LOCUS       NM_153256               3375 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens proline and serine rich 2 (PROSER2), mRNA.
ACCESSION   NM_153256
VERSION     NM_153256.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3375)
  AUTHORS   Lee,Y.S., Im,J., Yang,Y., Lee,H.J., Lee,M.R., Woo,S.M., Park,S.J.,
            Kong,S.Y., Kim,J.Y., Hwang,H. and Kim,Y.H.
  TITLE     New Function Annotation of PROSER2 in Pancreatic Ductal
            Adenocarcinoma
  JOURNAL   J Proteome Res 23 (3), 905-915 (2024)
   PUBMED   38293943
  REMARK    GeneRIF: New Function Annotation of PROSER2 in Pancreatic Ductal
            Adenocarcinoma.
REFERENCE   2  (bases 1 to 3375)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3375)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3375)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   5  (bases 1 to 3375)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   6  (bases 1 to 3375)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL138898.19 and BC048800.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153256.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048800.1, SRR1163658.138849.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000277570.10/ ENSP00000277570.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AL138898.19        100143-100184
            43-1163             BC048800.1         1-1121
            1164-3261           AL138898.19        146853-148950
            3262-3375           BC048800.1         3220-3333
FEATURES             Location/Qualifiers
     source          1..3375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p14"
     gene            1..3375
                     /gene="PROSER2"
                     /gene_synonym="C10orf47"
                     /note="proline and serine rich 2"
                     /db_xref="GeneID:254427"
                     /db_xref="HGNC:HGNC:23728"
     exon            1..115
                     /gene="PROSER2"
                     /gene_synonym="C10orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            116..334
                     /gene="PROSER2"
                     /gene_synonym="C10orf47"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1504
                     /gene="PROSER2"
                     /gene_synonym="C10orf47"
                     /codon_start=1
                     /product="proline and serine-rich protein 2"
                     /protein_id="NP_694988.3"
                     /db_xref="CCDS:CCDS7085.1"
                     /db_xref="GeneID:254427"
                     /db_xref="HGNC:HGNC:23728"
                     /translation="MPVTHRKSDASDMNSDTSPSCRLRAFSRGGSLESRSSSSRSRSF
                     TLDDESLKYLTHEEKDVLLFFEETIDSLDEDFEEPVLCDGGVCCLCSPSLEESTSSPS
                     EPEDVIDLVQPAPGAGEAEGLPEGTQAAGPAPAGKEHRKQDAETPPPPDPPAPETLLA
                     PPPLPSTPDPPRRELRAPSPPVEHPRLLRSVPTPLVMAQKISERMAGNEALSPTSPFR
                     EGRPGEWRTPAARGPRSGDPGPGPSHPAQPKAPRFPSNIIVTNGAAREPRRTLSRAAV
                     SVQERRAQVLATIHGHAGAFPAAGDAGEGAPGGGSSPERVARGRGLPGPAESLRAGGQ
                     APRGPALANGFPSAHEALKSAPSSFAPAGKSLCFRPGPALPSTRARQSFPGPRQPNGA
                     QDWRRADSLPRPQGITVQFAGRGSSEEARREALRKLGLLRESS"
     exon            335..587
                     /gene="PROSER2"
                     /gene_synonym="C10orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            588..3375
                     /gene="PROSER2"
                     /gene_synonym="C10orf47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1949..1954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROSER2"
                     /gene_synonym="C10orf47"
                     /note="hexamer: AATAAA"
     polyA_site      1987
                     /gene="PROSER2"
                     /gene_synonym="C10orf47"
                     /note="major polyA site"
     regulatory      3351..3356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROSER2"
                     /gene_synonym="C10orf47"
                     /note="hexamer: AATAAA"
     polyA_site      3375
                     /gene="PROSER2"
                     /gene_synonym="C10orf47"
ORIGIN      
        1 gagagcgcgc ggcggggcgt cccggaacag tctgcgccag acgggcggcg gcgtgagggc
       61 tccgggtcgc tggcggcgtg gacacctgag tcccggggta ggggtctccc gcgaggagtg
      121 agctgttgcc gcagaatggg ctgctggctc ctgccctgct tcctgtgatc gagccggccc
      181 tgaggactct gtggagatgc ctgtaaccca ccggaaatca gacgcatctg acatgaactc
      241 agacacgtcc cccagctgca ggctccgagc cttcagcaga ggcggcagcc tggagagtcg
      301 aagcagcagc tctcgctcca gaagcttcac tttggatgat gagagcctga agtacctcac
      361 ccatgaggaa aaggatgtgc tcctgttttt tgaagagacg attgactccc tagacgagga
      421 ctttgaggag ccagtgctgt gcgatggagg agtgtgctgc ctctgctccc cgtctctgga
      481 ggagagcacc tccagtccct ccgagcctga agatgtcatc gacttagtgc agccagcacc
      541 tggcgccggg gaagccgagg gccttccaga ggggacccag gcagcagggc ctgcacctgc
      601 tgggaaggag cacaggaaac aagatgctga gactcctcca cctccagacc ccccggctcc
      661 cgagaccctt cttgcgccac cacccctgcc tagcaccccc gatcccccca ggagggagct
      721 gcgcgccccc tccccgccgg tggagcaccc cagactcctg cgctctgttc ccacgcccct
      781 cgttatggcg cagaagattt ccgagaggat ggcggggaac gaagccctct cgcccacctc
      841 cccgttcagg gagggccggc ccggggagtg gaggacacct gccgcccggg ggccccgcag
      901 tggagaccct ggcccggggc ccagccaccc ggcgcagccc aaggcacccc gcttccccag
      961 caacatcatc gtcaccaacg gcgcggcccg ggagccccgc aggaccctgt ccagggcggc
     1021 cgtcagcgtg caggagcgca gggcgcaggt gttggccacc atccacggcc acgccggcgc
     1081 cttccccgcc gcgggggacg ccggcgaggg ggccccaggg ggcggctcct ccccggagcg
     1141 ggtggcgcgt ggccggggcc tgccgggccc cgctgagagt ctccgggcag ggggtcaggc
     1201 tccgcggggc ccggcgctgg ccaacggctt cccaagtgcg cacgaggccc tgaagagcgc
     1261 acccagctcc ttcgcgcccg ctgggaagtc cctctgcttc cgccctggcc cggccctgcc
     1321 cagcacgcgg gcccgtcaga gcttccccgg gccccggcag cccaacggcg cccaggactg
     1381 gcgccgcgca gactccctgc cccggcccca gggcatcacc gtgcagttcg cgggccgcgg
     1441 ctcctcggag gaggcgcgca gggaggccct gcggaagctg gggctgctca gggagagttc
     1501 gtgagggccg cgcgggctcc agtccacccc gtttctcccc accctgaaga gagggtgaaa
     1561 gagtcgctgc acccaggagc tgtttggtct aaaatggaag tgacagcggg agcccctgcc
     1621 ctctgtggca catcggagtc tagaggtgcc tggctggggc ctcctggctg agcacgcacc
     1681 gcaagctcca gccaccggca cagagaactc ttccctaaag gaatctggcc gagggcttgt
     1741 ctcccttttc ccaagaactg agagagagag aataacctgt tagacccata ggtttccgtg
     1801 atgtgtaaat gccatctttt gggggttggg aggagtagga ctggtctgat tatcattctt
     1861 gagtctcatc taccctcttc tcgaagtaca tgacatgaaa gttcagatcc cttccactca
     1921 ggattctcgc cgccttttct aagaaaataa taaaaaaaaa tgcttgtttc attttttaat
     1981 gtcttaatat acttgctttt gtttttgaag ggtgaggcat catggtactt tgcttttgtt
     2041 tcttgacgta ctttagtttg cccagttttg ttttttactg aaaactgaaa tgaaaccttt
     2101 agatattgag ttttgggagt gaaatggaaa ggtggtaatt ttgagaaagc aagtctcatc
     2161 agactctgag gtctgggacg tgtgcgtgag cctgtgtttg tgtgtgtatg tttttagata
     2221 cgtacgtgtc aacacataca tgcataggta tcctgtgtgt ccacatgcat cattattata
     2281 taaatagaaa cttctgaaca ccctcctaag tcactacagg atgccagcgc ttcctattct
     2341 tgggtagaca gagccacctc agcatcctga tggatgatac aagaaattgt tacttcctag
     2401 tatggaagtg tcttaaggac acgtctccat gatattttgg tgaaccaaaa gtgctttatc
     2461 ctcaacaaaa tgttcctctg ttcccagtta aagtaatatt ccctgcttcc aagtaagcaa
     2521 gactgttcac taaagaagga actttttaga aaactaatct cctttatcat ccaattttag
     2581 ttctgcatgt tccgaggtag ccagtcaaca gaaggaagca aaagattctt aaagatccac
     2641 cgactgtcat gttccacaag caagatctca gggtagggaa aaaccagtga atgaggttac
     2701 acagcaggaa aagaaccggt ttcctcccag actatgtctt acacgctgag ttatgccaca
     2761 agcgttatca tcaaaactat ttaaggctgg agtcttagac ctctaaaaat agacaggaag
     2821 ggctgccctg agcagtgaca cctttgtgtt tttatgtctc cgccagcgcc gtaacagagc
     2881 ctgtttcttt cccgttgagt attacttaaa ttcaggctta aatgtgctat gaagggcatt
     2941 tttcatagta tcccatttgc cttgtaagtt atataaagtg catgattata attttttcct
     3001 tagaaatgca atatttagtt tcatccagct cttatgaata ataacctcat agattcctga
     3061 tcttaattta aataggtgct ttaattttac agctttcaaa agtagttact gtaaatttta
     3121 ctcctgttaa tgctggattg gtttaaagga tttataaggg ctgtgtttgc tctttacaag
     3181 gcaagatgcc atacagtgtt caataataga aggtcttgat acaaccgaca ttttaaatat
     3241 tctttataca tgaggactgc atctttttca ctgaccctat gatttcactg tgagtagggt
     3301 gaactggact gcatattagt ttatttgttg ccataatcac atttttgaaa aataaattta
     3361 agagtttttt cttaa
//
