LOCUS       NM_001145167            2416 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens protein arginine methyltransferase 3 (PRMT3),
            transcript variant 3, mRNA.
ACCESSION   NM_001145167
VERSION     NM_001145167.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2416)
  AUTHORS   Gupta,S., Verma,M., Kadumuri,R.V., Chutani,N., Khan,M.I.K.,
            Chavali,S. and Dhayalan,A.
  TITLE     The uncharacterized protein ZNF200 interacts with PRMT3 and aids
            its stability and nuclear translocation
  JOURNAL   Biochem J 481 (23), 1723-1740 (2024)
   PUBMED   39513743
REFERENCE   2  (bases 1 to 2416)
  AUTHORS   Wang,Y., Wang,C., Guan,X., Ma,Y., Zhang,S., Li,F., Yin,Y., Sun,Z.,
            Chen,X. and Yin,H.
  TITLE     PRMT3-Mediated Arginine Methylation of METTL14 Promotes Malignant
            Progression and Treatment Resistance in Endometrial Carcinoma
  JOURNAL   Adv Sci (Weinh) 10 (36), e2303812 (2023)
   PUBMED   37973560
  REMARK    GeneRIF: PRMT3-Mediated Arginine Methylation of METTL14 Promotes
            Malignant Progression and Treatment Resistance in Endometrial
            Carcinoma.
REFERENCE   3  (bases 1 to 2416)
  AUTHORS   Zhi,R., Wu,K., Zhang,J., Liu,H., Niu,C., Li,S. and Fu,L.
  TITLE     PRMT3 regulates the progression of invasive micropapillary
            carcinoma of the breast
  JOURNAL   Cancer Sci 114 (5), 1912-1928 (2023)
   PUBMED   36637351
  REMARK    GeneRIF: PRMT3 regulates the progression of invasive micropapillary
            carcinoma of the breast.
REFERENCE   4  (bases 1 to 2416)
  AUTHORS   Shi,Y., Niu,Y., Yuan,Y., Li,K., Zhong,C., Qiu,Z., Li,K., Lin,Z.,
            Yang,Z., Zuo,D., Qiu,J., He,W., Wang,C., Liao,Y., Wang,G., Yuan,Y.
            and Li,B.
  TITLE     PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin
            resistance in liver cancer
  JOURNAL   Nat Commun 14 (1), 1932 (2023)
   PUBMED   37024475
  REMARK    GeneRIF: PRMT3-mediated arginine methylation of IGF2BP1 promotes
            oxaliplatin resistance in liver cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2416)
  AUTHORS   Hsu,S.H. and Hung,W.C.
  TITLE     Protein arginine methyltransferase 3: A crucial regulator in
            metabolic reprogramming and gene expression in cancers
  JOURNAL   Cancer Lett 554, 216008 (2023)
   PUBMED   36400311
  REMARK    GeneRIF: Protein arginine methyltransferase 3: A crucial regulator
            in metabolic reprogramming and gene expression in cancers.
            Review article
REFERENCE   6  (bases 1 to 2416)
  AUTHORS   Swiercz,R., Person,M.D. and Bedford,M.T.
  TITLE     Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein
            arginine methyltransferase 3)
  JOURNAL   Biochem J 386 (Pt 1), 85-91 (2005)
   PUBMED   15473865
REFERENCE   7  (bases 1 to 2416)
  AUTHORS   Singh,V., Miranda,T.B., Jiang,W., Frankel,A., Roemer,M.E.,
            Robb,V.A., Gutmann,D.H., Herschman,H.R., Clarke,S. and Newsham,I.F.
  TITLE     DAL-1/4.1B tumor suppressor interacts with protein arginine
            N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate
            substrates in vitro and in vivo
  JOURNAL   Oncogene 23 (47), 7761-7771 (2004)
   PUBMED   15334060
  REMARK    GeneRIF: DAL-1/4.1B protein significantly inhibits PRMT3
            methylation of cellular substrates, which may affect mechanism
            through which DAL-1/4.1B affects tumor cell growth.
REFERENCE   8  (bases 1 to 2416)
  AUTHORS   Bachand,F. and Silver,P.A.
  TITLE     PRMT3 is a ribosomal protein methyltransferase that affects the
            cellular levels of ribosomal subunits
  JOURNAL   EMBO J 23 (13), 2641-2650 (2004)
   PUBMED   15175657
  REMARK    GeneRIF: PRMT3 is a ribosomal protein methyltransferase that
            affects the cellular level of ribosomal subunits.
REFERENCE   9  (bases 1 to 2416)
  AUTHORS   Smith,J.J., Rucknagel,K.P., Schierhorn,A., Tang,J., Nemeth,A.,
            Linder,M., Herschman,H.R. and Wahle,E.
  TITLE     Unusual sites of arginine methylation in Poly(A)-binding protein II
            and in vitro methylation by protein arginine methyltransferases
            PRMT1 and PRMT3
  JOURNAL   J Biol Chem 274 (19), 13229-13234 (1999)
   PUBMED   10224081
REFERENCE   10 (bases 1 to 2416)
  AUTHORS   Tang,J., Gary,J.D., Clarke,S. and Herschman,H.R.
  TITLE     PRMT 3, a type I protein arginine N-methyltransferase that differs
            from PRMT1 in its oligomerization, subcellular localization,
            substrate specificity, and regulation
  JOURNAL   J Biol Chem 273 (27), 16935-16945 (1998)
   PUBMED   9642256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025972.6, AC108005.8, KC877396.1 and KF459543.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001145167.1.
            
            Summary: This gene belongs to the protein arginine
            methyltransferase (PRMT) family. The encoded enzyme catalyzes the
            methylation of guanidino nitrogens of arginyl residues of proteins.
            The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its
            major in-vivo substrate, and is involved in the proper maturation
            of the 80S ribosome. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (3) is missing a coding exon at
            the 5' end compared to transcript variant 1. This results in
            translation initiation from an in-frame downstream AUG by leaky
            scanning, and a shorter isoform (3) with a truncated N-terminus
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK298185.1, BC019339.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC025972.6         159262-159320
            60-142              AC108005.8         163880-163962       c
            143-192             AC108005.8         161446-161495       c
            193-295             AC108005.8         160707-160809       c
            296-455             AC108005.8         157744-157903       c
            456-600             AC108005.8         155985-156129       c
            601-666             AC108005.8         150722-150787       c
            667-788             AC108005.8         145674-145795       c
            789-888             AC108005.8         126841-126940       c
            889-967             AC108005.8         101498-101576       c
            968-1155            AC108005.8         91539-91726         c
            1156-1242           AC108005.8         89160-89246         c
            1243-1293           KC877396.1         196-246
            1294-1381           KC877396.1         444-531
            1382-1547           KF459543.1         97-262
            1548-2416           AC108005.8         44368-45236         c
FEATURES             Location/Qualifiers
     source          1..2416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..2416
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="protein arginine methyltransferase 3"
                     /db_xref="GeneID:10196"
                     /db_xref="HGNC:HGNC:30163"
                     /db_xref="MIM:603190"
     exon            1..59
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            60..142
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1491
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /EC_number="2.1.1.319"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein arginine N-methyltransferase 3; heterogeneous
                     nuclear ribonucleoprotein methyltransferase-like protein
                     3; HMT1 hnRNP methyltransferase-like 3"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 3 isoform
                     3"
                     /protein_id="NP_001138639.1"
                     /db_xref="GeneID:10196"
                     /db_xref="HGNC:HGNC:30163"
                     /db_xref="MIM:603190"
                     /translation="MVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYL
                     KPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARA
                     REDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDK
                     IRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMD
                     IIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLA
                     KGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKT
                     LISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVF
                     STGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQT
                     YGLQ"
     exon            143..192
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            193..295
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            296..455
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            456..600
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            601..666
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            667..788
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            789..888
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            889..967
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1155
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1242
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1293
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1381
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..2416
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1964..1969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="hexamer: AATAAA"
     polyA_site      1991
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="major polyA site"
     regulatory      2325..2330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="hexamer: AATAAA"
     regulatory      2336..2341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="hexamer: AATAAA"
     polyA_site      2346
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="major polyA site"
     regulatory      2353..2358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="hexamer: TATAAA"
     polyA_site      2361
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="major polyA site"
     polyA_site      2372
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
     regulatory      2393..2398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
                     /note="hexamer: AATAAA"
     polyA_site      2416
                     /gene="PRMT3"
                     /gene_synonym="HRMT1L3"
ORIGIN      
        1 agacacgccg ggctctcggg gcaccacagc catgtgctcg ttagcgtcag gcgctaccgg
       61 ttattcacat ctgctgaaga aacattttca cactgtaagt ctgagcatca gtttaatatt
      121 gacagcatgg ttcataaaca tggacttgaa ttttatggat acattaagct aataaatttt
      181 attagactta agaatcctac agttgagtac atgaattcca tatacaaccc agtgccttgg
      241 gagaaagaag agtatttgaa gccagtatta gaagatgacc ttttacttca atttgatgta
      301 gaagatcttt atgaaccggt gtcagtaccc ttctcatacc ccaatggact cagtgaaaat
      361 acatctgttg ttgaaaaatt gaaacatatg gaagccaggg cactgtctgc tgaagccgca
      421 ttggccagag cacgtgagga tctgcaaaaa atgaaacaat ttgctcagga ttttgtgatg
      481 cacacagatg tcagaacctg ctcgtcatct actagtgtca ttgcggacct ccaggaggat
      541 gaggatggtg tttatttcag ctcatacggg cattatggga tacatgaaga aatgctaaag
      601 gacaaaatac gaacagaaag ctaccgagat ttcatatacc aaaatccaca tatcttcaaa
      661 gacaaggtag ttttggatgt tgggtgtgga actggaattc tctctatgtt tgctgctaaa
      721 gctggggcga agaaggttct tggagttgat caatctgaaa tactttacca ggcaatggat
      781 attataagac taaataaact tgaagatact attacactaa ttaaaggaaa gattgaagaa
      841 gttcatcttc ctgtagaaaa agtagatgtt atcatatctg agtggatggg ctattttctt
      901 ctgtttgagt ctatgttaga ttctgtcctt tatgcaaaga acaaatactt ggcaaaagga
      961 ggctcggtct accctgacat ttgcactatc agccttgtag cagtgagtga tgtgaataaa
     1021 catgctgata gaattgcttt ttgggatgat gtctatggct tcaagatgtc ctgcatgaag
     1081 aaagcagtta ttccagaagc tgttgtggaa gttttagatc cgaagactct tatttcagaa
     1141 ccttgtggta ttaagcatat agattgccat acgacgtcta tctcagattt ggaattttca
     1201 tcagatttta ccctgaaaat cacaaggaca tccatgtgca cggcaattgc tggctacttt
     1261 gatatatatt ttgagaagaa ttgccacaac agggtcgtgt tctctacggg ccctcagagc
     1321 accaaaacac actggaaaca aacagtattt ctactggaaa aaccattttc agttaaagca
     1381 ggtgaagcct tgaaaggaaa ggtcacagtt cacaagaata agaaagatcc acgttctctc
     1441 accgtgaccc tcacgttgaa taattcaact caaacttatg gtctccagtg aaacagccat
     1501 aaaagcacac taccttgtag tttttaatgt gggggtagag tgggtcagca ggagggagct
     1561 ggttttatgt gagcagatgg atggatgatg gaccctttcc taatgagcct cctcaataag
     1621 agagaagttc tcattgtggg aatctgacat agttcagctg aggaagagaa tcagctgatc
     1681 ctcatggtct gccacgtaat cattttctta gacgtttgct ccaccagatt taaccaaatg
     1741 taactcccac attgagttta tctatattga aaatcattta cattggccta tatttggaag
     1801 agagatagtc ttttgttttt aataagtttc ttactataaa ttttaaacaa attggttagt
     1861 tatttggata ttttattaaa ctagtaacac aggtactaca cattttatta tggactcctc
     1921 tgaggaggag tttttaattg tatttgctag aaaatcagga tgtaataaag atttgtataa
     1981 aaaaactaaa atatggaaaa gagcttcagc cttcatatac aaatcatata tgcagacagc
     2041 ctagttgatt atctagcata cttagggttc tcattttgta gtttcttccc tctttgtgac
     2101 tattccttag ccttatagat ttctagtact gcccaggaaa tctaatttca atacatttat
     2161 cctaggtttc atgaaagttt ttaaagattg ggataaatat gtacttattt actaacgtat
     2221 tatctttttc aaaccagatt tatgtgcaaa ggttaaacat gtaactgtta ctaagcagtc
     2281 tataaagttg tcatttacaa ttactgattc aatttgaaat gtagaataaa attttaataa
     2341 aatgtatcaa cttataaaat attttaaaaa tattgatatt ataaaagttt tcaataaaat
     2401 atatcaaaca acatta
//
