LOCUS       NM_001366301            1684 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens protein interacting with cyclin A1 (PROCA1),
            transcript variant 7, mRNA.
ACCESSION   NM_001366301 XM_005257927
VERSION     NM_001366301.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1684)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1684)
  AUTHORS   Diederichs,S., Baumer,N., Ji,P., Metzelder,S.K., Idos,G.E.,
            Cauvet,T., Wang,W., Moller,M., Pierschalski,S., Gromoll,J.,
            Schrader,M.G., Koeffler,H.P., Berdel,W.E., Serve,H. and
            Muller-Tidow,C.
  TITLE     Identification of interaction partners and substrates of the cyclin
            A1-CDK2 complex
  JOURNAL   J Biol Chem 279 (32), 33727-33741 (2004)
   PUBMED   15159402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010761.10.
            
            On Sep 28, 2018 this sequence version replaced XM_005257927.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.408172.1,
                                           SRR5189667.34105.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682792.1/ ENSP00000507242.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               AC010761.10        63722-64040         c
            320-403             AC010761.10        58832-58915         c
            404-539             AC010761.10        56860-56995         c
            540-668             AC010761.10        56459-56587         c
            669-1684            AC010761.10        55349-56364         c
FEATURES             Location/Qualifiers
     source          1..1684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..1684
                     /gene="PROCA1"
                     /note="protein interacting with cyclin A1"
                     /db_xref="GeneID:147011"
                     /db_xref="HGNC:HGNC:28600"
                     /db_xref="MIM:617376"
     exon            1..319
                     /gene="PROCA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1323
                     /gene="PROCA1"
                     /note="isoform f is encoded by transcript variant 7;
                     protein PROCA1; proline-rich cyclin A1-interacting
                     protein"
                     /codon_start=1
                     /product="protein PROCA1 isoform f"
                     /protein_id="NP_001353230.1"
                     /db_xref="CCDS:CCDS92283.1"
                     /db_xref="GeneID:147011"
                     /db_xref="HGNC:HGNC:28600"
                     /db_xref="MIM:617376"
                     /translation="MWVRTTLTIERWTKEKTEPKARSWDESRCRDVNRLPSWERGHLL
                     AGVASSTDVSTFSEGDCKEPDKCCWRHKQCTGHIIYPFASDCVRHSLHLHSVNHCNCN
                     SRLKDSSEDSSSSRGAGPTCSHVIESPCFELTPEEEHVERFRYGWCKSYRPVSVAVIH
                     HPLYHECGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIW
                     RSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPS
                     PPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENT
                     VQAKKTGAKPSQARKVNKRKSPPGSNPNLS"
     exon            320..403
                     /gene="PROCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..539
                     /gene="PROCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..668
                     /gene="PROCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..1684
                     /gene="PROCA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1662..1667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PROCA1"
                     /note="hexamer: AATAAA"
     polyA_site      1684
                     /gene="PROCA1"
                     /note="major polyA site"
ORIGIN      
        1 ggatgaagaa cgcggctgac gctgagaccc agctgggaag actacgcagc ctggagccgg
       61 gctggggagg ccggcggggg ctgcgccagc atgaggcggg gttaggggct aggcgggggc
      121 gaagccgaga ctggagttca cggctgggcc gagggctcgg ccgggctgag gctcagggtt
      181 ggacttcacg caagagtcct gtagagacga agacctgggc ggagagcgat gtgggtcagg
      241 acgacgctca caattgaaag atggactaag gaaaagaccg agcccaaggc ccgctcgtgg
      301 gatgagagca gatgccgcga tgtaaacagg ttacccagct gggagagagg acatctgctg
      361 gctggtgtgg cgtccagcac tgatgtgtct accttctctg aaggtgactg caaggagcct
      421 gacaagtgct gctggagaca caagcagtgc actgggcaca tcatctaccc tttcgcctct
      481 gactgtgtcc gccacagcct gcacctacac tctgtcaacc actgcaactg taattctagg
      541 ctgaaggact cttcagagga tagcagcagc tcccggggcg cgggcccaac ctgctcccat
      601 gtcatcgagt ccccttgctt tgagctcaca ccggaggagg agcatgtgga gcgattccgg
      661 tatggctggt gcaaaagcta cagacctgtc tctgtggcag tgatccacca tccactctac
      721 catgagtgtg gggcagatga tctaaatgaa gaagaggaag aggaggagga ggaaagcaag
      781 ccccccatcc cgacacaggt ggggcccgcc accgcctccc ctgacctagg caccagcatg
      841 gccactggta cccctgactc cacagcgccc atcaccatct ggcgctctga gagccccaca
      901 gggaagggtc agggcagcaa ggtgatcaag aaggtaaaga agaaaaagga aaaagagaaa
      961 gacaaggagg agatggatga gaaggcaaag ctgaagaaaa aagccaagaa aggccagttg
     1021 actaagaaga aaagcccggt taaattggag ccttccccgc cagacgtgag ccgatcatta
     1081 agcgcaagac agctggccag gatgtccgag tccagcccag aaagccggga agagctggag
     1141 agcgaggaca gttacaatgg ccgggggcag ggagaactgt ccagcgagga tattgtggaa
     1201 tcatcatcgc ccaggaagag agagaacaca gtccaggcca aaaagacagg ggcaaagccc
     1261 tcacaagcca ggaaggtaaa caagagaaaa tctcccccag gatcaaaccc caacctcagt
     1321 tgaggccagg gtggtcaggg tgcagaataa atgccatcga gcctgtggct ggccctctgc
     1381 tgctgttctc tccctccaac ctggctgttt cttgcggggc aaggggtggg ctcagggctg
     1441 caggggtttc tcaaaggcaa tccagctttc acaaaggaag cccatgggaa ggcaggtggg
     1501 agggaaagga aggggcacag ccctatttct tcctacctgc taggacaagg tggaagagtg
     1561 tatctggggt gggaaggagg gcttcccctc tctgctgcga gagactggtc tgtgtgaaat
     1621 ccacttctgg gacaggcagt actgtctgca gcgatacccc caataaacgg aactttttaa
     1681 ccca
//
