LOCUS       NM_001126128            1555 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens prokineticin 2 (PROK2), transcript variant 1, mRNA.
ACCESSION   NM_001126128
VERSION     NM_001126128.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1555)
  AUTHORS   Li,X., Chang,E., Cui,J., Zhao,H., Hu,C., O'Dea,K.P., Tirlapur,N.,
            Balboni,G., Zhang,J., Ying,L. and Ma,D.
  TITLE     Bv8 mediates myeloid cell migration and enhances malignancy of
            colorectal cancer
  JOURNAL   Front Immunol 14, 1158045 (2023)
   PUBMED   37090721
  REMARK    GeneRIF: Bv8 mediates myeloid cell migration and enhances
            malignancy of colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1555)
  AUTHORS   Schirinzi,T., Lattanzi,R., Maftei,D., Grillo,P., Zenuni,H.,
            Boffa,L., Albanese,M., Simonetta,C., Bovenzi,R., Maurizi,R.,
            Loccisano,L., Vincenzi,M., Greco,A., Di Girolamo,S., Mercuri,N.B.,
            Passali,F.M. and Severini,C.
  TITLE     Substance P and Prokineticin-2 are overexpressed in olfactory
            neurons and play differential roles in persons with persistent
            post-COVID-19 olfactory dysfunction
  JOURNAL   Brain Behav Immun 108, 302-308 (2023)
   PUBMED   36549578
  REMARK    GeneRIF: Substance P and Prokineticin-2 are overexpressed in
            olfactory neurons and play differential roles in persons with
            persistent post-COVID-19 olfactory dysfunction.
REFERENCE   3  (bases 1 to 1555)
  AUTHORS   Yin,T.C., Mittal,A., Buscaglia,P., Li,W. and Sebag,J.A.
  TITLE     Activation of amygdala prokineticin receptor 2 neurons drives the
            anorexigenic activity of the neuropeptide PK2
  JOURNAL   J Biol Chem 299 (1), 102814 (2023)
   PUBMED   36539034
  REMARK    GeneRIF: Activation of amygdala prokineticin receptor 2 neurons
            drives the anorexigenic activity of the neuropeptide PK2.
REFERENCE   4  (bases 1 to 1555)
  AUTHORS   Schirinzi,T., Maftei,D., Passali,F.M., Grillo,P., Zenuni,H.,
            Mascioli,D., Maurizi,R., Loccisano,L., Vincenzi,M., Rinaldi,A.M.,
            Ralli,M., Di Girolamo,S., Stefani,A., Lattanzi,R., Severini,C. and
            Mercuri,N.B.
  TITLE     Olfactory Neuron Prokineticin-2 as a Potential Target in
            Parkinson's Disease
  JOURNAL   Ann Neurol 93 (1), 196-204 (2023)
   PUBMED   36218142
  REMARK    GeneRIF: Olfactory Neuron Prokineticin-2 as a Potential Target in
            Parkinson's Disease.
REFERENCE   5  (bases 1 to 1555)
  AUTHORS   Xiang,Q., Wang,Z., Mu,G., Xie,Q., Liu,Z., Zhou,S., Zhang,H.,
            Wang,Z., Hu,K., Song,H., Yuan,D., Xia,Q., Huang,Y. and Cui,Y.
  TITLE     PROK2, HRNR, and FIG4 as potential genetic biomarkers of high
            bleeding propensity in East Asian patients with acute coronary
            syndrome using ticagrelor
  JOURNAL   Pharmacotherapy 42 (12), 872-879 (2022)
   PUBMED   36263704
  REMARK    GeneRIF: PROK2, HRNR, and FIG4 as potential genetic biomarkers of
            high bleeding propensity in East Asian patients with acute coronary
            syndrome using ticagrelor.
REFERENCE   6  (bases 1 to 1555)
  AUTHORS   Cheng,M.Y., Bullock,C.M., Li,C., Lee,A.G., Bermak,J.C.,
            Belluzzi,J., Weaver,D.R., Leslie,F.M. and Zhou,Q.Y.
  TITLE     Prokineticin 2 transmits the behavioural circadian rhythm of the
            suprachiasmatic nucleus
  JOURNAL   Nature 417 (6887), 405-410 (2002)
   PUBMED   12024206
  REMARK    GeneRIF: Prokineticin 2 transmits the behavioural circadian rhythm
            of the suprachiasmatic nucleus.
REFERENCE   7  (bases 1 to 1555)
  AUTHORS   Li,M., Bullock,C.M., Knauer,D.J., Ehlert,F.J. and Zhou,Q.Y.
  TITLE     Identification of two prokineticin cDNAs: recombinant proteins
            potently contract gastrointestinal smooth muscle
  JOURNAL   Mol Pharmacol 59 (4), 692-698 (2001)
   PUBMED   11259612
REFERENCE   8  (bases 1 to 1555)
  AUTHORS   Jilek,A., Engel,E., Beier,D. and Lepperdinger,G.
  TITLE     Murine Bv8 gene maps near a synteny breakpoint of mouse chromosome
            6 and human 3p21
  JOURNAL   Gene 256 (1-2), 189-195 (2000)
   PUBMED   11054548
REFERENCE   9  (bases 1 to 1555)
  AUTHORS   Wechselberger,C., Puglisi,R., Engel,E., Lepperdinger,G., Boitani,C.
            and Kreil,G.
  TITLE     The mammalian homologues of frog Bv8 are mainly expressed in
            spermatocytes
  JOURNAL   FEBS Lett 462 (1-2), 177-181 (1999)
   PUBMED   10580115
REFERENCE   10 (bases 1 to 1555)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096970.2 and BC098162.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001126128.1.
            
            Summary: This gene encodes a protein expressed in the
            suprachiasmatic nucleus (SCN) circadian clock that may function as
            the output component of the circadian clock. The secreted form of
            the encoded protein may also serve as a chemoattractant for
            neuronal precursor cells in the olfactory bulb. Proteins from other
            vertebrates which are similar to this gene product were isolated
            based on homology to snake venom and secretions from frog skin, and
            have been shown to have diverse functions. Mutations in this gene
            are associated with Kallmann syndrome 4. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.169665.1, AF182069.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295619.4/ ENSP00000295619.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC096970.2         128147-128233
            88-536              BC098162.1         1-449
            537-1555            AC096970.2         140622-141640
FEATURES             Location/Qualifiers
     source          1..1555
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p13"
     gene            1..1555
                     /gene="PROK2"
                     /gene_synonym="BV8; HH4; KAL4; MIT1; PK2"
                     /note="prokineticin 2"
                     /db_xref="GeneID:60675"
                     /db_xref="HGNC:HGNC:18455"
                     /db_xref="MIM:607002"
     exon            1..192
                     /gene="PROK2"
                     /gene_synonym="BV8; HH4; KAL4; MIT1; PK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..486
                     /gene="PROK2"
                     /gene_synonym="BV8; HH4; KAL4; MIT1; PK2"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; protein Bv8 homolog"
                     /codon_start=1
                     /product="prokineticin-2 isoform a precursor"
                     /protein_id="NP_001119600.1"
                     /db_xref="CCDS:CCDS46868.1"
                     /db_xref="GeneID:60675"
                     /db_xref="HGNC:HGNC:18455"
                     /db_xref="MIM:607002"
                     /translation="MRSLCCAPLLLLLLLPPLLLTPRAGDAAVITGACDKDSQCGGGM
                     CCAVSIWVKSIRICTPMGKLGDSCHPLTRKNNFGNGRQERRKRKRSKRKKEVPFFGRR
                     MHHTCPCLPGLACLRTSFNRFICLAQK"
     exon            193..318
                     /gene="PROK2"
                     /gene_synonym="BV8; HH4; KAL4; MIT1; PK2"
                     /inference="alignment:Splign:2.1.0"
     exon            319..381
                     /gene="PROK2"
                     /gene_synonym="BV8; HH4; KAL4; MIT1; PK2"
                     /inference="alignment:Splign:2.1.0"
     exon            382..1555
                     /gene="PROK2"
                     /gene_synonym="BV8; HH4; KAL4; MIT1; PK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1535..1540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROK2"
                     /gene_synonym="BV8; HH4; KAL4; MIT1; PK2"
                     /note="hexamer: ATTATA"
     polyA_site      1555
                     /gene="PROK2"
                     /gene_synonym="BV8; HH4; KAL4; MIT1; PK2"
                     /note="major polyA site"
ORIGIN      
        1 gccgcgcccg tccgcccgcc gctccgcgct ccacccagcg cacccgggcc ccgcgccccc
       61 aactgcctcc ggcggccgcc cagtcccgag ggcgccatga ggagcctgtg ctgcgcccca
      121 ctcctgctcc tcttgctgct gccgccgctg ctgctcacgc cccgcgctgg ggacgccgcc
      181 gtgatcaccg gggcttgtga caaggactcc caatgtggtg gaggcatgtg ctgtgctgtc
      241 agtatctggg tcaagagcat aaggatttgc acacctatgg gcaaactggg agacagctgc
      301 catccactga ctcgtaaaaa caattttgga aatggaaggc aggaaagaag aaagaggaag
      361 agaagcaaaa ggaaaaagga ggttccattt tttgggcgga ggatgcatca cacttgccca
      421 tgtctgccag gcttggcctg tttacggact tcatttaacc gatttatttg tttagcccaa
      481 aagtaatcgc tctggagtag aaaccaaatg tgaatagcca catcttacct gtaaagtctt
      541 acttgtgatt gtgccaaaca aaaaatgtgc cagaaagaaa tgctcttgct tcctcaactt
      601 tccaagtaac atttttatct ttgatttgta aatgattttt tttttttttt atcgaaagag
      661 aattttactt ttggatagaa atatgaagtg taaggcatta tggaactggt tcttatttcc
      721 ctgtttgtgt tttggtttga tttggctttt ttcttaaatg tcaaaaacgt acccattttc
      781 acaaaaatga ggaaaataag aatttgatat tttgttagaa aaactttttt ttttttttct
      841 caccacccca agccccattt gtgccctgcc acacaaatac acctacagct tttggtccct
      901 tgcctcttcc acctcaaaga atttcaaggc tcttacctta ctttattttt gtccatttct
      961 cttccctcct cttgcatttt aaagtggagg gtttgtctct ttgagtttga tggcagaatc
     1021 actgatggga atccagcttt ttgctggcat ttaaatagtg aaaagagtgt atatgtgaac
     1081 ttgacactcc aaactcctgt catggcacgg aagctaggag tgctgctgga cccttcctaa
     1141 acctgtcact caagaggact tcagctctgc tgttgggctg gtgtgtggac agaaggaatg
     1201 gaaagccaaa ttaatttagt ccagatttct aggtttgggt ttttctaaaa ataaaagatt
     1261 acatttactt cttttacttt ttataaagtt ttttttcctt agtctcctac ttagagatat
     1321 tctagaaaat gtcacttgaa gaggaagtat ttattttaat ctggcacaac actaattacc
     1381 atttttaaag cagtattaag ttgtaattta aaccttgttt gtaactgaaa ggtcgattgt
     1441 aatggattgc cgtttgtacc tgtatcagta ttgctgtgta aaaattctgt atcagaataa
     1501 taacagtact gtatatcatt tgatttattt taatattata tccttatttt tgtca
//
