LOCUS       NP_079414                944 aa            linear   PRI 28-APR-2025
DEFINITION  proline and serine-rich protein 1 isoform 1 [Homo sapiens].
ACCESSION   NP_079414
VERSION     NP_079414.3
DBSOURCE    REFSEQ: accession NM_025138.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 944)
  AUTHORS   Wang,X., Rosikiewicz,W., Sedkov,Y., Martinez,T., Hansen,B.S.,
            Schreiner,P., Christensen,J., Xu,B., Pruett-Miller,S.M., Helin,K.
            and Herz,H.M.
  TITLE     PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation
            on UTX-dependent enhancers and CpG islands
  JOURNAL   Life Sci Alliance 5 (1), e202101228 (2021)
   PUBMED   34667079
  REMARK    GeneRIF: PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA
            demethylation on UTX-dependent enhancers and CpG islands.
            Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445590.4, AB107354.1,
            BC064348.1 and AW294041.1.
            
            On Feb 13, 2007 this sequence version replaced NP_079414.2.
            
            Summary: This gene encodes a conserved protein containing proline
            and serine rich regions. These regions may be important in
            protein-protein interactions. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB107354.1, BX647471.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352251.8/ ENSP00000332034.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..944
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.3"
     Protein         1..944
                     /product="proline and serine-rich protein 1 isoform 1"
                     /note="proline and serine-rich protein 1"
                     /calculated_mol_wt=95567
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0007744|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (Q86XN7.2)"
     Region          29..121
                     /region_name="DUF4476"
                     /note="Domain of unknown function (DUF4476); pfam14771"
                     /db_xref="CDD:434196"
     Region          <146..603
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          233..285
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86XN7.2)"
     Region          369..396
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86XN7.2)"
     Region          <537..939
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          608..633
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86XN7.2)"
     Region          912..944
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86XN7.2)"
     CDS             1..944
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /coded_by="NM_025138.5:848..3682"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS9368.2"
                     /db_xref="GeneID:80209"
                     /db_xref="HGNC:HGNC:20291"
                     /db_xref="MIM:620773"
ORIGIN      
        1 mdkksfemvl deirkavlte yklkaieyvh gyfsseqvvd llryfswaep qlkamkalqh
       61 kmvavqptev vnilncftfs kdklvalell asniidaqns rpiedlfrvn msekkrckri
      121 leqafkggck aphamisscg tipgnpypkg rpsringifp gtplkkdgee ctnegkgiaa
      181 rilgpskppp stynphkpvp ypippcrpha tiapsaynna glvplanvia pppppytpnp
      241 vgtenedlsn pskpiqnqtf stpasqlfsp hgsnpstpaa tpvptaspvk ainhpsasaa
      301 atvsgmnlln tvlpvfpgqv ssavhtpqps ipnptvirtp slptapvtsi hsttttpvps
      361 ifsglvslpg psatptaatp tpgptprstl gsseafasts apftslpfst sssaastsnp
      421 nsaslssvfa glplplppts qglsnptpvi aggstpsvag plgvnsplls alkgfltsnd
      481 tnlinssals savtsglasl ssltlqnsds sasapnkcya psaiptpqrt stpglalfpg
      541 lpspvansts tpltlpvqsp lataasasts vpvscgssas llrgphpgts dlhisstpaa
      601 ttlpvmikte ptsptpsafk gpshsgnpsh gtlglsgtlg raytstsvpi slsaclnpal
      661 sglsslstpl ngsnplssis lpphgsstpi apvftalpsf tsltnnfplt gnpslnpsvs
      721 lpgsliatss taatstslph psstaavlsg lsasapvsaa pfplnlstav pslfsvtqgp
      781 lsssnpsypg fsvsntpsvt palpsfpglq apstvaavtp lpvaatapsp apvlpgfasa
      841 fssnfnsalv aqaglssglq aagssvfpgl lslpgipgfp qnpsqsslqe lqhnaaaqsa
      901 llqqvhsasa lesypaqpdg fpsypsapgt pfslqpslsq sgwq
//
