LOCUS       NM_006109               2304 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens protein arginine methyltransferase 5 (PRMT5),
            transcript variant 1, mRNA.
ACCESSION   NM_006109
VERSION     NM_006109.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2304)
  AUTHORS   Kurdi,M., Alkhotani,A., Sabbagh,A., Faizo,E., Lary,A.I.,
            Bamaga,A.K., Almansouri,M., Hafiz,B., Alsharif,T. and Baeesa,S.
  TITLE     The interplay mechanism between IDH mutation, MGMT-promoter
            methylation, and PRMT5 activity in the progression of grade 4
            astrocytoma: unraveling the complex triad theory
  JOURNAL   Oncol Res 32 (6), 1037-1045 (2024)
   PUBMED   38827324
  REMARK    GeneRIF: The interplay mechanism between IDH mutation,
            MGMT-promoter methylation, and PRMT5 activity in the progression of
            grade 4 astrocytoma: unraveling the complex triad theory.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2304)
  AUTHORS   Abe,Y., Sano,T., Otsuka,N., Ogawa,M. and Tanaka,N.
  TITLE     PRMT5-mediated methylation of STAT3 is required for lung cancer
            stem cell maintenance and tumour growth
  JOURNAL   Commun Biol 7 (1), 593 (2024)
   PUBMED   38760429
  REMARK    GeneRIF: PRMT5-mediated methylation of STAT3 is required for lung
            cancer stem cell maintenance and tumour growth.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2304)
  AUTHORS   Zhang,X., Liu,Q., Wang,L. and Peng,Q.
  TITLE     Identification of protein methyltransferases 5 associated with
            ferroptosis and immune cell infiltration of head and neck squamous
            cell carcinoma
  JOURNAL   Aging (Albany NY) 16 (8), 7426-7436 (2024)
   PUBMED   38663941
  REMARK    GeneRIF: Identification of protein methyltransferases 5 associated
            with ferroptosis and immune cell infiltration of head and neck
            squamous cell carcinoma.
REFERENCE   4  (bases 1 to 2304)
  AUTHORS   Liu,Y., Jiang,H., Hu,K., Zou,H., Zhang,W., Liu,J. and Jian,X.
  TITLE     CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP
            to regulate the translation and stability of CDK6 mRNA
  JOURNAL   PLoS One 19 (4), e0298947 (2024)
   PUBMED   38626179
  REMARK    GeneRIF: CircPRMT5 promotes progression of osteosarcoma by
            recruiting CNBP to regulate the translation and stability of CDK6
            mRNA.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2304)
  AUTHORS   Ichikawa,T., Suekane,A., Nakahata,S., Iha,H., Shimoda,K.,
            Murakami,T. and Morishita,K.
  TITLE     Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity
            Causes Cancer Vulnerability in NDRG2low Adult T-Cell
            Leukemia/Lymphoma
  JOURNAL   Int J Mol Sci 25 (5), 2842 (2024)
   PUBMED   38474089
  REMARK    GeneRIF: Inhibition of PRMT5/MEP50 Arginine Methyltransferase
            Activity Causes Cancer Vulnerability in NDRG2[low] Adult T-Cell
            Leukemia/Lymphoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2304)
  AUTHORS   Rho,J., Choi,S., Seong,Y.R., Cho,W.K., Kim,S.H. and Im,D.S.
  TITLE     Prmt5, which forms distinct homo-oligomers, is a member of the
            protein-arginine methyltransferase family
  JOURNAL   J Biol Chem 276 (14), 11393-11401 (2001)
   PUBMED   11152681
REFERENCE   7  (bases 1 to 2304)
  AUTHORS   Schwarzler,A., Kreienkamp,H.J. and Richter,D.
  TITLE     Interaction of the somatostatin receptor subtype 1 with the human
            homolog of the Shk1 kinase-binding protein from yeast
  JOURNAL   J Biol Chem 275 (13), 9557-9562 (2000)
   PUBMED   10734105
REFERENCE   8  (bases 1 to 2304)
  AUTHORS   Pollack,B.P., Kotenko,S.V., He,W., Izotova,L.S., Barnoski,B.L. and
            Pestka,S.
  TITLE     The human homologue of the yeast proteins Skb1 and Hsl7p interacts
            with Jak kinases and contains protein methyltransferase activity
  JOURNAL   J Biol Chem 274 (44), 31531-31542 (1999)
   PUBMED   10531356
REFERENCE   9  (bases 1 to 2304)
  AUTHORS   Gilbreth,M., Yang,P., Bartholomeusz,G., Pimental,R.A., Kansra,S.,
            Gadiraju,R. and Marcus,S.
  TITLE     Negative regulation of mitosis in fission yeast by the shk1
            interacting protein skb1 and its human homolog, Skb1Hs
  JOURNAL   Proc Natl Acad Sci U S A 95 (25), 14781-14786 (1998)
   PUBMED   9843966
REFERENCE   10 (bases 1 to 2304)
  AUTHORS   Krapivinsky,G., Pu,W., Wickman,K., Krapivinsky,L. and Clapham,D.E.
  TITLE     pICln binds to a mammalian homolog of a yeast protein involved in
            regulation of cell morphology
  JOURNAL   J Biol Chem 273 (18), 10811-10814 (1998)
   PUBMED   9556550
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC395183.1 and AL833612.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006109.4.
            
            Summary: This gene encodes an enzyme that belongs to the
            methyltransferase family. The encoded protein catalyzes the
            transfer of methyl groups to the amino acid arginine, in target
            proteins that include histones, transcriptional elongation factors
            and the tumor suppressor p53. This gene plays a role in several
            cellular processes, including transcriptional regulation, and the
            assembly of small nuclear ribonucleoproteins. A pseudogene of this
            gene has been defined on chromosome 4. Alternative splicing results
            in multiple transcript variants encoding different isoforms.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025979.2, AL833612.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324366.13/ ENSP00000319169.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DC395183.1         210-220
            12-2304             AL833612.1         6-2298
FEATURES             Location/Qualifiers
     source          1..2304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..2304
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /note="protein arginine methyltransferase 5"
                     /db_xref="GeneID:10419"
                     /db_xref="HGNC:HGNC:10894"
                     /db_xref="MIM:604045"
     exon            1..125
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1929
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /EC_number="2.1.1.320"
                     /note="isoform a is encoded by transcript variant 1;
                     protein arginine N-methyltransferase 5; HMT1 hnRNP
                     methyltransferase-like 5; jak-binding protein 1; 72 kDa
                     ICln-binding protein; shk1 kinase-binding protein 1
                     homolog; histone-arginine N-methyltransferase PRMT5; SKB1
                     homolog"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 5 isoform
                     a"
                     /protein_id="NP_006100.2"
                     /db_xref="CCDS:CCDS9579.1"
                     /db_xref="GeneID:10419"
                     /db_xref="HGNC:HGNC:10894"
                     /db_xref="MIM:604045"
                     /translation="MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMP
                     VFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRN
                     SEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAP
                     EDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVI
                     DRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKE
                     FCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKY
                     SQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVE
                     KNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECL
                     DGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHN
                     FHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLS
                     IRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSA
                     IHNPTGRSYTIGL"
     exon            126..244
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            245..330
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            331..465
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            466..578
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            579..628
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            629..792
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            793..954
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1032
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1091
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1214
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1390
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1500
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1594
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1711
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1776
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..2304
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2280..2285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /note="hexamer: AATAAA"
     polyA_site      2304
                     /gene="PRMT5"
                     /gene_synonym="HRMT1L5; HSL7; IBP72; JBP1; SKB1; SKB1Hs"
                     /note="major polyA site"
ORIGIN      
        1 agcgcgagga gaaagatggc ggcgatggcg gtcgggggtg ctggtgggag ccgcgtgtcc
       61 agcgggaggg acctgaattg cgtccccgaa atagctgaca cactaggggc tgtggccaag
      121 caggggtttg atttcctctg catgcctgtc ttccatccgc gtttcaagag ggagttcatt
      181 caggaacctg ctaagaatcg gcccggtccc cagacacgat cagacctact gctgtcagga
      241 agggactgga atacgctaat tgtgggaaag ctttctccat ggattcgtcc agactcaaaa
      301 gtggagaaga ttcgcaggaa ctccgaggcg gccatgttac aggagctgaa ttttggtgca
      361 tatttgggtc ttccagcttt cctgctgccc cttaatcagg aagataacac caacctggcc
      421 agagttttga ccaaccacat ccacactggc catcactctt ccatgttctg gatgcgggta
      481 cccttggtgg caccagagga cctgagagat gatataattg agaatgcacc aactacacac
      541 acagaggagt acagtgggga ggagaaaacg tggatgtggt ggcacaactt ccggactttg
      601 tgtgactata gtaagaggat tgcagtggct cttgaaattg gggctgacct cccatctaat
      661 catgtcattg atcgctggct tggggagccc atcaaagcag ccattctccc cactagcatt
      721 ttcctgacca ataagaaggg atttcctgtt ctttctaaga tgcaccagag gctcatcttc
      781 cggctcctca agttggaggt gcagttcatc atcacaggca ccaaccacca ctcagagaag
      841 gagttctgct cctacctcca atacctggaa tacttaagcc agaaccgtcc tccacctaat
      901 gcctatgaac tctttgccaa gggctatgaa gactatctgc agtccccgct tcagccactg
      961 atggacaatc tggaatctca gacatatgaa gtgtttgaaa aggaccccat caaatactct
     1021 cagtaccagc aggccatcta taaatgtctg ctagaccgag taccagaaga ggagaaggat
     1081 accaatgtcc aggtactgat ggtgctggga gcaggacggg gacccctggt gaacgcttcc
     1141 ctgcgggcag ccaagcaggc cgaccggcgg ataaagctgt atgctgtgga gaaaaaccca
     1201 aatgccgtgg tgacgctaga gaactggcag tttgaagaat ggggaagcca agtgaccgta
     1261 gtctcatcag acatgaggga atgggtggct ccagagaaag cagacatcat tgtcagtgag
     1321 cttctgggct catttgctga caatgaattg tcgcctgagt gcctggatgg agcccagcac
     1381 ttcctaaaag atgatggtgt gagcatcccc ggggagtaca cttcctttct ggctcccatc
     1441 tcttcctcca agctgtacaa tgaggtccga gcctgtaggg agaaggaccg tgaccctgag
     1501 gcccagtttg agatgcctta tgtggtacgg ctgcacaact tccaccagct ctctgcaccc
     1561 cagccctgtt tcaccttcag ccatcccaac agagatccta tgattgacaa caaccgctat
     1621 tgcaccttgg aatttcctgt ggaggtgaac acagtactac atggctttgc cggctacttt
     1681 gagactgtgc tttatcagga catcactctg agtatccgtc cagagactca ctctcctggg
     1741 atgttctcat ggtttcccat cctcttccct attaagcagc ccataacggt acgtgaaggc
     1801 caaaccatct gtgtgcgttt ctggcgatgc agcaattcca agaaggtgtg gtatgagtgg
     1861 gctgtgacag caccagtctg ttctgctatt cataacccca caggccgctc atataccatt
     1921 ggcctctagc cctgcgtgcc aagtgtccag agccttggaa gcagcttcag gttctgctcc
     1981 tgtagtacag aaggtgcagt acatctatgg gctgtgattc cccttgccca tcagagagga
     2041 gcatttcaat ctgctttcct gccttacatc aaggtgggca agggattata attaattgca
     2101 gggctcaagc caccaatcta tgaagacctc aggccagggg gtgaggaatt agtgctggat
     2161 ttgaagctac gcactcagcc tcaagaactc cctggaatat ccctgagaac atggggtttg
     2221 aacggatttt cagccttttt ctgttcttgt tttgatggtt ttgtgtaaga ggaaatacaa
     2281 ataaagttat agccctttac tgca
//
