LOCUS       NM_025138               5182 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens proline and serine rich 1 (PROSER1), transcript
            variant 1, mRNA.
ACCESSION   NM_025138
VERSION     NM_025138.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5182)
  AUTHORS   Wang,X., Rosikiewicz,W., Sedkov,Y., Martinez,T., Hansen,B.S.,
            Schreiner,P., Christensen,J., Xu,B., Pruett-Miller,S.M., Helin,K.
            and Herz,H.M.
  TITLE     PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation
            on UTX-dependent enhancers and CpG islands
  JOURNAL   Life Sci Alliance 5 (1), e202101228 (2021)
   PUBMED   34667079
  REMARK    GeneRIF: PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA
            demethylation on UTX-dependent enhancers and CpG islands.
            Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445590.4, AB107354.1,
            BC064348.1 and AW294041.1.
            
            On Nov 23, 2018 this sequence version replaced NM_025138.4.
            
            Summary: This gene encodes a conserved protein containing proline
            and serine rich regions. These regions may be important in
            protein-protein interactions. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB107354.1, BX647471.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352251.8/ ENSP00000332034.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL445590.4         90900-90912         c
            14-4455             AB107354.1         1-4442
            4456-4866           BC064348.1         3698-4108
            4867-5182           AW294041.1         17-332              c
FEATURES             Location/Qualifiers
     source          1..5182
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.3"
     gene            1..5182
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /note="proline and serine rich 1"
                     /db_xref="GeneID:80209"
                     /db_xref="HGNC:HGNC:20291"
                     /db_xref="MIM:620773"
     exon            1..892
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /inference="alignment:Splign:2.1.0"
     CDS             848..3682
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proline and serine-rich protein 1"
                     /codon_start=1
                     /product="proline and serine-rich protein 1 isoform 1"
                     /protein_id="NP_079414.3"
                     /db_xref="CCDS:CCDS9368.2"
                     /db_xref="GeneID:80209"
                     /db_xref="HGNC:HGNC:20291"
                     /db_xref="MIM:620773"
                     /translation="MDKKSFEMVLDEIRKAVLTEYKLKAIEYVHGYFSSEQVVDLLRY
                     FSWAEPQLKAMKALQHKMVAVQPTEVVNILNCFTFSKDKLVALELLASNIIDAQNSRP
                     IEDLFRVNMSEKKRCKRILEQAFKGGCKAPHAMISSCGTIPGNPYPKGRPSRINGIFP
                     GTPLKKDGEECTNEGKGIAARILGPSKPPPSTYNPHKPVPYPIPPCRPHATIAPSAYN
                     NAGLVPLANVIAPPPPPYTPNPVGTENEDLSNPSKPIQNQTFSTPASQLFSPHGSNPS
                     TPAATPVPTASPVKAINHPSASAAATVSGMNLLNTVLPVFPGQVSSAVHTPQPSIPNP
                     TVIRTPSLPTAPVTSIHSTTTTPVPSIFSGLVSLPGPSATPTAATPTPGPTPRSTLGS
                     SEAFASTSAPFTSLPFSTSSSAASTSNPNSASLSSVFAGLPLPLPPTSQGLSNPTPVI
                     AGGSTPSVAGPLGVNSPLLSALKGFLTSNDTNLINSSALSSAVTSGLASLSSLTLQNS
                     DSSASAPNKCYAPSAIPTPQRTSTPGLALFPGLPSPVANSTSTPLTLPVQSPLATAAS
                     ASTSVPVSCGSSASLLRGPHPGTSDLHISSTPAATTLPVMIKTEPTSPTPSAFKGPSH
                     SGNPSHGTLGLSGTLGRAYTSTSVPISLSACLNPALSGLSSLSTPLNGSNPLSSISLP
                     PHGSSTPIAPVFTALPSFTSLTNNFPLTGNPSLNPSVSLPGSLIATSSTAATSTSLPH
                     PSSTAAVLSGLSASAPVSAAPFPLNLSTAVPSLFSVTQGPLSSSNPSYPGFSVSNTPS
                     VTPALPSFPGLQAPSTVAAVTPLPVAATAPSPAPVLPGFASAFSSNFNSALVAQAGLS
                     SGLQAAGSSVFPGLLSLPGIPGFPQNPSQSSLQELQHNAAAQSALLQQVHSASALESY
                     PAQPDGFPSYPSAPGTPFSLQPSLSQSGWQ"
     exon            893..958
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1027
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1122
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1216
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1327
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1411
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1490
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1577
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1622
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..3408
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3559
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..5182
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4876..4881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /note="hexamer: AATAAA"
     polyA_site      4897
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /note="major polyA site"
     regulatory      5161..5166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /note="hexamer: CATAAA"
     polyA_site      5182
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
ORIGIN      
        1 aggaaagagg ggcccaagct ggcggcgcag tgttgagttt acttgggcgc gactggcttt
       61 attgtaggtc cccatgagct ggtgggggct gtaggggtaa ccaggcaggg cgtctggcgc
      121 tgttggggct gcgtttttcc ggagtccccc tatgcgaggc cgtgcccctc ttcgcccggc
      181 tcctggtgct ccccagccgc cggcccgctc ccggaagctg cagcagctgg taacaaagag
      241 cctgccgggc cgcctgctgc cggggccgag gtatccagga gtcgggcgga gcggctgggg
      301 atgagcgcga gccggaccat gcgtccgggt tcgcggcggt gagggtcgcg gccggcggcc
      361 gaggcgcagg tgcgggtcga gagaccggcg cctccctccc cgccgcccgt ggactctgag
      421 cgcaggtgtt tctactctgc cggccgctcc acctgggaaa gcgccttcaa gagctacctc
      481 tggcggcacc tggccctcag ctgcagggaa accgcactca aacctgccgc cgagcccggg
      541 tttttctgca aaactcagag gacctggctc ttgcccgagg tgccctgaac cattgtgtga
      601 ataagctggg gaagcctgac tggagtgttt tttcttttta ataaaaagag tttttctgaa
      661 tctcaatttt tagaaatttt ttttgcgaag tttgcaatac tctctacctc ttcgcatcct
      721 ctcttgctcg tggagtcttt ttcctcctca gctataaata ttttttacta tcggcggagc
      781 agaccaggga tgaacgtctt ttaattgcaa gtataactgt taaaaccacg tcgggatagt
      841 agtcaagatg gataaaaagt cctttgaaat ggtgctggat gaaattagaa aggctgtttt
      901 gacagaatac aaattaaaag caattgaata tgtgcatgga tacttttcta gtgaacaggt
      961 ggttgatttg ctgagatatt tttcctgggc cgagccccag ttgaaggcaa tgaaagcatt
     1021 acagcataaa atggtggctg tccagccaac agaagtggtc aatatactca actgtttcac
     1081 tttcagtaaa gacaaactag ttgctcttga actgttagcc tcgaacatta ttgatgcaca
     1141 gaattctcgt cctattgaag atttattcag ggtaaatatg tctgagaaga aacggtgcaa
     1201 gagaatactt gaacaggctt tcaagggggg ctgcaaagct cctcatgcta tgatatcttc
     1261 ttgtggaaca atcccaggaa atccatatcc caaaggaaga cctagccgca taaatggaat
     1321 tttcccagga actcctttga aaaaagatgg tgaagaatgt actaacgaag gcaaaggaat
     1381 agctgcacga attcttgggc catccaaacc acctccttca acatataatc cacataaacc
     1441 tgttccttat ccgatacctc catgccgacc acatgcaact attgcaccaa gtgcttataa
     1501 caatgcaggt ctggtaccat tagcgaatgt catagctcca cctccacctc catatactcc
     1561 taatcctgta ggaacagaga atgaagacct ttcgaatccg tcaaaaccta tacagaatca
     1621 aacattttcc accccagcaa gtcaactctt ttctcctcat ggttctaatc cttcaacacc
     1681 tgctgcaact cctgttccta ctgcatcccc agtcaaggca attaatcatc catcagcatc
     1741 agcagctgcc accgtttctg gaatgaacct gctgaatact gtccttcctg tgttcccagg
     1801 gcaggtctcc tcagccgttc acacacctca gccatcaata ccaaacccaa cagttatcag
     1861 aaccccttca ttgcccactg cacctgttac atccatccac agtacaacca ccactcctgt
     1921 tccttccatt ttttctggcc tagtgtcact gccaggtcct tctgccactc ctaccgcagc
     1981 cactcctacc ccaggaccta caccacggtc cactcttggt tccagtgaag catttgcttc
     2041 tacttctgca cctttcacta gcctcccctt ttccaccagc tcttctgctg cttctaccag
     2101 caacccaaat tctgcttcat tgtcatcagt ttttgcaggg ctccctttgc ccttaccacc
     2161 aacatcccaa ggcctatcca acccgactcc tgtaattgct ggtggctcta ctcccagcgt
     2221 tgccggtcca cttggtgtga acagtcctct tttgtctgcg ttaaaaggtt ttctgacatc
     2281 caatgacacc aatttaatca actcctctgc tttatcctct gctgtcacaa gtgggctggc
     2341 ttcactatct tctcttactc ttcagaactc tgactcttct gcttcagccc ctaacaagtg
     2401 ctatgcccca tcagccatcc ctaccccaca gaggacttcc actccagggt tggccctgtt
     2461 cccaggcctg ccgtctcccg tggctaactc aacttccact cccctgacat tgcctgtaca
     2521 gtctccttta gccactgctg catcagcttc cacgtcagtg ccagttagct gtggctcctc
     2581 agcctccctt ttgcgtggcc cccacccagg tacctcagat ctgcatattt catctacccc
     2641 tgctgcaaca actcttcctg ttatgatcaa aactgagccc acaagtccta ctccctcggc
     2701 cttcaaaggt ccatctcatt ctgggaatcc ctctcatggc actttaggtt tgtcagggac
     2761 attgggccgt gcatatactt caacatccgt gcccatcagt ttatctgctt gccttaatcc
     2821 tgcattgtca ggtctctcca gcttgagtac tcctttaaat ggttcaaatc ctctttcctc
     2881 tatttccctt ccaccacatg gttcctccac tcccattgca ccagtattca ctgctcttcc
     2941 ttcttttact tctttgacca acaattttcc tttaactggc aacccatctc ttaatccgtc
     3001 agtatctctc ccagggtcat taatagccac ctcatctacc gctgccacct ccacatctct
     3061 ccctcatcct agctcaacgg cagctgttct ctcagggctt tctgcttcag caccagtctc
     3121 agcagcacct ttccccctca acctgtccac tgctgttccc tcacttttct ctgttactca
     3181 aggacctctg tcatcttcaa atccctccta tccaggcttt tctgtctcta ataccccaag
     3241 cgttacccct gctcttccct cattcccggg gctgcaggcg ccctctacag tcgcagctgt
     3301 cacaccacta cctgtggctg ccacagcccc atccccagct ccagtcctcc caggattcgc
     3361 ctcagcattc agttccaatt tcaactccgc tcttgttgca caagccggtt tatcatctgg
     3421 acttcaagct gcaggcagtt ctgtttttcc aggccttttg tccctcccgg gtatccctgg
     3481 gtttcctcag aatccttcac aatcatcctt gcaagaatta cagcataatg cggctgcgca
     3541 gtcagcattg ttacagcagg tccattcagc ttcggctctg gaaagctatc cagctcagcc
     3601 tgatgggttt cctagttatc cttcagcgcc aggaacacca ttttctttgc aaccaagcct
     3661 gtcccagagt gggtggcagt gaatactttt aacttttatt ctccttcaga gcaacatcag
     3721 aattgcctga gaactgcaat gaacaatctg acaaatgtga agctggccaa aagtcggaaa
     3781 atgagaatga gggtaatcct ggagaaattg tgacaacaat ttgaaaattg tggttgcatt
     3841 ttaaagtgtg aacactcccc tatgtaaata tgctgacaat aaattgtatg gagaatggta
     3901 tttaaaaagt gtttggagac ttttcacctg tcctataaaa ttttgaattg tgtatgtgat
     3961 ctacatagaa agaatattaa agagtaggtt gaactcttta tagccgaata cagccttaaa
     4021 tatgcttgta tagcatccac tggcagaagt aatagttgtg cctcagactt gggggttgca
     4081 tgtggccctg ggggagttac tacccttggt atgcatgagc ggttcctatt agcatcagtg
     4141 ggaactcagt actctgtatg tatccacaaa agggaacttg agacccacag ttattcttaa
     4201 tttctgatat taacaaccgt acatactgct gaatttaact caaaatattt caggtaagtg
     4261 aaagtggtgc ttaatgtaga ctatagaatg actttcaggt gttttcaact gaaagtatat
     4321 atccagaact gcatccttat agaaatacaa gtaagactta ggataatttg ccttcaaaac
     4381 agttttccta atctcagcag tatccagtga gtgaagaaca cttgactgac tcttgggcca
     4441 cctctgttac ttactgtact atggaagctc ctggtgaatg tttacaatta tgggatgtag
     4501 tatttctatt tgtactttaa gtcaaatgct tatatgaaat atgtgacaac aaatagagaa
     4561 gactggctct gttagtaatt atgcagtatg tactctattt aaggatctgt ggtagtataa
     4621 catgagtgaa tgtcattaat tttgaagtaa taactgccac atgtgggaag taggggagta
     4681 aggagaatga attccaatct gtgattaaaa gtgtaaacta tagactctac tgtagtacat
     4741 ttcaggatct agaagtttta cttttataaa gatggtgtcc ggaagatgtt gctaatgtat
     4801 tttacttcaa catagggaac aaacttttta agtatattaa taaacctgta tggttagttt
     4861 ttaacagttt tttaaaataa actatggata tgacaaatat tctgtgtttt actaagtgct
     4921 tggataggct ttctaatttt gtatacgtgc tagagttaat tattgaacat ttttatccaa
     4981 atttagttgt aactctgttt atactactga ttgctcattc gtttaaatga tattttaatg
     5041 taaaagtcat aaccaacata tgaacagaca gatttatgtc tttaaacaca gaatgtaagc
     5101 tatagtttaa tctgatacca gttgctggaa gttgccattt gtttttctta aatctatacc
     5161 cataaaactt cttttaagat ta
//
