LOCUS       NM_006017               4021 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens prominin 1 (PROM1), transcript variant 1, mRNA.
ACCESSION   NM_006017 XM_011513890
VERSION     NM_006017.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4021)
  AUTHORS   Moya-Molina,M., Dorgau,B., Flood,E., Letteboer,S.J.F.,
            Lorentzen,E., Coxhead,J., Smith,G., Roepman,R., Nagaraja
            Grellscheid,S., Armstrong,L. and Lako,M.
  TITLE     Deciphering the impact of PROM1 alternative splicing on human
            photoreceptor development and maturation
  JOURNAL   Cell Death Dis 15 (10), 721 (2024)
   PUBMED   39353897
  REMARK    GeneRIF: Deciphering the impact of PROM1 alternative splicing on
            human photoreceptor development and maturation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4021)
  AUTHORS   Puertas-Neyra,K., Coco-Martin,R.M., Hernandez-Rodriguez,L.A.,
            Gobelli,D., Garcia-Ferrer,Y., Palma-Vecino,R., Telleria,J.J.,
            Simarro,M., de la Fuente,M.A. and Fernandez-Bueno,I.
  TITLE     Clinical exome analysis and targeted gene repair of the c.1354dupT
            variant in iPSC lines from patients with PROM1-related
            retinopathies exhibiting diverse phenotypes
  JOURNAL   Stem Cell Res Ther 15 (1), 192 (2024)
   PUBMED   38956727
  REMARK    GeneRIF: Clinical exome analysis and targeted gene repair of the
            c.1354dupT variant in iPSC lines from patients with PROM1-related
            retinopathies exhibiting diverse phenotypes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4021)
  AUTHORS   Simbulan-Rosenthal,C.M., Islam,N., Haribabu,Y., Alobaidi,R.,
            Shalamzari,A., Graham,G., Kuo,L.W., Sykora,P. and Rosenthal,D.S.
  TITLE     CD133 Stimulates Cell Proliferation via the Upregulation of
            Amphiregulin in Melanoma
  JOURNAL   Cells 13 (9), 777 (2024)
   PUBMED   38727313
  REMARK    GeneRIF: CD133 Stimulates Cell Proliferation via the Upregulation
            of Amphiregulin in Melanoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4021)
  AUTHORS   Zhang,Y., Xu,L., Guo,C., Li,X., Tian,Y., Liao,L. and Dong,J.
  TITLE     High CD133 expression in proximal tubular cells in diabetic kidney
            disease: good or bad?
  JOURNAL   J Transl Med 22 (1), 159 (2024)
   PUBMED   38365731
  REMARK    GeneRIF: High CD133 expression in proximal tubular cells in
            diabetic kidney disease: good or bad?
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4021)
  AUTHORS   Masadah,R., Ikram,D., Riadi,R., Tangdiung,Y., Nelwan,B.J.,
            Ghaznawie,M., Rauf,S. and Faruk,M.
  TITLE     CD133, CD47, and PD-L1 Expression in Ovarian High-grade Serous
            Carcinoma and Its Association with Metastatic Disease: A
            Cross-sectional Study
  JOURNAL   Asian Pac J Cancer Prev 25 (1), 249-255 (2024)
   PUBMED   38285791
  REMARK    GeneRIF: CD133, CD47, and PD-L1 Expression in Ovarian High-grade
            Serous Carcinoma and Its Association with Metastatic Disease: A
            Cross-sectional Study.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4021)
  AUTHORS   Kniazeva,M., Chiang,M.F., Morgan,B., Anduze,A.L., Zack,D.J., Han,M.
            and Zhang,K.
  TITLE     A new locus for autosomal dominant stargardt-like disease maps to
            chromosome 4
  JOURNAL   Am J Hum Genet 64 (5), 1394-1399 (1999)
   PUBMED   10205271
REFERENCE   7  (bases 1 to 4021)
  AUTHORS   Horn,P.A., Tesch,H., Staib,P., Kube,D., Diehl,V. and Voliotis,D.
  TITLE     Expression of AC133, a novel hematopoietic precursor antigen, on
            acute myeloid leukemia cells
  JOURNAL   Blood 93 (4), 1435-1437 (1999)
   PUBMED   10075457
REFERENCE   8  (bases 1 to 4021)
  AUTHORS   Miraglia,S., Godfrey,W., Yin,A.H., Atkins,K., Warnke,R.,
            Holden,J.T., Bray,R.A., Waller,E.K. and Buck,D.W.
  TITLE     A novel five-transmembrane hematopoietic stem cell antigen:
            isolation, characterization, and molecular cloning
  JOURNAL   Blood 90 (12), 5013-5021 (1997)
   PUBMED   9389721
REFERENCE   9  (bases 1 to 4021)
  AUTHORS   Yin,A.H., Miraglia,S., Zanjani,E.D., Almeida-Porada,G., Ogawa,M.,
            Leary,A.G., Olweus,J., Kearney,J. and Buck,D.W.
  TITLE     AC133, a novel marker for human hematopoietic stem and progenitor
            cells
  JOURNAL   Blood 90 (12), 5002-5012 (1997)
   PUBMED   9389720
REFERENCE   10 (bases 1 to 4021)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108063.3 and AC005598.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Jul 11, 2019 this sequence version replaced
            XM_011513890.1, NM_006017.2.
            
            Summary: This gene encodes a pentaspan transmembrane glycoprotein.
            The protein localizes to membrane protrusions and is often
            expressed on adult stem cells, where it is thought to function in
            maintaining stem cell properties by suppressing differentiation.
            Mutations in this gene have been shown to result in retinitis
            pigmentosa and Stargardt disease. Expression of this gene is also
            associated with several types of cancer. This gene is expressed
            from at least five alternative promoters that are expressed in a
            tissue-dependent manner. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Mar 2009].
            
            Transcript Variant: This variant (1) represents the longest isoform
            (1), also known as s2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2064684.1,
                                           SRR14038194.4346382.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000447510.7/ ENSP00000415481.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC108063.3         56698-56743         c
            47-478              AC108063.3         48407-48838         c
            479-534             AC108063.3         11666-11721         c
            535-561             AC108063.3         8455-8481           c
            562-767             AC108063.3         6024-6229           c
            768-888             AC005598.6         3969-4089
            889-952             AC005598.6         4923-4986
            953-1042            AC005598.6         5866-5955
            1043-1260           AC005598.6         10741-10958
            1261-1335           AC005598.6         13041-13115
            1336-1399           AC005598.6         15943-16006
            1400-1559           AC005598.6         20173-20332
            1560-1712           AC005598.6         22591-22743
            1713-1836           AC005598.6         28662-28785
            1837-1940           AC005598.6         30793-30896
            1941-2025           AC005598.6         35210-35294
            2026-2169           AC005598.6         36890-37033
            2170-2241           AC005598.6         37988-38059
            2242-2334           AC005598.6         39457-39549
            2335-2388           AC005598.6         41565-41618
            2389-2469           AC005598.6         43244-43324
            2470-2538           AC005598.6         43453-43521
            2539-2631           AC005598.6         44926-45018
            2632-2747           AC005598.6         48744-48859
            2748-2771           AC005598.6         49377-49400
            2772-2840           AC005598.6         49818-49886
            2841-2880           AC005598.6         58199-58238
            2881-4021           AC005598.6         59913-61053
FEATURES             Location/Qualifiers
     source          1..4021
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.32"
     gene            1..4021
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /note="prominin 1"
                     /db_xref="GeneID:8842"
                     /db_xref="HGNC:HGNC:9454"
                     /db_xref="MIM:604365"
     exon            1..46
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            47..478
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..2856
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; hProminin; hematopoietic stem cell antigen;
                     antigen AC133; prominin-like protein 1; AC133 antigen;
                     Retinitis pigmentosa 41, Cone-rod dystrophy 12"
                     /codon_start=1
                     /product="prominin-1 isoform 1 precursor"
                     /protein_id="NP_006008.1"
                     /db_xref="CCDS:CCDS47029.1"
                     /db_xref="GeneID:8842"
                     /db_xref="HGNC:HGNC:9454"
                     /db_xref="MIM:604365"
                     /translation="MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQ
                     DSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETVILGLKI
                     VYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAI
                     SLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQ
                     YNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNST
                     LKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQ
                     LPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSD
                     IDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVI
                     FYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLFCWILMIIVVLTFVFG
                     ANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKN
                     RGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAAC
                     GIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQ
                     QRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETK
                     KYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGI
                     GKATVFLLPALIFAVKLAKYYRRMDSEDVYDDVETIPMKNMENGNNGYHKDHVYGIHN
                     PVMTSPSQH"
     exon            479..534
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            535..561
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            562..767
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            768..888
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            889..952
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1042
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1260
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1335
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1399
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1559
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1712
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1836
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1940
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2025
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2169
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2241
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2334
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2388
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2469
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2538
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2631
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2747
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2771
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2840
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2880
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..4021
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3999..4004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /note="hexamer: AATAAA"
     polyA_site      4021
                     /gene="PROM1"
                     /gene_synonym="AC133; CD133; CORD12; MCDR2; MSTP061;
                     PROML1; RP41; STGD4"
                     /note="major polyA site"
ORIGIN      
        1 agatccccac gcggcacctg gccatgctct cagctctccc gccgcgggat ggtgccttga
       61 gtgaatgacc cccttggaga acattcttcc gcatccctcg cctcaagcca gcctcagaca
      121 gaaaactgaa gattcagcag atccagtgct tcctgctcct cttctgccca ggaacacgct
      181 tgccttcccc aaggcttcca gaagctctga ggcaggaggc accaagttct acctcatgtt
      241 tggaggatct tgctagctat ggccctcgta ctcggctccc tgttgctgct ggggctgtgc
      301 gggaactcct tttcaggagg gcagccttca tccacagatg ctcctaaggc ttggaattat
      361 gaattgcctg caacaaatta tgagacccaa gactcccata aagctggacc cattggcatt
      421 ctctttgaac tagtgcatat ctttctctat gtggtacagc cgcgtgattt cccagaagat
      481 actttgagaa aattcttaca gaaggcatat gaatccaaaa ttgattatga caagccagaa
      541 actgtaatct taggtctaaa gattgtctac tatgaagcag ggattattct atgctgtgtc
      601 ctggggctgc tgtttattat tctgatgcct ctggtggggt atttcttttg tatgtgtcgt
      661 tgctgtaaca aatgtggtgg agaaatgcac cagcgacaga aggaaaatgg gcccttcctg
      721 aggaaatgct ttgcaatctc cctgttggtg atttgtataa taataagcat tggcatcttc
      781 tatggttttg tggcaaatca ccaggtaaga acccggatca aaaggagtcg gaaactggca
      841 gatagcaatt tcaaggactt gcgaactctc ttgaatgaaa ctccagagca aatcaaatat
      901 atattggccc agtacaacac taccaaggac aaggcgttca cagatctgaa cagtatcaat
      961 tcagtgctag gaggcggaat tcttgaccga ctgagaccca acatcatccc tgttcttgat
     1021 gagattaagt ccatggcaac agcgatcaag gagaccaaag aggcgttgga gaacatgaac
     1081 agcaccttga agagcttgca ccaacaaagt acacagctta gcagcagtct gaccagcgtg
     1141 aaaactagcc tgcggtcatc tctcaatgac cctctgtgct tggtgcatcc atcaagtgaa
     1201 acctgcaaca gcatcagatt gtctctaagc cagctgaata gcaaccctga actgaggcag
     1261 cttccacccg tggatgcaga acttgacaac gttaataacg ttcttaggac agatttggat
     1321 ggcctggtcc aacagggcta tcaatccctt aatgatatac ctgacagagt acaacgccaa
     1381 accacgactg tcgtagcagg tatcaaaagg gtcttgaatt ccattggttc agatatcgac
     1441 aatgtaactc agcgtcttcc tattcaggat atactctcag cattctctgt ttatgttaat
     1501 aacactgaaa gttacatcca cagaaattta cctacattgg aagagtatga ttcatactgg
     1561 tggctgggtg gcctggtcat ctgctctctg ctgaccctca tcgtgatttt ttactacctg
     1621 ggcttactgt gtggcgtgtg cggctatgac aggcatgcca ccccgaccac ccgaggctgt
     1681 gtctccaaca ccggaggcgt cttcctcatg gttggagttg gattaagttt cctcttttgc
     1741 tggatattga tgatcattgt ggttcttacc tttgtctttg gtgcaaatgt ggaaaaactg
     1801 atctgtgaac cttacacgag caaggaatta ttccgggttt tggatacacc ctacttacta
     1861 aatgaagact gggaatacta tctctctggg aagctattta ataaatcaaa aatgaagctc
     1921 acttttgaac aagtttacag tgactgcaaa aaaaatagag gcacttacgg cactcttcac
     1981 ctgcagaaca gcttcaatat cagtgaacat ctcaacatta atgagcatac tggaagcata
     2041 agcagtgaat tggaaagtct gaaggtaaat cttaatatct ttctgttggg tgcagcagga
     2101 agaaaaaacc ttcaggattt tgctgcttgt ggaatagaca gaatgaatta tgacagctac
     2161 ttggctcaga ctggtaaatc ccccgcagga gtgaatcttt tatcatttgc atatgatcta
     2221 gaagcaaaag caaacagttt gcccccagga aatttgagga actccctgaa aagagatgca
     2281 caaactatta aaacaattca ccagcaacga gtccttccta tagaacaatc actgagcact
     2341 ctataccaaa gcgtcaagat acttcaacgc acagggaatg gattgttgga gagagtaact
     2401 aggattctag cttctctgga ttttgctcag aacttcatca caaacaatac ttcctctgtt
     2461 attattgagg aaactaagaa gtatgggaga acaataatag gatattttga acattatctg
     2521 cagtggatcg agttctctat cagtgagaaa gtggcatcgt gcaaacctgt ggccaccgct
     2581 ctagatactg ctgttgatgt ctttctgtgt agctacatta tcgacccctt gaatttgttt
     2641 tggtttggca taggaaaagc tactgtattt ttacttccgg ctctaatttt tgcggtaaaa
     2701 ctggctaagt actatcgtcg aatggattcg gaggacgtgt acgatgatgt tgaaactata
     2761 cccatgaaaa atatggaaaa tggtaataat ggttatcata aagatcatgt atatggtatt
     2821 cacaatcctg ttatgacaag cccatcacaa cattgatagc tgatgttgaa actgcttgag
     2881 catcaggata ctcaaagtgg aaaggatcac agatttttgg tagtttctgg gtctacaagg
     2941 actttccaaa tccaggagca acgccagtgg caacgtagtg actcaggcgg gcaccaaggc
     3001 aacggcacca ttggtctctg ggtagtgctt taagaatgaa cacaatcacg ttatagtcca
     3061 tggtccatca ctattcaagg atgactccct cccttcctgt ctatttttgt tttttacttt
     3121 tttacactga gtttctattt agacactaca acatatgggg tgtttgttcc cattggatgc
     3181 atttctatca aaactctatc aaatgtgatg gctagattct aacatattgc catgtgtgga
     3241 gtgtgctgaa cacacaccag tttacaggaa agatgcattt tgtgtacagt aaacggtgta
     3301 tatacctttt gttaccacag agttttttaa acaaatgagt attataggac tttcttctaa
     3361 atgagctaaa taagtcacca ttgacttctt ggtgctgttg aaaataatcc attttcacta
     3421 aaagtgtgtg aaacctacag catattcttc acgcagagat tttcatctat tatactttat
     3481 caaagattgg ccatgttcca cttggaaatg gcatgcaaaa gcaatcatag agaaacctgc
     3541 gtaactccat ctgacaaatt caaaagagag agagagatct tgagagagaa atgctgttcg
     3601 ttcaaaagtg gagttgtttt aacagatgcc aattacggtg tacagtttaa cagagttttc
     3661 tgttgcatta cgataaacat taattggagt gcagctaaca tgagtatcat cagactagta
     3721 tcaagtgttc taaaatgaaa tatgagaaga tcctgtcaca attcttagat ctggtgtcca
     3781 gcatggatga aacctttgag tttggtccct aaatttgcat gaaagcacaa ggtaaatatt
     3841 catttgcttc aggagtttca tgttggatct gtcattatca aaagtgatca gcaatgaaga
     3901 actggtcgga caaaatttaa cgttgatgta atgaaattcc agatgtaggc attcccccca
     3961 ggtcttttca tgtgcagatt gcagttctga ttcatttgaa taaaaaggaa cttggaaaac
     4021 a
//
