LOCUS       NM_018137               2621 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens protein arginine methyltransferase 6 (PRMT6), mRNA.
ACCESSION   NM_018137 XR_017838
VERSION     NM_018137.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2621)
  AUTHORS   Hong,J., Li,X., Hao,Y., Xu,H., Yu,L., Meng,Z., Zhang,J. and Zhu,M.
  TITLE     The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic
            nephropathy
  JOURNAL   Cell Death Differ 31 (11), 1561-1575 (2024)
   PUBMED   39134684
  REMARK    GeneRIF: The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in
            diabetic nephropathy.
REFERENCE   2  (bases 1 to 2621)
  AUTHORS   Wang,J., Shen,S., You,J., Wang,Z., Li,Y., Chen,Y., Tuo,Y., Chen,D.,
            Yu,H., Zhang,J., Wang,F., Pang,X., Xiao,Z., Lan,Q. and Wang,Y.
  TITLE     PRMT6 facilitates EZH2 protein stability by inhibiting
            TRAF6-mediated ubiquitination degradation to promote glioblastoma
            cell invasion and migration
  JOURNAL   Cell Death Dis 15 (7), 524 (2024)
   PUBMED   39043634
  REMARK    GeneRIF: PRMT6 facilitates EZH2 protein stability by inhibiting
            TRAF6-mediated ubiquitination degradation to promote glioblastoma
            cell invasion and migration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2621)
  AUTHORS   Xu,L., Zhang,F., Yu,B., Jia,S. and Fan,S.
  TITLE     PRMT6 Promotes the Immune Evasion of Gastric Cancer by Upregulating
            ANXA1
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (5), 69-79 (2024)
   PUBMED   38842205
  REMARK    GeneRIF: PRMT6 Promotes the Immune Evasion of Gastric Cancer by
            Upregulating ANXA1.
REFERENCE   4  (bases 1 to 2621)
  AUTHORS   Chen,Q., Hu,Q., Chen,Y., Shen,N., Zhang,N., Li,A., Li,L. and Li,J.
  TITLE     PRMT6 methylation of STAT3 regulates tumor metastasis in breast
            cancer
  JOURNAL   Cell Death Dis 14 (10), 655 (2023)
   PUBMED   37813837
  REMARK    GeneRIF: PRMT6 methylation of STAT3 regulates tumor metastasis in
            breast cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2621)
  AUTHORS   Li,X., Liu,B., Wang,S., Li,J. and Ge,X.
  TITLE     MiR-141-3p promotes malignant progression in prostate cancer
            through AlkB homolog 5-mediated m6A modification of protein
            arginine methyltransferase 6
  JOURNAL   Chin J Physiol 66 (1), 43-51 (2023)
   PUBMED   36814156
  REMARK    GeneRIF: MiR-141-3p promotes malignant progression in prostate
            cancer through AlkB homolog 5-mediated m[6]A modification of
            protein arginine methyltransferase 6.
REFERENCE   6  (bases 1 to 2621)
  AUTHORS   Sgarra,R., Lee,J., Tessari,M.A., Altamura,S., Spolaore,B.,
            Giancotti,V., Bedford,M.T. and Manfioletti,G.
  TITLE     The AT-hook of the chromatin architectural transcription factor
            high mobility group A1a is arginine-methylated by protein arginine
            methyltransferase 6
  JOURNAL   J Biol Chem 281 (7), 3764-3772 (2006)
   PUBMED   16293633
REFERENCE   7  (bases 1 to 2621)
  AUTHORS   Miranda,T.B., Webb,K.J., Edberg,D.D., Reeves,R. and Clarke,S.
  TITLE     Protein arginine methyltransferase 6 specifically methylates the
            nonhistone chromatin protein HMGA1a
  JOURNAL   Biochem Biophys Res Commun 336 (3), 831-835 (2005)
   PUBMED   16157300
REFERENCE   8  (bases 1 to 2621)
  AUTHORS   Boulanger,M.C., Liang,C., Russell,R.S., Lin,R., Bedford,M.T.,
            Wainberg,M.A. and Richard,S.
  TITLE     Methylation of Tat by PRMT6 regulates human immunodeficiency virus
            type 1 gene expression
  JOURNAL   J Virol 79 (1), 124-131 (2005)
   PUBMED   15596808
  REMARK    GeneRIF: methylates HIV-1 Tat protein and acts as a restriction
            factor for HIV-1 replication
REFERENCE   9  (bases 1 to 2621)
  AUTHORS   Frankel,A., Yadav,N., Lee,J., Branscombe,T.L., Clarke,S. and
            Bedford,M.T.
  TITLE     The novel human protein arginine N-methyltransferase PRMT6 is a
            nuclear enzyme displaying unique substrate specificity
  JOURNAL   J Biol Chem 277 (5), 3537-3543 (2002)
   PUBMED   11724789
REFERENCE   10 (bases 1 to 2621)
  AUTHORS   Jia,L., Young,M.F., Powell,J., Yang,L., Ho,N.C., Hotchkiss,R.,
            Robey,P.G. and Francomano,C.A.
  TITLE     Gene expression profile of human bone marrow stromal cells:
            high-throughput expressed sequence tag sequencing analysis
  JOURNAL   Genomics 79 (1), 7-17 (2002)
   PUBMED   11827452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA073209.1, AY043278.1 and AI754232.1.
            
            On May 17, 2019 this sequence version replaced NM_018137.2.
            
            Summary: The protein encoded by this gene belongs to the arginine
            N-methyltransferase family, which catalyze the sequential transfer
            of methyl group from S-adenosyl-L-methionine to the side chain
            nitrogens of arginine residues within proteins, to form methylated
            arginine derivatives and S-adenosyl-L-homocysteine. This protein
            can catalyze both, the formation of omega-N monomethylarginine and
            asymmetrical dimethylarginine, with a strong preference for the
            latter. It specifically mediates the asymmetric dimethylation of
            Arg2 of histone H3, and the methylated form represents a specific
            tag for epigenetic transcriptional repression. This protein also
            forms a complex with, and methylates DNA polymerase beta, resulting
            in stimulation of polymerase activity by enhancing DNA binding and
            processivity. [provided by RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7346977.818124.1, SRR1660807.96327.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370078.2/ ENSP00000359095.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                DA073209.1         30-71
            43-2619             AY043278.1         1-2577
            2620-2621           AI754232.1         16-17               c
FEATURES             Location/Qualifiers
     source          1..2621
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..2621
                     /gene="PRMT6"
                     /gene_synonym="HRMT1L6"
                     /note="protein arginine methyltransferase 6"
                     /db_xref="GeneID:55170"
                     /db_xref="HGNC:HGNC:18241"
                     /db_xref="MIM:608274"
     exon            1..2621
                     /gene="PRMT6"
                     /gene_synonym="HRMT1L6"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1170
                     /gene="PRMT6"
                     /gene_synonym="HRMT1L6"
                     /EC_number="2.1.1.319"
                     /note="histone-arginine N-methyltransferase PRMT6;
                     heterogeneous nuclear ribonucleoprotein
                     methyltransferase-like protein 6; HMT1 hnRNP
                     methyltransferase-like 6"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 6"
                     /protein_id="NP_060607.2"
                     /db_xref="CCDS:CCDS41360.2"
                     /db_xref="GeneID:55170"
                     /db_xref="HGNC:HGNC:18241"
                     /db_xref="MIM:608274"
                     /translation="MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERD
                     QLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQ
                     AGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYG
                     LLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVD
                     MSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFR
                     CSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQD
                     TDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED"
     regulatory      2331..2336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT6"
                     /gene_synonym="HRMT1L6"
                     /note="hexamer: AATAAA"
     polyA_site      2373
                     /gene="PRMT6"
                     /gene_synonym="HRMT1L6"
                     /note="major polyA site"
     regulatory      2595..2600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT6"
                     /gene_synonym="HRMT1L6"
                     /note="hexamer: ATTAAA"
     polyA_site      2621
                     /gene="PRMT6"
                     /gene_synonym="HRMT1L6"
                     /note="major polyA site"
ORIGIN      
        1 gtgccgcgct acgcccgccg ggagccgggc agagcggcca agatgtcgca gcccaagaaa
       61 agaaagcttg agtcgggggg cggcggcgaa ggaggggagg gaactgaaga ggaagatggc
      121 gcggagcggg aggcggccct ggagcgaccc cggaggacta agcgggaacg ggaccagctg
      181 tactacgagt gctactcgga cgtttcggtc cacgaggaga tgatcgcgga ccgcgtccgc
      241 accgatgcct accgcctggg tatccttcgg aactgggcag cactgcgagg caagacggta
      301 ctggacgtgg gcgcgggcac cggcattctg agcatcttct gtgcccaggc cggggcccgg
      361 cgcgtgtacg cggtagaggc cagcgccatc tggcaacagg cccgggaggt ggtgcggttc
      421 aacgggctgg aggaccgggt gcacgtcctg ccgggaccag tggagactgt agagttgccg
      481 gaacaggtgg atgccatcgt gagcgagtgg atgggctacg gactcctgca cgagtccatg
      541 ctgagctccg tcctccacgc gcgaaccaag tggctgaagg agggcggtct tctcctgccg
      601 gcctccgccg agctcttcat agcccccatc agcgaccaga tgctggaatg gcgcctgggc
      661 ttctggagcc aggtgaagca gcactatggt gtggacatga gctgcctgga gggcttcgcc
      721 acgcgctgtc tcatgggcca ctcggagatc gttgtgcagg gattgtccgg cgaggacgtg
      781 ctggcccggc cgcagcgctt tgctcagcta gagctctccc gcgccggctt ggagcaggag
      841 ctggaggccg gagtgggcgg gcgcttccgc tgcagctgct atggctcggc gcccatgcat
      901 ggctttgcca tctggttcca ggtgaccttc cctggagggg agtcggagaa acccctggtg
      961 ctgtccacct cgccttttca cccggccact cactggaaac aggcgctcct ctacctgaac
     1021 gagccggtgc aagtggagca agacacggac gtttcaggag agatcacgct gctgccctcc
     1081 cgggacaacc cccgtcgcct gcgcgtgctg ctgcgctaca aagtgggaga ccaggaggag
     1141 aagaccaaag actttgccat ggaggactga gcgttgcctt ttctcccagc tacctcccaa
     1201 agcagcctga cctgcgtggg agaggcgtag cgaggtcgga ggggaaaggg agatcccacg
     1261 tgcaagtagg gggaatatct cccccttttc cctcatagcc tctagggagg gagagtgact
     1321 tcattctcca tttgaagaga ttcttctggt gatgtttact taaaaagtga tccccctcaa
     1381 caacggatac agcgtgctta ttattgggca tttagcctca aaagcatgta gtaccaagca
     1441 cttgtatttc cgtatatttt gtttcgcggg ggagtgaggg ggaagaacac ggatgaaaat
     1501 gtcagttttt gaagggtcca tgcacatccc tgacacctca caccttatct aagtctgaag
     1561 ctggggagaa aggggttcat ttagacttca tacatttcca gtacgacttt agtatctctc
     1621 cagagccata ttttctcagt ccgaattaat tccccctccc taggtgcctg taggctatgg
     1681 tacttcttcc tcattgtttt ctaggtaaac ttcactactg gtaattaagg ggaaggatat
     1741 gaggaagcag tttaaatagc cctgttctca ttactctgac cacatacatc atagggtgct
     1801 aaagttgatg aacacattaa tccgttaagt aaaatggact ttgtaattgt acagcatacc
     1861 taagaaactc agaaggtgca tttaagagag agacctgaaa gaaatagtat ggatttttaa
     1921 aaattcttgt ctctactatt ataaccaaaa aatatttctt gtatgtccca taaaaatatt
     1981 tgtgtaattc ttatgaaaca ggctggtaga ggaggtttct gagcctagcc caagggctta
     2041 ttcatcacca tgggtaaatt atttaaactc acttaattaa ggaaaatatt ttcccagcta
     2101 gaaaagtata ctcattctca tttaaactct ctcatttgga gggatcatgt gagttggcct
     2161 acttacaagt agtgaaagtt cccttttcag ttttgttttg ttttgttttg tttttctctt
     2221 tcactcagcc aaatgtgaaa gttgtgaatt taggaaaatc acttgtaatg aagtgtgaat
     2281 cttgttatca aatttatttc tctgatgttt ccttccttat ccttgtagcc aataaaacat
     2341 tgacattctc acgttttata gatgaggtaa aaagtcttgt gtgctgtgag ttataatgct
     2401 tttgcctttt taatattatt agttcttaag tgttacagcc ccttcagaat ataacttcag
     2461 gacaattcaa actatgctta atgtatgatt ttcgagcttc tgtatgctaa gaaaataggt
     2521 gtgaaaaact ggtgttctga aatagcctaa catttattgt aattctgaat tttctgccct
     2581 tttattcatt gcatattaaa gtattagagt ataaaaacta a
//
