LOCUS       NM_005788               2552 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens protein arginine methyltransferase 3 (PRMT3),
            transcript variant 1, mRNA.
ACCESSION   NM_005788 XM_058460
VERSION     NM_005788.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2552)
  AUTHORS   Gupta,S., Verma,M., Kadumuri,R.V., Chutani,N., Khan,M.I.K.,
            Chavali,S. and Dhayalan,A.
  TITLE     The uncharacterized protein ZNF200 interacts with PRMT3 and aids
            its stability and nuclear translocation
  JOURNAL   Biochem J 481 (23), 1723-1740 (2024)
   PUBMED   39513743
REFERENCE   2  (bases 1 to 2552)
  AUTHORS   Wang,Y., Wang,C., Guan,X., Ma,Y., Zhang,S., Li,F., Yin,Y., Sun,Z.,
            Chen,X. and Yin,H.
  TITLE     PRMT3-Mediated Arginine Methylation of METTL14 Promotes Malignant
            Progression and Treatment Resistance in Endometrial Carcinoma
  JOURNAL   Adv Sci (Weinh) 10 (36), e2303812 (2023)
   PUBMED   37973560
  REMARK    GeneRIF: PRMT3-Mediated Arginine Methylation of METTL14 Promotes
            Malignant Progression and Treatment Resistance in Endometrial
            Carcinoma.
REFERENCE   3  (bases 1 to 2552)
  AUTHORS   Zhi,R., Wu,K., Zhang,J., Liu,H., Niu,C., Li,S. and Fu,L.
  TITLE     PRMT3 regulates the progression of invasive micropapillary
            carcinoma of the breast
  JOURNAL   Cancer Sci 114 (5), 1912-1928 (2023)
   PUBMED   36637351
  REMARK    GeneRIF: PRMT3 regulates the progression of invasive micropapillary
            carcinoma of the breast.
REFERENCE   4  (bases 1 to 2552)
  AUTHORS   Shi,Y., Niu,Y., Yuan,Y., Li,K., Zhong,C., Qiu,Z., Li,K., Lin,Z.,
            Yang,Z., Zuo,D., Qiu,J., He,W., Wang,C., Liao,Y., Wang,G., Yuan,Y.
            and Li,B.
  TITLE     PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin
            resistance in liver cancer
  JOURNAL   Nat Commun 14 (1), 1932 (2023)
   PUBMED   37024475
  REMARK    GeneRIF: PRMT3-mediated arginine methylation of IGF2BP1 promotes
            oxaliplatin resistance in liver cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2552)
  AUTHORS   Hsu,S.H. and Hung,W.C.
  TITLE     Protein arginine methyltransferase 3: A crucial regulator in
            metabolic reprogramming and gene expression in cancers
  JOURNAL   Cancer Lett 554, 216008 (2023)
   PUBMED   36400311
  REMARK    GeneRIF: Protein arginine methyltransferase 3: A crucial regulator
            in metabolic reprogramming and gene expression in cancers.
            Review article
REFERENCE   6  (bases 1 to 2552)
  AUTHORS   Swiercz,R., Person,M.D. and Bedford,M.T.
  TITLE     Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein
            arginine methyltransferase 3)
  JOURNAL   Biochem J 386 (Pt 1), 85-91 (2005)
   PUBMED   15473865
REFERENCE   7  (bases 1 to 2552)
  AUTHORS   Singh,V., Miranda,T.B., Jiang,W., Frankel,A., Roemer,M.E.,
            Robb,V.A., Gutmann,D.H., Herschman,H.R., Clarke,S. and Newsham,I.F.
  TITLE     DAL-1/4.1B tumor suppressor interacts with protein arginine
            N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate
            substrates in vitro and in vivo
  JOURNAL   Oncogene 23 (47), 7761-7771 (2004)
   PUBMED   15334060
  REMARK    GeneRIF: DAL-1/4.1B protein significantly inhibits PRMT3
            methylation of cellular substrates, which may affect mechanism
            through which DAL-1/4.1B affects tumor cell growth.
REFERENCE   8  (bases 1 to 2552)
  AUTHORS   Bachand,F. and Silver,P.A.
  TITLE     PRMT3 is a ribosomal protein methyltransferase that affects the
            cellular levels of ribosomal subunits
  JOURNAL   EMBO J 23 (13), 2641-2650 (2004)
   PUBMED   15175657
  REMARK    GeneRIF: PRMT3 is a ribosomal protein methyltransferase that
            affects the cellular level of ribosomal subunits.
REFERENCE   9  (bases 1 to 2552)
  AUTHORS   Smith,J.J., Rucknagel,K.P., Schierhorn,A., Tang,J., Nemeth,A.,
            Linder,M., Herschman,H.R. and Wahle,E.
  TITLE     Unusual sites of arginine methylation in Poly(A)-binding protein II
            and in vitro methylation by protein arginine methyltransferases
            PRMT1 and PRMT3
  JOURNAL   J Biol Chem 274 (19), 13229-13234 (1999)
   PUBMED   10224081
REFERENCE   10 (bases 1 to 2552)
  AUTHORS   Tang,J., Gary,J.D., Clarke,S. and Herschman,H.R.
  TITLE     PRMT 3, a type I protein arginine N-methyltransferase that differs
            from PRMT1 in its oligomerization, subcellular localization,
            substrate specificity, and regulation
  JOURNAL   J Biol Chem 273 (27), 16935-16945 (1998)
   PUBMED   9642256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025972.6, AC108005.8, KC877396.1 and KF459543.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005788.3.
            
            Summary: This gene belongs to the protein arginine
            methyltransferase (PRMT) family. The encoded enzyme catalyzes the
            methylation of guanidino nitrogens of arginyl residues of proteins.
            The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its
            major in-vivo substrate, and is involved in the proper maturation
            of the 80S ribosome. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.76860.1,
                                           SRR1803611.134617.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331079.11/ ENSP00000331879.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC025972.6         159262-159320
            60-195              AC025972.6         159565-159700
            196-278             AC108005.8         163880-163962       c
            279-328             AC108005.8         161446-161495       c
            329-431             AC108005.8         160707-160809       c
            432-591             AC108005.8         157744-157903       c
            592-736             AC108005.8         155985-156129       c
            737-802             AC108005.8         150722-150787       c
            803-924             AC108005.8         145674-145795       c
            925-1024            AC108005.8         126841-126940       c
            1025-1103           AC108005.8         101498-101576       c
            1104-1291           AC108005.8         91539-91726         c
            1292-1378           AC108005.8         89160-89246         c
            1379-1429           KC877396.1         196-246
            1430-1517           KC877396.1         444-531
            1518-1683           KF459543.1         97-262
            1684-2552           AC108005.8         44368-45236         c
FEATURES             Location/Qualifiers
     source          1..2552
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..2552
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="protein arginine methyltransferase 3"
                     /db_xref="GeneID:10196"
                     /db_xref="HGNC:HGNC:30163"
                     /db_xref="MIM:603190"
     exon            1..59
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1627
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /EC_number="2.1.1.319"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein arginine N-methyltransferase 3; heterogeneous
                     nuclear ribonucleoprotein methyltransferase-like protein
                     3; HMT1 hnRNP methyltransferase-like 3"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 3 isoform
                     1"
                     /protein_id="NP_005779.1"
                     /db_xref="CCDS:CCDS7853.1"
                     /db_xref="GeneID:10196"
                     /db_xref="HGNC:HGNC:30163"
                     /db_xref="MIM:603190"
                     /translation="MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHG
                     KQQTPCLFCNRLFTSAEETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPT
                     VEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVE
                     KLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDG
                     VYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKA
                     GAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYF
                     LLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMS
                     CMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTA
                     IAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKN
                     KKDPRSLTVTLTLNNSTQTYGLQ"
     exon            60..195
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            196..278
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            279..328
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            329..431
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            432..591
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            592..736
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            737..802
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            803..924
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1024
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1103
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1291
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1378
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1429
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1517
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..2552
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2100..2105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="hexamer: AATAAA"
     polyA_site      2127
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="major polyA site"
     regulatory      2461..2466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="hexamer: AATAAA"
     regulatory      2472..2477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="hexamer: AATAAA"
     polyA_site      2482
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="major polyA site"
     regulatory      2489..2494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="hexamer: TATAAA"
     polyA_site      2497
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="major polyA site"
     polyA_site      2508
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
     regulatory      2529..2534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="hexamer: AATAAA"
     polyA_site      2552
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
ORIGIN      
        1 agacacgccg ggctctcggg gcaccacagc catgtgctcg ttagcgtcag gcgctaccgg
       61 cggccggggc gctgtggaga atgaggagga cctgccagaa ctgtcggaca gcggggacga
      121 ggccgcctgg gaggatgagg acgatgcaga tctcccccac ggcaagcagc agaccccctg
      181 cctgttctgt aacaggttat tcacatctgc tgaagaaaca ttttcacact gtaagtctga
      241 gcatcagttt aatattgaca gcatggttca taaacatgga cttgaatttt atggatacat
      301 taagctaata aattttatta gacttaagaa tcctacagtt gagtacatga attccatata
      361 caacccagtg ccttgggaga aagaagagta tttgaagcca gtattagaag atgacctttt
      421 acttcaattt gatgtagaag atctttatga accggtgtca gtacccttct cataccccaa
      481 tggactcagt gaaaatacat ctgttgttga aaaattgaaa catatggaag ccagggcact
      541 gtctgctgaa gccgcattgg ccagagcacg tgaggatctg caaaaaatga aacaatttgc
      601 tcaggatttt gtgatgcaca cagatgtcag aacctgctcg tcatctacta gtgtcattgc
      661 ggacctccag gaggatgagg atggtgttta tttcagctca tacgggcatt atgggataca
      721 tgaagaaatg ctaaaggaca aaatacgaac agaaagctac cgagatttca tataccaaaa
      781 tccacatatc ttcaaagaca aggtagtttt ggatgttggg tgtggaactg gaattctctc
      841 tatgtttgct gctaaagctg gggcgaagaa ggttcttgga gttgatcaat ctgaaatact
      901 ttaccaggca atggatatta taagactaaa taaacttgaa gatactatta cactaattaa
      961 aggaaagatt gaagaagttc atcttcctgt agaaaaagta gatgttatca tatctgagtg
     1021 gatgggctat tttcttctgt ttgagtctat gttagattct gtcctttatg caaagaacaa
     1081 atacttggca aaaggaggct cggtctaccc tgacatttgc actatcagcc ttgtagcagt
     1141 gagtgatgtg aataaacatg ctgatagaat tgctttttgg gatgatgtct atggcttcaa
     1201 gatgtcctgc atgaagaaag cagttattcc agaagctgtt gtggaagttt tagatccgaa
     1261 gactcttatt tcagaacctt gtggtattaa gcatatagat tgccatacga cgtctatctc
     1321 agatttggaa ttttcatcag attttaccct gaaaatcaca aggacatcca tgtgcacggc
     1381 aattgctggc tactttgata tatattttga gaagaattgc cacaacaggg tcgtgttctc
     1441 tacgggccct cagagcacca aaacacactg gaaacaaaca gtatttctac tggaaaaacc
     1501 attttcagtt aaagcaggtg aagccttgaa aggaaaggtc acagttcaca agaataagaa
     1561 agatccacgt tctctcaccg tgaccctcac gttgaataat tcaactcaaa cttatggtct
     1621 ccagtgaaac agccataaaa gcacactacc ttgtagtttt taatgtgggg gtagagtggg
     1681 tcagcaggag ggagctggtt ttatgtgagc agatggatgg atgatggacc ctttcctaat
     1741 gagcctcctc aataagagag aagttctcat tgtgggaatc tgacatagtt cagctgagga
     1801 agagaatcag ctgatcctca tggtctgcca cgtaatcatt ttcttagacg tttgctccac
     1861 cagatttaac caaatgtaac tcccacattg agtttatcta tattgaaaat catttacatt
     1921 ggcctatatt tggaagagag atagtctttt gtttttaata agtttcttac tataaatttt
     1981 aaacaaattg gttagttatt tggatatttt attaaactag taacacaggt actacacatt
     2041 ttattatgga ctcctctgag gaggagtttt taattgtatt tgctagaaaa tcaggatgta
     2101 ataaagattt gtataaaaaa actaaaatat ggaaaagagc ttcagccttc atatacaaat
     2161 catatatgca gacagcctag ttgattatct agcatactta gggttctcat tttgtagttt
     2221 cttccctctt tgtgactatt ccttagcctt atagatttct agtactgccc aggaaatcta
     2281 atttcaatac atttatccta ggtttcatga aagtttttaa agattgggat aaatatgtac
     2341 ttatttacta acgtattatc tttttcaaac cagatttatg tgcaaaggtt aaacatgtaa
     2401 ctgttactaa gcagtctata aagttgtcat ttacaattac tgattcaatt tgaaatgtag
     2461 aataaaattt taataaaatg tatcaactta taaaatattt taaaaatatt gatattataa
     2521 aagttttcaa taaaatatat caaacaacat ta
//
