LOCUS       NM_001204316            1785 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens prolactin receptor (PRLR), transcript variant 3, mRNA.
ACCESSION   NM_001204316
VERSION     NM_001204316.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1785)
  AUTHORS   Shen,S., Radhakrishnan,S.K., Harrell,J.C., Puchalapalli,M.,
            Koblinski,J. and Clevenger,C.
  TITLE     The Human Intermediate Prolactin Receptor I-tail Contributes Breast
            Oncogenesis by Targeting Ras/MAPK Pathway
  JOURNAL   Endocrinology 165 (6) (2024)
   PUBMED   38713636
  REMARK    GeneRIF: The Human Intermediate Prolactin Receptor I-tail
            Contributes Breast Oncogenesis by Targeting Ras/MAPK Pathway.
REFERENCE   2  (bases 1 to 1785)
  AUTHORS   Amin,M. and Gragnoli,C.
  TITLE     The prolactin receptor gene (PRLR) is linked and associated with
            the risk of polycystic ovarian syndrome
  JOURNAL   J Ovarian Res 16 (1), 222 (2023)
   PUBMED   37993904
  REMARK    GeneRIF: The prolactin receptor gene (PRLR) is linked and
            associated with the risk of polycystic ovarian syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1785)
  AUTHORS   Araya-Secchi,R., Bugge,K., Seiffert,P., Petry,A., Haxholm,G.W.,
            Lindorff-Larsen,K., Pedersen,S.F., Arleth,L. and Kragelund,B.B.
  TITLE     The prolactin receptor scaffolds Janus kinase 2 via co-structure
            formation with phosphoinositide-4,5-bisphosphate
  JOURNAL   Elife 12, e84645 (2023)
   PUBMED   37232489
  REMARK    GeneRIF: The prolactin receptor scaffolds Janus kinase 2 via
            co-structure formation with phosphoinositide-4,5-bisphosphate.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1785)
  AUTHORS   Begon,E. and Bernard,V.
  TITLE     [Prolactin and its receptor: From animal models to pituitary
            pathophysiology]
  JOURNAL   Biol Aujourdhui 216 (3-4), 105-110 (2022)
   PUBMED   36744975
  REMARK    GeneRIF: [Prolactin and its receptor: From animal models to
            pituitary pathophysiology].
REFERENCE   5  (bases 1 to 1785)
  AUTHORS   Trott,J.F., Hovey,R.C., Koduri,S. and Vonderhaar,B.K.
  TITLE     Alternative splicing to exon 11 of human prolactin receptor gene
            results in multiple isoforms including a secreted prolactin-binding
            protein
  JOURNAL   J Mol Endocrinol 30 (1), 31-47 (2003)
   PUBMED   12580759
REFERENCE   6  (bases 1 to 1785)
  AUTHORS   Kline,J.B., Rycyzyn,M.A. and Clevenger,C.V.
  TITLE     Characterization of a novel and functional human prolactin receptor
            isoform (deltaS1PRLr) containing only one extracellular
            fibronectin-like domain
  JOURNAL   Mol Endocrinol 16 (10), 2310-2322 (2002)
   PUBMED   12351696
  REMARK    GeneRIF: Given its apparent widespread expression, this PRLr
            isoform may contribute to PRL action.
REFERENCE   7  (bases 1 to 1785)
  AUTHORS   Kline,J.B., Roehrs,H. and Clevenger,C.V.
  TITLE     Functional characterization of the intermediate isoform of the
            human prolactin receptor
  JOURNAL   J Biol Chem 274 (50), 35461-35468 (1999)
   PUBMED   10585417
REFERENCE   8  (bases 1 to 1785)
  AUTHORS   Rozakis-Adcock,M. and Kelly,P.A.
  TITLE     Identification of ligand binding determinants of the prolactin
            receptor
  JOURNAL   J Biol Chem 267 (11), 7428-7433 (1992)
   PUBMED   1559983
REFERENCE   9  (bases 1 to 1785)
  AUTHORS   Di Carlo,R., Muccioli,G., Papotti,M. and Bussolati,G.
  TITLE     Characterization of prolactin receptor in human brain and choroid
            plexus
  JOURNAL   Brain Res 570 (1-2), 341-346 (1992)
   PUBMED   1617425
REFERENCE   10 (bases 1 to 1785)
  AUTHORS   Arden,K.C., Boutin,J.M., Djiane,J., Kelly,P.A. and Cavenee,W.K.
  TITLE     The receptors for prolactin and growth hormone are localized in the
            same region of human chromosome 5
  JOURNAL   Cytogenet Cell Genet 53 (2-3), 161-165 (1990)
   PUBMED   2369845
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M31661.1 and AF416619.1.
            
            Summary: This gene encodes a receptor for the anterior pituitary
            hormone, prolactin, and belongs to the type I cytokine receptor
            family. Prolactin-dependent signaling occurs as the result of
            ligand-induced dimerization of the prolactin receptor. Several
            alternatively spliced transcript variants encoding different
            membrane-bound and soluble isoforms have been described for this
            gene, which may function to modulate the endocrine and autocrine
            effects of prolactin in normal tissue and cancer. [provided by
            RefSeq, Feb 2011].
            
            Transcript Variant: This variant (3) contains an alternate 3'
            terminal exon compared to variant 1. This results in a frame-shift
            and a shorter isoform (3, also known as SF1a for short form 1a)
            with a distinct C-terminus compared to isoform 1. This isoform is
            functional with a dominant-negative effect on the function of
            isoform 1 (PMID:12580759).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF416619.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1114              M31661.1           180-1293
            1115-1785           AF416619.1         1027-1697
FEATURES             Location/Qualifiers
     source          1..1785
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.2"
     gene            1..1785
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /note="prolactin receptor"
                     /db_xref="GeneID:5618"
                     /db_xref="HGNC:HGNC:9446"
                     /db_xref="MIM:176761"
     exon            1..62
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            63..175
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1236
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; hPRL receptor; secreted prolactin binding
                     protein"
                     /codon_start=1
                     /product="prolactin receptor isoform 3 precursor"
                     /protein_id="NP_001191245.1"
                     /db_xref="CCDS:CCDS56361.1"
                     /db_xref="GeneID:5618"
                     /db_xref="HGNC:HGNC:9446"
                     /db_xref="MIM:176761"
                     /translation="MKENVASATVFTLLLFLNTCLLNGQLPPGKPEIFKCRSPNKETF
                     TCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMM
                     VNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLK
                     TGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAW
                     SPATFIQIPSDFTMNDTTVWISVAVLSAVICLIIVWAVALKGYSMVTCIFPPVPGPKI
                     KGFDAHLLEKGKSEELLSALGCQDFPPTSDYEDLLVEYLEVDDSEDQHLMSVHSKEHP
                     SQGDPLMLGASHYKNLKSYRPRKISSQGRLAVFTKATLTTVQ"
     exon            176..308
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            309..478
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            479..648
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            649..790
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            791..890
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            891..960
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1114
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1767
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1767
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
ORIGIN      
        1 ctaaagaact ctcctattca tggaggcgaa cactgaggat gctttccaca tgaaccctga
       61 agtgaacttc tgatacattt cctgcagcaa gagaaggcag ccaacatgaa ggaaaatgtg
      121 gcatctgcaa ccgttttcac tctgctactt tttctcaaca cctgccttct gaatggacag
      181 ttacctcctg gaaaacctga gatctttaaa tgtcgttctc ccaataagga aacattcacc
      241 tgctggtgga ggcctgggac agatggagga cttcctacca attattcact gacttaccac
      301 agggaaggag agacactcat gcatgaatgt ccagactaca taaccggtgg ccccaactcc
      361 tgccactttg gcaagcagta cacctccatg tggaggacat acatcatgat ggtcaatgcc
      421 actaaccaga tgggaagcag tttctcggat gaactttatg tggacgtgac ttacatagtt
      481 cagccagacc ctcctttgga gctggctgtg gaagtaaaac agccagaaga cagaaaaccc
      541 tacctgtgga ttaaatggtc tccacctacc ctgattgact taaaaactgg ttggttcacg
      601 ctcctgtatg aaattcgatt aaaacccgag aaagcagctg agtgggagat ccattttgct
      661 gggcagcaaa cagagtttaa gattctcagc ctacatccag gacagaaata ccttgtccag
      721 gttcgctgca aaccagacca tggatactgg agtgcatgga gtccagcgac cttcattcag
      781 atacctagtg acttcaccat gaatgataca accgtgtgga tctctgtggc tgtcctttct
      841 gctgtcatct gtttgattat tgtctgggca gtggctttga agggctatag catggtgacc
      901 tgcatctttc cgccagttcc tgggccaaaa ataaaaggat ttgatgctca tctgttggag
      961 aagggcaagt ctgaagaact actgagtgcc ttgggatgcc aagactttcc tcccacttct
     1021 gactatgagg acttgctggt ggagtattta gaagtagatg atagtgagga ccagcatcta
     1081 atgtcagtcc attcaaaaga acacccaagt caaggtgacc ccttgatgtt gggtgcctct
     1141 cattacaaaa atctcaaatc ttacagacca agaaaaatct caagtcaagg aagacttgcg
     1201 gtgttcacaa aggcaacatt gaccacagtc cagtagagct gaagagcata taccagaatt
     1261 caggaactca acattttctc ccctctgtcc aaccacagga cagactgtgc accccaggga
     1321 gatgctgtgt gtccactggc ctcactgact tggattactc ctgcagcacg tgaccagcca
     1381 gctcatatga tcactcccta ctgcccccaa agcagaattg actgggagct ggaaacccac
     1441 acaaaaaggg acaattatat tgaatgtaac atactccctc tgcttaccta gtgccttcac
     1501 ctcctatggg catttggagt aaaaggttgt tatgcaggtg tttgtgaagg atgtggccaa
     1561 gtcagttgtc tcccttacag ggtgacccaa gattaatgat atctacccat ccccagtccc
     1621 tcgaccccct agttgcaatc agctttgtca ctgtccccct taggcactgc catgtaaagc
     1681 acgtggtccc ccattctgaa gcagtgggaa acctagaaga gatgtactct tcgcaacctg
     1741 gttggatctt aaaaacatgg ttctaacaaa aaaaaaaaaa aaaaa
//
