LOCUS       NM_001243007            4438 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens prospero homeobox 2 (PROX2), transcript variant 1,
            mRNA.
ACCESSION   NM_001243007
VERSION     NM_001243007.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4438)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   2  (bases 1 to 4438)
  AUTHORS   Cornelis,M.C., Monda,K.L., Yu,K., Paynter,N., Azzato,E.M.,
            Bennett,S.N., Berndt,S.I., Boerwinkle,E., Chanock,S.,
            Chatterjee,N., Couper,D., Curhan,G., Heiss,G., Hu,F.B.,
            Hunter,D.J., Jacobs,K., Jensen,M.K., Kraft,P., Landi,M.T.,
            Nettleton,J.A., Purdue,M.P., Rajaraman,P., Rimm,E.B., Rose,L.M.,
            Rothman,N., Silverman,D., Stolzenberg-Solomon,R., Subar,A.,
            Yeager,M., Chasman,D.I., van Dam,R.M. and Caporaso,N.E.
  TITLE     Genome-wide meta-analysis identifies regions on 7p21 (AHR) and
            15q24 (CYP1A2) as determinants of habitual caffeine consumption
  JOURNAL   PLoS Genet 7 (4), e1002033 (2011)
   PUBMED   21490707
REFERENCE   3  (bases 1 to 4438)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006530.4.
            
            On Jun 16, 2020 this sequence version replaced NM_001243007.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 3 encode the same isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC105720.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000556489.4/ ENSP00000451223.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AC006530.4         26297-26547         c
            252-386             AC006530.4         21505-21639         c
            387-1865            AC006530.4         12932-14410         c
            1866-1973           AC006530.4         8809-8916           c
            1974-2168           AC006530.4         7203-7397           c
            2169-4438           AC006530.4         3435-5704           c
FEATURES             Location/Qualifiers
     source          1..4438
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..4438
                     /gene="PROX2"
                     /gene_synonym="PROX-2"
                     /note="prospero homeobox 2"
                     /db_xref="GeneID:283571"
                     /db_xref="HGNC:HGNC:26715"
                     /db_xref="MIM:615094"
     exon            1..251
                     /gene="PROX2"
                     /gene_synonym="PROX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            252..386
                     /gene="PROX2"
                     /gene_synonym="PROX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            387..1865
                     /gene="PROX2"
                     /gene_synonym="PROX-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             561..2339
                     /gene="PROX2"
                     /gene_synonym="PROX-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox prospero-like protein PROX2"
                     /codon_start=1
                     /product="prospero homeobox protein 2 isoform 1"
                     /protein_id="NP_001229936.1"
                     /db_xref="CCDS:CCDS73663.1"
                     /db_xref="GeneID:283571"
                     /db_xref="HGNC:HGNC:26715"
                     /db_xref="MIM:615094"
                     /translation="MDPNSILLSPQPQICSHLAEACTEGERSSSPPELDRDSPFPWSQ
                     VPSSSPTDPEWFGDEHIQAKRARVETIVRGMCLSPNPLVPGNAQAGVSPRCPKKARER
                     KRKQNLPTPQGLLMPAPAWDQGNRKGGPRVREQLHLLKQQLRHLQEHILQAAKPRDTA
                     QGPGGCGTGKGPLSAKQGNGCGPRPWVVDGDHQQGTSKDLSGAEKHQESEKPSFLPSG
                     APASLEILRKELTRAVSQAVDSVLQKVLLDPPGHLTQLGRSFQGQVAEGRSEPSPPVG
                     GACKDPLALAALPRRVQLQAGVPVGNLSLAKRLDSPRYPIPPRMTPKPCQDPPANFPL
                     TAPSHIQENQILSQLLGHRYNNGHWSSSPPQDSSSQRHPSSEPALRPWRTTKPQPLVL
                     SQQQCPLPFTSAHLESLPLLPSVKMEQRGLHAVMEALPFSLVHIQEGLNPGHLKKAKL
                     MFFFTRYPSSNLLKVYFPDVQFNRCITSQMIKWFSNFREFYYIQMEKSARQAISDGVT
                     NPKMLVVLRNSELFQALNMHYNKGNDFEVPDCFLEIASLTLQEFFRAVSAGRDSDPSW
                     KKPIYKIISKLDSDIPEIFKSSSYPQ"
     exon            1866..1973
                     /gene="PROX2"
                     /gene_synonym="PROX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2168
                     /gene="PROX2"
                     /gene_synonym="PROX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..4438
                     /gene="PROX2"
                     /gene_synonym="PROX-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2680..2685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROX2"
                     /gene_synonym="PROX-2"
                     /note="hexamer: ATTAAA"
     polyA_site      2710
                     /gene="PROX2"
                     /gene_synonym="PROX-2"
                     /note="major polyA site"
ORIGIN      
        1 agagtcagcg gctgcagcaa gactgggtct gtcagacagt gccttgtgct aagaaggggc
       61 cagagcctcc cctcacccag ccacgggcac ccggcctgcc tggagaggaa gcagggaaac
      121 cagaagcact tcctgaccat ggctctgtct gcccagggct ggtgaagagt gggctgctcc
      181 gtcttctaga gtggttggcc ccacctggcc acagagccca agacaaggac ctcccagagg
      241 acctcttccc tagacagggt cttactttgt tgcccaggct ggaatgcagt ggctattcat
      301 tggcatgatc gtagcacact acagctttga actcctgggc tcaagcagtc ttcccacctc
      361 agcttcctga gtagctgaga ctacaggagt ctgcccagga ggttcatgag ccctggcatc
      421 ccagaatctg aatccttcct cagtgacagt ggctctttac ccttctaagt gcagaggagg
      481 aagcccagcg cattctgggt gcacttccag ctgaggaaat aaggaggagg aattcctgaa
      541 gccctgaaca agtgcctggg atggatccaa actccatctt gctttctcct cagccccaga
      601 tctgctccca cctagcagaa gcttgtacgg aaggcgagag aagctcatcc cctccagagc
      661 tggatagaga ctccccgttt ccctggagtc aggtccccag ctccagccct acagaccccg
      721 aatggtttgg tgatgagcac atccaggcaa agagggccag agtggagacc attgtccgag
      781 gcatgtgtct ctccccgaat cctctggtgc caggcaatgc gcaagctggg gtcagcccac
      841 gctgcccaaa gaaggcccga gagaggaaga ggaagcagaa ccttcccaca ccgcaaggcc
      901 tcctgatgcc agcccctgcc tgggaccagg gcaacaggaa ggggggccct cgtgtgagag
      961 aacaacttca tctgctgaag caacagctaa gacatctgca agagcacatc ctacaggctg
     1021 ccaagcccag ggacacagct caggggccag gaggctgtgg cacggggaaa ggccctctga
     1081 gtgcaaagca ggggaatggc tgtgggcctc gcccctgggt tgtggacggt gaccaccagc
     1141 aaggtaccag caaggacctc tctggggcag aaaaacacca agagtctgag aagcccagtt
     1201 tccttccttc tggagcacca gcttcactag agattctgag gaaagagctg accagggcag
     1261 tgtcccaggc tgtggactcg gtattacaaa aggtactatt ggatccacca ggccacctga
     1321 ctcagctggg cagaagcttc caggggcagg tggcagaggg tagaagcgag ccctcacctc
     1381 ctgtgggagg ggcctgtaaa gatccacttg ctttggctgc cttgcccagg agggtccagc
     1441 tacaagctgg ggtcccagta ggaaatttat cactggccaa gcgtctagat tctcctaggt
     1501 accctatccc tccaagaatg acccccaaac cctgtcagga tcccccagca aactttccct
     1561 tgactgcacc ttcccacatc caggaaaatc agattcttag ccagctactg ggtcatagat
     1621 acaacaatgg ccattggagt agcagtcctc cccaggactc atcttcccag aggcacccct
     1681 cctcagagcc tgccctacga ccttggagaa ctactaagcc gcaaccattg gtcctgagcc
     1741 agcagcagtg tcccttgcct ttcacctctg cccatctgga aagtctaccc cttcttccct
     1801 cggtgaagat ggaacagaga ggcctgcatg ctgtcatgga ggcactgcct ttctctttgg
     1861 tccacatcca ggagggtcta aaccctggtc acttgaagaa ggccaaacta atgtttttct
     1921 tcacacgata tcccagctcc aacctcctga aggtttattt tcctgatgtt cagttcaacc
     1981 gctgcattac ctcccagatg atcaagtggt tcagcaactt tcgtgagttt tattacatcc
     2041 aaatggaaaa atctgcccgg caagcaattt cagatggtgt cacaaatccc aaaatgctgg
     2101 tggttctccg caattcagaa ctttttcaag ctctcaatat gcactacaac aagggaaatg
     2161 actttgaggt tccagattgc ttcttggaaa ttgccagctt gacgttacag gagttcttca
     2221 gggctgtctc cgcagggaga gactcagatc cttcctggaa gaaacccatt tataaaatta
     2281 tttcgaaact ggacagtgac atcccagaga tattcaaatc ttccagctat ccccagtagc
     2341 tgtttcgggg ttaagatccc acaacgtgag gagtgactgg ctagggtttc ctgggtttgt
     2401 cttaaagggc aatttagctg tagtcatata aaaagggcac aaggaaatct cctctatcaa
     2461 aacaggtact attaccattt tgatcattta tttccctttc cagaatcatc agaaatttaa
     2521 ctataaaatg tactaactat attggtgtat tggtagtata ttgtaaaagg aacacaagtt
     2581 tccaatcaga agacttgaag ctcaactcca ttgtttccag gtgttgtgac cctgggaact
     2641 tcctggtatc tctgtatctg taaaatgagg ttgttaagga ttaaaggaca gtatgtccta
     2701 tgcaatgtca ttcacacaca aatgtcagtt ttttgagccc ctctttcaga taaggttatc
     2761 ttatttgggg tttttacaaa ttgctgtttt tagtcaccta attataaagc gccatctatt
     2821 tgctagatac tttcacatac tttaagcttt tcaccctgaa aagtagttat tatcatcatt
     2881 taaaagatga ccaaacagaa gctttagaac tgcaaggtaa ctcgccaaag cctatgaggc
     2941 taggacatct gggttgatag ggacagtcag gagcctggag gaaccaagac tttctgatgc
     3001 ccaactgcat gctggaccca tctcctgcag ctaactcagg atctcaagca ggaccccacc
     3061 cctagtaagc atccagcgct gacagggcac cgtcacctga caactcctgc ccagcactta
     3121 ggagcacttc accgcccaag atttctgctg atcatttcag caaactcaag acaaacttta
     3181 tgcaggactt gagtgttgct gtttattcac atttgtctgc tggaagagtt tatcagctgg
     3241 ataatgcaaa tagtctccag ctgaccattg caattggtgc cccaacctca tatatgcaga
     3301 agaagctgaa cttcagactg tgaaaggtag aaagggcctt aggagatcat ctggcccatg
     3361 ctgcttaaat tgggaaggaa gaaccgcagt ccagacagga ggcttgcaca ggctgtgcac
     3421 agccttgcag atgataaatg gcataactgg gacaaatgca gcatcacaca gaaatggaaa
     3481 ttctcccact ccataacaaa attacagtcc atggctgacc ttccactgat gaaggaattc
     3541 atgaaatcaa catttccccc tgctgctggc ccagcacaat tgtgacccac tcttgagtat
     3601 ataggcaagg catgtacaaa gctgagtaac tgcatctgtc ttctaagcta gtcaggatca
     3661 agtctttgta agcactgcca aaggtacgcc gggtggggtg gggtgggggt aatacacagc
     3721 tcgggctttg tagtcctgat aaggggtgtc tgtgagttca ttagcttctt tcctgtctat
     3781 ataaaacaag tttcatattc ggctactcaa cttccataat ttttctggtg gggtgttgct
     3841 ggagcagatg agataaaatc cctaaactat tactagaact atcagcataa aaagtatgaa
     3901 agatgaattt tcctttgaat tttctcttca aacagctgaa aggaaaaaca aaacagactt
     3961 agcccaaacc catctttaca ggctaaaggt taagtgccct ccagtacatc caattgcact
     4021 cagaagatct ttgccctatt ttcacaaaaa tgaaggaatc tgccaaacct aagttttaaa
     4081 cacaggcaag catggagtgc tctgagcaag ggcaatcagt tttctgtgtc cggacatagt
     4141 agaagaaccc tctatccaga gtgacattac atacctaagt tagacataca ggggaaacaa
     4201 gttcacatga ctgtccaata gagagcagcc cttcttctgt cccaaacctg aaattcatta
     4261 gtgtgtgttt aaagactgag ccaagtcacc tccagggcag tgaaccttgt ctcagggacc
     4321 aatgagatga aatgtacaag ctcaaattga aaacatttgt gtactgcagt ctttccagga
     4381 agtgttctct aaccactgag ctaaacacag aagaatgtat aaatatgtat gctctgcc
//
