LOCUS       NM_001536               1328 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens protein arginine methyltransferase 1 (PRMT1),
            transcript variant 1, mRNA.
ACCESSION   NM_001536
VERSION     NM_001536.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1328)
  AUTHORS   Zhang,Y., Mao,L., Jiang,A., Liu,J., Lu,Y., Yao,C. and Huang,G.
  TITLE     PRMT1 mediates the proliferation of Y79 retinoblastoma cells by
            regulating the p53/p21/CDC2/cyclin B pathway
  JOURNAL   Exp Eye Res 247, 110040 (2024)
   PUBMED   39134132
  REMARK    GeneRIF: PRMT1 mediates the proliferation of Y79 retinoblastoma
            cells by regulating the p53/p21/CDC2/cyclin B pathway.
REFERENCE   2  (bases 1 to 1328)
  AUTHORS   Walton,J., Ng,A.S.N., Arevalo,K., Apostoli,A., Meens,J.,
            Karamboulas,C., St-Germain,J., Prinos,P., Dmytryshyn,J., Chen,E.,
            Arrowsmith,C.H., Raught,B. and Ailles,L.
  TITLE     PRMT1 inhibition perturbs RNA metabolism and induces DNA damage in
            clear cell renal cell carcinoma
  JOURNAL   Nat Commun 15 (1), 8232 (2024)
   PUBMED   39300069
  REMARK    GeneRIF: PRMT1 inhibition perturbs RNA metabolism and induces DNA
            damage in clear cell renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1328)
  AUTHORS   Wang,H., Li,Y., Wu,N., Lv,C. and Wang,Y.
  TITLE     P4HB regulates the TGFbeta/SMAD3 signaling pathway through PRMT1 to
            participate in high glucose-induced epithelial-mesenchymal
            transition and fibrosis of renal tubular epithelial cells
  JOURNAL   BMC Nephrol 25 (1), 297 (2024)
   PUBMED   39251943
  REMARK    GeneRIF: P4HB regulates the TGFbeta/SMAD3 signaling pathway through
            PRMT1 to participate in high glucose-induced epithelial-mesenchymal
            transition and fibrosis of renal tubular epithelial cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1328)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1328)
  AUTHORS   Yoshimatsu,M., Toyokawa,G., Hayami,S., Unoki,M., Tsunoda,T.,
            Field,H.I., Kelly,J.D., Neal,D.E., Maehara,Y., Ponder,B.A.,
            Nakamura,Y. and Hamamoto,R.
  TITLE     Dysregulation of PRMT1 and PRMT6, Type I arginine
            methyltransferases, is involved in various types of human cancers
  JOURNAL   Int J Cancer 128 (3), 562-573 (2011)
   PUBMED   20473859
  REMARK    GeneRIF: PRMT1 may be involved in human carcinogenesis and may thus
            be a therapeutic target for various types of cancer.
REFERENCE   6  (bases 1 to 1328)
  AUTHORS   Scorilas,A., Black,M.H., Talieri,M. and Diamandis,E.P.
  TITLE     Genomic organization, physical mapping, and expression analysis of
            the human protein arginine methyltransferase 1 gene
  JOURNAL   Biochem Biophys Res Commun 278 (2), 349-359 (2000)
   PUBMED   11097842
REFERENCE   7  (bases 1 to 1328)
  AUTHORS   Abramovich,C., Yakobson,B., Chebath,J. and Revel,M.
  TITLE     A protein-arginine methyltransferase binds to the intracytoplasmic
            domain of the IFNAR1 chain in the type I interferon receptor
  JOURNAL   EMBO J 16 (2), 260-266 (1997)
   PUBMED   9029147
REFERENCE   8  (bases 1 to 1328)
  AUTHORS   Lin,W.J., Gary,J.D., Yang,M.C., Clarke,S. and Herschman,H.R.
  TITLE     The mammalian immediate-early TIS21 protein and the
            leukemia-associated BTG1 protein interact with a protein-arginine
            N-methyltransferase
  JOURNAL   J Biol Chem 271 (25), 15034-15044 (1996)
   PUBMED   8663146
REFERENCE   9  (bases 1 to 1328)
  AUTHORS   Rajpurohit,R., Lee,S.O., Park,J.O., Paik,W.K. and Kim,S.
  TITLE     Enzymatic methylation of recombinant heterogeneous nuclear RNP
            protein A1. Dual substrate specificity for
            S-adenosylmethionine:histone-arginine N-methyltransferase
  JOURNAL   J Biol Chem 269 (2), 1075-1082 (1994)
   PUBMED   8288564
REFERENCE   10 (bases 1 to 1328)
  AUTHORS   Baldwin,G.S. and Carnegie,P.R.
  TITLE     Specific enzymic methylation of an arginine in the experimental
            allergic encephalomyelitis protein from human myelin
  JOURNAL   Science 171 (3971), 579-581 (1971)
   PUBMED   4924231
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC421815.1, Y10806.1 and
            AK304660.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 20, 2020 this sequence version replaced NM_001536.5.
            
            Summary: This gene encodes a member of the protein arginine
            N-methyltransferase (PRMT) family. Post-translational modification
            of target proteins by PRMTs plays an important regulatory role in
            many biological processes, whereby PRMTs methylate arginine
            residues by transferring methyl groups from S-adenosyl-L-methionine
            to terminal guanidino nitrogen atoms. The encoded protein is a type
            I PRMT and is responsible for the majority of cellular arginine
            methylation activity. Increased expression of this gene may play a
            role in many types of cancer. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene, and a pseudogene of this gene is located on the long arm of
            chromosome 5. [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y10806.1, D66904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000454376.7/ ENSP00000406162.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DC421815.1         120-134
            16-362              Y10806.1           4-350
            363-363             AK304660.1         428-428
            364-1328            Y10806.1           352-1316
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1328
                     /gene="PRMT1"
                     /gene_synonym="ANM1; HCP1; HRMT1L2; IR1B4"
                     /note="protein arginine methyltransferase 1"
                     /db_xref="GeneID:3276"
                     /db_xref="HGNC:HGNC:5187"
                     /db_xref="MIM:602950"
     exon            1..46
                     /gene="PRMT1"
                     /gene_synonym="ANM1; HCP1; HRMT1L2; IR1B4"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1126
                     /gene="PRMT1"
                     /gene_synonym="ANM1; HCP1; HRMT1L2; IR1B4"
                     /EC_number="2.1.1.319"
                     /note="isoform 1 is encoded by transcript variant 1; HMT1
                     (hnRNP methyltransferase, S. cerevisiae)-like 2; protein
                     arginine N-methyltransferase 1; interferon receptor
                     1-bound protein 4; histone-arginine N-methyltransferase
                     PRMT1; heterogeneous nuclear ribonucleoprotein
                     methyltransferase 1-like 2; highly conserved protein 1"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 1 isoform
                     1"
                     /protein_id="NP_001527.3"
                     /db_xref="CCDS:CCDS46145.1"
                     /db_xref="GeneID:3276"
                     /db_xref="HGNC:HGNC:5187"
                     /db_xref="MIM:602950"
                     /translation="MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNA
                     EDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGIL
                     CMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIII
                     SEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWEN
                     VYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVK
                     RNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGT
                     IGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR"
     exon            47..100
                     /gene="PRMT1"
                     /gene_synonym="ANM1; HCP1; HRMT1L2; IR1B4"
                     /inference="alignment:Splign:2.1.0"
     exon            101..202
                     /gene="PRMT1"
                     /gene_synonym="ANM1; HCP1; HRMT1L2; IR1B4"
                     /inference="alignment:Splign:2.1.0"
     exon            203..358
                     /gene="PRMT1"
                     /gene_synonym="ANM1; HCP1; HRMT1L2; IR1B4"
                     /inference="alignment:Splign:2.1.0"
     exon            359..422
                     /gene="PRMT1"
                     /gene_synonym="ANM1; HCP1; HRMT1L2; IR1B4"
                     /inference="alignment:Splign:2.1.0"
     exon            423..565
                     /gene="PRMT1"
                     /gene_synonym="ANM1; HCP1; HRMT1L2; IR1B4"
                     /inference="alignment:Splign:2.1.0"
     exon            566..653
                     /gene="PRMT1"
                     /gene_synonym="ANM1; HCP1; HRMT1L2; IR1B4"
                     /inference="alignment:Splign:2.1.0"
     exon            654..769
                     /gene="PRMT1"
                     /gene_synonym="ANM1; HCP1; HRMT1L2; IR1B4"
                     /inference="alignment:Splign:2.1.0"
     exon            770..920
                     /gene="PRMT1"
                     /gene_synonym="ANM1; HCP1; HRMT1L2; IR1B4"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1042
                     /gene="PRMT1"
                     /gene_synonym="ANM1; HCP1; HRMT1L2; IR1B4"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1328
                     /gene="PRMT1"
                     /gene_synonym="ANM1; HCP1; HRMT1L2; IR1B4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1311..1316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRMT1"
                     /gene_synonym="ANM1; HCP1; HRMT1L2; IR1B4"
                     /note="hexamer: AATAAA"
     polyA_site      1328
                     /gene="PRMT1"
                     /gene_synonym="ANM1; HCP1; HRMT1L2; IR1B4"
                     /note="major polyA site"
ORIGIN      
        1 gcgggtgaag atggcggcag ccgaggccgc gaactgcatc atggagaatt ttgtagccac
       61 cttggctaat gggatgagcc tccagccgcc tcttgaagaa gtgtcctgtg gccaggcgga
      121 aagcagtgag aagcccaacg ctgaggacat gacatccaaa gattactact ttgactccta
      181 cgcacacttt ggcatccacg aggagatgct gaaggacgag gtgcgcaccc tcacttaccg
      241 caactccatg tttcataacc ggcacctctt caaggacaag gtggtgctgg acgtcggctc
      301 gggcaccggc atcctctgca tgtttgctgc caaggccggg gcccgcaagg tcatcgggat
      361 cgagtgttcc agtatctctg attatgcggt gaagatcgtc aaagccaaca agttagacca
      421 cgtggtgacc atcatcaagg ggaaggtgga ggaggtggag ctcccagtgg agaaggtgga
      481 catcatcatc agcgagtgga tgggctactg cctcttctac gagtccatgc tcaacaccgt
      541 gctctatgcc cgggacaagt ggctggcgcc cgatggcctc atcttcccag accgggccac
      601 gctgtatgtg acggccatcg aggaccggca gtacaaagac tacaagatcc actggtggga
      661 gaacgtgtat ggcttcgaca tgtcttgcat caaagatgtg gccattaagg agcccctagt
      721 ggatgtcgtg gaccccaaac agctggtcac caacgcctgc ctcataaagg aggtggacat
      781 ctataccgtc aaggtggaag acctgacctt cacctccccg ttctgcctgc aagtgaagcg
      841 gaatgactac gtgcacgccc tggtggccta cttcaacatc gagttcacac gctgccacaa
      901 gaggaccggc ttctccacca gccccgagtc cccgtacacg cactggaagc agacggtgtt
      961 ctacatggag gactacctga ccgtgaagac gggcgaggag atcttcggca ccatcggcat
     1021 gcggcccaac gccaagaaca accgggacct ggacttcacc atcgacctgg acttcaaggg
     1081 ccagctgtgc gagctgtcct gctccaccga ctaccggatg cgctgaggcc cggctctccc
     1141 gccctgcacg agcccagggg ctgagcgttc ctaggcggtt tcggggctcc cccttcctct
     1201 ccctccctcc cgcagaaggg ggttttaggg gcctgggctg gggggatggg gagggcacat
     1261 cgtgactgtg tttttcataa cttatgtttt tatatggttg catttacgcc aataaatcct
     1321 cagctggg
//
