LOCUS       NM_001165978            4731 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens prominin 2 (PROM2), transcript variant 1, mRNA.
ACCESSION   NM_001165978
VERSION     NM_001165978.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4731)
  AUTHORS   Paris,J., Wilhelm,C., Lebbe,C., Elmallah,M., Pamoukdjian,F.,
            Heraud,A., Gapihan,G., Walle,A.V., Tran,V.N., Hamdan,D.,
            Allayous,C., Battistella,M., Van Glabeke,E., Lim,K.W., Leboeuf,C.,
            Roger,S., Falgarone,G., Phan,A.T. and Bousquet,G.
  TITLE     PROM2 overexpression induces metastatic potential through
            epithelial-to-mesenchymal transition and ferroptosis resistance in
            human cancers
  JOURNAL   Clin Transl Med 14 (3), e1632 (2024)
   PUBMED   38515278
  REMARK    GeneRIF: PROM2 overexpression induces metastatic potential through
            epithelial-to-mesenchymal transition and ferroptosis resistance in
            human cancers.
REFERENCE   2  (bases 1 to 4731)
  AUTHORS   Tang,J., Shu,D., Fang,Z. and Yang,G.
  TITLE     Prominin 2 decreases cisplatin sensitivity in non-small cell lung
            cancer and is modulated by CTCC binding factor
  JOURNAL   Radiol Oncol 57 (3), 325-336 (2023)
   PUBMED   37665741
  REMARK    GeneRIF: Prominin 2 decreases cisplatin sensitivity in non-small
            cell lung cancer and is modulated by CTCC binding factor.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4731)
  AUTHORS   Luo,W., Wang,J., Xu,W., Ma,C., Wan,F., Huang,Y., Yao,M., Zhang,H.,
            Qu,Y., Ye,D. and Zhu,Y.
  TITLE     LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance
            through PROM2-activated iron export by sponging miR-129-5p in
            bladder cancer
  JOURNAL   Cell Death Dis 12 (11), 1043 (2021)
   PUBMED   34728613
  REMARK    GeneRIF: LncRNA RP11-89 facilitates tumorigenesis and ferroptosis
            resistance through PROM2-activated iron export by sponging
            miR-129-5p in bladder cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4731)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4731)
  AUTHORS   Li,W., Zhu,Y., Zhang,K., Yu,X., Lin,H., Wu,W., Peng,Y. and Sun,J.
  TITLE     PROM2 promotes gemcitabine chemoresistance via activating the Akt
            signaling pathway in pancreatic cancer
  JOURNAL   Exp Mol Med 52 (3), 409-422 (2020)
   PUBMED   32123287
  REMARK    GeneRIF: PROM2 promotes gemcitabine chemoresistance via activating
            the Akt signaling pathway in pancreatic cancer.
REFERENCE   6  (bases 1 to 4731)
  AUTHORS   Yao,J., Zhang,T., Ren,J., Yu,M. and Wu,G.
  TITLE     Effect of CD133/prominin-1 antisense oligodeoxynucleotide on in
            vitro growth characteristics of Huh-7 human hepatocarcinoma cells
            and U251 human glioma cells
  JOURNAL   Oncol Rep 22 (4), 781-787 (2009)
   PUBMED   19724856
  REMARK    GeneRIF: prominin-2, another protein in the same family as
            CD133/prominin-1, may not play an important functional role in the
            growth of human glioma and hepatocellular carcinoma cells
REFERENCE   7  (bases 1 to 4731)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   8  (bases 1 to 4731)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 4731)
  AUTHORS   Jaszai,J., Fargeas,C.A., Haase,M., Farkas,L.M., Huttner,W.B. and
            Corbeil,D.
  TITLE     Robust expression of Prominin-2 all along the adult male
            reproductive system and urinary bladder
  JOURNAL   Histochem Cell Biol 130 (4), 749-759 (2008)
   PUBMED   18536929
  REMARK    GeneRIF: Prominin-2 is widely and abundantly expressed along the
            epithelia of various segments of the adult male genitourinary
            tract.
REFERENCE   10 (bases 1 to 4731)
  AUTHORS   Fargeas,C.A., Florek,M., Huttner,W.B. and Corbeil,D.
  TITLE     Characterization of prominin-2, a new member of the prominin family
            of pentaspan membrane glycoproteins
  JOURNAL   J Biol Chem 278 (10), 8586-8596 (2003)
   PUBMED   12514187
  REMARK    GeneRIF: identification as well as molecular and cell biological
            characterization
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY060111.1, AY358377.1 and
            AC009238.4.
            
            On Nov 23, 2018 this sequence version replaced NM_001165978.2.
            
            Summary: This gene encodes a member of the prominin family of
            pentaspan membrane glycoproteins. The encoded protein localizes to
            basal epithelial cells and may be involved in the organization of
            plasma membrane microdomains. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Oct 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358377.1, AK091175.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317620.14/ ENSP00000318270.9
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                HY060111.1         3-50
            49-1659             AY358377.1         1-1611
            1660-1660           AC009238.4         158921-158921       c
            1661-2886           AY358377.1         1613-2838
            2887-4731           AC009238.4         148956-150800       c
FEATURES             Location/Qualifiers
     source          1..4731
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.1"
     gene            1..4731
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /note="prominin 2"
                     /db_xref="GeneID:150696"
                     /db_xref="HGNC:HGNC:20685"
                     /db_xref="MIM:617160"
     exon            1..381
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..2642
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; prominin-related protein; prominin-like protein
                     2"
                     /codon_start=1
                     /product="prominin-2 isoform 1 precursor"
                     /protein_id="NP_001159450.1"
                     /db_xref="CCDS:CCDS2012.1"
                     /db_xref="GeneID:150696"
                     /db_xref="HGNC:HGNC:20685"
                     /db_xref="MIM:617160"
                     /translation="MKHTLALLAPLLGLGLGLALSQLAAGATDCKFLGPAEHLTFTPA
                     ARARWLAPRVRAPGLLDSLYGTVRRFLSVVQLNPFPSELVKALLNELASVKVNEVVRY
                     EAGYVVCAVIAGLYLLLVPTAGLCFCCCRCHRRCGGRVKTEHKALACERAALMVFLLL
                     TTLLLLIGVVCAFVTNQRTHEQMGPSIEAMPETLLSLWGLVSDVPQELQAVAQQFSLP
                     QEQVSEELDGVGVSIGSAIHTQLRSSVYPLLAAVGSLGQVLQVSVHHLQTLNATVVEL
                     QAGQQDLEPAIREHRDRLLELLQEARCQGDCAGALSWARTLELGADFSQVPSVDHVLH
                     QLKGVPEANFSSMVQEENSTFNALPALAAMQTSSVVQELKKAVAQQPEGVRTLAEGFP
                     GLEAASRWAQALQEVEESSRPYLQEVQRYETYRWIVGCVLCSVVLFVVLCNLLGLNLG
                     IWGLSARDDPSHPEAKGEAGARFLMAGVGLSFLFAAPLILLVFATFLVGGNVQTLVCQ
                     SWENGELFEFADTPGNLPPSMNLSQLLGLRKNISIHQAYQQCKEGAALWTVLQLNDSY
                     DLEEHLDINQYTNKLRQELQSLKVDTQSLDLLSSAARRDLEALQSSGLQRIHYPDFLV
                     QIQRPVVKTSMEQLAQELQGLAQAQDNSVLGQRLQEEAQGLRNLHQEKVVPQQSLVAK
                     LNLSVRALESSAPNLQLETSDVLANVTYLKGELPAWAARILRNVSECFLAREMGYFSQ
                     YVAWVREEVTQRIATCQPLSGALDNSRVILCDMMADPWNAFWFCLAWCTFFLIPSIIF
                     AVKTSKYFRPIRKRLSSTSSEETQLFHIPRVTSLKL"
     exon            382..431
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..634
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            635..755
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..819
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            820..909
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1112
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1187
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1251
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1411
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1564
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1688
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1780
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1865
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2012
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2084
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2177
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2231
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2312
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2381
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2471
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2578
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2652
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..4731
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4704..4709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /note="hexamer: AATAAA"
     polyA_site      4731
                     /gene="PROM2"
                     /gene_synonym="PROML2"
                     /note="major polyA site"
ORIGIN      
        1 ggtagctcag gaacccaaac ctgtcgggca ggttttgaga gctgtggaga gagggacaga
       61 ggctggagaa ggatgtatgg cctgccctgg gcttgtctgt tccctcctga gcctgagccc
      121 cttaccttcc tgaccccatg aagcacacac tggctctgct ggctcccctg ctgggcctgg
      181 gcctggggct ggccctgagt cagctggctg caggggccac agactgcaag ttccttggcc
      241 cggcagagca cctgacattc accccagcag ccagggcccg gtggctggcc cctcgagttc
      301 gtgcgccagg actcctggac tccctctatg gcaccgtgcg ccgcttcctc tcggtggtgc
      361 agctcaatcc tttcccttca gagttggtaa aggccctact gaatgagctg gcctccgtga
      421 aggtgaatga ggtggtgcgg tacgaggcgg gctacgtggt atgcgctgtg atcgcgggcc
      481 tctacctgct gctggtgccc actgccgggc tttgcttctg ctgctgccgc tgccaccggc
      541 gctgcggggg acgagtgaag acagagcaca aggcgctggc ctgtgagcgc gcggccctca
      601 tggtcttcct gctgctgacc accctcttgc tgctgattgg tgtggtctgt gcctttgtca
      661 ccaaccagcg cacgcatgaa cagatgggcc ccagcatcga ggccatgcct gagaccctgc
      721 tcagcctctg gggcctggtc tctgatgtcc cccaagagct gcaggccgtg gcacagcaat
      781 tctccctgcc ccaggagcaa gtctcagagg agctggatgg tgttggtgtg agcattggga
      841 gcgcgatcca cactcagctc aggagctccg tgtacccctt gctggcggcc gtgggcagtt
      901 tgggccaggt cctgcaggtc tccgtgcacc acctgcaaac cttgaatgct acagtggtag
      961 agctgcaggc cgggcagcag gacctggagc cagccatccg ggaacaccgg gaccgcctcc
     1021 ttgagctgct gcaggaggcc aggtgccagg gagattgtgc aggggccctg agctgggccc
     1081 gcaccctgga gctgggtgct gacttcagcc aggtgccctc tgtggaccat gtcctgcacc
     1141 agctaaaagg tgtccccgag gccaacttct ccagcatggt ccaggaggag aacagcacct
     1201 tcaacgccct tccagccctg gctgccatgc agacatccag cgtggtgcaa gagctgaaga
     1261 aggcagtggc ccagcagccg gaaggggtga ggacactggc tgaagggttc ccgggcttgg
     1321 aggcagcttc ccgctgggcc caggcactgc aggaggtgga ggagagcagc cgcccctacc
     1381 tgcaggaggt gcagagatac gagacctaca ggtggatcgt gggctgcgtg ctgtgctccg
     1441 tggtcctatt cgtggtgctc tgcaacctgc tgggcctcaa tctgggcatc tggggcctgt
     1501 ctgccaggga cgaccccagc cacccagaag ccaagggcga ggctggagcc cgcttcctca
     1561 tggcaggtgt gggcctcagc ttcctctttg ctgcacccct catcctcctg gtgttcgcca
     1621 ccttcctggt gggtggcaac gtgcagacgc tggtgtgcca gagctgggag aacggcgagc
     1681 tctttgagtt tgcagacacc ccagggaacc tgcccccgtc catgaacctg tcgcaacttc
     1741 ttggcctgag gaagaacatc agcatccacc aagcctatca gcagtgcaag gaaggggcag
     1801 cgctctggac agtcctgcag ctcaacgact cctacgacct ggaggagcac ctggatatca
     1861 accagtatac caacaagcta cggcaggagt tgcagagcct gaaagtagac acacagagcc
     1921 tggacctgct gagctcagcc gcccgccggg acctggaggc cctgcagagc agtgggcttc
     1981 agcgcatcca ctaccccgac ttcctcgttc agatccagag gcccgtggtg aagaccagca
     2041 tggagcagct ggcccaggag ctgcaaggac tggcccaggc ccaagacaat tctgtgctgg
     2101 ggcagcggct gcaggaggag gcccaaggac tcagaaacct tcaccaggag aaggtcgtcc
     2161 cccagcagag ccttgtggca aagctcaacc tcagcgtcag ggccctggag tcctctgccc
     2221 cgaatctcca gctggagacc tcagatgtcc tagccaatgt cacctacctg aaaggagagc
     2281 tgcctgcctg ggcagccagg atcctgagga atgtgagtga gtgtttcctg gcccgggaga
     2341 tgggctactt ctcccagtac gtggcctggg tgagagagga ggtgactcag cgcattgcca
     2401 cctgccagcc cctctccgga gccctggaca acagccgtgt gatcctgtgt gacatgatgg
     2461 ctgacccctg gaatgccttc tggttctgcc tggcatggtg caccttcttc ctgatcccca
     2521 gcatcatctt tgccgtcaag acctccaaat acttccgtcc tatccggaaa cgcctcagct
     2581 ccaccagctc tgaggagact cagctcttcc acatcccccg ggttacctcc ctgaagctgt
     2641 agggccttgt ggggtgaggt gaccctgagg ctgcctgtcc tcccctttga tttagcctgg
     2701 gccacaggac ttcggtagct cttgccccag agcccaggct ggcatccagg cctggactgt
     2761 ccccagttcc ggcttacctg gccccacctt gcctgctcct ttccacccct ttctgctcac
     2821 gacccccatc attcacgctc agaatcacat gggacttctg tgcagctgca gagccagcaa
     2881 gtccctccag gtgtcacccc ttacccccat gctggtggca tcctcacagg aagagcctgt
     2941 tctccacctg ctggagcctg gaccctgggg tgggacagag gcctcgtcca accccactcc
     3001 ccttcccgtg tgtcttcccc ctgccaagcc tccccctgcc aagcctcccc ctgcccctct
     3061 ctgagcccct cgccccccac accgtcctca tctggcctcc cccctggccc ccacttccct
     3121 cttatgccct tcctggccct ttgcttcctc ccttagtccc ctcttcacca tatctccact
     3181 gctaccttgc tggccccaga gaccaccctg cccaaccaaa ccactcaggt aacgccacta
     3241 atcaggcagg ggccaccatg gcctaggtct gggctggctg caggccctgc ctcatggcct
     3301 ctgagccctc cactgcccca gggccttggg ccctctgcag atctcatcca ggatttattg
     3361 gtgtccagtg gggtgaggga ggcctgtctg aaggccgagc ctccctgcct gcacccaagt
     3421 tagaaatggg ggtaccagca cttagcttct ctctgagtgc tggctcccaa ggaagggacc
     3481 tgggacctgg gccacagtgg gggcttgccc ttacctcttc agaaggaagc atcttccaca
     3541 gcccccaccc aactttctta ggagtgatct ggtggccaga acaggatttt gcacggcccc
     3601 ttttatcctg cgcatgtggc ctagggtcat ccccagccca tccctgtgtc agccctgagt
     3661 gctggacact gcgttccaga aatgaggaag aggagagaga agagatggac agacctcaga
     3721 tccattaaag tgttctcact tccctgagac ttggttctgg gtccttaaaa ccaggtttcc
     3781 taggctggga ccctgtacat agttggtgtt taatgagtgt ttatggagag gagagttcta
     3841 aggtcacctc tggctgcagg catccaggga ttattccagc aatctgcagg tagggagtgg
     3901 gtcccagcct gggagcctgc tgtcaggagc aggcagacct ggactcacag cctggctgtg
     3961 atgcttgttc gctcagcttc tccatttatg agatggggag aatagtcaca gcctcctcaa
     4021 agggttgtga aaatcaaatg tgataatttg tggaaagccc ttagcagtgg cctggcacaa
     4081 aacaaatgct cagtggatgg aagctgccta ttattattgt cgttgttgtt gtttgccatg
     4141 actgctctgg gccgggggta gagctagcat ccgggcatgt acgagggaag agggaggcag
     4201 gcctctattc aaaggcagaa attcctttaa gattgtggtc tgctgggttt cagggagtgt
     4261 ctgtgttgtt tgtttttgtt tgtttgtttg ttttgagaca gggtctcgct ctgtcaccca
     4321 ggctggagtg tagtggtgca gtcttggctc actgcaacct ccacctcctg ggctcaagcg
     4381 attctcatgc ctcagcctcc cgagtagctg ggactacagg tgtgtgccac tatgcctggc
     4441 taatttttgt attttttgta gagacggggt tttgccatgt tgcccaggct ggaagtgtct
     4501 atgtttaact gcatcttata aaccagcaac aagttttcta ctgggaatta gaatggtgca
     4561 tacacaatgt attattatca ctgtcagatg agcatgcttg aatgtagcat gactgcctct
     4621 ttttgctttt cctagaggtt ttttttttgc ttgttactca tctgttgacc tacctggggg
     4681 aagtagcacc cttgcatttc aaaaataaaa ttgatggcat tacaaatgga a
//
