LOCUS       NM_138364               3461 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens protein arginine methyltransferase 9 (PRMT9),
            transcript variant 1, mRNA.
ACCESSION   NM_138364 XM_352955
VERSION     NM_138364.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3461)
  AUTHORS   Shen,L., Ma,X., Wang,Y., Wang,Z., Zhang,Y., Pham,H.Q.H., Tao,X.,
            Cui,Y., Wei,J., Lin,D., Abeywanada,T., Hardikar,S., Halabelian,L.,
            Smith,N., Chen,T., Barsyte-Lovejoy,D., Qiu,S., Xing,Y. and Yang,Y.
  TITLE     Loss-of-function mutation in PRMT9 causes abnormal synapse
            development by dysregulation of RNA alternative splicing
  JOURNAL   Nat Commun 15 (1), 2809 (2024)
   PUBMED   38561334
  REMARK    GeneRIF: Loss-of-function mutation in PRMT9 causes abnormal synapse
            development by dysregulation of RNA alternative splicing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3461)
  AUTHORS   Deng,W., Ai,J., Zhang,W., Zhou,Z., Li,M., Yan,L., Zhang,L.,
            Huang,Z., Wu,Z., Ai,J. and Jiang,H.
  TITLE     Arginine methylation of HSPA8 by PRMT9 inhibits ferroptosis to
            accelerate hepatitis B virus-associated hepatocellular carcinoma
            progression
  JOURNAL   J Transl Med 21 (1), 625 (2023)
   PUBMED   37715221
  REMARK    GeneRIF: Arginine methylation of HSPA8 by PRMT9 inhibits
            ferroptosis to accelerate hepatitis B virus-associated
            hepatocellular carcinoma progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3461)
  AUTHORS   Bai,X., Sui,C., Liu,F., Chen,T., Zhang,L., Zheng,Y., Liu,B. and
            Gao,C.
  TITLE     The protein arginine methyltransferase PRMT9 attenuates MAVS
            activation through arginine methylation
  JOURNAL   Nat Commun 13 (1), 5016 (2022)
   PUBMED   36028484
  REMARK    GeneRIF: The protein arginine methyltransferase PRMT9 attenuates
            MAVS activation through arginine methylation.
            Erratum:[Nat Commun. 2024 Jan 4;15(1):282. doi:
            10.1038/s41467-023-44545-9.. PMID: 38177165]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3461)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3461)
  AUTHORS   Jiang,H., Zhou,Z., Jin,S., Xu,K., Zhang,H., Xu,J., Sun,Q., Wang,J.
            and Xu,J.
  TITLE     PRMT9 promotes hepatocellular carcinoma invasion and metastasis via
            activating PI3K/Akt/GSK-3beta/Snail signaling
  JOURNAL   Cancer Sci 109 (5), 1414-1427 (2018)
   PUBMED   29603830
  REMARK    GeneRIF: Study demonstrated that PRMT9 is an oncogene that plays an
            important role in hepatocellular carcinoma cells invasion and
            metastasis through EMT by regulating Snail expression via
            activation of the PI3K/Akt/GSK-3beta/Snail signaling pathway.
REFERENCE   6  (bases 1 to 3461)
  AUTHORS   Hadjikyriacou,A., Yang,Y., Espejo,A., Bedford,M.T. and Clarke,S.G.
  TITLE     Unique Features of Human Protein Arginine Methyltransferase 9
            (PRMT9) and Its Substrate RNA Splicing Factor SF3B2
  JOURNAL   J Biol Chem 290 (27), 16723-16743 (2015)
   PUBMED   25979344
  REMARK    GeneRIF: Although amino acid substitutions of residues surrounding
            Arg-508 had no great effect on PRMT9 recognition of SF3B2, moving
            the arginine residue within this sequence abolished methylation.
REFERENCE   7  (bases 1 to 3461)
  AUTHORS   Yang,Y., Hadjikyriacou,A., Xia,Z., Gayatri,S., Kim,D.,
            Zurita-Lopez,C., Kelly,R., Guo,A., Li,W., Clarke,S.G. and
            Bedford,M.T.
  TITLE     PRMT9 is a type II methyltransferase that methylates the splicing
            factor SAP145
  JOURNAL   Nat Commun 6, 6428 (2015)
   PUBMED   25737013
  REMARK    GeneRIF: PRMT9 is a type II methyltransferase that methylates the
            splicing factor SAP145.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3461)
  AUTHORS   Harada,N., Takagi,T., Nakano,Y., Yamaji,R. and Inui,H.
  TITLE     Protein arginine methyltransferase 10 is required for
            androgen-dependent proliferation of LNCaP prostate cancer cells
  JOURNAL   Biosci Biotechnol Biochem 79 (9), 1430-1437 (2015)
   PUBMED   25799006
  REMARK    GeneRIF: The decrease in PRMT10 was canceled by knockdown of AR or
            an AR antagonist. These results indicate that PRMT10 plays an
            important role in androgen-dependent proliferation of prostate
            cancer cells
REFERENCE   9  (bases 1 to 3461)
  AUTHORS   Wolf,S.S.
  TITLE     The protein arginine methyltransferase family: an update about
            function, new perspectives and the physiological role in humans
  JOURNAL   Cell Mol Life Sci 66 (13), 2109-2121 (2009)
   PUBMED   19300908
  REMARK    Review article
REFERENCE   10 (bases 1 to 3461)
  AUTHORS   Pal,S. and Sif,S.
  TITLE     Interplay between chromatin remodelers and protein arginine
            methyltransferases
  JOURNAL   J Cell Physiol 213 (2), 306-315 (2007)
   PUBMED   17708529
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB077123.1, BC064403.1,
            BC004337.1 and AC093835.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_138364.3.
            
            Summary: This gene encodes a type II methyltransferase.
            Post-translational modification of target proteins by PRMTs plays
            an important regulatory role in many biological processes, whereby
            PRMTs methylate arginine residues by transferring methyl groups
            from S-adenosyl-L-methionine to the guanidino nitrogen atoms of
            arginine. The protein encoded by this gene methylates spliceosome
            associated protein 145 to regulate alternative splicing and acts as
            a modulator of small nuclear ribonucleoprotein maturation.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Apr
            2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292904.1, SRR1803612.183161.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322396.7/ ENSP00000314396.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-494               DB077123.1         68-561
            495-2864            BC064403.1         461-2830
            2865-3260           BC004337.1         1211-1606
            3261-3261           AC093835.3         23954-23954         c
            3262-3461           BC004337.1         1608-1807
FEATURES             Location/Qualifiers
     source          1..3461
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.23"
     gene            1..3461
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /note="protein arginine methyltransferase 9"
                     /db_xref="GeneID:90826"
                     /db_xref="HGNC:HGNC:25099"
                     /db_xref="MIM:616125"
     exon            1..365
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..2714
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /EC_number="2.1.1.320"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative protein arginine N-methyltransferase 10; protein
                     arginine methyltransferase 10 (putative); putative protein
                     arginine N-methyltransferase 9"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 9 isoform
                     1"
                     /protein_id="NP_612373.2"
                     /db_xref="CCDS:CCDS3771.1"
                     /db_xref="GeneID:90826"
                     /db_xref="HGNC:HGNC:25099"
                     /db_xref="MIM:616125"
                     /translation="MSNSRPRSRRDAGGGAGAAGRDELVSRSLQSAEHCLGVQDFGTA
                     YAHYLLVLSLAPELKHDVKETFQYTLFRWAEELDALSRIQDLLGCYEQALELFPDDEV
                     ICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFSDAKENFYRVANWLVERWHFIMLNDT
                     KRNTIYNAAIQKAVCLGSKSVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACD
                     VVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLFGEGIVESLIHAWEH
                     LLLQPKTKGESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAGIHLPTNVK
                     FQSPAYSSVDTEETIEPYTTEKMSRVPGGYLALTECFEIMTVDFNNLQELKSLATKKP
                     DKIGIPVIKEGILDAIMVWFVLQLDDEHSLSTSPSEETCWEQAVYPVQDLADYWIKPG
                     DHVMMEVSCQDCYLRIQSISVLGLECEMDVAKSFTQNKDLLSLGNEAELCSALANLQT
                     SKPDAVEQTCILESTEIALLNNIPYHEGFKMAMSKVLSSLTPEKLYQTMDTHCQNEMS
                     SGTGQSNTVQNILEPFYVLDVSEGFSVLPVIAGTLGQVKPYSSVEKDQHRIALDLISE
                     ANHFPKETLEFWLRHVEDESAMLQRPKSDKLWSIIILDVIEPSGLIQQEIMEKAAISR
                     CLLQSGGKIFPQYVLMFGLLVESQTLLEENAVQGTERTLGLNIAPFINQFQVPIRVFL
                     DLSSLPCIPLSKPVELLRLDLMTPYLNTSNREVKVYVCKSGRLTAIPFWYHMYLDEEI
                     RLDTSSEASHWKQAAVVLDNPIQVEMGEELVLSIQHHKSNVSITVKQ"
     exon            366..514
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /inference="alignment:Splign:2.1.0"
     exon            515..751
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /inference="alignment:Splign:2.1.0"
     exon            752..919
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1022
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1129
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1322
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1506
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..2221
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2375
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2498
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..3461
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2863..2868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /note="hexamer: AATAAA"
     polyA_site      2889
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /note="major polyA site"
     regulatory      3432..3437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /note="hexamer: AATAAA"
     polyA_site      3461
                     /gene="PRMT9"
                     /gene_synonym="PRMT10"
                     /note="major polyA site"
ORIGIN      
        1 aggacggggc ggagcttccg cctgggctgg ggttggcgag ttcacccgcg gcggagggta
       61 actttgctgt gctgtttttt gagcagttgt ctggtccctg gaagtgtagc atcgagagag
      121 ttttctaatt acgtttacaa aatatcttcc ctttggccat acaagtggtg actgccatgt
      181 cgaactcgcg gcccaggtcc cgccgagacg ccgggggtgg cgctggggca gccggccggg
      241 acgagctggt gtcgcggtcc ttgcagagcg cagagcactg tctgggcgtc caggacttcg
      301 gcactgccta tgcccactac ctcctcgtgc tcagcctggc gccggagctg aaacacgacg
      361 tgaaggaaac ttttcagtac acacttttca gatgggctga agagcttgat gctctcagtc
      421 ggatacaaga cttacttggt tgctatgagc aggccttgga actgtttcct gatgatgaag
      481 tgatttgcaa tagtatgggg gagcatctct tcagaatggg ctttagggat gaagcagctg
      541 ggtattttca taaagcagtg aagctaaacc ctgatttcag tgatgcaaag gagaattttt
      601 atcgtgttgc aaactggttg gtggaacgct ggcactttat catgcttaat gacaccaaga
      661 ggaatacaat ttataatgca gcaatccaaa aggcagtttg tttggggtcc aaaagtgttt
      721 tggacattgg agcaggaact ggaatactaa gcatgtttgc taaaaaagct ggagcacatt
      781 ccgtgtatgc ctgtgagtta tccaagacca tgtatgaact tgcctgtgat gtcgtggcag
      841 caaacaagat ggaagcaggg atcaaactct tacatacgaa gtcacttgac atagagattc
      901 caaaacatat tcccgaaaga gtgtccctag ttgtaacaga aactgtcgat gcaggtttat
      961 ttggagaagg aattgtggag agtttgattc atgcatggga gcatttactt ttacagccaa
     1021 agaccaaagg tgaaagtgct aattgtgaaa agtatgggaa agttatacca gcaagtgctg
     1081 ttatatttgg gatggcagta gaatgtgcag agataagaag acatcataga gtgggtatta
     1141 aggacattgc tggtatccat ttgccaacaa atgtgaaatt tcagagtccg gcttattctt
     1201 ctgtagatac tgaagaaaca attgaacctt atacaactga aaagatgagt cgagttcctg
     1261 gaggatattt ggctttgaca gagtgctttg aaattatgac agtagatttc aacaaccttc
     1321 aggaattaaa aagtcttgca actaaaaagc ctgataagat tggtattcct gttattaaag
     1381 aaggcatact agatgctatt atggtttggt ttgtgctcca gcttgatgat gaacatagtt
     1441 tatccacaag tcctagtgag gaaacatgtt gggaacaggc tgtctacccc gtacaggacc
     1501 ttgcagacta ctggataaag cctggagacc atgtgatgat ggaagtatct tgtcaagact
     1561 gttacttaag aatccagagt attagtgtct tgggtttgga atgtgaaatg gatgttgcaa
     1621 aaagttttac ccagaataaa gacttgttat cgttaggaaa tgaggctgaa ctttgtagtg
     1681 ccctcgctaa ccttcagacc agtaaaccag atgctgtaga gcagacatgt atattggaat
     1741 ctacagaaat tgctttgctt aacaacatcc catatcatga aggctttaaa atggcaatga
     1801 gcaaagtttt gtcttcactg actccagaga aactgtatca gaccatggat actcactgtc
     1861 agaatgagat gagctctgga actggacaga gtaatactgt acagaacatc cttgaacctt
     1921 tctacgtgtt agatgtgtcc gaaggcttct ctgttctgcc tgttattgct ggcacacttg
     1981 ggcaggttaa accatacagt tctgtggaga aagaccagca tcgtattgct ctggacctca
     2041 tatctgaagc caatcacttt cctaaagaaa cacttgagtt ttggctgaga catgtggagg
     2101 atgaatctgc tatgttacaa aggccaaaat cagacaagtt atggagcata attatattgg
     2161 atgtcattga gccatctggg ctcattcagc aggaaataat ggaaaaagct gcaatatcca
     2221 ggtgtttact acaatctgga ggcaagatct ttcctcagta tgtgctgatg tttgggttgc
     2281 ttgtggaatc acagacactc ctagaggaga atgctgttca aggaacagaa cgtactcttg
     2341 gattaaatat agcacctttt attaaccagt ttcaggtacc tatacgtgta tttttggacc
     2401 tatcctcatt gccctgtata cctttaagca agccagtgga actcttaaga ctagatttaa
     2461 tgactccgta tttgaacacc tctaacagag aagtaaaggt atacgtttgt aaatctggaa
     2521 gactgactgc tattccattt tggtatcata tgtaccttga tgaagagatt aggttggata
     2581 cttcaagtga agcctcccac tggaaacaag ctgcagttgt tttagataat cccatccagg
     2641 ttgaaatggg agaggaactt gtactcagca ttcagcatca caaaagcaat gtcagcatca
     2701 cagtaaagca atgaagagca gttttccaat gaaaactgtg taaatagagc atcaacaagt
     2761 acaaaattct tgtcttaatt agtgggggta tataaaaatt ccttgtaatg gtcaaatatt
     2821 ttttaaaatt gacattaata aagcatattt taaaagattc taaataaaag ggtagcatta
     2881 ttatagaaat actgctgcag atttgctttc tggaaaagga tacatcacta gttttttaaa
     2941 ttaggaaact tcttttgctc gattttacag aatagggatt ttaaaagtct tatcgttatt
     3001 gacatgtgta agtaaagcaa aactttactt ttgtaggcat cttggccttt tttcttaaat
     3061 ccaaacttgt aattgggaaa cactgaaagg cttccactga agactgaggg ttatggttac
     3121 ctgtaaattc caatcttgct tcctttaaat actcagtgta catctgaaac atctcaggtt
     3181 ttgttttgag aatgcaagct tgaaaaagaa tttaagctat aagctaaatg taattaaaac
     3241 agtaaaggag ttagggaata catcttcagg aggcagcatt tttcttggtc tactttggca
     3301 aaagaacatt taaaagctgg taacaaaaca aagttaaatt gaaggaagac ttaatcctat
     3361 actatttttc aaagttttga tttggatgta caataagtac attaattgat ccaattttta
     3421 caaacttttg aaataaagga agatcattat tatgcctcct a
//
