LOCUS       NM_138964               4287 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens prokineticin receptor 1 (PROKR1), mRNA.
ACCESSION   NM_138964
VERSION     NM_138964.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4287)
  AUTHORS   Casella,I. and Ambrosio,C.
  TITLE     Prokineticin receptors interact unselectively with several G
            protein subtypes but bind selectively to beta-arrestin 2
  JOURNAL   Cell Signal 83, 110000 (2021)
   PUBMED   33811988
  REMARK    GeneRIF: Prokineticin receptors interact unselectively with several
            G protein subtypes but bind selectively to beta-arrestin 2.
REFERENCE   2  (bases 1 to 4287)
  AUTHORS   Mok,J., Park,T.S., Kim,S., Kim,D., Choi,C.S. and Park,J.
  TITLE     Prokineticin receptor 1 ameliorates insulin resistance in skeletal
            muscle
  JOURNAL   FASEB J 35 (2), e21179 (2021)
   PUBMED   33184929
  REMARK    GeneRIF: Prokineticin receptor 1 ameliorates insulin resistance in
            skeletal muscle.
REFERENCE   3  (bases 1 to 4287)
  AUTHORS   Karaer,A., Tuncay,G., Uysal,O., Semerci Sevimli,T., Sahin,N.,
            Karabulut,U. and Sariboyaci,A.E.
  TITLE     The role of prokineticins in recurrent implantation failure
  JOURNAL   J Gynecol Obstet Hum Reprod 49 (9), 101835 (2020)
   PUBMED   32585394
  REMARK    GeneRIF: The role of prokineticins in recurrent implantation
            failure.
REFERENCE   4  (bases 1 to 4287)
  AUTHORS   Wu,Y. and Wu,X.
  TITLE     [Expression of PROK 1 and its receptor PROKR 1 in endometriosis and
            its clinical significance]
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 44 (6), 621-627 (2019)
   PUBMED   31304922
  REMARK    GeneRIF: PROK-1 and its receptors are involved in the pathogenesis
            and development of endometriosis
REFERENCE   5  (bases 1 to 4287)
  AUTHORS   Cao,Y.L., Zhang,Z.F., Wang,J., Miao,M.H., Xu,J.H., Shen,Y.P.,
            Chen,A.M., Du,J. and Yuan,W.
  TITLE     Association between polymorphisms of prokineticin receptor (PKR1
            rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss
  JOURNAL   J Zhejiang Univ Sci B 17 (3), 218-224 (2016)
   PUBMED   26984842
  REMARK    GeneRIF: a significant association between PKR2 rs6053283
            polymorphism and Recurrent pregnancy loss (RPL)(P=0.003), whereas
            no association was observed between PKR1 rs4627609 polymorphism and
            RPL (P=0.929) in the Chinese Han population.
REFERENCE   6  (bases 1 to 4287)
  AUTHORS   Battersby,S., Critchley,H.O., Morgan,K., Millar,R.P. and
            Jabbour,H.N.
  TITLE     Expression and regulation of the prokineticins (endocrine
            gland-derived vascular endothelial growth factor and Bv8) and their
            receptors in the human endometrium across the menstrual cycle
  JOURNAL   J Clin Endocrinol Metab 89 (5), 2463-2469 (2004)
   PUBMED   15126578
  REMARK    GeneRIF: Paracrine role for the PKs and their receptors in
            endometrial vascular function.
REFERENCE   7  (bases 1 to 4287)
  AUTHORS   Soga,T., Matsumoto,Si., Oda,T., Saito,T., Hiyama,H., Takasaki,J.,
            Kamohara,M., Ohishi,T., Matsushime,H. and Furuichi,K.
  TITLE     Molecular cloning and characterization of prokineticin receptors
  JOURNAL   Biochim Biophys Acta 1579 (2-3), 173-179 (2002)
   PUBMED   12427552
  REMARK    GeneRIF: molecular cloning, amino acid sequence and expression in
            several human tissues
REFERENCE   8  (bases 1 to 4287)
  AUTHORS   Lin,D.C., Bullock,C.M., Ehlert,F.J., Chen,J.L., Tian,H. and
            Zhou,Q.Y.
  TITLE     Identification and molecular characterization of two closely
            related G protein-coupled receptors activated by
            prokineticins/endocrine gland vascular endothelial growth factor
  JOURNAL   J Biol Chem 277 (22), 19276-19280 (2002)
   PUBMED   11886876
REFERENCE   9  (bases 1 to 4287)
  AUTHORS   Masuda,Y., Takatsu,Y., Terao,Y., Kumano,S., Ishibashi,Y.,
            Suenaga,M., Abe,M., Fukusumi,S., Watanabe,T., Shintani,Y.,
            Yamada,T., Hinuma,S., Inatomi,N., Ohtaki,T., Onda,H. and Fujino,M.
  TITLE     Isolation and identification of EG-VEGF/prokineticins as cognate
            ligands for two orphan G-protein-coupled receptors
  JOURNAL   Biochem Biophys Res Commun 293 (1), 396-402 (2002)
   PUBMED   12054613
REFERENCE   10 (bases 1 to 4287)
  AUTHORS   Parker,R., Liu,M., Eyre,H.J., Copeland,N.G., Gilbert,D.J.,
            Crawford,J., Sutherland,G.R., Jenkins,N.A. and Herzog,H.
  TITLE     Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic
            organisation and assignment to human chromosome 11q21.1 and 2p14
            and mouse chromosome 9 and 6
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 369-375 (2000)
   PUBMED   10760605
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105054.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 21, 2019 this sequence version replaced NM_138964.3.
            
            Summary: This gene encodes a member of the G-protein-coupled
            receptor family. The encoded protein binds to prokineticins (1 and
            2), leading to the activation of MAPK and STAT signaling pathways.
            Prokineticins are protein ligands involved in angiogenesis and
            inflammation. The encoded protein is expressed in peripheral
            tissues such as those comprising the circulatory system, lungs,
            reproductive system, endocrine system and the gastrointestinal
            system. The protein may be involved in signaling in human fetal
            ovary during initiation of primordial follicle formation. Sequence
            variants in this gene may be associated with recurrent miscarriage.
            [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1750895.1,
                                           SRR14038192.1142140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303786.5/ ENSP00000303775.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               AC105054.6         109759-110028
            271-915             AC105054.6         111842-112486
            916-4287            AC105054.6         121060-124431
FEATURES             Location/Qualifiers
     source          1..4287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..4287
                     /gene="PROKR1"
                     /gene_synonym="GPR73; GPR73a; PK-R1; PKR1; ZAQ"
                     /note="prokineticin receptor 1"
                     /db_xref="GeneID:10887"
                     /db_xref="HGNC:HGNC:4524"
                     /db_xref="MIM:607122"
     exon            1..270
                     /gene="PROKR1"
                     /gene_synonym="GPR73; GPR73a; PK-R1; PKR1; ZAQ"
                     /inference="alignment:Splign:2.1.0"
     exon            271..915
                     /gene="PROKR1"
                     /gene_synonym="GPR73; GPR73a; PK-R1; PKR1; ZAQ"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..1612
                     /gene="PROKR1"
                     /gene_synonym="GPR73; GPR73a; PK-R1; PKR1; ZAQ"
                     /note="G protein-coupled receptor 73; G protein-coupled
                     receptor ZAQ"
                     /codon_start=1
                     /product="prokineticin receptor 1"
                     /protein_id="NP_620414.1"
                     /db_xref="CCDS:CCDS1889.1"
                     /db_xref="GeneID:10887"
                     /db_xref="HGNC:HGNC:4524"
                     /db_xref="MIM:607122"
                     /translation="METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDM
                     PLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIA
                     NLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAI
                     DRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCG
                     QIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRL
                     RCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSN
                     SMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRL
                     K"
     exon            916..4287
                     /gene="PROKR1"
                     /gene_synonym="GPR73; GPR73a; PK-R1; PKR1; ZAQ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4261..4266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROKR1"
                     /gene_synonym="GPR73; GPR73a; PK-R1; PKR1; ZAQ"
                     /note="hexamer: AATGAA"
     polyA_site      4287
                     /gene="PROKR1"
                     /gene_synonym="GPR73; GPR73a; PK-R1; PKR1; ZAQ"
                     /note="major polyA site"
ORIGIN      
        1 agctggcgac acgcctcgcc aagagcccgc acctcggcgc ctcacggcca ccggaggcgg
       61 ggacagggag tccggcgcgg gccgggtcgg gggatctgca gcggcggcgc gaaggtaact
      121 cccccgccag agccgggaaa gagccccgag cagaggagga agggagcggg gacctgccct
      181 tcgcctgccg gcttctggaa gaagcgtctc ctgatccggc cccggaataa gaaacccgga
      241 ccttgcctgc cgggctccgc gatgccgcag gtttagaatg gagctcagat accatacccc
      301 aaagatgctg gcagagacat tctgactcat taagggagag ctggctgata gcagagaggg
      361 gtgacatcag ccttgcagac attgccctgg ggaattctga gcagtgttgc tcacagcacc
      421 acctggccag atggagacca ccatggggtt catggatgac aatgccacca acacttccac
      481 cagcttcctt tctgtgctca accctcatgg agcccatgcc acttccttcc cattcaactt
      541 cagctacagc gactatgata tgcctttgga tgaagatgag gatgtgacca attccaggac
      601 gttctttgct gccaagattg tcattgggat ggccctggtg ggcatcatgc tggtctgcgg
      661 cattggaaac ttcatcttta tcgctgccct ggtccgctac aagaaactgc gcaacctcac
      721 caacctgctc atcgccaacc tggccatctc tgacttcctg gtggccattg tctgctgccc
      781 ctttgagatg gactactatg tggtgcgcca gctctcctgg gagcacggcc acgtcctgtg
      841 cacctctgtc aactacctgc gcactgtctc tctctatgtc tccaccaatg ccctgctggc
      901 catcgccatt gacaggtatc tggctattgt ccatccgctg agaccacgga tgaagtgcca
      961 aacagccact ggcctgattg ccttggtgtg gacggtgtcc atcctgatcg ccatcccttc
     1021 cgcctacttc accaccgaga cggtcctcgt cattgtcaag agccaggaaa agatcttctg
     1081 cggccagatc tggcctgtgg accagcagct ctactacaag tcctacttcc tctttatctt
     1141 tggcatagaa ttcgtgggcc ccgtggtcac catgaccctg tgctatgcca ggatctcccg
     1201 ggagctctgg ttcaaggcgg tccctggatt ccagacagag cagatccgca agaggctgcg
     1261 ctgccgcagg aagacggtcc tggtgctcat gtgcatcctc accgcctacg tgctatgctg
     1321 ggcgcccttc tacggcttca ccatcgtgcg cgacttcttc cccaccgtgt ttgtgaagga
     1381 gaagcactac ctcactgcct tctacatcgt cgagtgcatc gccatgagca acagcatgat
     1441 caacactctg tgcttcgtga ccgtcaagaa cgacaccgtc aagtacttca aaaagatcat
     1501 gttgctccac tggaaggctt cttacaatgg cggtaagtcc agtgcagacc tggacctcaa
     1561 gacaattggg atgcctgcca ccgaagaggt ggactgcatc agactaaaat aaccccctgg
     1621 actttgcaaa gtttaaacac aaagcagggt cctgtggaca ctgactagtg tgcttggatg
     1681 cacatcaacc tggaactttt tgtttgctgc agagggtaaa gtaaatggac cactctgtga
     1741 gcaatgtttt caaggagctc agagtttcta aaatgcatgt gaccagacac tatcaacagt
     1801 ggcatttgct gaatgtctaa tttacacgcc agtaggtact ggtaaaacct atatatgttg
     1861 atgacattta gttggcaaaa tgaaattgga attaaaccaa ggaaaatgtg gtggtgtaga
     1921 tagaaataag ggagtttcca caaaagaact ggagtaggta tctaggattg cagtacatgt
     1981 gttcgtagtg tgagagtatc tctgggacta ttcttgcact ggacttcatg cctaacattt
     2041 gcaaggctgg agcaagaata cgaaagggac tctaggctcc ttctgtagcc cttatcctct
     2101 catctttcat ggcgaggggc cttgcatgca tgtgcacgga catcccagta ttcatggcca
     2161 agttctgtgc aaactcttcc tcccacactg ctctatggcc accctcaggc ccagggctct
     2221 gcacataggt ggtaaggctc ttcatcagaa ggactggctt ggcgaagaag acacatagac
     2281 cctggatgcc atttggacag ggaattatgg ggttctgggt acctggagta agtccagagg
     2341 gggaagcctg gattcagggt aagcatgtcc cctggctcca tggacttttt gccttcagtg
     2401 agaagggaga tgcaagtgga ggagactcag aacgggaagg caaaactgga agcatgcagg
     2461 gctcaatgca gctcaggtgt ggcaggggct caggctctcc aggtatacag atgataccgt
     2521 tcccacctgt tatttcattt ggaccaatta ggcttcccct taagtccttc ccttccctct
     2581 cacgcctcca tgcttgtgaa gcatagaatc tttgaaaatg gacacaatac ctcctggatg
     2641 tggccttcat tcatttttct gttttcacca gctctcaaat gtgagtgatg aagagttccc
     2701 tcctaaccag acagcatggt aaggtatcct catcgatatg atttgagggc aagatatcct
     2761 tattactggc acctgaatcc catcctagtc tttgttcctt tggattaaga cttgctttgc
     2821 ttctaaaata ggggtcctct taggagggat aagccacacg tttctagtcc tcagcgtgaa
     2881 tgaagtcatg tgatccagtg gcaggggatg caggtcagat gcatcttcca gaagtctggg
     2941 cacccaggaa agaaggggac acacagatag gtagtgtcag accaaacaat gagcttcagt
     3001 gaccccatag gttgttgaag actcatccca ctttctaacc tgcctccttt gtttgatgtt
     3061 ttgagttttg gagtttggta ttttggagtt ggaagatctg agagccagac ttgactctgt
     3121 caactgtgta gccctgggca aagcctctcc gaggggacaa aggtaacacc tttgtccttc
     3181 tgtggtacct tctgtgatac ctgtgatacc ttctgactga gtggctatga gaagccaatg
     3241 agacaatacg tgggagatgc cttcaaccac acaagttatc aaaaggatgg gctaggaact
     3301 acgtgtagtg cgcctggaca agaaaaacct cttactttgg cttgtgtatc cagaaacctg
     3361 gccgtctcca cttttatttt tctttgtgta aattattcct ttgtgcttca taacagtgct
     3421 gtatgcatta tgtgcctaat gacatggttg tgcaaacaag gtcatgagat ttgctggtag
     3481 acgcataaag gaaagggtgg ctgagtctcc ggttagaaga tgagtttagg ggtttggata
     3541 ctccagaatc ggagtatctt tgtgatacta gaagtgctga tcatcttccc atgactgttc
     3601 ccagccagca tgaatctggg caatggaata gttgtttctc agtctgtttt tattctcacg
     3661 agtgtgtagg ctacagcgtg gacttgtctt tttcttattt aactctagag cagcgcactt
     3721 acaaggttat ttaagtggca cctgtatgac atgttcccct ccaaatatag tcaactcctt
     3781 attttgggca gcaaagttta ttttgtatag ttactttatt tccctgaaag acacattaca
     3841 aaaacctatt tatttcttcc catttatcac ccagtagact taccctacaa tttaatcaga
     3901 atgctcttgg agagtaaaat taattaaaat attagcctaa atcaaaaatg cattggaggg
     3961 ccatttttat tttttatata agatcatata ttgcattcta aaatctggaa ggttagcttt
     4021 tgtattaaaa agttaaaaat gatacaattt attgtcatta tgttcaccgc tttcattaag
     4081 aatgctaaac aagagttgat tgtattaaac aggagctttt tatatgcggc aaccaaagcc
     4141 cactctgctt ttcagcctaa aatgtatcaa tttttcactc aactatctgt gttacttcca
     4201 aatattagtg tctgcttgta attttgtagt gaatgagggt gttgtgttgt tatcaagtga
     4261 aatgaaaata cttggatata cagaaaa
//
