LOCUS       NM_144773               4446 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens prokineticin receptor 2 (PROKR2), mRNA.
ACCESSION   NM_144773 XM_005260663
VERSION     NM_144773.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4446)
  AUTHORS   Ichioka,K., Yoshikawa,T., Kimura,H. and Saito,R.
  TITLE     Additional mutation in PROKR2 and phenotypic differences in a
            Kallmann syndrome/normosmic congenital hypogonadotropic
            hypogonadism family carrying FGFR1 missense mutation
  JOURNAL   BMJ Case Rep 17 (1), e258042 (2024)
   PUBMED   38272512
  REMARK    GeneRIF: Additional mutation in PROKR2 and phenotypic differences
            in a Kallmann syndrome/normosmic congenital hypogonadotropic
            hypogonadism family carrying FGFR1 missense mutation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4446)
  AUTHORS   Kardelen,A.D., Najafli,A., Bas,F., Karaman,B., Toksoy,G.,
            Poyrazoglu,S., Avci,S., Altunoglu,U., Yavas Abali,Z., Ozturk,A.P.,
            Karakilic Ozturan,E., Basaran,S., Darendeliler,F. and Uyguner,Z.O.
  TITLE     PROKR2 Mutations in Patients with Short Stature Who Have Isolated
            Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiency
  JOURNAL   J Clin Res Pediatr Endocrinol 15 (4), 338-347 (2023)
   PUBMED   37338295
  REMARK    GeneRIF: PROKR2 Mutations in Patients with Short Stature Who Have
            Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone
            Deficiency.
REFERENCE   3  (bases 1 to 4446)
  AUTHORS   Zeng,L., Wang,C., Song,Z., Liu,Q., Chen,D. and Yu,X.
  TITLE     Prokineticin 2 as a potential biomarker for the diagnosis of
            Kawasaki disease
  JOURNAL   Clin Exp Med 23 (7), 3443-3451 (2023)
   PUBMED   37188888
  REMARK    GeneRIF: Prokineticin 2 as a potential biomarker for the diagnosis
            of Kawasaki disease.
REFERENCE   4  (bases 1 to 4446)
  AUTHORS   Wang,X., Chen,D., Zhao,Y., Men,M., Chen,Z., Jiang,F., Zheng,R.,
            Stamou,M.I., Plummer,L., Balasubramanian,R. and Li,J.D.
  TITLE     A functional spectrum of PROKR2 mutations identified in isolated
            hypogonadotropic hypogonadism
  JOURNAL   Hum Mol Genet 32 (10), 1722-1729 (2023)
   PUBMED   36694982
  REMARK    GeneRIF: A functional spectrum of PROKR2 mutations identified in
            isolated hypogonadotropic hypogonadism.
REFERENCE   5  (bases 1 to 4446)
  AUTHORS   Xie,Y.D., Zheng,R.Z., Han,H.J., Yuan,J.D. and Li,J.
  TITLE     [Analysis of PROKR2 gene mutation in patients with hypogonadotropic
            hypogonadism]
  JOURNAL   Zhonghua Nei Ke Za Zhi 61 (8), 933-936 (2022)
   PUBMED   35922219
  REMARK    GeneRIF: [Analysis of PROKR2 gene mutation in patients with
            hypogonadotropic hypogonadism].
REFERENCE   6  (bases 1 to 4446)
  AUTHORS   Battersby,S., Critchley,H.O., Morgan,K., Millar,R.P. and
            Jabbour,H.N.
  TITLE     Expression and regulation of the prokineticins (endocrine
            gland-derived vascular endothelial growth factor and Bv8) and their
            receptors in the human endometrium across the menstrual cycle
  JOURNAL   J Clin Endocrinol Metab 89 (5), 2463-2469 (2004)
   PUBMED   15126578
  REMARK    GeneRIF: Paracrine role for the PKs and their receptors in
            endometrial vascular function.
REFERENCE   7  (bases 1 to 4446)
  AUTHORS   Soga,T., Matsumoto,Si., Oda,T., Saito,T., Hiyama,H., Takasaki,J.,
            Kamohara,M., Ohishi,T., Matsushime,H. and Furuichi,K.
  TITLE     Molecular cloning and characterization of prokineticin receptors
  JOURNAL   Biochim Biophys Acta 1579 (2-3), 173-179 (2002)
   PUBMED   12427552
  REMARK    GeneRIF: molecular cloning, amino acid sequence and expression in
            several human tissues
REFERENCE   8  (bases 1 to 4446)
  AUTHORS   Lin,D.C., Bullock,C.M., Ehlert,F.J., Chen,J.L., Tian,H. and
            Zhou,Q.Y.
  TITLE     Identification and molecular characterization of two closely
            related G protein-coupled receptors activated by
            prokineticins/endocrine gland vascular endothelial growth factor
  JOURNAL   J Biol Chem 277 (22), 19276-19280 (2002)
   PUBMED   11886876
REFERENCE   9  (bases 1 to 4446)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 4446)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121757.7 and AL121755.23.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 1, 2020 this sequence version replaced NM_144773.3.
            
            Summary: Prokineticins are secreted proteins that can promote
            angiogenesis and induce strong gastrointestinal smooth muscle
            contraction. The protein encoded by this gene is an integral
            membrane protein and G protein-coupled receptor for prokineticins.
            The encoded protein is similar in sequence to GPR73, another G
            protein-coupled receptor for prokineticins. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1214623.1,
                                           SRR14038192.4031805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000678254.1/ ENSP00000504128.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-461               AL121757.7         166446-166906
            462-927             AL121755.23        141322-141787       c
            928-4446            AL121755.23        126628-130146       c
FEATURES             Location/Qualifiers
     source          1..4446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.3"
     gene            1..4446
                     /gene="PROKR2"
                     /gene_synonym="dJ680N4.3; GPR73b; GPR73L1; GPRg2; HH3;
                     KAL3; PKR2"
                     /note="prokineticin receptor 2"
                     /db_xref="GeneID:128674"
                     /db_xref="HGNC:HGNC:15836"
                     /db_xref="MIM:607123"
     exon            1..461
                     /gene="PROKR2"
                     /gene_synonym="dJ680N4.3; GPR73b; GPR73L1; GPRg2; HH3;
                     KAL3; PKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            462..927
                     /gene="PROKR2"
                     /gene_synonym="dJ680N4.3; GPR73b; GPR73L1; GPRg2; HH3;
                     KAL3; PKR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             470..1624
                     /gene="PROKR2"
                     /gene_synonym="dJ680N4.3; GPR73b; GPR73L1; GPRg2; HH3;
                     KAL3; PKR2"
                     /note="G protein-coupled receptor 73-like 1; PK-R2;
                     G-protein coupled receptor I5E"
                     /codon_start=1
                     /product="prokineticin receptor 2"
                     /protein_id="NP_658986.1"
                     /db_xref="CCDS:CCDS13089.1"
                     /db_xref="GeneID:128674"
                     /db_xref="HGNC:HGNC:15836"
                     /db_xref="MIM:607123"
                     /translation="MAAQNGNTSFTPNFNPPQDHASSLSFNFSYGDYDLPMDEDEDMT
                     KTRTFFAAKIVIGIALAGIMLVCGIGNFVFIAALTRYKKLRNLTNLLIANLAISDFLV
                     AIICCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHP
                     LKPRMNYQTASFLIALVWMVSILIAIPSAYFATETVLFIVKSQEKIFCGQIWPVDQQL
                     YYKSYFLFIFGVEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLV
                     LMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFV
                     TVKNNTMKYFKKMMLLHWRPSQRGSKSSADLDLRTNGVPTTEEVDCIRLK"
     exon            928..4446
                     /gene="PROKR2"
                     /gene_synonym="dJ680N4.3; GPR73b; GPR73L1; GPRg2; HH3;
                     KAL3; PKR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4425..4430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROKR2"
                     /gene_synonym="dJ680N4.3; GPR73b; GPR73L1; GPRg2; HH3;
                     KAL3; PKR2"
                     /note="hexamer: AATAAT"
     polyA_site      4446
                     /gene="PROKR2"
                     /gene_synonym="dJ680N4.3; GPR73b; GPR73L1; GPRg2; HH3;
                     KAL3; PKR2"
                     /note="major polyA site"
ORIGIN      
        1 agacgggatg cgaaggcgct gaaatccgtg cgagaggctg cccccgctgc cggggactcg
       61 cgtcagcgcg gccggagcta cggtgcccgc gccctggacg caccagcccg agagcacgcg
      121 gtggggtggg ggagctgggc atccaccctt ggcctggact aggaggcagg cggggacccc
      181 ggggcggagt ccagcgcggg gcggggcgca caggtccgag acgctggaaa gagctgtggg
      241 gccggagcgc caactccagc tggaacccag agaccctgac acgccggagg agcccgccgg
      301 ggcgaggaaa aaagagggac atcccccacg cagcggctct gcaagtgcaa gtccgggtcc
      361 tcgaggtgaa aaccgagcgg cccgcctgcg cccaaccaca ctgtgactct cgatccggct
      421 tccggagcag cagagcgcac agaaaggagg cgccgagaca gacatcacca tggcagccca
      481 gaatggaaac accagtttca cacccaactt taatccaccc caagaccatg cctcctccct
      541 ctcctttaac ttcagttatg gtgattatga cctccctatg gatgaggatg aggacatgac
      601 caagacccgg accttcttcg cagccaagat cgtcattggc attgcactgg caggcatcat
      661 gctggtctgc ggcatcggta actttgtctt tatcgctgcc ctcacccgct ataagaagtt
      721 gcgcaacctc accaatctgc tcattgccaa cctggccatc tccgacttcc tggtggccat
      781 catctgctgc cccttcgaga tggactacta cgtggtacgg cagctctcct gggagcatgg
      841 ccacgtgctc tgtgcctccg tcaactacct gcgcaccgtc tccctctacg tctccaccaa
      901 tgccttgctg gccattgcca ttgacagata tctcgccatc gttcacccct tgaaaccacg
      961 gatgaattat caaacggcct ccttcctgat cgccttggtc tggatggtgt ccattctcat
     1021 tgccatccca tcggcttact ttgcaacaga aacggtcctc tttattgtca agagccagga
     1081 gaagatcttc tgtggccaga tctggcctgt ggatcagcag ctctactaca agtcctactt
     1141 cctcttcatc tttggtgtcg agttcgtggg ccctgtggtc accatgaccc tgtgctatgc
     1201 caggatctcc cgggagctct ggttcaaggc agtccctggg ttccagacgg agcagattcg
     1261 caagcggctg cgctgccgca ggaagacggt cctggtgctc atgtgcattc tcacggccta
     1321 tgtgctgtgc tgggcaccct tctacggttt caccatcgtt cgtgacttct tccccactgt
     1381 gttcgtgaag gaaaagcact acctcactgc cttctacgtg gtcgagtgca tcgccatgag
     1441 caacagcatg atcaacaccg tgtgcttcgt gacggtcaag aacaacacca tgaagtactt
     1501 caagaagatg atgctgctgc actggcgtcc ctcccagcgg gggagcaagt ccagtgctga
     1561 ccttgacctc agaaccaacg gggtgcccac cacagaagag gtggactgta tcaggctgaa
     1621 gtgacccact ggtgtcacac aattgaaaac cccagtccag tactcagagc atcacccacc
     1681 atcaaccaag ttcataggct gcatgggaaa tgacatctgt gttcatgcct cccccgtgcc
     1741 ctcaagaagc tgaatgctgc aaagtcgtaa catacaatga gactagacat gaaccaaatc
     1801 agctgacatt tactgatatc cgctcgacac ctactgtgtc cacaatccca acaaggagat
     1861 tagacacaag gagcagcaac tgacatggac tgaacatgta ctgtgtgcaa accacaccaa
     1921 tgagattaga cagggacagc aggagctgac atttactctt cacctactgt aataaaaaac
     1981 acttgatttg attacaatca aaaacatata aaaaacataa caaagtagca gaagctattg
     2041 gagtttccaa gctatctcca gatatataga tagttcaccc tccatcttcc ctaattctgt
     2101 atcttaccag tgcaggaata tcaaaaggct ataggccagg catgatggct catgcctgta
     2161 atcccagcac ttggggaggc tgaggcacgt ggaacacttg aggtcaggag ttcaacccag
     2221 gctggccaac atggtgaaac cctgtctcta ctaaaaatac aaaattagct aggcgtggtg
     2281 gcgggcgcct gtaatcccag ttactcagga ggctgaagca ggagaatagc ttgaacctgg
     2341 gagttggagt ttgcagtgag ctgagattgc tccactgcac tccagcctga gtgacagagt
     2401 gagactctgt ctcaggaaaa aaacaaacaa acaaacaaca aaacaacaac aacaacaacc
     2461 aacggctata gaagaagact cttagacaca atggaaatgt aacgataagt ttgtcagtgc
     2521 gtggtttaca gcatcatggg aggtgtgtta cagccatcat actgaacttt cccacccacc
     2581 tcctactgcc tcccagggca ttctctagga ttttggcttc aagaaaaaaa aaattcttat
     2641 agtcagccca gccttatgtg gttatccaca atggtgtaat ttcaaaggaa agaacctaaa
     2701 aatcactttc ccactgatgc ttgaaagctt atcattttat ttgggtggag atgggtaatc
     2761 ctgaggtgtc aatttttgcc tcctcagtgc aaaggatttc agtggctctg gggtcagggg
     2821 gaaagaggac agagaaaaaa gtggaggttg ccactggcaa tgaacataat ctctgtgggc
     2881 attttgctaa ggactggacc actttctaga acactccctc ttttacaaaa ggaactctac
     2941 ctagaatcca aagacctggg ttcaggtcct aactctaaga ctcaagtcct aaattcatga
     3001 tgttttctct ctgtgtctca gttttgcttt aatgaaatgg cgatgatgaa aatatccgct
     3061 cttcatacct tgcaagactg ttgggagagc ccattgaggc catggtttgt gaatgtgctt
     3121 ttcaactgtg cacacgataa gaatggagaa gtgatattga acagtttatt tggagggagt
     3181 ttatttggaa accccatcca ctgtgattta ttagagaaat acccacactt tttcatccct
     3241 gttctttgga tgaaagactc ctgaagactt cacagtgtac cttgtctaca gtgggccaaa
     3301 aagggatccc tgttcttggt tataatctgg gaaatttaac ctcagattct cagtgacccc
     3361 aagactctca gcatccctgc ggtcttagaa gtgttgacag tcctccctgc atgttgcaaa
     3421 atagcaccct agtgctgcat aaatatcact tctgaatctg tttgtattat acatttgtgg
     3481 taactgtagg tacacgtctt catttcttct tgattcattt tgatgtggta gctatgcaaa
     3541 tggtacctgg tttgggactg acccaaccat atttgaccaa ttcctaattt tttatagaca
     3601 aggaattaat tgtttgcttg tttgattgtt tctattattt gttgatttgt ttctctgact
     3661 gaagtttcaa ccaatatttc tttctatcac cacccagcag actcaccttc agcccaatca
     3721 ttgtactctc agaaaatgca ggccggcatg gtggctcaca tctgtaatcc cagcacttcg
     3781 ggaggccaag atgggcagat cacctgaggt caggagttca agaccagcct ggccaacatg
     3841 gccaaaaacc ccatctctag aaaaatacag aaattagctg gcgtggtggc acatgcctgt
     3901 ggtcccagct cctcaggagg ctgaggcatg agaattgctt gaaccccaga ggcagaggtt
     3961 gcagtgaatt gagatcacac cactgcactc cagcctgggt gatagagcaa gattccatct
     4021 caaaaggaaa ataaaagaaa atgcaaacac actataatat tagcctaagc aaaactgtta
     4081 attctgattt acaaaaattc ttacttgctt ggctttgaaa tgcattgtgt aataatgcat
     4141 ttcaaagcca agcaagtaac aattttaggt tatgtacatt tctataaata taataattgt
     4201 atttttattt attattctat cctggctctt agccgaatca ggagattctt taggaatgga
     4261 ccatgtacca gtcaagtctg tcagcaggat tcatcaccct gttccttttt gtcctagaat
     4321 ataccaactt cctttcattg aaatttaact gaaaaaactt ttgtaaatat cagtgtgtat
     4381 ttgtgatttt ccagtgatta aagtgtaatg ttgttatcca attaaataat taacatgtgg
     4441 aattta
//
