LOCUS       NM_021247                431 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens protamine 3 (PRM3), mRNA.
ACCESSION   NM_021247 XM_929446
VERSION     NM_021247.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 431)
  AUTHORS   Wade,T.D., Gordon,S., Medland,S., Bulik,C.M., Heath,A.C.,
            Montgomery,G.W. and Martin,N.G.
  TITLE     Genetic variants associated with disordered eating
  JOURNAL   Int J Eat Disord 46 (6), 594-608 (2013)
   PUBMED   23568457
REFERENCE   2  (bases 1 to 431)
  AUTHORS   Imken,L., Rouba,H., El Houate,B., Louanjli,N., Barakat,A.,
            Chafik,A. and McElreavey,K.
  TITLE     Mutations in the protamine locus: association with spermatogenic
            failure?
  JOURNAL   Mol Hum Reprod 15 (11), 733-738 (2009)
   PUBMED   19602509
  REMARK    GeneRIF: Mutations in the protamine locus may be an infrequent
            cause of male infertility.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 431)
  AUTHORS   Oliva,R.
  TITLE     Protamines and male infertility
  JOURNAL   Hum Reprod Update 12 (4), 417-435 (2006)
   PUBMED   16581810
  REMARK    Review article
REFERENCE   4  (bases 1 to 431)
  AUTHORS   Kramer,J.A. and Krawetz,S.A.
  TITLE     Genesis of a novel human sequence from the protamine PRM1 gene
  JOURNAL   Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 120 (3),
            467-473 (1998)
   PUBMED   9827065
REFERENCE   5  (bases 1 to 431)
  AUTHORS   Schluter,G., Celik,A., Obata,R., Schlicker,M., Hofferbert,S.,
            Schlung,A., Adham,I.M. and Engel,W.
  TITLE     Sequence analysis of the conserved protamine gene cluster shows
            that it contains a fourth expressed gene
  JOURNAL   Mol Reprod Dev 43 (1), 1-6 (1996)
   PUBMED   8720108
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009121.8, AW666005.1 and KF459690.1.
            
            On May 17, 2019 this sequence version replaced NM_021247.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: ERR279831.10881.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327157.4/ ENSP00000325638.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC009121.8         90374-90459
            87-332              AW666005.1         101-346             c
            333-333             KF459690.1         6-6
            334-423             AW666005.1         10-99               c
            424-431             KF459690.1         97-104
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.13"
     gene            1..431
                     /gene="PRM3"
                     /note="protamine 3"
                     /db_xref="GeneID:58531"
                     /db_xref="HGNC:HGNC:13732"
     exon            1..431
                     /gene="PRM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..346
                     /gene="PRM3"
                     /note="gene 4; sperm protamine P3"
                     /codon_start=1
                     /product="protamine-3"
                     /protein_id="NP_067070.2"
                     /db_xref="CCDS:CCDS76821.1"
                     /db_xref="GeneID:58531"
                     /db_xref="HGNC:HGNC:13732"
                     /translation="MGSRCAKLNTGQSPGHSPGHSTGHGRGHESSMKKLMACVSQDNF
                     SLSSAGEEEEEEEEEGEEEEKEELPVQGKLLLLEPERQEEGHKDNAEAQQSPEPKRTP
                     S"
     regulatory      412..417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRM3"
                     /note="hexamer: AATAAA"
     polyA_site      431
                     /gene="PRM3"
                     /note="major polyA site"
ORIGIN      
        1 acctccttgc ccagagagac aggcaacgta gaccatgggt tcccgctgtg ccaagctcaa
       61 cacaggccag agcccaggcc acagcccagg ccacagcacg ggccatggcc ggggccacga
      121 atcctccatg aaaaagctca tggcctgtgt gagtcaggat aacttctcct tgtcatcagc
      181 gggcgaggaa gaggaggaag aggaggagga gggggaagag gaggagaaag aagagctgcc
      241 ggtgcagggc aagctgctgc tgctggagcc tgagcggcag gaggagggcc acaaggacaa
      301 cgccgaggcc cagcagagcc ccgagcccaa gcggacaccc tcctgacccg caacgaaggc
      361 ccaggaaggg acgcccactg ctgctccggc gacagtgttc agagaagagt caataaaaag
      421 tctctgagga a
//
