LOCUS       NM_001367856            4836 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens proline and serine rich 3 (PROSER3), transcript
            variant 2, mRNA.
ACCESSION   NM_001367856
VERSION     NM_001367856.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4836)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4836)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002398.1 and KF495725.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000646935.2/ ENSP00000496769.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC002398.1         7780-7830
            52-148              AC002398.1         8978-9074
            149-351             AC002398.1         9393-9595
            352-479             AC002398.1         11623-11750
            480-583             AC002398.1         11857-11960
            584-666             AC002398.1         14458-14540
            667-809             AC002398.1         14638-14780
            810-997             AC002398.1         16372-16559
            998-1786            AC002398.1         16676-17464
            1787-1991           KF495725.1         1-205
            1992-2040           KF495725.1         295-343
            2041-2073           AC002398.1         17809-17841
            2074-4836           AC002398.1         18009-20771
FEATURES             Location/Qualifiers
     source          1..4836
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..4836
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /note="proline and serine rich 3"
                     /db_xref="GeneID:148137"
                     /db_xref="HGNC:HGNC:25204"
     exon            1..51
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..2215
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /note="isoform 2 is encoded by transcript variant 2;
                     proline and serine-rich protein 3"
                     /codon_start=1
                     /product="proline and serine-rich protein 3 isoform 2"
                     /protein_id="NP_001354785.1"
                     /db_xref="CCDS:CCDS92595.1"
                     /db_xref="GeneID:148137"
                     /db_xref="HGNC:HGNC:25204"
                     /translation="MDRSLPVFSIQDSPFGDAPLGRSHYWPSQSQTWCPKTLSPSRSQ
                     RSRLPQAPKALATGPNSPELFEESWPSSSGTPSLPSTTEGQMWASPAPTLIDSGDSVV
                     AKYINRFRQAQPTSREERQPAGPTPADFWWLQSDSPDPSSQSAAAGANKPEGRPHTAV
                     PTAVNVTSASHAVAPLQEIKQNLHTWNSSLLDLETLSLQSRAARLLKRSKASISSSSS
                     LSPSDASTSSFPTSSDGLSPFSETFIPDSSKGLGPRAPASPAPAQAQTPTPAPAPASS
                     QAPLRPEDDILYQWRQRRKLEQAQGSKGDRAWVPPLTPALRTLTSPAPVETLSSLGTQ
                     PNHVPLWSSVAQPGPPEAFYVERPPFPSVSSPHIFWAPSSHGFFWAPQSGPWVSLGAV
                     PPTQQASTLAHLGSTLAPPASLASTLEPPASTPAPLASTLAPPASTPAPLACTPAPPA
                     STLASPAVPQGLPIPDPSSCAQPKSLGPKSRRSRAPRPEAAEQVPAAGQGPGPQLRGV
                     LGQVVAARLFPDSLEDTPPHFEGPPPPKAGSPKVQATQPQTKVTPPPSESQCRAKAES
                     LKAKALPPAAGSVIRKSEATPSPGACLQPEVPLSPAEQATTVKASPPAFQVGSPEALA
                     PPPPAADHAPSEALLAQAALLLQAAEDSDGSEFQDDPVLQVLRAHRAELSRQKREADA
                     RLSFLLDQAEDLGSWSPPAGSPPRSPRRLLRREGDSLEARRL"
     exon            52..148
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /inference="alignment:Splign:2.1.0"
     exon            149..351
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /inference="alignment:Splign:2.1.0"
     exon            352..479
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /inference="alignment:Splign:2.1.0"
     exon            480..583
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /inference="alignment:Splign:2.1.0"
     exon            584..666
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /inference="alignment:Splign:2.1.0"
     exon            667..809
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /inference="alignment:Splign:2.1.0"
     exon            810..997
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1991
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2073
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..4836
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4670..4675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /note="hexamer: AAGAAA"
     polyA_site      4694
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /note="major polyA site"
     regulatory      4813..4818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
                     /note="hexamer: AATAAA"
     polyA_site      4836
                     /gene="PROSER3"
                     /gene_synonym="C19orf55"
ORIGIN      
        1 gaaggagcag agcggccgga agcgcggagg gagccgcggg atggaccgca gcctgccagt
       61 tttctccatt caagatagtc cctttggaga tgcgcccctg ggtcgaagcc actactggcc
      121 atcccagagc cagacctggt gtcccaagac cctgagccca tccaggtctc agagatccag
      181 gctcccacaa gctcccaagg ctctagccac aggtcccaac tcccctgagc tgtttgagga
      241 gtcctggcca tccagttcag ggaccccctc cctgcccagc accactgagg gacagatgtg
      301 ggcctcccca gcacccaccc tgattgacag cggggactcc gtggtggcca agtatataaa
      361 caggttccgc caggctcagc ccaccagtcg agaggagcgc cagcctgcag gcccaacccc
      421 agctgacttt tggtggctgc agtctgactc tccagacccc agcagtcaaa gtgcagcagc
      481 aggagccaac aaaccagaag gaagacccca tacagctgtc cctactgcgg tcaacgtgac
      541 cagtgcatcc catgctgtgg ctccccttca ggaaataaag cagaacctcc acacatggaa
      601 ctcatccctg ctggacctgg agacgctgag cctacagagc agagctgcca ggctgctcaa
      661 acgcagcaaa gcctccatct cctcctcctc ctccctcagc cccagcgatg ccagcacttc
      721 ctcattcccc accagctctg atggcctctc tcccttctcg gagaccttca tccctgactc
      781 cagcaagggc cttggcccca gggcacccgc atccccggca ccagcccagg cccagacccc
      841 cacccctgct ccagccccag cctcctccca agcacccctt cggccagagg atgacattct
      901 gtaccagtgg cggcagcggc ggaagcttga acaggctcag ggaagcaagg gtgacagagc
      961 ttgggtgccg cctctgaccc ctgccctccg cacgttgacc tctcctgctc cagtggagac
     1021 cctcagttct ctggggaccc agcctaacca tgtcccactg tggagcagtg tggcccagcc
     1081 tggtccacca gaggccttct atgtggagag gcctcctttt ccctcagtgt cctctccaca
     1141 catcttttgg gcccccagct cccacgggtt cttctgggcc ccacagtctg ggccttgggt
     1201 atcccttggg gctgttcctc ccacgcagca ggcctccacc ctagcacatc tgggctctac
     1261 cctcgcgccc ccggcttccc tggcctccac cctcgaaccc ccggcctcca ccccagctcc
     1321 cctggcctcc acccttgcac ccccagcctc caccccggct cccctggcct gtacccctgc
     1381 acctccagcc tccaccctcg catccccagc tgtcccccag ggcctgccca tccctgaccc
     1441 aagcagctgt gcccagccta agagcctggg gcccaagtct cggaggagca gagcccctcg
     1501 cccagaggct gccgagcaag tccctgcagc tggccaggga cctggccctc agctcagggg
     1561 tgtcctgggc caggtagtgg cagctcggct gttccctgac agcctggagg acacgcctcc
     1621 tcacttcgag ggcccccctc cacccaaggc tggatctccg aaagtccagg ccacacaacc
     1681 ccaaaccaag gtcactcccc ctccatctga atcccagtgt cgggccaagg ccgagtctct
     1741 gaaagccaag gccttgccgc ccgcagcggg gtcagtgata cggaagagcg aagccactcc
     1801 ttcccctgga gcctgcctgc agcccgaggt cccactctct ccagctgagc aggcaaccac
     1861 agtcaaggcc tcgccgccag ccttccaggt ggggtctccg gaggccctgg ccccgccccc
     1921 gcccgctgct gaccacgccc cctcggaggc cctgcttgcc caggccgccc tgctgctgca
     1981 ggctgcagaa gactccgacg gcagcgagtt ccaggacgat cccgtgctgc aggtgctaag
     2041 agcccatagg gcagagctga gtcggcagaa aagggaagcg gatgcccgat tatcgttcct
     2101 gttggaccag gctgaagacc tgggatcttg gtcccctcca gccgggtcgc cccctaggtc
     2161 cccaaggagg ctgctaagaa gggaaggaga ttccctggag gccagaagac tttgaattgt
     2221 acagattcta ttttacccag tgaggctctt tttttttttt tcatacagtt actggttatc
     2281 tgtgagaaag gggttgtttg gaaaggccaa ggggtcatgc caatttaagg aaatgccccc
     2341 catcctccgc tgccccatgg ctctgccctg ccccccaccc cttcctgacc acggaaacaa
     2401 gatctccttt ctggttatat cttccttggg gcagagggag tttcagacaa gacttctggc
     2461 aagactggga cccaccttat ctggcttcac tcaggagccc tggctcaaat ggaccaaagg
     2521 actgccctcc acggaggaag ctactagggt catcagagtg ttggatgatg gtcaggctat
     2581 agcccacaca tgcttgagca gcagcagcat ctggtgcagc tgacccctcc ctccttgaag
     2641 cactttctct ccctgcttcc agcccttctc tctgcacctc tctggtcagg cctagtcact
     2701 agcccagcat gtcaactttg gcatgaccca gggccatggc gttgacatct ctatctgcac
     2761 ccacccatag gtgctcttgt ctagcttaat gactctaaac cccgtctcta ttctgataat
     2821 cctcaaattt ctgtctgtaa cctagacctg gccacgaaac cttgggctcc tacctcatta
     2881 ccatttctac ccaagggttt aaaagacatc tcaaattcca taggtcctaa atggagtttc
     2941 caatctttcc ccctaggcgt gcctctcccc agcttctttt tttttttttt tttggatgga
     3001 gtctagctct gtcacccagg ctggagtgcc atagtgtgat ctcggctcac tgcaagcttc
     3061 gcctcccggg ttcacgccat tctcctgcct cagcctcccg agtagctggg actacaggtg
     3121 cccgccacca cggtcggcta attttttttg tatttttagt agagacgggg tttcactgtg
     3181 ttagccagga tggtcttggt ctcctgacct cgtgatccac ccgcctcggc ctcccaaagt
     3241 gctgggattg caggcgtgag ccaccgtgct gggccccccc tccccaactt tcttcggctc
     3301 tgtcctttgc cgctcagacc aaaaacctta gagttgtctt tgacttctgt ctttcccttc
     3361 cacccacagt taaccaggaa atcctgccat ctccgccttt attttatttt attttttgag
     3421 atggagtttc acccttgttg cccaggctgt agtacaatgg catgatctcg gctcacggca
     3481 acctccacct cccgggttca agcgattctc ctgcctcagc cttctgagta gctgggatta
     3541 caggcacctg ccaccacgcc cagctaattt tctttgtttg tttgtttgtt ttgagacaga
     3601 gtcttgctct gtcccccagg ctggagggca gtggcacgat ctcggctcac tgcaacctct
     3661 gccttgcagg ttcaagctat tcttctgcct cagcctccct agtagctggg actacaggcg
     3721 tgtgccacca cgcctggcta atttttgtat ttttagtaga gacggggttt caccatattg
     3781 gccaggctgg tctcaaactc atgacctcgt gatcctcctg cctcagcctc ccaaagcgct
     3841 gggattacag gcatgagcca tcatgcctgg caattttttg tatttttagt agagacgagg
     3901 tttcaccatg ttggccaggc tggtctcgaa ctcctaacct caggtgtccc acccacctca
     3961 gcctcccaaa gtgctaggat tacagatgtg agccaccgca cctggcctcc acctttaaaa
     4021 tctatccaga attcaactgc ttctcccctt ctactgctca cacctcaatc taggctgtca
     4081 tcacctcctc tctggactgt tggaaaactt aacggttttt ataaacctga tattctttga
     4141 cacacttgcc atcaagaggc agagtctatg tcccttcatc ttgaaactgg gcccctcaac
     4201 aaataaaatg cagaggaagt gatgcagctt aacttctaaa gtgcagttag aaaagatgat
     4261 ttctcagctg ggcatggtgg ctcacgcctg taatcccagc actttgggag gctcaggtgg
     4321 gcagattact tgaggtcagg ggttcaagac cagcctggcc aacatggtga aatgtctcta
     4381 ctaaaaatac aaaaattggc caggcattgg tggtgggtgc ctgtaatccc agctactcag
     4441 gaggctgagg caagagaatt gcttgaactc agaaggcaga ggttgcagtg gaaaaaaaaa
     4501 aaaagataat ttctctctct ttctctctct ctctgacact tgctttagag gctacattaa
     4561 aaaaaaaaac tagttgccat gctggggagg ggtttgggtt acacaggtgt atgcacttat
     4621 gaaacttagt gaagtgtgtg aatttcattg tatgtaaagt ttacctcaaa agaaaatatt
     4681 gaacgccagt taaagatacg cctgtaatct gacttctttg ggaggccaag gcgggaggat
     4741 cacttgaggc caggagtttg agactaccct gggcaacaca gcaagacctg tctctacaaa
     4801 aataaataag taaataaata gccagatgtg gtggca
//
