LOCUS       NM_014672               6186 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens protein only RNase P catalytic subunit (PRORP),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_014672 XM_375074
VERSION     NM_014672.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6186)
  AUTHORS   Zhang,E., Sun,Q., Zhang,C., Ma,H., Zhang,J., Ding,Y., Wang,G.,
            Jin,C., Jin,C., Fu,Y., Yan,C., Zhu,M., Wang,C., Dai,J., Jin,G.,
            Hu,Z., Shen,H. and Ma,H.
  TITLE     Comprehensive functional interrogation of susceptibility loci in
            GWASs identified KIAA0391 as a novel oncogenic driver via
            regulating pyroptosis in NSCLC
  JOURNAL   Cancer Lett 585, 216646 (2024)
   PUBMED   38262497
  REMARK    GeneRIF: Comprehensive functional interrogation of susceptibility
            loci in GWASs identified KIAA0391 as a novel oncogenic driver via
            regulating pyroptosis in NSCLC.
REFERENCE   2  (bases 1 to 6186)
  AUTHORS   Smith,T.B., Rea,A., Thomas,H.B., Thompson,K., Olahova,M.,
            Maroofian,R., Zamani,M., He,L., Sadeghian,S., Galehdari,H.,
            Lotan,N.S., Gilboa,T., Herman,K.C., McCorvie,T.J., Yue,W.W.,
            Houlden,H., Taylor,R.W., Newman,W.G. and O'Keefe,R.T.
  TITLE     Novel homozygous variants in PRORP expand the genotypic spectrum of
            combined oxidative phosphorylation deficiency 54
  JOURNAL   Eur J Hum Genet 31 (10), 1190-1194 (2023)
   PUBMED   37558808
  REMARK    GeneRIF: Novel homozygous variants in PRORP expand the genotypic
            spectrum of combined oxidative phosphorylation deficiency 54.
REFERENCE   3  (bases 1 to 6186)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 6186)
  AUTHORS   Hochberg,I., Demain,L.A.M., Richer,J., Thompson,K., Urquhart,J.E.,
            Rea,A., Pagarkar,W., Rodriguez-Palmero,A., Schluter,A., Verdura,E.,
            Pujol,A., Quijada-Fraile,P., Amberger,A., Deutschmann,A.J.,
            Demetz,S., Gillespie,M., Belyantseva,I.A., McMillan,H.J.,
            Barzik,M., Beaman,G.M., Motha,R., Ng,K.Y., O'Sullivan,J.,
            Williams,S.G., Bhaskar,S.S., Lawrence,I.R., Jenkinson,E.M.,
            Zambonin,J.L., Blumenfeld,Z., Yalonetsky,S., Oerum,S.,
            Rossmanith,W., Yue,W.W., Zschocke,J., Munro,K.J., Battersby,B.J.,
            Friedman,T.B., Taylor,R.W., O'Keefe,R.T. and Newman,W.G.
  CONSRTM   Genomics England Research Consortium
  TITLE     Bi-allelic variants in the mitochondrial RNase P subunit PRORP
            cause mitochondrial tRNA processing defects and pleiotropic
            multisystem presentations
  JOURNAL   Am J Hum Genet 108 (11), 2195-2204 (2021)
   PUBMED   34715011
  REMARK    GeneRIF: Bi-allelic variants in the mitochondrial RNase P subunit
            PRORP cause mitochondrial tRNA processing defects and pleiotropic
            multisystem presentations.
REFERENCE   5  (bases 1 to 6186)
  AUTHORS   Bhatta,A., Dienemann,C., Cramer,P. and Hillen,H.S.
  TITLE     Structural basis of RNA processing by human mitochondrial RNase P
  JOURNAL   Nat Struct Mol Biol 28 (9), 713-723 (2021)
   PUBMED   34489609
  REMARK    GeneRIF: Structural basis of RNA processing by human mitochondrial
            RNase P.
REFERENCE   6  (bases 1 to 6186)
  AUTHORS   Stuart,P.E., Nair,R.P., Ellinghaus,E., Ding,J., Tejasvi,T.,
            Gudjonsson,J.E., Li,Y., Weidinger,S., Eberlein,B., Gieger,C.,
            Wichmann,H.E., Kunz,M., Ike,R., Krueger,G.G., Bowcock,A.M.,
            Mrowietz,U., Lim,H.W., Voorhees,J.J., Abecasis,G.R.,
            Weichenthal,M., Franke,A., Rahman,P., Gladman,D.D. and Elder,J.T.
  TITLE     Genome-wide association analysis identifies three psoriasis
            susceptibility loci
  JOURNAL   Nat Genet 42 (11), 1000-1004 (2010)
   PUBMED   20953189
REFERENCE   7  (bases 1 to 6186)
  AUTHORS   Alsmadi,O., Muiya,P., Khalak,H., Al-Saud,H., Meyer,B.F.,
            Al-Mohanna,F., Alshahid,M. and Dzimiri,N.
  TITLE     Haplotypes encompassing the KIAA0391 and PSMA6 gene cluster confer
            a genetic link for myocardial infarction and coronary artery
            disease
  JOURNAL   Ann Hum Genet 73 (Pt 5), 475-483 (2009)
   PUBMED   19624571
  REMARK    GeneRIF: Haplotypes in KIAA0391 and PSMA6 genes is a genetic link
            for myocardial infarction and coronary artery disease.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6186)
  AUTHORS   Holzmann,J., Frank,P., Loffler,E., Bennett,K.L., Gerner,C. and
            Rossmanith,W.
  TITLE     RNase P without RNA: identification and functional reconstitution
            of the human mitochondrial tRNA processing enzyme
  JOURNAL   Cell 135 (3), 462-474 (2008)
   PUBMED   18984158
REFERENCE   9  (bases 1 to 6186)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   10 (bases 1 to 6186)
  AUTHORS   Anantharaman,V. and Aravind,L.
  TITLE     The NYN domains: novel predicted RNAses with a PIN domain-like fold
  JOURNAL   RNA Biol 3 (1), 18-27 (2006)
   PUBMED   17114934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA459368.1, BX161394.1, AA838769.1 and AL121594.6.
            
            On May 17, 2019 this sequence version replaced NM_014672.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 and 6 both encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.119171.1,
                                           SRR1803612.144679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000534898.9/ ENSP00000440915.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                DA459368.1         216-252
            38-2600             BX161394.1         1-2563
            2601-2642           AA838769.1         11-52               c
            2643-6186           AL121594.6         23474-27017         c
FEATURES             Location/Qualifiers
     source          1..6186
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q13.2"
     gene            1..6186
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
                     /note="protein only RNase P catalytic subunit"
                     /db_xref="GeneID:9692"
                     /db_xref="HGNC:HGNC:19958"
                     /db_xref="MIM:609947"
     exon            1..84
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            85..1364
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             379..2130
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
                     /EC_number="3.1.26.5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; mitochondrial ribonuclease P protein 3;
                     mitochondrial RNase P protein 3; mitochondrial RNase P
                     subunit 3; proteinaceous RNase P; mitochondrial
                     ribonuclease P catalytic subunit"
                     /codon_start=1
                     /product="mitochondrial ribonuclease P catalytic subunit
                     isoform 1 precursor"
                     /protein_id="NP_055487.2"
                     /db_xref="CCDS:CCDS32063.1"
                     /db_xref="GeneID:9692"
                     /db_xref="HGNC:HGNC:19958"
                     /db_xref="MIM:609947"
                     /translation="MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQR
                     LFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAAKERSQMNSQTED
                     HALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKS
                     LLAWVAAKNNGIVSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIR
                     GLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQELLGHDIV
                     PMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQ
                     WKGQFTTVRKSGQCSGCGKTIESIQLSPEEYECLKGKIMRDVIDGGDQYRKTTPQELK
                     RFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLLLNVVSQLAKRNLRLLVLGRKHMLR
                     RSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACL
                     PDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYDEDLVE
                     RCSCEVPTKWLCLHQKT"
     exon            1365..1412
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1545
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1653
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1802
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1998
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..6186
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2607..2612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
                     /note="hexamer: AATAAA"
     polyA_site      2629
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
                     /note="major polyA site"
     regulatory      4019..4024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
                     /note="hexamer: ATTAAA"
     polyA_site      4048
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
     regulatory      6162..6167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
                     /note="hexamer: AATAAA"
     polyA_site      6186
                     /gene="PRORP"
                     /gene_synonym="COXPD54; KIAA0391; MRPP3"
ORIGIN      
        1 agtttccgcc gcgtttatgg ccgcgttaag tctgagtgcc gctttgagtt gttgaatgaa
       61 gtgaacttca tttgtcagcg ttcggttcat gaactggaat gtaagaggca ccagaggatt
      121 cctgctctgt cccctggttt gcggcttgcg acgttggaca tccccggatt gttgtttaat
      181 agagaaaact cacctgcctt cttgctttta agtagcccca aaagcagaac cttgatttgt
      241 ctgtaaggaa gaaacacaaa ccttttaaaa agttccactt cgactctgca ccgccgaccc
      301 ccaatctctt taattttgcc atagaagagg ggttttttca acatctctct cactatctgg
      361 tgctgatctc actgcataat gactttctat ttgtttggta ttcgaagctt tccgaagctt
      421 tggaagagcc cataccttgg gctaggccca gggcactctt atgtctcgct gtttctggca
      481 gaccgctgtg gcatcaggaa ccagcagagg ttgttttctc ttaaaacaat gtctccacag
      541 aataccaaag caacgaatct gattgccaag gccagatatc tcaggaaaga tgagggcagt
      601 aataagcaag tttattctgt tcctcatttt tttttagctg gagcagctaa ggagagatca
      661 cagatgaatt ctcaaactga agatcatgcc ttggcacctg tgaggaacac tattcaactc
      721 ccaacacaac ctttgaattc agaggagtgg gataaactta aggaagattt aaaagaaaac
      781 accggaaaga ccagtttcga aagttggatc atttcacaga tggctggctg tcatagctct
      841 atagatgtgg ctaaatctct gctggcatgg gtagcagcca aaaataatgg tattgtaagt
      901 tacgatttac tggtcaagta tttgtatctc tgtgtctttc atatgcagac atctgaagtt
      961 attgatgtct ttgaaattat gaaagccaga tataagactt tagaacctag aggttacagt
     1021 cttctcatcc ggggattgat ccattcagac agatggagag aagcattgtt gctgttagag
     1081 gacatcaaaa aagttataac tccttcaaaa aagaactata atgactgtat ccagggagct
     1141 ctccttcatc aagatgtaaa cacagcttgg aatttatatc aggaattgct aggtcatgat
     1201 attgttccta tgttggaaac tttaaaagct ttctttgatt ttggaaaaga cataaaggat
     1261 gataactatt caaataaact actagatatt ctttcatatc taagaaataa tcagctgtat
     1321 ccaggggagt catttgcaca cagtataaaa acatggtttg agagtgttcc tggaaaacaa
     1381 tggaaaggac aattcaccac agtccgaaaa agtggccagt gttcgggctg tggaaaaacc
     1441 atagagtcta ttcagctgag tccagaagaa tatgaatgtc ttaagggaaa aatcatgagg
     1501 gatgtgatag atggaggtga ccagtacaga aagacaacac ctcaggaact taagagattt
     1561 gagaacttca taaaatctcg tcctcctttt gatgttgtca ttgatggtct caatgttgcc
     1621 aaaatgtttc ctaaagttcg tgaatctcaa cttctcttga atgtcgtctc tcaactagcc
     1681 aaacggaatc tgcgactgct ggtcctaggc cggaagcaca tgctaagacg gagttcccag
     1741 tggagtcggg atgagatgga agaggtgcaa aagcaagcca gctgtttttt tgctgatgac
     1801 atctcggagg atgatccatt ccttctgtat gccacactgc actccgggaa tcactgcagg
     1861 tttatcacaa gagacctgat gcgggaccac aaggcctgtc tgcctgatgc caagacccaa
     1921 cgcctgtttt ttaagtggca gcagggacat cagctggcaa ttgtaaatag gtttccagga
     1981 tcaaaactaa cctttcagcg tattctcagc tatgacacag tggtgcaaac aactggagac
     2041 tcgtggcaca taccatatga tgaagacttg gtagaaagat gttcctgtga agtaccaacc
     2101 aaatggcttt gcctccacca aaagacatag agattcttac ctctatgcta agtttgtgtt
     2161 tgggtaccct ctaggttggc atcagaggct cttgagctgg tgtttgttta gggcattgcc
     2221 tctgtcctga agataaaagg attctattaa cagcattgac attgattttt taatgaaatg
     2281 agatatatct tttcataacc agctgcgttt ttttccccta acatttgttt ttggaggctt
     2341 atcaagagtt ggagaactta gtgtagagca aaacctgcat ttctcctact gggccagcta
     2401 ttccacttag cttgggtgac taatagtgct tttggtatcc attttttgct acttctgacc
     2461 ttgccttcca ggcctaccaa tagcagaatc aatccatctg tccctgagat actcatgttg
     2521 tttcaaatgc ctcctcccat ttctggcata gtctcattct ctgtatgtta tgccctatcc
     2581 acatggaatc atttatcgtc ctctgtaata aactggccaa gatactaaag gcttactatt
     2641 catagcagtt tttaattact tatcatccaa ttatttggat tggagaagag ggggcattca
     2701 ctcctctttt tcttattttt tttggaaata gagtctcaac ttactctgtc gccagggctg
     2761 gagtgcagtg acgtgatcac agttcactgc agcctcaaac tcccaggctc aagcaatctt
     2821 cctacctcag ccctcctgag taattgggac tacaggcatg tatcaccagg cttggctaat
     2881 tttttttttt ttttttgtag agatggctgt ctcactctgt tgacaagact agtctccaac
     2941 ccctggcctc agtcgatccc cagcaatttg ggagattgaa gcgagagaat cacttgagtc
     3001 taggagttca agaccagcct aggcaacata gtaagatctc atttctacaa aaaatttaaa
     3061 aattagccag gcatggtagt ttgcacacat agtcccagct actttggggg ctgaggtagg
     3121 aggattgctt gagcctcaga ggtcaaggct gcaatgagcc aacgttgcac cactgcactc
     3181 tagcctgggt gacagagcga gaccttgtct caaaacaaaa caaagtgctg gaattgcaga
     3241 cttgagccac agtgcccagc ctcacttctc tagactatga tggttttttc ttcattctat
     3301 aatctctttt ccaaattggt tcaacatttt gtgaacacta ttaatttcat cattcagtat
     3361 atgtgggctt tctaaaatat gccaattttt ttccacttaa tcaagtttga cttaatttaa
     3421 caaagtgatt atattttaat agttacattt ctgttttttc cactcactag ccagcttaca
     3481 gtttattagc ccttgatttc agctgaaaat attcatgtct gcaccccttc atgatagttc
     3541 tttctttacg tatacatact gtattcaata tgcaagaaca ggcaaaaact actctattgt
     3601 gataaaaatc agaatagtaa ttgcctgagg aaagggatat gagagaactt gagagaactt
     3661 tctcggggtg atggaaagtt tcttatattg atttgggtaa tagtaacata gctatatgta
     3721 tatattagtt aaaattcctc acactaaaca ttttaaattg atatatttac atttatgaca
     3781 atatacctca aagtaagtta gggtaagaaa agataattac ttacatgaaa taaacaatga
     3841 cctcttttat atcaaaccat atacatgtgt ataattaggg tatgtattat gcacagagaa
     3901 acaatttagg aaaatccaag gaggggacgt tttatcttct tacctattta ctgaatgcaa
     3961 cattactgca caccaagaca aaagagctct ccaggaaaac attggatata ttgagagcat
     4021 taaaagatac tgcaaaagct ctaataaatt cagtctgctt attttccaaa tttcataaac
     4081 tacatactta ggaaactgtg ctttcagtga gctaaacttc tttttttaag taactatcat
     4141 agttttaaga aaaacatttt aagaagacaa aaagtattta ttaagcccat ctaaaaggct
     4201 aatgcaaatt cccaaaaaag gagcacatag agatagagga ggaggccgaa gtggtggctc
     4261 atacctgtta attccagcac tttgggaggc caagacagga ggatcacttt aggcccagag
     4321 ttggagacca acctgggcaa catagcaaga ccctgtctct taaaaaaaaa aaaaaaagac
     4381 gggagaagct acaagaagaa aactagaact ttagagcagg agtaacctta gagcatgtaa
     4441 agtccatttt ggagatgagg aacagaccca ggaagatgac ctggcttccc tgaatcccac
     4501 ggctagttag tgcagacatt tcagccataa cccagctctt ctaattccca aatactcttt
     4561 cttctactgg cacatagaga tgggggagga gtcagggcat ggtggcccac acctacagtt
     4621 ccagcacttt gggaggccaa atgggagaat tgcttgaagc caggagttgg agaccagcct
     4681 aggcaacaca gggagacccg tgtcgacaaa aaatttaaaa attagctggg catggtagca
     4741 catgcctgtg gtcccagcta ctcagaaggc tgaggtggga ggatcacttg agccccagag
     4801 gtcaaggcta cagtgagcta tgatcatgct actacactcc agcctaggtg acagagtgag
     4861 accctgtctc aaagggaggg aggtaagaat gagaagaagg aacaggggtg tacctctttt
     4921 aagggcccaa gtatcctgaa tggctcagca gtatagaaca ttgtggtaga gaaattacat
     4981 tttaaaataa ctctaatact gtttagaaac aaaaccctaa cttctgcttg agataaactg
     5041 aagtgcatct gtcccttgtc caggagtggg gaaccattgt agggttgctc agcataagtc
     5101 atactgccac ggtgaccttg aggagtgcag ggattccctg aaggaagcag ctggtaccag
     5161 acacttaggc tgcccatttg tgttctgatc atttgagtga aaaaaaggta cctgtcaagc
     5221 aagctcctgg acaccacaag aaggaggaat tattttaaaa gctgtactct taaattgtta
     5281 gtatctttaa aatcagttgt gaacaatgaa ggatttgaaa gagcattgac tttgccactt
     5341 aaaagtattt ctaaaatact ttgtgcttcc cccttgcatt ctgaatttat acacttttcc
     5401 tcctgctgtt ctcagaccca gtggaaagaa aatctcaagg aagaaggctg agtttattct
     5461 ctcagggctc tgttgggtct acctcatctg aggtggctta ttcttcatag gaaattaatt
     5521 tttcttctca agtatgcact taaatataat tactgcttcc ttggtcctct agcagatttc
     5581 tcacttttat ttattttttt ttttgagaca gagtcttgat cttttttcat ctaggctgga
     5641 gtgcaatggt ttgatctcag ttcactgcaa cctctgcctc ctgggttcaa gcaattctca
     5701 tgcctctgcc tctcgggcag ctggaattac aggcatgcgc catgacgcct ggctaatttt
     5761 tgcattttta gtagagacgg gttttcacca tgttgccccg gttgctctca aactcctgac
     5821 ctcaggtgat ccacccacct cagcctccca aagtgctggg attacaggtg tgagtcaccc
     5881 cgcacagcct gaaatgaggc atctctatct atagtccagc agccctacag gaggcaggag
     5941 gggagcaaga ataagaaagg aaatttgtaa aaggcactta ggagtgagca gaaaggaaat
     6001 aggaccagct tttacctgcc cagtcctggc cagtgacaag cagtctgctt gagtctgtgc
     6061 taaataaaca aaggaagttc catttagagc tctacagagg ggaagccata gaaattaaca
     6121 ggatgaaaat acaagagaca ggaacacaga tgaataaatg taataaaatt tgagaaataa
     6181 tcttta
//
