LOCUS       NM_032414               1393 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens prokineticin 1 (PROK1), mRNA.
ACCESSION   NM_032414
VERSION     NM_032414.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1393)
  AUTHORS   Goto,S., Ozaki,Y., Ozawa,F., Yoshihara,H., Ujvari,D., Kitaori,T.
            and Sugiura-Ogasawara,M.
  TITLE     Impaired decidualization and relative increase of PROK1 expression
            in the decidua of patients with unexplained recurrent pregnancy
            loss showing insulin resistance
  JOURNAL   J Reprod Immunol 160, 104155 (2023)
   PUBMED   37801889
  REMARK    GeneRIF: Impaired decidualization and relative increase of PROK1
            expression in the decidua of patients with unexplained recurrent
            pregnancy loss showing insulin resistance.
REFERENCE   2  (bases 1 to 1393)
  AUTHORS   Raia-Barjat,T., Chauleur,C., Collet,C., Rancon,F., Hoffmann,P.,
            Desseux,M., Lemaitre,N., Benharouga,M., Giraud,A. and Alfaidy,N.
  TITLE     EG-VEGF maternal levels predict spontaneous preterm birth in the
            second and third trimesters in pregnant women with risk factors for
            placenta-mediated complications
  JOURNAL   Sci Rep 13 (1), 19921 (2023)
   PUBMED   37963927
  REMARK    GeneRIF: EG-VEGF maternal levels predict spontaneous preterm birth
            in the second and third trimesters in pregnant women with risk
            factors for placenta-mediated complications.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1393)
  AUTHORS   Tagai,N., Goi,T., Shimada,M. and Kurebayashi,H.
  TITLE     Plasma Prokineticin 1, a prognostic biomarker in colorectal cancer
            patients with curative resection: a retrospective cohort study
  JOURNAL   World J Surg Oncol 19 (1), 302 (2021)
   PUBMED   34657605
  REMARK    GeneRIF: Plasma Prokineticin 1, a prognostic biomarker in
            colorectal cancer patients with curative resection: a retrospective
            cohort study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1393)
  AUTHORS   Zhang,X., Sheng,Y., Li,B., Wang,Q., Liu,X. and Han,J.
  TITLE     Ovarian cancer derived PKR1 positive exosomes promote angiogenesis
            by promoting migration and tube formation in vitro
  JOURNAL   Cell Biochem Funct 39 (2), 308-316 (2021)
   PUBMED   32876972
  REMARK    GeneRIF: Ovarian cancer derived PKR1 positive exosomes promote
            angiogenesis by promoting migration and tube formation in vitro.
REFERENCE   5  (bases 1 to 1393)
  AUTHORS   Ujvari,D., Graells Brugalla,C. and Hirschberg,A.L.
  TITLE     Dihydrotestosterone potentiates insulin to up-regulate
            prokineticin-1 in decidualizing human endometrial stromal cells
  JOURNAL   J Cell Mol Med 24 (5), 3242-3245 (2020)
   PUBMED   31991505
  REMARK    GeneRIF: Dihydrotestosterone potentiates insulin to up-regulate
            prokineticin-1 in decidualizing human endometrial stromal cells.
REFERENCE   6  (bases 1 to 1393)
  AUTHORS   LeCouter,J., Lin,R., Tejada,M., Frantz,G., Peale,F., Hillan,K.J.
            and Ferrara,N.
  TITLE     The endocrine-gland-derived VEGF homologue Bv8 promotes
            angiogenesis in the testis: Localization of Bv8 receptors to
            endothelial cells
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2685-2690 (2003)
   PUBMED   12604792
  REMARK    GeneRIF: Bv8 and EG-VEGF, along with other factors such as VEGF-A,
            may maintain the integrity and also regulate proliferation of the
            blood vessels in the testis
REFERENCE   7  (bases 1 to 1393)
  AUTHORS   Zhang,L., Yang,N., Conejo-Garcia,J.R., Katsaros,D.,
            Mohamed-Hadley,A., Fracchioli,S., Schlienger,K., Toll,A.,
            Levine,B., Rubin,S.C. and Coukos,G.
  TITLE     Expression of endocrine gland-derived vascular endothelial growth
            factor in ovarian carcinoma
  JOURNAL   Clin Cancer Res 9 (1), 264-272 (2003)
   PUBMED   12538479
REFERENCE   8  (bases 1 to 1393)
  AUTHORS   Soga,T., Matsumoto,Si., Oda,T., Saito,T., Hiyama,H., Takasaki,J.,
            Kamohara,M., Ohishi,T., Matsushime,H. and Furuichi,K.
  TITLE     Molecular cloning and characterization of prokineticin receptors
  JOURNAL   Biochim Biophys Acta 1579 (2-3), 173-179 (2002)
   PUBMED   12427552
REFERENCE   9  (bases 1 to 1393)
  AUTHORS   LeCouter,J., Kowalski,J., Foster,J., Hass,P., Zhang,Z.,
            Dillard-Telm,L., Frantz,G., Rangell,L., DeGuzman,L., Keller,G.A.,
            Peale,F., Gurney,A., Hillan,K.J. and Ferrara,N.
  TITLE     Identification of an angiogenic mitogen selective for endocrine
            gland endothelium
  JOURNAL   Nature 412 (6850), 877-884 (2001)
   PUBMED   11528470
REFERENCE   10 (bases 1 to 1393)
  AUTHORS   Li,M., Bullock,C.M., Knauer,D.J., Ehlert,F.J. and Zhou,Q.Y.
  TITLE     Identification of two prokineticin cDNAs: recombinant proteins
            potently contract gastrointestinal smooth muscle
  JOURNAL   Mol Pharmacol 59 (4), 692-698 (2001)
   PUBMED   11259612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL390797.16, BM544315.1, AY029225.1 and AL358215.16.
            
            On Nov 23, 2018 this sequence version replaced NM_032414.2.
            
            Summary: The protein encoded by this gene induces proliferation,
            migration, and fenestration (the formation of membrane
            discontinuities) in capillary endothelial cells derived from
            endocrine glands. It has little or no effect on a variety of other
            endothelial and non-endothelial cell types. Its expression is
            restricted to the steroidogenic glands (ovary, testis, adrenal, and
            placenta), is induced by hypoxia, and often complementary to the
            expression of vascular endothelial growth factor (VEGF), suggesting
            that these molecules function in a coordinated manner. [provided by
            RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.162299.1,
                                           SRR5189667.173366.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271331.4/ ENSP00000271331.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL390797.16        57819-57835
            18-20               BM544315.1         27-29
            21-1389             AY029225.1         1-1369
            1390-1393           AL358215.16        3754-3757
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..1393
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /note="prokineticin 1"
                     /db_xref="GeneID:84432"
                     /db_xref="HGNC:HGNC:18454"
                     /db_xref="MIM:606233"
     exon            1..140
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..386
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /note="black mamba toxin-related protein; mambakine;
                     EG-VEGF; endocrine-gland-derived vascular endothelial
                     growth factor"
                     /codon_start=1
                     /product="prokineticin-1 precursor"
                     /protein_id="NP_115790.1"
                     /db_xref="CCDS:CCDS825.1"
                     /db_xref="GeneID:84432"
                     /db_xref="HGNC:HGNC:18454"
                     /db_xref="MIM:606233"
                     /translation="MRGATRVSIMLLLVTVSDCAVITGACERDVQCGAGTCCAISLWL
                     RGLRMCTPLGREGEECHPGSHKVPFFRKRKHHTCPCLPNLLCSRFPDGRYRCSMDLKN
                     INF"
     exon            141..266
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..1393
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1371..1376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /note="hexamer: AATAAA"
     polyA_site      1393
                     /gene="PROK1"
                     /gene_synonym="EGVEGF; PK1; PRK1"
                     /note="major polyA site"
ORIGIN      
        1 acaaggctga gcgggaggaa gcgagaggca tctaagcagg cagtgttttg ccttcacccc
       61 aagtgaccat gagaggtgcc acgcgagtct caatcatgct cctcctagta actgtgtctg
      121 actgtgctgt gatcacaggg gcctgtgagc gggatgtcca gtgtggggca ggcacctgct
      181 gtgccatcag cctgtggctt cgagggctgc ggatgtgcac cccgctgggg cgggaaggcg
      241 aggagtgcca ccccggcagc cacaaggtcc ccttcttcag gaaacgcaag caccacacct
      301 gtccttgctt gcccaacctg ctgtgctcca ggttcccgga cggcaggtac cgctgctcca
      361 tggacttgaa gaacatcaat ttttaggcgc ttgcctggtc tcaggatacc caccatcctt
      421 ttcctgagca cagcctggat ttttatttct gccatgaaac ccagctccca tgactctccc
      481 agtccctaca ctgactaccc tgatctctct tgtctagtac gcacatatgc acacaggcag
      541 acatacctcc catcatgaca tggtccccag gctggcctga ggatgtcaca gcttgaggct
      601 gtggtgtgaa aggtggccag cctggttctc ttccctgctc aggctgccag agaggtggta
      661 aatggcagaa aggacattcc ccctcccctc cccaggtgac ctgctctctt tcctgggccc
      721 tgcccctctc cccacatgta tccctcggtc tgaattagac attcctgggc acaggctctt
      781 gggtgcattg ctcagagtcc caggtcctgg cctgaccctc aggcccttca cgtgaggtct
      841 gtgaggacca atttgtgggt agttcatctt ccctcgattg gttaactcct tagtttcaga
      901 ccacagactc aagattggct cttcccagag ggcagcagac agtcacccca aggcaggtgt
      961 agggagccca gggaggccaa tcagccccct gaagactctg gtcccagtca gcctgtggct
     1021 tgtggcctgt gacctgtgac cttctgccag aattgtcatg cctctgaggc cccctcttac
     1081 cacactttac cagttaacca ctgaagcccc caattcccac agcttttcca ttaaaatgca
     1141 aatggtggtg gttcaatcta atctgatatt gacatattag aaggcaatta gggtgtttcc
     1201 ttaaacaact cctttccaag gatcagccct gagagcaggt tggtgacttt gaggagggca
     1261 gtcctctgtc cagattgggg tgggagcaag ggacagggag cagggcaggg gctgaaaggg
     1321 gcactgattc agaccaggga ggcaactaca caccaacctg ctggctttag aataaaagca
     1381 ccaactgaac tga
//
