LOCUS       NM_002761                399 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens protamine 1 (PRM1), mRNA.
ACCESSION   NM_002761
VERSION     NM_002761.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 399)
  AUTHORS   Schon,S.B., Moritz,L., Rabbani,M., Meguid,J., Juliano,B.R.,
            Ruotolo,B.T., Aston,K. and Hammoud,S.S.
  TITLE     Proteomic analysis of human sperm reveals changes in protamine 1
            phosphorylation in men with infertility
  JOURNAL   F S Sci 5 (2), 121-129 (2024)
   PUBMED   38065301
  REMARK    GeneRIF: Proteomic analysis of human sperm reveals changes in
            protamine 1 phosphorylation in men with infertility.
REFERENCE   2  (bases 1 to 399)
  AUTHORS   Pathak,D., Baksi,A., Vasan,S.S. and Dighe,R.R.
  TITLE     Molecular and Functional Characterization of Human Sex-Determining
            Region on the Y Chromosome Variants Using Protamine 1 Promoter
  JOURNAL   DNA Cell Biol 43 (1), 12-25 (2024)
   PUBMED   38170186
  REMARK    GeneRIF: Molecular and Functional Characterization of Human
            Sex-Determining Region on the Y Chromosome Variants Using Protamine
            1 Promoter.
REFERENCE   3  (bases 1 to 399)
  AUTHORS   Qin,L., Dong,Z., Huang,C., Liu,H., Beebe,J., Subramaniyan,B.,
            Hao,Y., Liu,Y., He,Z., Liu,J.Y. and Zhang,J.T.
  TITLE     Reversible promoter demethylation of PDGFD confers gemcitabine
            resistance through STAT3 activation and RRM1 upregulation
  JOURNAL   Cancer Lett 567, 216266 (2023)
   PUBMED   37321532
  REMARK    GeneRIF: Reversible promoter demethylation of PDGFD confers
            gemcitabine resistance through STAT3 activation and RRM1
            upregulation.
REFERENCE   4  (bases 1 to 399)
  AUTHORS   Ren,S., Yang,D., Dong,Y., Ni,W., Wang,M., Xing,L., Liu,T., Hou,W.,
            Sun,W., Zhang,H., Yu,Z., Liu,Y., Cao,J., Yan,H., Feng,Y., Fang,X.,
            Wang,Q. and Chen,F.
  TITLE     Protamine 1 as a secreted colorectal cancer-specific antigen
            facilitating G1/S phase transition under nutrient stress conditions
  JOURNAL   Cell Oncol (Dordr) 46 (2), 357-373 (2023)
   PUBMED   36593375
  REMARK    GeneRIF: Protamine 1 as a secreted colorectal cancer-specific
            antigen facilitating G1/S phase transition under nutrient stress
            conditions.
REFERENCE   5  (bases 1 to 399)
  AUTHORS   Amor,H., Jankowski,P.M., Dahadhah,F.W., Al Zoubi,M.S. and
            Hammadeh,M.E.
  TITLE     Impact of tobacco smoking in association with H2BFWT, PRM1 and PRM2
            genes variants on male infertility
  JOURNAL   Andrologia 54 (11), e14611 (2022)
   PUBMED   36217675
  REMARK    GeneRIF: Impact of tobacco smoking in association with H2BFWT, PRM1
            and PRM2 genes variants on male infertility.
REFERENCE   6  (bases 1 to 399)
  AUTHORS   Domenjoud,L., Nussbaum,G., Adham,I.M., Greeske,G. and Engel,W.
  TITLE     Genomic sequences of human protamines whose genes, PRM1 and PRM2,
            are clustered
  JOURNAL   Genomics 8 (1), 127-133 (1990)
   PUBMED   2081589
REFERENCE   7  (bases 1 to 399)
  AUTHORS   Viguie,F., Domenjoud,L., Rousseau-Merck,M.F., Dadoune,J.P. and
            Chevaillier,P.
  TITLE     Chromosomal localization of the human protamine genes, PRM1 and
            PRM2, to 16p13.3 by in situ hybridization
  JOURNAL   Hum Genet 85 (2), 171-174 (1990)
   PUBMED   2370044
REFERENCE   8  (bases 1 to 399)
  AUTHORS   Krawetz,S.A., Herfort,M.H., Hamerton,J.L., Pon,R.T. and Dixon,G.H.
  TITLE     Chromosomal localization and structure of the human P1 protamine
            gene
  JOURNAL   Genomics 5 (3), 639-645 (1989)
   PUBMED   2613245
REFERENCE   9  (bases 1 to 399)
  AUTHORS   Lee,C.H., Hoyer-Fender,S. and Engel,W.
  TITLE     The nucleotide sequence of a human protamine 1 cDNA
  JOURNAL   Nucleic Acids Res 15 (18), 7639 (1987)
   PUBMED   3658707
REFERENCE   10 (bases 1 to 399)
  AUTHORS   Ammer,H., Henschen,A. and Lee,C.H.
  TITLE     Isolation and amino-acid sequence analysis of human sperm
            protamines P1 and P2. Occurrence of two forms of protamine P2
  JOURNAL   Biol Chem Hoppe Seyler 367 (6), 515-522 (1986)
   PUBMED   3527226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009121.8, AY651260.1 and CD360017.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002761.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP371182.1, HM005404.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312511.4/ ENSP00000310515.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC009121.8         82673-82686
            15-230              AY651260.1         1-216
            231-231             AC009121.8         82994-82994
            232-399             CD360017.1         211-378
FEATURES             Location/Qualifiers
     source          1..399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.13"
     gene            1..399
                     /gene="PRM1"
                     /gene_synonym="CT94.1; P1"
                     /note="protamine 1"
                     /db_xref="GeneID:5619"
                     /db_xref="HGNC:HGNC:9447"
                     /db_xref="MIM:182880"
     exon            1..204
                     /gene="PRM1"
                     /gene_synonym="CT94.1; P1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..248
                     /gene="PRM1"
                     /gene_synonym="CT94.1; P1"
                     /note="cancer/testis antigen family 94, member 1; testis
                     specific protamine 1; cysteine-rich protamine; testicular
                     tissue protein Li 91"
                     /codon_start=1
                     /product="sperm protamine P1"
                     /protein_id="NP_002752.1"
                     /db_xref="CCDS:CCDS10547.1"
                     /db_xref="GeneID:5619"
                     /db_xref="HGNC:HGNC:9447"
                     /db_xref="MIM:182880"
                     /translation="MARYRCCRSQSRSRYYRQRQRSRRRRRRSCQTRRRAMRCCRPRY
                     RPRCRRH"
     exon            205..399
                     /gene="PRM1"
                     /gene_synonym="CT94.1; P1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      381..386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRM1"
                     /gene_synonym="CT94.1; P1"
                     /note="hexamer: AATAAA"
     polyA_site      399
                     /gene="PRM1"
                     /gene_synonym="CT94.1; P1"
                     /note="major polyA site"
ORIGIN      
        1 acagcccaca gagttccacc tgctcacagg ttggctggct cagccaaggt ggtgccctgc
       61 tctgagcatt caggccaagc ccatcctgca ccatggccag gtacagatgc tgtcgcagcc
      121 agagccggag cagatattac cgccagagac aaagaagtcg cagacgaagg aggcggagct
      181 gccagacacg gaggagagcc atgaggtgct gccgccccag gtacagaccg cgatgtagaa
      241 gacactaatt gcacaaaata gcacatccac caaactcctg cctgagaatg ttaccagact
      301 tcaagatcct cttgccacat cttgaaaatg ccaccatcca ataaaaatca ggagcctgct
      361 aaggaacaat gccgcctgtc aataaatgtt gaaaagtca
//
