
  AUTHORS   Hogg,P.J. and Stenflo,J.
  TITLE     Interaction of vitamin K-dependent protein Z with thrombin.
            Consequences for the amidolytic activity of thrombin and the
            interaction of thrombin with phospholipid vesicles
  JOURNAL   J Biol Chem 266 (17), 10953-10958 (1991)
   PUBMED   2040612
REFERENCE   8  (bases 1 to 1497)
  AUTHORS   Ichinose,A., Takeya,H., Espling,E., Iwanaga,S., Kisiel,W. and
            Davie,E.W.
  TITLE     Amino acid sequence of human protein Z, a vitamin K-dependent
            plasma glycoprotein
  JOURNAL   Biochem Biophys Res Commun 172 (3), 1139-1144 (1990)
   PUBMED   2244898
REFERENCE   9  (bases 1 to 1497)
  AUTHORS   Iwanaga,S., Nishimura,H., Kawabata,S., Kisiel,W., Hase,S. and
            Ikenaka,T.
  TITLE     A new trisaccharide sugar chain linked to a serine residue in the
            first EGF-like domain of clotting factors VII and IX and protein Z
  JOURNAL   Adv Exp Med Biol 281, 121-131 (1990)
   PUBMED   2129367
REFERENCE   10 (bases 1 to 1497)
  AUTHORS   Broze,G.J. Jr. and Miletich,J.P.
  TITLE     Human Protein Z
  JOURNAL   J Clin Invest 73 (4), 933-938 (1984)
   PUBMED   6707212
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL137002.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_003891.2.
            
            Summary: This gene encodes a liver vitamin K-dependent glycoprotein
            that is synthesized in the liver and secreted into the plasma. The
            encoded protein plays a role in regulating blood coagulation by
            complexing with protein Z-dependent protease inhibitor to directly
            inhibit activated factor X at the phospholipid surface.
            Deficiencies in this protein are associated with an increased risk
            of ischemic arterial diseases and fetal loss. Mutations in this
            gene are the cause of protein Z deficiency. Alternate splicing
            results in multiple transcript variants. [provided by RefSeq, Jan
            2012].
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding region, compared to variant 1. The encoded isoform (2) is
            shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.152222.1, M55670.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375547.7/ ENSP00000364697.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AL137002.19        83291-83373
            84-247              AL137002.19        84657-84820
            248-272             AL137002.19        85591-85615
            273-386             AL137002.19        87652-87765
            387-518             AL137002.19        89156-89287
            519-586             AL137002.19        89696-89763
            587-704             AL137002.19        95056-95173
            705-1497            AL137002.19        96237-97029
FEATURES             Location/Qualifiers
     source          1..1497
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..1497
                     /gene="PROZ"
                     /gene_synonym="PZ"
                     /note="protein Z, vitamin K dependent plasma glycoprotein"
                     /db_xref="GeneID:8858"
                     /db_xref="HGNC:HGNC:9460"
                     /db_xref="MIM:176895"
     exon            1..83
                     /gene="PROZ"
                     /gene_synonym="PZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1216
                     /gene="PROZ"
                     /gene_synonym="PZ"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="vitamin K-dependent protein Z isoform 2
                     precursor"
                     /protein_id="NP_003882.1"
                     /db_xref="CCDS:CCDS9531.1"
                     /db_xref="GeneID:8858"
                     /db_xref="HGNC:HGNC:9460"
                     /db_xref="MIM:176895"
                     /translation="MAGCVPLLQGLVLVLALHRVEPSVFLPASKANDVLVRWKRAGSY
                     LLEELFEGNLEKECYEEICVYEEAREVFENEVVTDEFWRRYKGGSPCISQPCLHNGSC
                     QDSIWGYTCTCSPGYEGSNCELAKNECHPERTDGCQHFCLPGQESYTCSCAQGYRLGE
                     DHKQCVPHDQCACGVLTSEKRAPDLQDLPWQVKLTNSEGKDFCGGVIIRENFVLTTAK
                     CSLLHRNITVKTYFNRTSQDPLMIKITHVHVHMRYDADAGENDLSLLELEWPIQCPGA
                     GLPVCTPEKDFAEHLLIPRTRGLLSGWARNGTDLGNSLTTRPVTLVEGEECGQVLNVT
                     VTTRTYCERSSVAAMHWMDGSVVTREHRGSWFLTGVLGSQPVGGQAHMVLVTKVSRYS
                     LWFKQIMN"
     exon            84..247
                     /gene="PROZ"
                     /gene_synonym="PZ"
                     /inference="alignment:Splign:2.1.0"
     exon            248..272
                     /gene="PROZ"
                     /gene_synonym="PZ"
                     /inference="alignment:Splign:2.1.0"
     exon            273..386
                     /gene="PROZ"
                     /gene_synonym="PZ"
                     /inference="alignment:Splign:2.1.0"
     exon            387..518
                     /gene="PROZ"
                     /gene_synonym="PZ"
                     /inference="alignment:Splign:2.1.0"
     exon            519..586
                     /gene="PROZ"
                     /gene_synonym="PZ"
                     /inference="alignment:Splign:2.1.0"
     exon            587..704
                     /gene="PROZ"
                     /gene_synonym="PZ"
                     /inference="alignment:Splign:2.1.0"
     exon            705..1497
                     /gene="PROZ"
                     /gene_synonym="PZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1470..1475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROZ"
                     /gene_synonym="PZ"
                     /note="hexamer: AATAAG"
     polyA_site      1497
                     /gene="PROZ"
                     /gene_synonym="PZ"
                     /note="major polyA site"
ORIGIN      
        1 gctccgggtg ggaatggcag gctgcgtccc actgctccag ggcctggtcc tggtcctcgc
       61 cctccatcgt gtggagccct cagtatttct cccggcctcc aaagcaaacg acgttctggt
      121 gaggtggaag cgtgcgggct cctatcttct ggaagaactc ttcgagggaa acttggaaaa
      181 agaatgttat gaagaaatct gtgtctatga agaagcaaga gaagtgtttg aaaatgaagt
      241 agtcactgat gaattctgga gacgatataa gggcggctcc ccgtgcatct cccagccctg
      301 cctccacaac ggctcttgcc aggacagcat ctggggctac acctgcacct gctcccccgg
      361 ctatgagggc agcaactgcg agctggctaa aaatgaatgt cacccagagc ggactgatgg
      421 gtgtcaacac ttctgcctcc caggacagga atcctacaca tgcagctgtg ctcagggcta
      481 caggcttggt gaggaccaca aacagtgtgt gccccacgac cagtgtgcct gcggggtgct
      541 gacctctgag aagcgtgcac cggatctaca ggacctcccg tggcaggtaa agttaacaaa
      601 ttccgaagga aaagacttct gtggtggtgt tataatacgg gaaaattttg tactgacaac
      661 agcaaaatgt tcactgttac acaggaatat tactgtaaaa acatatttta acagaacgag
      721 ccaagacccg ctgatgatca agataacgca cgtccatgtg cacatgcggt atgacgcgga
      781 cgcgggggag aatgacctgt cactgctgga gctggagtgg cccatccagt gcccaggtgc
      841 ggggctcccc gtgtgcaccc ctgagaaaga cttcgctgag cacctcctca tcccacgcac
      901 caggggcctc ctcagcggct gggcacgcaa tggcactgac ctgggcaact cgctgaccac
      961 gcggcctgtc acacttgtgg agggggagga gtgcgggcag gtcctgaatg tgactgtcac
     1021 caccaggacc tactgtgaga gaagcagcgt ggcggccatg cactggatgg atggaagtgt
     1081 ggtcaccaga gaacacagag gctcctggtt tctcacgggg gtcctgggct cgcagccagt
     1141 aggagggcag gctcacatgg tccttgtcac caaggtctcc aggtactcac tctggtttaa
     1201 acagatcatg aactaactga aactcagcta gccagaatga acaacacaac cggaagcggg
     1261 attccaagct ggcactgcca ctgtggaggg cgctgaaact tcatcacaca ctgagaggcc
     1321 gtcacagccc cagaccaccc gcttggccca cgcagcagca gagccgccgt ttgctgggtt
     1381 gtttaccgag cactgtgacc tttctttccc tggaactctt tatctcaata gagaccttaa
     1441 aagaaaacat gagatacgtt aaataataaa ataagataat ctgtcagtca taaagca
//
