LOCUS       NM_006404               1349 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens protein C receptor (PROCR), mRNA.
ACCESSION   NM_006404
VERSION     NM_006404.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1349)
  AUTHORS   Xue,M., Lin,H., Liang,H.P.H., Bereza-Malcolm,L., Lynch,T.,
            Sinnathurai,P., Weiler,H., Jackson,C. and March,L.
  TITLE     EPCR deficiency ameliorates inflammatory arthritis in mice by
            suppressing the activation and migration of T cells and dendritic
            cells
  JOURNAL   Rheumatology (Oxford) 63 (2), 571-580 (2024)
   PUBMED   37228024
  REMARK    GeneRIF: EPCR deficiency ameliorates inflammatory arthritis in mice
            by suppressing the activation and migration of T cells and
            dendritic cells.
REFERENCE   2  (bases 1 to 1349)
  AUTHORS   Gill,J. and Sharma,A.
  TITLE     Structural and genomic analysis of single nucleotide polymorphisms
            in human host factor endothelial protein C receptor (EPCR) reveals
            complex interplay with malaria parasites
  JOURNAL   Infect Genet Evol 110, 105413 (2023)
   PUBMED   36775045
  REMARK    GeneRIF: Structural and genomic analysis of single nucleotide
            polymorphisms in human host factor endothelial protein C receptor
            (EPCR) reveals complex interplay with malaria parasites.
REFERENCE   3  (bases 1 to 1349)
  AUTHORS   Thakar,M., Noumbissi,M.E. and Stins,M.F.
  TITLE     Microvascular Environment Influences Brain Microvascular
            Heterogeneity: Relative Roles of Astrocytes and Oligodendrocytes
            for the EPCR Expression in the Brain Endothelium
  JOURNAL   Int J Mol Sci 24 (8), 6908 (2023)
   PUBMED   37108071
  REMARK    GeneRIF: Microvascular Environment Influences Brain Microvascular
            Heterogeneity: Relative Roles of Astrocytes and Oligodendrocytes
            for the EPCR Expression in the Brain Endothelium.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1349)
  AUTHORS   Hesham,M., Ali,A.S., Abogabela,S.M., Fawzy,A., Mohamed,N.M. and
            Mokhtar,W.A.
  TITLE     Genetic variant of endothelial protein C receptor genes and its
            serum level in B thalassemic children
  JOURNAL   Expert Rev Hematol 16 (2), 141-146 (2023)
   PUBMED   36523147
  REMARK    GeneRIF: Genetic variant of endothelial protein C receptor genes
            and its serum level in B thalassemic children.
REFERENCE   5  (bases 1 to 1349)
  AUTHORS   Hayashi,T., Nakamura,H., Okada,A., Takebayashi,S., Wakita,T.,
            Yuasa,H., Okumura,K. and Suzuki,K.
  TITLE     Organization and chromosomal localization of the human endothelial
            protein C receptor gene
  JOURNAL   Gene 238 (2), 367-373 (1999)
   PUBMED   10570964
REFERENCE   6  (bases 1 to 1349)
  AUTHORS   Rothbarth,K., Dabaghian,A.R., Stammer,H. and Werner,D.
  TITLE     One single mRNA encodes the centrosomal protein CCD41 and the
            endothelial cell protein C receptor (EPCR)
  JOURNAL   FEBS Lett 458 (1), 77-80 (1999)
   PUBMED   10518938
REFERENCE   7  (bases 1 to 1349)
  AUTHORS   Simmonds,R.E. and Lane,D.A.
  TITLE     Structural and functional implications of the intron/exon
            organization of the human endothelial cell protein C/activated
            protein C receptor (EPCR) gene: comparison with the structure of
            CD1/major histocompatibility complex alpha1 and alpha2 domains
  JOURNAL   Blood 94 (2), 632-641 (1999)
   PUBMED   10397730
REFERENCE   8  (bases 1 to 1349)
  AUTHORS   Ye,X., Fukudome,K., Tsuneyoshi,N., Satoh,T., Tokunaga,O.,
            Sugawara,K., Mizokami,H. and Kimoto,M.
  TITLE     The endothelial cell protein C receptor (EPCR) functions as a
            primary receptor for protein C activation on endothelial cells in
            arteries, veins, and capillaries
  JOURNAL   Biochem Biophys Res Commun 259 (3), 671-677 (1999)
   PUBMED   10364477
REFERENCE   9  (bases 1 to 1349)
  AUTHORS   Laszik,Z., Mitro,A., Taylor,F.B. Jr., Ferrell,G. and Esmon,C.T.
  TITLE     Human protein C receptor is present primarily on endothelium of
            large blood vessels: implications for the control of the protein C
            pathway
  JOURNAL   Circulation 96 (10), 3633-3640 (1997)
   PUBMED   9396465
REFERENCE   10 (bases 1 to 1349)
  AUTHORS   Fukudome,K. and Esmon,C.T.
  TITLE     Identification, cloning, and regulation of a novel endothelial cell
            protein C/activated protein C receptor
  JOURNAL   J Biol Chem 269 (42), 26486-26491 (1994)
   PUBMED   7929370
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314887.1 and BQ939781.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006404.4.
            
            Summary: The protein encoded by this gene is a receptor for
            activated protein C, a serine protease activated by and involved in
            the blood coagulation pathway. The encoded protein is an
            N-glycosylated type I membrane protein that enhances the activation
            of protein C. Mutations in this gene have been associated with
            venous thromboembolism and myocardial infarction, as well as with
            late fetal loss during pregnancy. The encoded protein may also play
            a role in malarial infection and has been associated with cancer.
            [provided by RefSeq, Jul 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014451.1, SRR5189652.204729.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216968.5/ ENSP00000216968.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-800               AK314887.1         102-901
            801-1349            BQ939781.1         268-816
FEATURES             Location/Qualifiers
     source          1..1349
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..1349
                     /gene="PROCR"
                     /gene_synonym="CCCA; CCD41; EPCR"
                     /note="protein C receptor"
                     /db_xref="GeneID:10544"
                     /db_xref="HGNC:HGNC:9452"
                     /db_xref="MIM:600646"
     exon            1..153
                     /gene="PROCR"
                     /gene_synonym="CCCA; CCD41; EPCR"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..800
                     /gene="PROCR"
                     /gene_synonym="CCCA; CCD41; EPCR"
                     /note="APC receptor; CD201 antigen; cell cycle,
                     centrosome-associated protein; centrocyclin; activated
                     protein C receptor; protein C receptor, endothelial"
                     /codon_start=1
                     /product="endothelial protein C receptor precursor"
                     /protein_id="NP_006395.2"
                     /db_xref="CCDS:CCDS13248.1"
                     /db_xref="GeneID:10544"
                     /db_xref="HGNC:HGNC:9452"
                     /db_xref="MIM:600646"
                     /translation="MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWY
                     QGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQ
                     ERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGV
                     VTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVG
                     SFIIAGVAVGIFLCTGGRRC"
     exon            154..405
                     /gene="PROCR"
                     /gene_synonym="CCCA; CCD41; EPCR"
                     /inference="alignment:Splign:2.1.0"
     exon            406..684
                     /gene="PROCR"
                     /gene_synonym="CCCA; CCD41; EPCR"
                     /inference="alignment:Splign:2.1.0"
     exon            685..1349
                     /gene="PROCR"
                     /gene_synonym="CCCA; CCD41; EPCR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1180..1185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROCR"
                     /gene_synonym="CCCA; CCD41; EPCR"
                     /note="hexamer: AATACA"
     polyA_site      1181
                     /gene="PROCR"
                     /gene_synonym="CCCA; CCD41; EPCR"
                     /note="major polyA site"
     regulatory      1326..1331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROCR"
                     /gene_synonym="CCCA; CCD41; EPCR"
                     /note="hexamer: AATAAA"
     polyA_site      1349
                     /gene="PROCR"
                     /gene_synonym="CCCA; CCD41; EPCR"
                     /note="major polyA site"
ORIGIN      
        1 acttctcttt tccctagact gcagccagcg gagcccgcag ccggcccgag ccaggaaccc
       61 aggtccggag cctcaacttc aggatgttga caacattgct gccgatactg ctgctgtctg
      121 gctgggcctt ttgtagccaa gacgcctcag atggcctcca aagacttcat atgctccaga
      181 tctcctactt ccgcgacccc tatcacgtgt ggtaccaggg caacgcgtcg ctggggggac
      241 acctaacgca cgtgctggaa ggcccagaca ccaacaccac gatcattcag ctgcagccct
      301 tgcaggagcc cgagagctgg gcgcgcacgc agagtggcct gcagtcctac ctgctccagt
      361 tccacggcct cgtgcgcctg gtgcaccagg agcggacctt ggcctttcct ctgaccatcc
      421 gctgcttcct gggctgtgag ctgcctcccg agggctctag agcccatgtc ttcttcgaag
      481 tggctgtgaa tgggagctcc tttgtgagtt tccggccgga gagagccttg tggcaggcag
      541 acacccaggt cacctccgga gtggtcacct tcaccctgca gcagctcaat gcctacaacc
      601 gcactcggta tgaactgcgg gaattcctgg aggacacctg tgtgcagtat gtgcagaaac
      661 atatttccgc ggaaaacacg aaagggagcc aaacaagccg ctcctacact tcgctggtcc
      721 tgggcgtcct ggtgggcagt ttcatcattg ctggtgtggc tgtaggcatc ttcctgtgca
      781 caggtggacg gcgatgttaa ttactctcca gccccctcag aaggggctgg attgatggag
      841 gctggcaagg gaaagtttca gctcactgtg aagccagact ccccaactga aacaccagaa
      901 ggtttggagt gacagctcct ttcttctccc acatctgccc actgaagatt tgagggaggg
      961 gagatggaga ggagaggtgg acaaagtact tggtttgcta agaacctaag aacgtgtatg
     1021 ctttgctgaa ttagtctgat aagtgaatgt ttatctatct ttgtggaaaa cagataatgg
     1081 agttggggca ggaagcctat ggcccatcct ccaaagacag acagaatcac ctgaggcgtt
     1141 caaaagatat aaccaaataa acaagtcatc cacaatcaaa atacaacatt caatacttcc
     1201 aggtgtgtca gacttgggat gggacgctga tataataggg tagaaagaag taacacgaag
     1261 aagtggtgga aatgtaaaat ccaagtcata tggcagtgat caattattaa tcaattaata
     1321 atattaataa atttcttata tttaaggca
//
