LOCUS       NM_019023               3738 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens protein arginine methyltransferase 7 (PRMT7),
            transcript variant 1, mRNA.
ACCESSION   NM_019023
VERSION     NM_019023.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3738)
  AUTHORS   Bondoc,T.J., Lowe,T.L. and Clarke,S.G.
  TITLE     The exquisite specificity of human protein arginine
            methyltransferase 7 (PRMT7) toward Arg-X-Arg sites
  JOURNAL   PLoS One 18 (5), e0285812 (2023)
   PUBMED   37216364
  REMARK    GeneRIF: The exquisite specificity of human protein arginine
            methyltransferase 7 (PRMT7) toward Arg-X-Arg sites.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3738)
  AUTHORS   Rodari,G., Villa,R., Porro,M., Gangi,S., Iascone,M., Elli,F.,
            Giacchetti,F., Profka,E., Collini,V., Dall'Antonia,A., Arosio,M.,
            Mantovani,G., Bedeschi,M.F. and Giavoli,C.
  TITLE     Short stature in PRMT7 Mutations: first evidence of response to
            growth hormone treatment
  JOURNAL   Eur J Hum Genet 31 (2), 195-201 (2023)
   PUBMED   36348013
  REMARK    GeneRIF: Short stature in PRMT7 Mutations: first evidence of
            response to growth hormone treatment.
REFERENCE   3  (bases 1 to 3738)
  AUTHORS   Cali,E., Suri,M., Scala,M., Ferla,M.P., Alavi,S., Faqeih,E.A.,
            Bijlsma,E.K., Wigby,K.M., Baralle,D., Mehrjardi,M.Y.V., Schwab,J.,
            Platzer,K., Steindl,K., Hashem,M., Jones,M., Niyazov,D.M.,
            Jacober,J., Littlejohn,R.O., Weis,D., Zadeh,N., Rodan,L.,
            Goldenberg,A., Lecoquierre,F., Dutra-Clarke,M., Horvath,G.,
            Young,D., Orenstein,N., Bawazeer,S., Vulto-van Silfhout,A.T.,
            Herenger,Y., Dehghani,M., Seyedhassani,S.M., Bahreini,A.,
            Nasab,M.E., Ercan-Sencicek,A.G., Firoozfar,Z., Movahedinia,M.,
            Efthymiou,S., Striano,P., Karimiani,E.G., Salpietro,V.,
            Taylor,J.C., Redman,M., Stegmann,A.P.A., Laner,A., Abdel-Salam,G.,
            Li,M., Bengala,M., Muller,A.J., Digilio,M.C., Rauch,A., Gunel,M.,
            Titheradge,H., Schweitzer,D.N., Kraus,A., Valenzuela,I.,
            McLean,S.D., Phornphutkul,C., Salih,M., Begtrup,A., Schnur,R.E.,
            Torti,E., Haack,T.B., Prada,C.E., Alkuraya,F.S., Houlden,H. and
            Maroofian,R.
  TITLE     Biallelic PRMT7 pathogenic variants are associated with a
            recognizable syndromic neurodevelopmental disorder with short
            stature, obesity, and craniofacial and digital abnormalities
  JOURNAL   Genet Med 25 (1), 135-142 (2023)
   PUBMED   36399134
  REMARK    GeneRIF: Biallelic PRMT7 pathogenic variants are associated with a
            recognizable syndromic neurodevelopmental disorder with short
            stature, obesity, and craniofacial and digital abnormalities.
REFERENCE   4  (bases 1 to 3738)
  AUTHORS   Gunes Gunsel,G., Conlon,T.M., Jeridi,A., Kim,R., Ertuz,Z.,
            Lang,N.J., Ansari,M., Novikova,M., Jiang,D., Strunz,M.,
            Gaianova,M., Hollauer,C., Gabriel,C., Angelidis,I., Doll,S.,
            Pestoni,J.C., Edelmann,S.L., Kohlhepp,M.S., Guillot,A., Bassler,K.,
            Van Eeckhoutte,H.P., Kayalar,O., Konyalilar,N., Kanashova,T.,
            Rodius,S., Ballester-Lopez,C., Genes Robles,C.M., Smirnova,N.,
            Rehberg,M., Agarwal,C., Krikki,I., Piavaux,B., Verleden,S.E.,
            Vanaudenaerde,B., Konigshoff,M., Dittmar,G., Bracke,K.R.,
            Schultze,J.L., Watz,H., Eickelberg,O., Stoeger,T., Burgstaller,G.,
            Tacke,F., Heissmeyer,V., Rinkevich,Y., Bayram,H., Schiller,H.B.,
            Conrad,M., Schneider,R. and Yildirim,A.O.
  TITLE     The arginine methyltransferase PRMT7 promotes extravasation of
            monocytes resulting in tissue injury in COPD
  JOURNAL   Nat Commun 13 (1), 1303 (2022)
   PUBMED   35288557
  REMARK    GeneRIF: The arginine methyltransferase PRMT7 promotes
            extravasation of monocytes resulting in tissue injury in COPD.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3738)
  AUTHORS   Shen,T., Ni,T., Chen,J., Chen,H., Ma,X., Cao,G., Wu,T., Xie,H.,
            Zhou,B., Wei,G., Saiyin,H., Shen,S., Yu,P., Xiao,Q., Liu,H.,
            Gao,Y., Long,X., Yin,J., Guo,Y., Wu,J., Wei,G.H., Hou,J. and
            Jiang,D.K.
  TITLE     An enhancer variant at 16q22.1 predisposes to hepatocellular
            carcinoma via regulating PRMT7 expression
  JOURNAL   Nat Commun 13 (1), 1232 (2022)
   PUBMED   35264579
  REMARK    GeneRIF: An enhancer variant at 16q22.1 predisposes to
            hepatocellular carcinoma via regulating PRMT7 expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3738)
  AUTHORS   Gonsalvez,G.B., Tian,L., Ospina,J.K., Boisvert,F.M., Lamond,A.I.
            and Matera,A.G.
  TITLE     Two distinct arginine methyltransferases are required for
            biogenesis of Sm-class ribonucleoproteins
  JOURNAL   J Cell Biol 178 (5), 733-740 (2007)
   PUBMED   17709427
  REMARK    GeneRIF: that in human cells, PRMT5 and PRMT7 are required for Sm
            protein sDMA modification, and that Sm protein symmetric
            dimethylarginine modification is required for snRNP biogenesis in
            human cells.
REFERENCE   7  (bases 1 to 3738)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 3738)
  AUTHORS   Lee,J., Sayegh,J., Daniel,J., Clarke,S. and Bedford,M.T.
  TITLE     PRMT8, a new membrane-bound tissue-specific member of the protein
            arginine methyltransferase family
  JOURNAL   J Biol Chem 280 (38), 32890-32896 (2005)
   PUBMED   16051612
REFERENCE   9  (bases 1 to 3738)
  AUTHORS   Lee,J.H., Cook,J.R., Yang,Z.H., Mirochnitchenko,O., Gunderson,S.I.,
            Felix,A.M., Herth,N., Hoffmann,R. and Pestka,S.
  TITLE     PRMT7, a new protein arginine methyltransferase that synthesizes
            symmetric dimethylarginine
  JOURNAL   J Biol Chem 280 (5), 3656-3664 (2005)
   PUBMED   15494416
  REMARK    GeneRIF: PRMT7 (like PRMT5) is a Type II methyltransferase capable
            of producing symmetric dimethylarginine modifications in proteins.
REFERENCE   10 (bases 1 to 3738)
  AUTHORS   Miranda,T.B., Miranda,M., Frankel,A. and Clarke,S.
  TITLE     PRMT7 is a member of the protein arginine methyltransferase family
            with a distinct substrate specificity
  JOURNAL   J Biol Chem 279 (22), 22902-22907 (2004)
   PUBMED   15044439
  REMARK    GeneRIF: both domains are required for functionality
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020978.10, DB150163.1,
            AK001502.1, AK022739.1 and AC099521.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 24, 2020 this sequence version replaced NM_019023.4.
            
            Summary: This gene encodes a member of the protein arginine
            N-methyltransferase family of proteins. The encoded enzyme
            transfers single methyl groups to arginine residues to generate
            monomethylarginines on histone proteins as well as other protein
            substrates. This enzyme plays a role in a wide range of biological
            processes, including neuronal differentiation, male germ line
            imprinting, small nuclear ribonucleoprotein biogenesis, and
            regulation of the Wnt signaling pathway. Mutations in this gene
            underlie multiple related syndromes in human patients characterized
            by intellectual disability, short stature and other features. The
            encoded protein may promote breast cancer cell invasion and
            metastasis in human patients. [provided by RefSeq, May 2017].
            
            Transcript Variant: This variant (1) includes a 3' terminal exon
            that extends past a splice site that is used in variant 4, which
            results in a novel 3' coding region and 3' UTR compared to variant
            4. The encoded isoform (1) is shorter and has a distinct C-terminus
            compared to isoform 4. Both variants 1 and 3 encode the same
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001502.1, SRR18074969.31297.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000441236.3/ ENSP00000409324.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC020978.10        30001-30037         c
            38-150              DB150163.1         6-118
            151-1468            AK001502.1         128-1445
            1469-1490           AK022739.1         941-962
            1491-2413           AK001502.1         1468-2390
            2414-3738           AC099521.2         37420-38744
FEATURES             Location/Qualifiers
     source          1..3738
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..3738
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /note="protein arginine methyltransferase 7"
                     /db_xref="GeneID:54496"
                     /db_xref="HGNC:HGNC:25557"
                     /db_xref="MIM:610087"
     exon            1..81
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            82..216
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            217..394
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..2378
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /EC_number="2.1.1.321"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein arginine N-methyltransferase 7; histone-arginine
                     N-methyltransferase PRMT7; [Myelin basic protein]-arginine
                     N-methyltransferase PRMT7"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 7 isoform
                     1"
                     /protein_id="NP_061896.1"
                     /db_xref="CCDS:CCDS10866.1"
                     /db_xref="GeneID:54496"
                     /db_xref="HGNC:HGNC:25557"
                     /db_xref="MIM:610087"
                     /translation="MKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDR
                     NVKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADA
                     AVKIVEKNGFSDKIKVINKHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPSYE
                     HAHRHLVEENCEAVPHRATVYAQLVESGRMWSWNKLFPIHVQTSLGEQVIVPPVDVES
                     CPGAPSVCDIQLNQVSPADFTVLSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQ
                     VVLSWWDIEMDPEGKIKCTMAPFWAHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALY
                     LVAHHDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLLWNRPRFGEINDQDRTDRYV
                     QALRTVLKPDSVCLCVSDGSLLSVLAHHLGVEQVFTVESSAASHKLLRKIFKANHLED
                     KINIIEKRPELLTNEDLQGRKVSLLLGEPFFTTSLLPWHNLYFWYVRTAVDQHLGPGA
                     MVMPQAASLHAVVVEFRDLWRIRSPCGDCEGFDVHIMDDMIKRALDFRESREAEPHPL
                     WEYPCRSLSEPWQILTFDFQQPVPLQPLCAEGTVELRRPGQSHAAVLWMEYHLTPECT
                     LSTGLLEPADPEGGCCWNPHCKQAVYFFSPAPDPRALLGGPRTVSYAVEFHPDTGDII
                     MEFRHADTPD"
     exon            395..431
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            432..581
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            582..690
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            691..803
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1045
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1226
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1354
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1490
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1574
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1622
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1712
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1874
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1949
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2110
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2207
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..3738
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2391..2396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /note="hexamer: AATAAA"
     polyA_site      2420
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /note="major polyA site"
     polyA_site      2500
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
     regulatory      3694..3699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /note="hexamer: AATACA"
     polyA_site      3707
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
     regulatory      3715..3720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
                     /note="hexamer: ATTAAA"
     polyA_site      3738
                     /gene="PRMT7"
                     /gene_synonym="SBIDDS"
ORIGIN      
        1 gacgctgcga ggtcccgccc cgcgtgctgg ccgcggtaaa agtggtagca gcggaggcga
       61 gcggagggtt tcccgcggcg gagtctcact ctgctgccta ggctgagtgc agtggtgtga
      121 tcgaggcgca ctgcagcctt gacctcctgg gctcaagcga tcctcacctc ggcctaccga
      181 gtagctggga ctacaggcac gcgccactac actcggattt ctgacagtca gacttgtcca
      241 caagaactca actggcaagg ctgcttttct gtgctaaaac tggggagcta gtgggcacca
      301 tgaagatctt ctgcagtcgg gccaatccga ccacggggtc tgtggagtgg ctggaggagg
      361 atgaacacta tgattaccac caggagattg caaggtcatc ttatgcagat atgctacatg
      421 acaaagacag aaatgtaaaa tactaccaag gtatccgggc tgccgtgagc agggtgaagg
      481 acagaggaca gaaggccttg gttctcgaca ttggcactgg cacgggactc ttgtcaatga
      541 tggcggtcac agcaggtgcc gacttctgct atgccatcga ggttttcaag cctatggctg
      601 atgctgctgt gaagattgtg gagaaaaatg gctttagtga taagattaag gttatcaaca
      661 agcattccac cgaggtgact gtaggtccag agggtgacat gccatgccgt gccaacatcc
      721 tggtcacaga gttgtttgac acagagctga tcggggaggg ggcgctgccc tcctatgagc
      781 acgcacacag gcatctcgtg gaggaaaatt gtgaggccgt gccccacaga gccaccgtct
      841 atgcacagct ggtggagtcc gggaggatgt ggtcgtggaa caagctattt cccatccacg
      901 tgcagaccag cctcggagag caggtcatcg tccctcccgt tgacgtggag agctgccctg
      961 gcgcaccctc tgtctgtgac attcagctga accaggtgtc accagccgac tttacagtcc
     1021 tcagcgatgt gctgcccatg ttcagcatag acttcagcaa gcaagtcagt agctcagcag
     1081 cctgccatag caggcggttt gaacctctga catctggccg agctcaggtg gttctctcgt
     1141 ggtgggacat tgaaatggac cctgagggga agatcaagtg caccatggcc cccttctggg
     1201 cacactcaga cccagaggag atgcagtggc gggaccactg gatgcagtgt gtgtacttcc
     1261 tgccacaaga ggagcctgtg gtgcagggct cagcgctcta tctggtagcc caccacgatg
     1321 actactgcgt atggtacagc ctgcagagga ccagccctga aaagaatgag agagtccgcc
     1381 agatgcgccc cgtgtgtgac tgccaggctc acctgctctg gaaccggcct cggtttggag
     1441 agatcaatga ccaggacaga actgatcgat acgtccaggc tctgaggacc gtgctgaagc
     1501 cagacagcgt gtgcctgtgt gtcagcgatg gcagcctgct ctccgtgctg gcccatcacc
     1561 tgggggtgga gcaggtgttt acagtcgaga gttcagcagc ttctcacaaa ctgttgagaa
     1621 aaatcttcaa ggctaaccac ttggaagata aaattaacat catagagaaa cggccggaat
     1681 tattaacaaa tgaggaccta cagggcagaa aggtctctct cctcctgggc gagccgttct
     1741 tcactaccag cctgctgccg tggcacaacc tctacttctg gtacgtgcgg accgctgtgg
     1801 accagcacct ggggccaggt gccatggtga tgccccaggc agcctcgctg cacgctgtgg
     1861 ttgtggagtt cagggacctg tggcggatcc ggagcccctg tggtgactgc gaaggcttcg
     1921 acgtgcacat catggacgac atgattaagc gtgccctgga cttcagggag agcagggaag
     1981 ctgagcccca cccgctgtgg gagtacccat gccgcagcct ctccgagccc tggcagatcc
     2041 tgacctttga cttccagcag ccggtgcccc tgcagcccct gtgtgccgag ggcaccgtgg
     2101 agctcagaag gcccgggcag agccacgcag cggtgctatg gatggagtac cacctgaccc
     2161 cggagtgcac gctcagcact ggcctcctgg agcctgcaga ccccgagggg ggctgctgct
     2221 ggaaccccca ctgcaagcag gccgtctact tcttcagccc tgccccagat cccagagcac
     2281 tgctgggtgg cccacggact gtcagctatg cagtggagtt tcaccccgac acaggcgaca
     2341 tcatcatgga gttcaggcat gcagataccc cagactgacc actcttgagc aataaagtgg
     2401 cctgagggct ggggttctga gtggctcatg gctttctagc ggggaaggct gaaggccctc
     2461 ctctcctctc tgggagctgc tcggcctcag ggatgggaaa gactgcgccg tgttgcatct
     2521 tgttgcatct ttgcactgct ggcctctggc tccagctgtg gcaggaagca tgagagggtg
     2581 actgaatttg gagccctgga ggggctggga agacccccct gcttgtgctt ctgaggtgct
     2641 gagaatgctc caacacagag acatctctcc ccagctggga agggagtgga agcacaggga
     2701 gcttgtgggg ctggccggtg gggttgtcca cgccgccctt ggcgagcagt ccccgtggcg
     2761 ggagcctgtc ctgtctgtct cactctcgag gatctccggg tccctgctct tctggcttct
     2821 gctaggaggg tggagatgct gagttgtggc tgggtctctg gggcttgaag accctggctg
     2881 ggcccgggct gagaggcctg ggttctggcc ctttcacctg acaggtaact tcaagccaca
     2941 tccataggtg tctggcctca gtgctgcacc agctggtggc ctgccaggac ctgagactgg
     3001 acacaaggca gctgtcccag agcagttcct gagatgcagg cccaggaaag tggctgtcag
     3061 gggagctggg aggcagccct gttccctgca cctccctcag attggaaagc ccctcctgca
     3121 ggtggggtat ggcagggagc agcccctgcc cagcgccgct tcaccaggaa ggtcagtagg
     3181 tgccgtggcc ttgcttctct cacacactaa cccccctttg gttatgtccc agctctcaga
     3241 ggtaacagca gacaccacgt gagagaaccc agtggcctct ggctcgcagc ttagaaggtg
     3301 aggcttgtgc caggccagcc gagccgcctg tatgagcaga gttccggtgt cctcggattc
     3361 agggcagact tgggcagtgc ctgtcctgca gttgggggca ggaactccct cccctgcccc
     3421 caggcgtgcc cctgaggcct ggccccagct tgtcgctgaa ataagtggag aacaccagcc
     3481 ttgagcctca cagttttatt ttctcctcgt tatccatcct tcctttcagc accagtaagg
     3541 aaaaagaaca cctctcttcg caaaatattt tatcaggtgt aaagacttgt ttttcttcta
     3601 gggaagaacc gtctggatat atatttgata atgtttttac caaaaccata ggtgtgctta
     3661 ccatagaaaa cccctaatgt cccatgaaga tacaatacag aaaaaaatac agaaattaaa
     3721 aaagttttta taacagta
//
