LOCUS       NM_001270616            8468 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens prospero homeobox 1 (PROX1), transcript variant 1,
            mRNA.
ACCESSION   NM_001270616
VERSION     NM_001270616.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8468)
  AUTHORS   Sakurai,K., Ando,T., Sakai,Y., Mori,Y., Nakamura,S., Kato,T. and
            Ito,H.
  TITLE     PROX1 is a regulator of neuroendocrine-related gene expression in
            lung carcinoid
  JOURNAL   Hum Cell 37 (5), 1559-1566 (2024)
   PUBMED   39066858
  REMARK    GeneRIF: PROX1 is a regulator of neuroendocrine-related gene
            expression in lung carcinoid.
REFERENCE   2  (bases 1 to 8468)
  AUTHORS   Liu,C., Chen,J., Cong,Y., Chen,K., Li,H., He,Q., Chen,L., Song,Y.
            and Xing,Y.
  TITLE     PROX1 drives neuroendocrine plasticity and liver metastases in
            prostate cancer
  JOURNAL   Cancer Lett 597, 217068 (2024)
   PUBMED   38901665
  REMARK    GeneRIF: PROX1 drives neuroendocrine plasticity and liver
            metastases in prostate cancer.
REFERENCE   3  (bases 1 to 8468)
  AUTHORS   Zhang,H.L., Li,N., Dong,L., Ma,H.X. and Yang,M.C.
  TITLE     Prox1 Suppresses Proliferation and Drug Resistance of
            Retinoblastoma Cells via Targeting Notch1
  JOURNAL   Curr Med Sci 44 (1), 223-231 (2024)
   PUBMED   38277016
  REMARK    GeneRIF: Prox1 Suppresses Proliferation and Drug Resistance of
            Retinoblastoma Cells via Targeting Notch1.
REFERENCE   4  (bases 1 to 8468)
  AUTHORS   Lai,S.W., Cheng,Y.C., Kiu,K.T., Yen,M.H., Chen,Y.W., Yadav,V.K.,
            Yeh,C.T., Kuo,K.T. and Chang,T.C.
  TITLE     PROX1 interaction with alpha-SMA-rich cancer-associated fibroblasts
            facilitates colorectal cancer progression and correlates with poor
            clinical outcomes and therapeutic resistance
  JOURNAL   Aging (Albany NY) 16 (2), 1620-1639 (2024)
   PUBMED   38244581
  REMARK    GeneRIF: PROX1 interaction with alpha-SMA-rich cancer-associated
            fibroblasts facilitates colorectal cancer progression and
            correlates with poor clinical outcomes and therapeutic resistance.
REFERENCE   5  (bases 1 to 8468)
  AUTHORS   Elsir,T., Smits,A., Lindstrom,M.S. and Nister,M.
  TITLE     Transcription factor PROX1: its role in development and cancer
  JOURNAL   Cancer Metastasis Rev 31 (3-4), 793-805 (2012)
   PUBMED   22733308
  REMARK    Review article
REFERENCE   6  (bases 1 to 8468)
  AUTHORS   Wilting,J., Papoutsi,M., Christ,B., Nicolaides,K.H., von
            Kaisenberg,C.S., Borges,J., Stark,G.B., Alitalo,K., Tomarev,S.I.,
            Niemeyer,C. and Rossler,J.
  TITLE     The transcription factor Prox1 is a marker for lymphatic
            endothelial cells in normal and diseased human tissues
  JOURNAL   FASEB J 16 (10), 1271-1273 (2002)
   PUBMED   12060670
REFERENCE   7  (bases 1 to 8468)
  AUTHORS   Chen,Q., Dowhan,D.H., Liang,D., Moore,D.D. and Overbeek,P.A.
  TITLE     CREB-binding protein/p300 co-activation of crystallin gene
            expression
  JOURNAL   J Biol Chem 277 (27), 24081-24089 (2002)
   PUBMED   11943779
REFERENCE   8  (bases 1 to 8468)
  AUTHORS   Duncan,M.K., Cui,W., Oh,D.J. and Tomarev,S.I.
  TITLE     Prox1 is differentially localized during lens development
  JOURNAL   Mech Dev 112 (1-2), 195-198 (2002)
   PUBMED   11850194
  REMARK    GeneRIF: Prox1 is differentially localized during lens development
REFERENCE   9  (bases 1 to 8468)
  AUTHORS   Mouta Carreira,C., Nasser,S.M., di Tomaso,E., Padera,T.P.,
            Boucher,Y., Tomarev,S.I. and Jain,R.K.
  TITLE     LYVE-1 is not restricted to the lymph vessels: expression in normal
            liver blood sinusoids and down-regulation in human liver cancer and
            cirrhosis
  JOURNAL   Cancer Res 61 (22), 8079-8084 (2001)
   PUBMED   11719431
  REMARK    GeneRIF: Prox 1 is expressed in both quiescent and proliferating
            lymphatic endothelial cells in the liver. Unlike the putative
            lymphatic marker LYVE-1, Prox 1 is not expressed in liver
            sinusoidal endothelial cells.
            GeneRIF: Prox 1 is expressed in both quiescent and proliferating
            lymphatic endothelial cells in the adult human and mouse liver.
            Unlike the putative lymphatic marker LYVE-1, Prox 1 is not
            expressed in liver sinusoidal endothelial cells.
REFERENCE   10 (bases 1 to 8468)
  AUTHORS   Zinovieva,R.D., Duncan,M.K., Johnson,T.R., Torres,R.,
            Polymeropoulos,M.H. and Tomarev,S.I.
  TITLE     Structure and chromosomal localization of the human homeobox gene
            Prox 1
  JOURNAL   Genomics 35 (3), 517-522 (1996)
   PUBMED   8812486
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011700.5 and AL606537.10.
            
            On May 17, 2019 this sequence version replaced NM_001270616.1.
            
            Summary: The protein encoded by this gene is a member of the
            homeobox transcription factor family. Members of this family
            contain a homeobox domain that consists of a 60-amino acid
            helix-turn-helix structure that binds DNA and RNA. The protein
            encoded by this gene is conserved across vertebrates and may play
            an essential role during development. Altered levels of this
            protein have been reported in cancers of different organs, such as
            colon, brain, blood, breast, pancreas, liver and esophagus.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.254765.1,
                                           SRR1660809.37704.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366958.9/ ENSP00000355925.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-511               AC011700.5         33238-33748         c
            512-2303            AC011700.5         23461-25252         c
            2304-2411           AC011700.5         16449-16556         c
            2412-2606           AC011700.5         10006-10200         c
            2607-8468           AL606537.10        96915-102776
FEATURES             Location/Qualifiers
     source          1..8468
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     gene            1..8468
                     /gene="PROX1"
                     /note="prospero homeobox 1"
                     /db_xref="GeneID:5629"
                     /db_xref="HGNC:HGNC:9459"
                     /db_xref="MIM:601546"
     exon            1..511
                     /gene="PROX1"
                     /inference="alignment:Splign:2.1.0"
     exon            512..2303
                     /gene="PROX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             579..2792
                     /gene="PROX1"
                     /note="prospero-related homeobox 1; homeobox prospero-like
                     protein PROX1"
                     /codon_start=1
                     /product="prospero homeobox protein 1"
                     /protein_id="NP_001257545.1"
                     /db_xref="CCDS:CCDS31021.1"
                     /db_xref="GeneID:5629"
                     /db_xref="HGNC:HGNC:9459"
                     /db_xref="MIM:601546"
                     /translation="MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSA
                     MNPQGSEQDVEYSVVQHADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMN
                     KNGGTEPSFQASGLSSTGSEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDMDRLCDE
                     HLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQ
                     QSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSE
                     DSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKER
                     DHGPNSLQPEGKHLAETLKQELNTAMSQVVDTVVKVFSAKPSRQVPQVFPPLQIPQAR
                     FAVNGENHNFHTANQRLQCFGDVIIPNPLDTFGNVQMASSTDQTEALPLVVRKNSSDQ
                     SASGPAAGGHHQPLHQSPLSATTGFTTSTFRHPFPLPLMAYPFQSPLGAPSGSFSGKD
                     RASPESLDLTRDTTSLRTKMSSHHLSHHPCSPAHPPSTAEGLSLSLIKSECGDLQDMS
                     EISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWF
                     SNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFL
                     EVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE"
     exon            2304..2411
                     /gene="PROX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2606
                     /gene="PROX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..8468
                     /gene="PROX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8188..8193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROX1"
                     /note="hexamer: AATAAA"
     polyA_site      8211
                     /gene="PROX1"
                     /note="major polyA site"
ORIGIN      
        1 agctgaggga gcgctctgaa ataatacacc attgcagccg gggaaagcag agcggcgcaa
       61 aagagctctc gccgggtccg cctgctccct ctccgcttcg ctcctcttct cttctttacc
      121 cttctcctct ctcctcctct gctgctctct cctctcctcc cgctcttctc tctcctcctc
      181 tcctgctctc tcctcttccc ttagctcctc ttcttttctt ctcctcttct tccctctcct
      241 cgcctctccc ctgctcctct tctctcgtct cccctcccct cccgcctctc tctcccctct
      301 ccctctccca ctcgccccgc tcgctcgctc gctgtcgcac agactcaccg tcccttgtcc
      361 aattatcata ttcatcaccc gcaagatatc accgtgtgtg cactcgcgtg ttttcctctc
      421 tctgccgggg gaaaaaaaag agagagagag agatagagag agagagagag agagagagag
      481 agaggctcgg tcccactgct ccctgcaccg cggtcccggg attcttgagc tgtgcccagc
      541 tgacgagctt ttgaagatgg cacaataacc gtccagtgat gcctgaccat gacagcacag
      601 ccctcttaag ccggcaaacc aagaggagaa gagttgacat tggagtgaaa aggacggtag
      661 ggacagcatc tgcatttttt gctaaggcaa gagcaacgtt ttttagtgcc atgaatcccc
      721 aaggttctga gcaggatgtt gagtattcag tggtgcagca tgcagatggg gaaaagtcaa
      781 atgtactccg caagctgctg aagagggcga actcgtatga agatgccatg atgccttttc
      841 caggagcaac cataatttcc cagctgttga aaaataacat gaacaaaaat ggtggcacgg
      901 agcccagttt ccaagccagc ggtctctcta gtacaggctc cgaagtacat caggaggata
      961 tatgcagcaa ctcttcaaga gacagccccc cagagtgtct ttcccctttt ggcaggccta
     1021 ctatgagcca gtttgatatg gatcgcttat gtgatgagca cctgagagca aagcgcgccc
     1081 gggttgagaa tataattcgg ggtatgagcc attcccccag tgtggcatta aggggcaatg
     1141 aaaatgaaag agagatggcc ccgcagtctg tgagtccccg agaaagttac agagaaaaca
     1201 aacgcaagca aaagcttccc cagcagcagc aacagagttt ccagcagctg gtttcagccc
     1261 gaaaagaaca gaagcgagag gagcgccgac agctgaaaca gcagctggag gacatgcaga
     1321 aacagctgcg ccagctgcag gaaaagttct accaaatcta tgacagcact gattcggaaa
     1381 atgatgaaga tggtaacctg tctgaagaca gcatgcgctc ggagatcctg gatgccaggg
     1441 cccaggactc tgtcggaagg tcagataatg agatgtgcga gctagaccca ggacagttta
     1501 ttgaccgagc tcgagccctg atcagagagc aggaaatggc tgaaaacaag ccgaagcgag
     1561 aaggcaacaa caaagaaaga gaccatgggc caaactcctt acaaccggaa ggcaaacatt
     1621 tggctgagac cttgaaacag gaactgaaca ctgccatgtc gcaagttgtg gacactgtgg
     1681 tcaaagtctt ttcggccaag ccctcccgcc aggttcctca ggtcttccca cctctccaga
     1741 tcccccaggc cagatttgca gtcaatgggg aaaaccacaa tttccacacc gccaaccagc
     1801 gcctgcagtg ctttggcgac gtcatcattc cgaaccccct ggacaccttt ggcaatgtgc
     1861 agatggccag ttccactgac cagacagaag cactgcccct ggttgtccgc aaaaactcct
     1921 ctgaccagtc tgcctccggc cctgccgctg gcggccacca ccagcccctg caccagtcgc
     1981 ctctctctgc caccacgggc ttcaccacgt ccaccttccg ccaccccttc ccccttccct
     2041 tgatggccta tccatttcag agcccattag gtgctccctc cggctccttc tctggaaaag
     2101 acagagcctc tcctgaatcc ttagacttaa ctagggatac cacgagtctg aggaccaaga
     2161 tgtcatctca ccacctgagc caccaccctt gttcaccagc acacccgccc agcaccgccg
     2221 aagggctctc cttgtcgctc ataaagtccg agtgcggcga tcttcaagat atgtctgaaa
     2281 tatcacctta ttcgggaagt gcaatgcagg aaggattgtc acccaatcac ttgaaaaaag
     2341 caaagctcat gtttttttat acccgttatc ccagctccaa tatgctgaag acctacttct
     2401 ccgacgtaaa gttcaacaga tgcattacct ctcagctcat caagtggttt agcaatttcc
     2461 gtgagtttta ctacattcag atggagaagt acgcacgtca agccatcaac gatggggtca
     2521 ccagtactga agagctgtct ataaccagag actgtgagct gtacagggct ctgaacatgc
     2581 actacaataa agcaaatgac tttgaggttc cagagagatt cctggaagtt gctcagatca
     2641 cattacggga gtttttcaat gccattatcg caggcaaaga tgttgatcct tcctggaaga
     2701 aggccatata caaggtcatc tgcaagctgg atagtgaagt ccctgagatt ttcaaatccc
     2761 cgaactgcct acaagagctg cttcatgagt agaaatttca acaactcttt ttgaatgtat
     2821 gaagagtagc agtccccttt ggatgtccaa gttatatgtg tctagatttt gatttcatat
     2881 atatgtgtat gggaggcatg gatatgttat gaaatcagct ggtaattcct cctcatcacg
     2941 tttctctcat tttcttttgt tttccattgc aaggggatgg ttgttttctt tctgccttta
     3001 gtttgctttt gcccaaggcc cttaacattt ggacacttaa aatagggtta attttcaggg
     3061 aaaaagaatg ttggcgtgtg taaagtctct attagcaatg aagggaattt gttaacgatg
     3121 catccacttg attgatgact tattgcaaat ggcggttggc tgaggaaaac ccatgacaca
     3181 gcacaactct acagacagtg atgtgtctct tgtttctact gctaagaagg tctgaaaatt
     3241 taatgaaacc acttcataca tttaagtatt ttgtttggtt tgaactcaat cagtagcttt
     3301 tccttacatg tttaaaaata attccaatga cagatgagca gctcactttt ccaaagtacc
     3361 ccaaaaggcc aaattaaaaa agaaaaataa tcactctcaa gccttgtcta agaaaagagg
     3421 caaactctga aagtcgtacc agtttcttct ggaggcaaag caattttgca caaaaccagc
     3481 tctctcaaga tgagactaga aattcatacc tggtcttgta gccacctctc taaacttgaa
     3541 aataggttct tcttcataag tgagcttaca tcattcttca taaagaaaaa tcctataact
     3601 tgttatcatt tttgcttcag atactaaaag gcactaagtt tccaatttac gctgctcaac
     3661 tttgtttata tgcttaaaag gattctgttt acttaacaat tttttcccct aaaatactat
     3721 tttctgaata cttccttcca gtaaggaata aaggaaagcc caacttggcc ataaaattct
     3781 tgcctacact agaagtttgt tgacagccat tagctgactt gatcgtcatc tcctaagagg
     3841 aacacatata ttttcacaag caattccaca ctatcctgat gggtatgcaa agtggtgaca
     3901 gtctaactca gtgtttcttc attttaggta taacatttta aagcaattga taatgcctct
     3961 tccaattcag aagctagtat tgaccaaaat gtgagaagag tgtatagcat aggaaaattt
     4021 ggggttaacc caaaagacac aattccagca cacataagaa agctagctgc tattttatgc
     4081 tttcttccat ggttctcctc ttttttccct tttatttttc cctgtttttc aatgatgtac
     4141 agtgttccct acttgcattg aaaaaactcg tatggcattc acactttttt tcttaggtgg
     4201 gtttttgtgt ccagatgcag taagaattca ttgttcatcc taaaactgtt ttccagaccc
     4261 ttccttcccc ttaggtaatt tgatatacac ctcctaaaat gacacagtaa caaatctggt
     4321 atttagaaca tatagaacat aaatgccatt ttttaattca actttaataa gaattacatt
     4381 tgactttgga gaatacaggt cttgacccat gtgactgact agctgacccg atcgctgtaa
     4441 tttaacgtca tttataaatt ctgctgatgg acaggaatgt atgaactcaa ttattgtcag
     4501 cacaaagcct taaaacctgc tgactttaaa ttaaatggtg cagtcctatg atgccctgca
     4561 ccatccaggg gactaacagg gcctcgcagt gtagacagag ggtgcagcca cacgggcggg
     4621 ggcaccagcc acctcactct gcacccgcgg cctcacacat ctcccagctc acactctact
     4681 aatgcacaga gtcattagat ccaatttgtt atttttctca cttgctttaa aaaaaagcag
     4741 tttggataat catgacattg gaataaagtg ggaaggaaaa attccatcag cacaaaatag
     4801 ggaagtaatc ccaacttgta gtcacagttt tctgactggc tttgttttaa aagaggatgg
     4861 cagtccttgt tcgtgtcagt gtgccactgg gtttttgctg ttccgtgtaa ttcatatcaa
     4921 ctttgtgttg ccatttgcaa ggtaaaaggc aaagctgtag tgtattcacc tatgtagaca
     4981 gattgctaga tatctttttg atctggggcg agttcaatat tgattccaga cttatttgga
     5041 tttttttagt attattttcc cctccctttc taatttaaat agacaaatta agcaaaagtg
     5101 tgtgttcaca accaaatgtt gatgccctta tctactgata atatcctctc aatgttcact
     5161 gaggcataga aattatttca gagtagaaat tgcagcatga ggataaactc acctctttgt
     5221 tctgaaaata gaactttatc actatgcttt ccggtggttt tcccttttac aatcgaaatc
     5281 ttgtgcctcc caagtgcatt ggaaaatgac aaaagcctgt ctctccaaat tcctatttaa
     5341 cagtttgatt tttttttttt aatcaccatc tttcaaatct tagctcaact ctcaccaagt
     5401 gaaaattggc tacttgggag aaagttaact ttctatggtg ggatggtgaa ggatgaggga
     5461 cagtttacat aggaaaagaa aaaaaaaagt ctaaagtcca tgttgaaaaa ccacactacc
     5521 acttattttc tgctaaccct aaattatttt tgcgtatacg cttgaggtta tagtctgtgc
     5581 ctagacctaa aatgcaccag cgggggggat tttaaaaaat ccttcaaaat accagttttt
     5641 tcccaacaag tacaattgtt cttgtgcctt ctgtggcttt cgatttcatc tttttgactt
     5701 tatttccaat tactacagct gcaataaaca ctagattttt tttctggctg tttgacataa
     5761 cgttgatagc tatgcatatt ttgtgtcttt ttaaaacaaa gcgggagaat acgtttttga
     5821 agaagagaat ttttagaaca gtttgatacc gcaaattatt ttttcctcaa ttgtttgagc
     5881 agcattcgag ttttgaaaat tcttgtagaa gccaattttt tgtaactgtg gtgcaaatct
     5941 tgtgttttct tagcctaatg aaaagtagta tagaagcaat atttcatacc atgtgctata
     6001 tatgtgtgcg cagatgtgtg aacataaaat cacatacaca catatacaca catgtaaaaa
     6061 tatacatata tatatatgcg tgtgaagtgg aaagcttacc ttttcctatc tagatttaag
     6121 aacctatttt agacatttgt tatgttttgt gaaaagaatg ttctatttgc aacaaaacat
     6181 ttaattctta ctgtatctct ggctgtttaa tgaggacgtt tcacattaaa tggtaaaaca
     6241 catggaagat gttagaatgt agtaattatt taagtaaacg ttcacccaca tattcctgaa
     6301 gtttgctttg tgcctccgag tattatttaa ttaaagaagt gttttatgtt tgcagaatct
     6361 ttgtcactgt actagggatg tgggtgaata tcatttaaaa aaatttaaaa caacaaaaaa
     6421 aaagcaaaac agaaacacta aagcaagagg ggaactttta taaagcaatg taaatattta
     6481 acctcatggc tgtcattatg taagacatga gattttaata aataactaca ttctcacgac
     6541 atctgttgaa tttactagga acactacagt gactgtatag acagttgaaa gcattcttga
     6601 aaatcctgct ctctcctttt aaaagttaac aatctctttt atcagatgtc aagggcaagg
     6661 gtaatgcagt ttctgtaaat ttatgaaatt tctttttcta tgtacatgaa gacatttagt
     6721 aagtaacacc cccccttccc atgcgcacat gtgcgcatac acacacacac acacacacac
     6781 acacacacaa acacacacac tgtcataaag ctaatgattt ggggacttta aaaaatagga
     6841 tgtcctccag gaacaatcat aaatttatga aagaaagagt agtttacaga ctcccctgaa
     6901 agaagcagtg tatatgtgaa gacagtgcaa aaatctcttt gccatgtata ttatagcgta
     6961 ttcattggtg tgaatagtac aaatgtttcc ttctggtaca aactctgtgt ttgcaaattt
     7021 acaagaagca ttgttttcaa aaagctcccc ttaaaaaatg taactggttt atatgagtaa
     7081 gcagttaccg tattgcactt aaatgttatg ttgaaggaaa tgcagttttg ttttctgtag
     7141 atctgttggt tgtaaaccat ctataaaact aaagctaaaa tgctcatatt cagagctggg
     7201 atcaaaactg gtatttaacc tttgcatctt cttataatta tccttctaag aatataacag
     7261 aatgtggaag tgtctggact ttgagtcttt tcaactgagc cttctctcaa atctgacacc
     7321 ccctcagaat gcacaaacat aagcagaaaa ggcaaacaag cttaccttct tttgtgaaaa
     7381 cgtattcatt ctgtattttt ttaaatattc aattccccta aaaatgggga gaaaatattt
     7441 taaaattgta tattacgact tcaaatttag aactaagaaa aaaatgtatt tgggattggt
     7501 ctcagcgcta cctagaagaa tcaaaggtca tggcttccct caatattgtc ccagccattt
     7561 ctcatatgta tatagtataa accgtgacaa aacactgcct ttatattatt tagcaatatg
     7621 ttgtaaatag cattattaag ctcttttttg taataaagac cctttgattt gaatatagta
     7681 caataactga actgataaag tcaatttttg atttttgttt gtttttttta gctagaggca
     7741 atttcaattg tgaatttttg ttgttgtcta ttgttctgaa gactttgcat aatttattgg
     7801 tttaatttat cctaatttat ttgatgaagg tgtacaattt tgtattacca aggatgtact
     7861 gtaatattaa ttgatatgat aaacacaatg agactccctg tccatattaa aaagaaaata
     7921 aaaaggtgca gtagacaatt gattttaaag gaaaagttaa aaaaattagt ttggcagcta
     7981 ctaaatttta aaacaggaaa aaaaaaagtt gttgtgggga gggtgggaaa ggggttttac
     8041 tttgtgtgtt ttaagctttt gtatactctc caaactttta ccttttgctt tgtaccactt
     8101 aaaggataca gtagtccaat tgccttgtgt gccttccatc tcctcttaaa ctgaatgtat
     8161 gtgcagtata tatgcaagct tgtgcaaaat aaaatataca ttacaagctc agtgccgttt
     8221 gattttctta aagaaagagt gacttttaat ttttggacct gtatccaatt gtaggacagt
     8281 aggctagttg tgccagtaat gtcaagtatg gagattttct ttcactacaa ttcttcattc
     8341 tgttagccta acgtgcagct cctagaaaca acctctttta ctttagatgc ttggaataat
     8401 tgcttggatt tctctctctg aaacatcttt caggcttaac tttatttagc cctgaaactt
     8461 aaaaaaaa
//
