LOCUS       NM_206962               2354 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens protein arginine methyltransferase 2 (PRMT2),
            transcript variant 1, mRNA.
ACCESSION   NM_206962
VERSION     NM_206962.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2354)
  AUTHORS   Sauter,C., Morin,T., Guidez,F., Simonet,J., Fournier,C., Row,C.,
            Masnikov,D., Pernon,B., Largeot,A., Aznague,A., Herault,Y.,
            Sauvageau,G., Maynadie,M., Callanan,M., Bastie,J.N., Aucagne,R. and
            Delva,L.
  TITLE     Protein arginine methyltransferase 2 controls inflammatory
            signaling in acute myeloid leukemia
  JOURNAL   Commun Biol 7 (1), 753 (2024)
   PUBMED   38902349
  REMARK    GeneRIF: Protein arginine methyltransferase 2 controls inflammatory
            signaling in acute myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2354)
  AUTHORS   Zhang,M., Xu,Y., Zhu,G., Zeng,Q., Gao,R., Qiu,J., Su,W. and Wang,R.
  TITLE     Human C15orf39 Inhibits Inflammatory Response via PRMT2 in Human
            Microglial HMC3 Cell Line
  JOURNAL   Int J Mol Sci 25 (11), 6025 (2024)
   PUBMED   38892217
  REMARK    GeneRIF: Human C15orf39 Inhibits Inflammatory Response via PRMT2 in
            Human Microglial HMC3 Cell Line.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2354)
  AUTHORS   Min,Z.Q., Jiang,M.J., Liu,X.L., Yuan,S.P., Chen,P.A., Wang,C.H.,
            Chen,Y.J. and Dai,X.P.
  TITLE     Advances in Research on Protein Arginine Methyltransferase 2:
            Functions and Diseases
  JOURNAL   Protein Pept Lett 31 (1), 25-42 (2024)
   PUBMED   38155464
  REMARK    GeneRIF: Advances in Research on Protein Arginine Methyltransferase
            2: Functions and Diseases.
            Review article
REFERENCE   4  (bases 1 to 2354)
  AUTHORS   Rowley,M.J., Prout-Holm,R.A., Liu,R.W., Hendrickson-Rebizant,T.,
            Ige,O.O., Lakowski,T.M. and Frankel,A.
  TITLE     Protein arginine N-methyltransferase 2 plays a noncatalytic role in
            the histone methylation activity of PRMT1
  JOURNAL   J Biol Chem 299 (12), 105360 (2023)
   PUBMED   37863263
  REMARK    GeneRIF: Protein arginine N-methyltransferase 2 plays a
            noncatalytic role in the histone methylation activity of PRMT1.
REFERENCE   5  (bases 1 to 2354)
  AUTHORS   Jin,J., Bai,H., Yan,H., Deng,T., Li,T., Xiao,R., Fan,L., Bai,X.,
            Ning,H., Liu,Z., Zhang,K., Wu,X., Liang,K., Ma,P., Gao,X. and Hu,D.
  TITLE     PRMT2 promotes HIV-1 latency by preventing nucleolar exit and phase
            separation of Tat into the Super Elongation Complex
  JOURNAL   Nat Commun 14 (1), 7274 (2023)
   PUBMED   37949879
  REMARK    GeneRIF: PRMT2 promotes HIV-1 latency by preventing nucleolar exit
            and phase separation of Tat into the Super Elongation Complex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2354)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
REFERENCE   7  (bases 1 to 2354)
  AUTHORS   Qi,C., Chang,J., Zhu,Y., Yeldandi,A.V., Rao,S.M. and Zhu,Y.J.
  TITLE     Identification of protein arginine methyltransferase 2 as a
            coactivator for estrogen receptor alpha
  JOURNAL   J Biol Chem 277 (32), 28624-28630 (2002)
   PUBMED   12039952
  REMARK    GeneRIF: PRMT2 is a novel ERalpha coactivator.
REFERENCE   8  (bases 1 to 2354)
  AUTHORS   Kzhyshkowska,J., Schutt,H., Liss,M., Kremmer,E., Stauber,R.,
            Wolf,H. and Dobner,T.
  TITLE     Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in
            its Arg-Gly-Gly (RGG) box and interacts with human arginine
            methyltransferase HRMT1L1
  JOURNAL   Biochem J 358 (Pt 2), 305-314 (2001)
   PUBMED   11513728
REFERENCE   9  (bases 1 to 2354)
  AUTHORS   Scott,H.S., Antonarakis,S.E., Lalioti,M.D., Rossier,C., Silver,P.A.
            and Henry,M.F.
  TITLE     Identification and characterization of two putative human arginine
            methyltransferases (HRMT1L1 and HRMT1L2)
  JOURNAL   Genomics 48 (3), 330-340 (1998)
   PUBMED   9545638
REFERENCE   10 (bases 1 to 2354)
  AUTHORS   Katsanis,N., Yaspo,M.L. and Fisher,E.M.
  TITLE     Identification and mapping of a novel human gene, HRMT1L1,
            homologous to the rat protein arginine N-methyltransferase 1
            (PRMT1) gene
  JOURNAL   Mamm Genome 8 (7), 526-529 (1997)
   PUBMED   9196002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA169949.1, BC000727.2, AK123650.1 and BQ267811.1.
            
            On Nov 23, 2018 this sequence version replaced NM_206962.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.60977.1,
                                           SRR1803614.67842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355680.8/ ENSP00000347906.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DA169949.1         82-82
            2-323               BC000727.2         1-322
            324-2170            AK123650.1         831-2677
            2171-2354           BQ267811.1         14-197              c
FEATURES             Location/Qualifiers
     source          1..2354
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..2354
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /note="protein arginine methyltransferase 2"
                     /db_xref="GeneID:3275"
                     /db_xref="HGNC:HGNC:5186"
                     /db_xref="MIM:601961"
     exon            1..90
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            91..199
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..294
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1557
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /EC_number="2.1.1.319"
                     /note="isoform 1 is encoded by transcript variant 1; HMT1
                     (hnRNP methyltransferase, S. cerevisiae)-like 1; protein
                     arginine N-methyltransferase 2; PRMT2 alpha; PRMT2 beta;
                     PRMT2 gamma; histone-arginine N-methyltransferase PRMT2;
                     HMT1 hnRNP methyltransferase-like 1"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 2 isoform
                     1"
                     /protein_id="NP_996845.1"
                     /db_xref="CCDS:CCDS13737.1"
                     /db_xref="GeneID:3275"
                     /db_xref="HGNC:HGNC:5186"
                     /db_xref="MIM:601961"
                     /translation="MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAAT
                     DETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDEYDPEDTWQDEEY
                     FGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYAR
                     PRAVYAVEASEMAQHTGQLVLQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLL
                     FEFMIESILYARDAWLKEDGVIWPTMAALHLVPCSADKDYRSKVLFWDNAYEFNLSAL
                     KSLAVKEFFSKPKYNHILKPEDCLSEPCTILQLDMRTVQISDLETLRGELRFDIRKAG
                     TLHGFTAWFSVHFQSLQEGQPPQVLSTGPFHPTTHWKQTLFMMDDPVPVHTGDVVTGS
                     VVLQRNPVWRRHMSVALSWAVTSRQDPTSQKVGEKVFPIWR"
     exon            295..399
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..582
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            583..744
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..909
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1085
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1215
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1352
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1524
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..2354
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2153..2158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /note="hexamer: AATAAA"
     polyA_site      2171
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /note="major polyA site"
     regulatory      2334..2339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
                     /note="hexamer: ATTAAA"
     polyA_site      2354
                     /gene="PRMT2"
                     /gene_synonym="HRMT1L1"
ORIGIN      
        1 gagggcggtg gctcaggctc ctggaaagga ccgtccaccc ctccgcgctg gcggtgtgga
       61 cgcggaactc agcggagaaa cgcgattgag agcagtgtgt ggattacact atcactggaa
      121 aaatacgaat tgagaagaag gaaaagactg gaagatgcag accttggttc ctgttagtgg
      181 aaacactgta aggtcccaga aatggaaaag aaaatgaaat aaatcagcag ttatgaggca
      241 gagcctaaga gaactatggc aacatcaggt gactgtccca gaagtgaatc gcagggagaa
      301 gagcctgctg agtgcagtga ggccggtctc ctgcaggagg gagtacagcc agaggagttt
      361 gtggccatcg cggactacgc tgccaccgat gagacccagc tcagtttttt gagaggagaa
      421 aaaattctta tcctgagaca aaccactgca gattggtggt ggggtgagcg tgcgggctgc
      481 tgtgggtaca ttccggcaaa ccatgtgggg aagcacgtgg atgagtacga ccccgaggac
      541 acgtggcagg atgaagagta cttcggcagc tatggaactc tgaaactcca cttggagatg
      601 ttggcagacc agccacgaac aactaaatac cacagtgtca tcctgcagaa taaagaatcc
      661 ctgacggata aagtcatcct ggacgtgggc tgtgggactg ggatcatcag tctcttctgt
      721 gcacactatg cgcggcctag agcggtgtac gcggtggagg ccagtgagat ggcacagcac
      781 acggggcagc tggtcctgca gaacggcttt gctgacatca tcaccgtgta ccagcagaag
      841 gtggaggatg tggtgctgcc cgagaaggtg gacgtgctgg tgtctgagtg gatggggacc
      901 tgcctgctgt ttgagttcat gatcgagtcc atcctgtatg cccgggatgc ctggctgaag
      961 gaggacgggg tcatttggcc caccatggct gcgttgcacc ttgtgccctg cagtgctgat
     1021 aaggattatc gtagcaaggt gctcttctgg gacaacgcgt acgagttcaa cctcagcgct
     1081 ctgaaatctt tagcagttaa ggagtttttt tcaaagccca agtataacca cattttgaaa
     1141 ccagaagact gtctctctga accgtgcact atattgcagt tggacatgag aaccgtgcaa
     1201 atttctgatc tagagaccct gaggggcgag ctgcgcttcg acatcaggaa ggcggggacc
     1261 ctgcacggct tcacggcctg gtttagcgtc cacttccaga gcctgcagga ggggcagccg
     1321 ccgcaggtgc tcagcaccgg gcccttccac cccaccacac actggaagca gacgctgttc
     1381 atgatggacg acccagtccc tgtccataca ggagacgtgg tcacgggttc agttgtgttg
     1441 cagagaaacc cagtgtggag aaggcacatg tctgtggctc tgagctgggc tgtcacttcc
     1501 agacaagacc ccacatctca aaaagttgga gaaaaagtct tccccatctg gagatgacag
     1561 ttgatgcttt atttggaaag cagtgtgcat atcttgaggg gtgatgaaca caagcaaacc
     1621 aagttgcacc tggcttctgc acactcctgc gaaagtcggt gaacattcac tccacattga
     1681 cccctcccta gcctggcagg tgacgtcagg gtccttcaca gacaaacacg cttgggctcg
     1741 gcaggagctg ccgtggccac ccccgctgcc cagtgtctgc cctctagaag taggctgtgt
     1801 ttccaggtgt tcacccgtgg tgcccacagt gccgacccgt ggctgggtcg gagctccatg
     1861 ttcctaagct aggtctaggt ctacactcct aggacgcacg catatcagcc cgtgtaccct
     1921 gtgacagtga ctgtccccac ctcctatgtt agtggtgccc ttactgccgt cgctcatcca
     1981 ctcgtgtggg acgtaggatt gcacagggct gtgccagtgg cgtgtaggga acactgccct
     2041 ggctcagcgt gcgagctaag gtggtgatgt atgcgatggg actctgcatg ggatagtaca
     2101 gttgtgtaga cgtcttccaa ataaattatg tgttggtcca tcgcacatgc tcaataaata
     2161 tttttaaatg agtgaatgtc attgtgtatc ctgttttatg catatatgtt attttttgta
     2221 attacaggat catactatat gcattgcttt ataagttttt ctcaatattg tgaaaaaact
     2281 tccacatcag tagatacatg tccataattt ttttttgtat tgttttgatt tttattaaat
     2341 tttattgaaa tata
//
