LOCUS       NM_001204314           11069 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens prolactin receptor (PRLR), transcript variant 6, mRNA.
ACCESSION   NM_001204314
VERSION     NM_001204314.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11069)
  AUTHORS   Shen,S., Radhakrishnan,S.K., Harrell,J.C., Puchalapalli,M.,
            Koblinski,J. and Clevenger,C.
  TITLE     The Human Intermediate Prolactin Receptor I-tail Contributes Breast
            Oncogenesis by Targeting Ras/MAPK Pathway
  JOURNAL   Endocrinology 165 (6) (2024)
   PUBMED   38713636
  REMARK    GeneRIF: The Human Intermediate Prolactin Receptor I-tail
            Contributes Breast Oncogenesis by Targeting Ras/MAPK Pathway.
REFERENCE   2  (bases 1 to 11069)
  AUTHORS   Amin,M. and Gragnoli,C.
  TITLE     The prolactin receptor gene (PRLR) is linked and associated with
            the risk of polycystic ovarian syndrome
  JOURNAL   J Ovarian Res 16 (1), 222 (2023)
   PUBMED   37993904
  REMARK    GeneRIF: The prolactin receptor gene (PRLR) is linked and
            associated with the risk of polycystic ovarian syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11069)
  AUTHORS   Araya-Secchi,R., Bugge,K., Seiffert,P., Petry,A., Haxholm,G.W.,
            Lindorff-Larsen,K., Pedersen,S.F., Arleth,L. and Kragelund,B.B.
  TITLE     The prolactin receptor scaffolds Janus kinase 2 via co-structure
            formation with phosphoinositide-4,5-bisphosphate
  JOURNAL   Elife 12, e84645 (2023)
   PUBMED   37232489
  REMARK    GeneRIF: The prolactin receptor scaffolds Janus kinase 2 via
            co-structure formation with phosphoinositide-4,5-bisphosphate.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11069)
  AUTHORS   Begon,E. and Bernard,V.
  TITLE     [Prolactin and its receptor: From animal models to pituitary
            pathophysiology]
  JOURNAL   Biol Aujourdhui 216 (3-4), 105-110 (2022)
   PUBMED   36744975
  REMARK    GeneRIF: [Prolactin and its receptor: From animal models to
            pituitary pathophysiology].
REFERENCE   5  (bases 1 to 11069)
  AUTHORS   Trott,J.F., Hovey,R.C., Koduri,S. and Vonderhaar,B.K.
  TITLE     Alternative splicing to exon 11 of human prolactin receptor gene
            results in multiple isoforms including a secreted prolactin-binding
            protein
  JOURNAL   J Mol Endocrinol 30 (1), 31-47 (2003)
   PUBMED   12580759
REFERENCE   6  (bases 1 to 11069)
  AUTHORS   Kline,J.B., Rycyzyn,M.A. and Clevenger,C.V.
  TITLE     Characterization of a novel and functional human prolactin receptor
            isoform (deltaS1PRLr) containing only one extracellular
            fibronectin-like domain
  JOURNAL   Mol Endocrinol 16 (10), 2310-2322 (2002)
   PUBMED   12351696
  REMARK    GeneRIF: Given its apparent widespread expression, this PRLr
            isoform may contribute to PRL action.
REFERENCE   7  (bases 1 to 11069)
  AUTHORS   Kline,J.B., Roehrs,H. and Clevenger,C.V.
  TITLE     Functional characterization of the intermediate isoform of the
            human prolactin receptor
  JOURNAL   J Biol Chem 274 (50), 35461-35468 (1999)
   PUBMED   10585417
REFERENCE   8  (bases 1 to 11069)
  AUTHORS   Rozakis-Adcock,M. and Kelly,P.A.
  TITLE     Identification of ligand binding determinants of the prolactin
            receptor
  JOURNAL   J Biol Chem 267 (11), 7428-7433 (1992)
   PUBMED   1559983
REFERENCE   9  (bases 1 to 11069)
  AUTHORS   Di Carlo,R., Muccioli,G., Papotti,M. and Bussolati,G.
  TITLE     Characterization of prolactin receptor in human brain and choroid
            plexus
  JOURNAL   Brain Res 570 (1-2), 341-346 (1992)
   PUBMED   1617425
REFERENCE   10 (bases 1 to 11069)
  AUTHORS   Arden,K.C., Boutin,J.M., Djiane,J., Kelly,P.A. and Cavenee,W.K.
  TITLE     The receptors for prolactin and growth hormone are localized in the
            same region of human chromosome 5
  JOURNAL   Cytogenet Cell Genet 53 (2-3), 161-165 (1990)
   PUBMED   2369845
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA640476.1, AF349939.1,
            AC010368.4, KF573643.1 and AI079645.1.
            
            On Apr 11, 2014 this sequence version replaced NM_001204314.1.
            
            Summary: This gene encodes a receptor for the anterior pituitary
            hormone, prolactin, and belongs to the type I cytokine receptor
            family. Prolactin-dependent signaling occurs as the result of
            ligand-induced dimerization of the prolactin receptor. Several
            alternatively spliced transcript variants encoding different
            membrane-bound and soluble isoforms have been described for this
            gene, which may function to modulate the endocrine and autocrine
            effects of prolactin in normal tissue and cancer. [provided by
            RefSeq, Feb 2011].
            
            Transcript Variant: This variant (6) lacks two in-frame coding
            exons compared to variant 1. This results in a shorter isoform (6,
            also known as deltaS1) missing an internal protein segment coding
            for the S1 motif, compared to isoform 1. This isoform has been
            shown to be expressed at the protein level on the cell surface, and
            is functional (PMID:12351696).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF349939.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               DA640476.1         156-260
            106-1671            AF349939.1         1-1566
            1672-7885           AC010368.4         77012-83225
            7886-8317           KF573643.1         1-432               c
            8318-10711          AC010368.4         83655-86048
            10712-11069         AI079645.1         1-358               c
FEATURES             Location/Qualifiers
     source          1..11069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.2"
     gene            1..11069
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /note="prolactin receptor"
                     /db_xref="GeneID:5618"
                     /db_xref="HGNC:HGNC:9446"
                     /db_xref="MIM:176761"
     exon            1..62
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            63..175
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1671
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /note="isoform 6 precursor is encoded by transcript
                     variant 6; hPRL receptor; secreted prolactin binding
                     protein"
                     /codon_start=1
                     /product="prolactin receptor isoform 6 precursor"
                     /protein_id="NP_001191243.1"
                     /db_xref="CCDS:CCDS56358.1"
                     /db_xref="GeneID:5618"
                     /db_xref="HGNC:HGNC:9446"
                     /db_xref="MIM:176761"
                     /translation="MKENVASATVFTLLLFLNTCLLNVQPDPPLELAVEVKQPEDRKP
                     YLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYL
                     VQVRCKPDHGYWSAWSPATFIQIPSDFTMNDTTVWISVAVLSAVICLIIVWAVALKGY
                     SMVTCIFPPVPGPKIKGFDAHLLEKGKSEELLSALGCQDFPPTSDYEDLLVEYLEVDD
                     SEDQHLMSVHSKEHPSQGMKPTYLDPDTDSGRGSCDSPSLLSEKCEEPQANPSTFYDP
                     EVIEKPENPETTHTWDPQCISMEGKIPYFHAGGSKCSTWPLPQPSQHNPRSSYHNITD
                     VCELAVGPAGAPATLLNEAGKDALKSSQTIKSREEGKATQQREVESFHSETDQDTPWL
                     LPQEKTPFGSAKPLDYVEIHKVNKDGALSLLPKQRENSGKPKKPGTPENNKEYAKVSG
                     VMDNNILVLVPDPHAKNVACFEESAKEAPPSLEQNQAEKALANFTATSSKCRLQLGGL
                     DYLDPACFTHSFH"
     exon            176..345
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            346..487
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            488..587
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            588..657
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            658..11063
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10880..10885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /note="hexamer: ATTACA"
     polyA_site      10898
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /note="major polyA site"
     regulatory      11038..11043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /note="hexamer: AATAAA"
     polyA_site      11058
                     /gene="PRLR"
                     /gene_synonym="HPRL; hPRLrI; MFAB; RI-PRLR"
                     /note="major polyA site"
ORIGIN      
        1 ctaaagaact ctcctattca tggaggcgaa cactgaggat gctttccaca tgaaccctga
       61 agtgaacttc tgatacattt cctgcagcaa gagaaggcag ccaacatgaa ggaaaatgtg
      121 gcatctgcaa ccgttttcac tctgctactt tttctcaaca cctgccttct gaatgttcag
      181 ccagaccctc ctttggagct ggctgtggaa gtaaaacagc cagaagacag aaaaccctac
      241 ctgtggatta aatggtctcc acctaccctg attgacttaa aaactggttg gttcacgctc
      301 ctgtatgaaa ttcgattaaa acccgagaaa gcagctgagt gggagatcca ttttgctggg
      361 cagcaaacag agtttaagat tctcagccta catccaggac agaaatacct tgtccaggtt
      421 cgctgcaaac cagaccatgg atactggagt gcatggagtc cagcgacctt cattcagata
      481 cctagtgact tcaccatgaa tgatacaacc gtgtggatct ctgtggctgt cctttctgct
      541 gtcatctgtt tgattattgt ctgggcagtg gctttgaagg gctatagcat ggtgacctgc
      601 atctttccgc cagttcctgg gccaaaaata aaaggatttg atgctcatct gttggagaag
      661 ggcaagtctg aagaactact gagtgccttg ggatgccaag actttcctcc cacttctgac
      721 tatgaggact tgctggtgga gtatttagaa gtagatgata gtgaggacca gcatctaatg
      781 tcagtccatt caaaagaaca cccaagtcaa ggtatgaaac ccacatacct ggatcctgac
      841 actgactcag gccgggggag ctgtgacagc ccttcccttt tgtctgaaaa gtgtgaggaa
      901 ccccaggcca atccctccac attctatgat cctgaggtca ttgagaagcc agagaatcct
      961 gaaacaaccc acacctggga cccccagtgc ataagcatgg aaggcaaaat cccctatttt
     1021 catgctggtg gatccaaatg ttcaacatgg cccttaccac agcccagcca gcacaacccc
     1081 agatcctctt accacaatat tactgatgtg tgtgagctgg ctgtgggccc tgcaggtgca
     1141 ccggccactc tgttgaatga agcaggtaaa gatgctttaa aatcctctca aaccattaag
     1201 tctagagaag agggaaaggc aacccagcag agggaggtag aaagcttcca ttctgagact
     1261 gaccaggata cgccctggct gctgccccag gagaaaaccc cctttggctc cgctaaaccc
     1321 ttggattatg tggagattca caaggtcaac aaagatggtg cattatcatt gctaccaaaa
     1381 cagagagaga acagcggcaa gcccaagaag cccgggactc ctgagaacaa taaggagtat
     1441 gccaaggtgt ccggggtcat ggataacaac atcctggtgt tggtgccaga tccacatgct
     1501 aaaaacgtgg cttgctttga agaatcagcc aaagaggccc caccatcact tgaacagaat
     1561 caagctgaga aagccctggc caacttcact gcaacatcaa gcaagtgcag gctccagctg
     1621 ggtggtttgg attacctgga tcccgcatgt tttacacact cctttcactg atagcttgac
     1681 taatggaatg attggttaaa atgtgatttt tcttcaggta acactacaga gtacgtgaaa
     1741 tgctcaagaa tgtagtcaga ctgacactac taaagctccc agctcctttc atgctccatt
     1801 tttaaccact tgcctctttc tccagcagct gattccagaa caaatcatta tgtttcctaa
     1861 ctgtgatttg tagatttact ttttgctgtt agttataaaa ctatgtgttc aatgaaataa
     1921 aagcacactg cttagtattc ttgagggaca atgccaatag gtatatcctc tggaaaaggc
     1981 tttcatgatt tggcatggga cagacggaaa tgaaattgtc aaaattgttt accatagaaa
     2041 gatgacaaaa gaaaattttc cacataggaa aatgccatga aaattgcttt tgaaaaacaa
     2101 ctgcataacc tttacactcc tcgtccattt tattaggatt acccaaatat aaccatttaa
     2161 agaaagaatg cattccagaa caaattgttt acataagttc ctatacctta ctgacacatt
     2221 gctgatatgc aagtaagaaa taatgcctcc aattttttct taaaatagtt tagatatgtt
     2281 aagcatggat tttcccccta aattctactc taaagcttct ataaaatata gtttggaaat
     2341 aaaaatgttc ttacacaagg ggcaaatgaa tttcatgtga atccctttag gatgttttcc
     2401 tccttcattt cagcatgata gataatttat tatacacctt agtctttcct tagttaaaaa
     2461 aaaattccct aaagactaac ttgaaaagaa aaccacagca ggatgctaat ggaattactg
     2521 ccttactgta catacaaatt ctactttaat ataaacccat aagtttaact gtatttttga
     2581 agactatttt tctatgactt aggtaaaata aaagactatt ttctattttc ccagtacagc
     2641 tgtttatgta ttcagtgggt acagtatttt ctgctgcaag gttataatgt gtatttacag
     2701 tacatagtag tatataaagt tcccgtttgt ggagtaaaat gccataccaa cccaaagccc
     2761 actgtgaaat atgaagtgaa tgacaaaatt cagttttcaa cgcaatatag tatagtttat
     2821 ctgattcttt tgatctccag gacactttaa acaactgcta ccaccaccac caacctaggg
     2881 atttaggatt ctccacagac cagaaattat ttctcctttg agtttcaggc tcctctggga
     2941 ctcctgttca tcaatgggtg aatcttccta aagctaccat aaaaagggag ggcgacgatt
     3001 tctaacagct gtttaaaaga gagaggtttt gcttttgtga gaaatcttgg gccacaaaaa
     3061 aattttaagc aaagccagga gttagtgtct ctctgaagta aattcaattg caaaatcttg
     3121 gcagaggcag aaatggctca tatcagaagt gtccaaataa aagttctggg aaactaggta
     3181 tttgcttccc agagcaatgg gaatagctcc aaaggtcaga gtaaggtaat gagaatctcc
     3241 cggtcaattc cagtgccagg cttcctgaaa gaagtcaaag cttggatcct cattttaaag
     3301 ggcgcatcca tgactcatct agcagcccct ctctattttt cccttcactt gatggtaaat
     3361 ccattctata tgtccattta ctagctggac atagagaact tgagctcacc tctgggagtt
     3421 aaatattcca ccccaactat cccatattga tagcaactgg actcagaggt ccccctcctg
     3481 tttgaaagtg aacacattgc caatgttttg agaatggcaa aagcaataga tacgaagctc
     3541 catttttcta atatataaac aatatcatgt gagtaaggga agcgtgtggg aaagttgtcc
     3601 aagctcattc agtcccctaa atcctcgata ctttaactgt ctgagaacca actgcatagg
     3661 catcacctgg gcagtgtttg aaaattccat ttgcagaatc ttaagcatca gaatctgcat
     3721 tttactaaga tccccaaatg attcaattgc acactgaagt ttgagaagca ttgttctaga
     3781 caaccatttc cactaaaggt tattttagtt catagtaaca atcctctttt ggaaaggaca
     3841 gatcaagtct gtttgacttg caatgaacaa cactgcatgt aagcaggcaa aaaaagaaac
     3901 atatcagtag tttaagattc acattatgct gaatcttata tgaattcaca taaaagaatg
     3961 acctgcaaaa ctacgcacaa cttctgaaag gccaaggaat ataatctacc ttgagagaca
     4021 ttaaccaaag acagtcaccc tcaaagccaa tgcagactaa atctttccta acatagtcta
     4081 ttctctaaga atagagaaga tatgtatcag tcactcttat agtctgaaaa cctaaacata
     4141 aaagtaatct gcttttgaca tataattttg tataatacgt atgaaaaaat gtgacagcta
     4201 aggacttgaa ttaaatccct aaaaaacaat tagccactca ttaggccaag actttaattc
     4261 tatgatcaat tagcactgtt tatctgaatt aagctttttt gtggtctaac aaaaagtttt
     4321 tttgtggtct atcaaggaga cagctgttca aatggaagga tacatgtggg gcaggggggc
     4381 ggtgaagaga cctagattct ggtcctaact gctttgcctt ggagagatta attcccccct
     4441 ctaagcctca gtttcctctg aagatgttgg accagataac ctctaaggtc ctttgaaact
     4501 gactccttga ttccatgact cactgaatat ttttctgcaa agataatccc aaccaatgcc
     4561 ttctatccta atctaacaaa aaattgctct tcatcataga aatacaaagt aatcttcagt
     4621 gatgtgctct ttatactttg ctttttaaac cgtccattcc agttggtctt aatatattgc
     4681 acaagtattt tataagtgaa atgtgtacag aatcatattc taagattatg tgcaaatata
     4741 tgtgtagaaa gaggcattta aaaaaagagg caggagattg agaagagaca tattgaatga
     4801 ggcactaatc tttagaaaaa tgatctttta ctgaatcaag ccatgctcat tccttgctga
     4861 atccaacagc cccaaatctc ttttcttata tttggctgtt aatttttttc cttgcaccat
     4921 cctagattgt taacaaccat tgcacagttg gctcatgtat ccttacactc tgagttataa
     4981 taagttgtat ttttataaac aaatacctaa atattcaagt tttaaggcgc atggaaactg
     5041 aatctaggca acgggtgatt tgtgtagctt acaacctgaa cagcaagatg ttccaattca
     5101 ttctaacaga tgtgtataag cacaagttat atcagctgtg tcagatattt aacagatcct
     5161 acatttatta gctatataac agactctaca ttttcctaag tgcctaagac caatcctggt
     5221 agtcacttaa gtacaaaaga ctcactttaa ctggcttggt ctgaaggggt caatccttta
     5281 ctgcctgtac aagatctggg cagttttgct ctgtgtcttg tgatgaccca gctgaatgtg
     5341 aaaagcctat gagttattga gcaaccagag gtccctgcat tccaagttgc agtttagctc
     5401 tggggaaact ctggctttct ctttcctcaa gtgtccacca ctgcccatca tttgcagaaa
     5461 gacttggccc tgcctttagc aacttcccta tctccttaga gtagacaaga aagaaacaga
     5521 tttgtgcaca ttttacaaag tgccttcctc tatttttttt taaagttttc attttgcaag
     5581 gaaaaatgta ttgattagaa agtaacattt gccttatagg gattatatat atatatagat
     5641 atagatatag atatgtatga atggagagat gagaagaagc cagaaagggc acaacaaaat
     5701 ggtctaaggg ccaaccagca atgttcagtg aatgtttacg tattgtttaa ttgaatcaac
     5761 acagagctgt tgtgaatagt gtgacttact ttgcctgata agaaattgag gctggctgtg
     5821 atttggggat aaacctgcca ccctgtgatt tgagactctc cataccaaaa cttattgata
     5881 catttttgaa tgtcattggc ttacatgcct aaacctgaag agaacaatgc atgcacattg
     5941 gaactttgta cacaaacaga aaaatataaa tgactttgaa ttaccatccc aagcattgct
     6001 aacgtagatg tgccattgac gaaagtctca tgtgttcttg agtgaacaaa tttccttttc
     6061 ttcctttttg gctcaagcac aataatgctg tcactgagac agtgactgag cactcaatgt
     6121 ccaagactaa atcacatcac cacgactaag taggcactat gtcctgggat gagtctttta
     6181 aactctggcc atcaggttcc ttacttgtta aataagtagg ttggcctaaa aggtttctaa
     6241 gacctctcat gatctaggta aaatccaggg tttcaggtca gtgtccctgg tgcagtgcaa
     6301 gaaagccttg ctgacacacc cttggcctga agcagtgagc acatgagatt gtgtgacaac
     6361 gcttcagaga aaaacagaga tctgttcctc caactcagat tgatttaaca tccttgcttc
     6421 tccttttcct tcctggcttt acatatttgt agggttttta ctccttctcc agagcctact
     6481 attttcctaa gagttagtag caaccatagg atccacaaga aatgaaatta ttcatcaaca
     6541 atgactttgg cactgcaaaa gactgagtca aaggttaaat cagtcacaca gatatccaag
     6601 gccaagttga agatcacaag tatatcccat ttagagattt gcatacttag agattaagcc
     6661 catgttcatt aattatttag ttaattcaaa agccattaat aaatccatgc ccagcctacg
     6721 caacatagta agacccagtc tctacaaaaa ttttaaaaat tagccagcca tggtgacacg
     6781 tacctgtagt cctagacact tgggaaggtg aagccagagg attgcttgag cccaggaggt
     6841 cgaggctgca gtgaaccgtg attgtgtcac tgcactccag cctgggtgag agagcaagac
     6901 cttgtctcaa taaataaacc caagttactt cgatgactag atactggagg tctgaaggag
     6961 aagctttaaa aatacagatt gattgcttca gagaaatcct atttataatt atgatctgaa
     7021 cttattctat gattagcaaa tatatcatct gaaaataaaa caggagttct ctccccagac
     7081 ttttgttttt caggatggtg agttttggtc tgggaccctc atggcaccca ttttgataaa
     7141 aggaaaaaga tagtaaaaca ggaaatagga agtttccaga gatttgggca tctcaggatt
     7201 ccatgaaatg ctgagactaa cccactaaat ccaaatttta ttggctatgg taaatctaaa
     7261 tctgttcagt gttctgaaca gattttatga gtttatgtct aagagtttat gtctaagaga
     7321 ggtacataat tcacaaacac tatcatgctg gcagctgttt tgtccacatc aattcccttg
     7381 atttaatgct ctgatttcaa tttagaaagt actgagacat gtaaagtctc aaaataggaa
     7441 aaacctatcc tgtttataag gtgtggtcaa taaatagacc acagataatc ttagtctatt
     7501 aattaactct cagatcatct tagactatta attaacattc tgcttgctgc tgattaaaaa
     7561 gaaaaaaacc ctaaaacctt cagcaactga agtagtaata taaaaaataa cctttaatag
     7621 ttatggtcaa attacgcttc acttggataa acctcaaaat gtagtctgag tttttttgtg
     7681 cacacttcac aaatcctggg ggaaaaatct tttttccacg ttatctgaaa aactatatgg
     7741 cgaagatacc gctgaaaaat aatttgtttt atgaaattcc tgaaaagcta attttgaatt
     7801 ttttaaagta actacctccc ttttgtgtcc taatgtcctt ccttcaaagc tgcttatagt
     7861 ttagaaatga aagatgtcat gtctcatgct ttgactggtt ttcggtggca tatttgatgt
     7921 atttgccaag tggcattact gactttacag taactgttac attattttgt actatattgc
     7981 tttatgtggt tcaaaaatag tatatgccat attgaaatat gtaatcctca tgttgtgaaa
     8041 ctcatcatgt aatacaaatg aaaatcatta cttaataact tacaatttat ccatatgtag
     8101 tttcaatatg attgtgtcta tgactgtaaa acaaaactga aaaaatatgt aatgtatttc
     8161 tgttgaaagc gtgaatgtac taattttttc ctaatctttg tctagaagaa agattctatg
     8221 tcattcattg tacagctgct ctggggtgtt acacatttaa agtacaatcc aacagttgtt
     8281 tgaaagtcag cctctcggct ttgtttcatg tgactgctga cacttctcaa gtgttctttg
     8341 cataatgagg ctggattttg tgcttcatcg ttcattttaa acaattgaaa agtctcatgt
     8401 ggaaaccaaa gcaatctaga accagcctgt tgggtgactg tgtcttctgt aaagccatat
     8461 tgaagtgaag ttatacataa tagcataagg ttccacattt tcaaagctac cactacctct
     8521 gcttttcctc tttccctaga aaatgccaag caaaattccc caacactaag tgagaaatta
     8581 gaagtaattg ttttataatt aagttgctgg gttttttttt taacaccttc taattcatca
     8641 ctttgtaggg ttatgcaaga gtttctgaat aaccattctt acatgtttat attttataaa
     8701 aaccggctgc aagaaagatt cagaaagaat acttagtaag tcatcatatg aaaaaccaac
     8761 aaaaccatag agtgcagatt ttttcctaac tataagtcac ctcatagttg tccaaagcca
     8821 tgataatgat atctcttaca aattgacttc tgtaaccccc ctagaaataa cccttttcct
     8881 tatttgattt tagtcatcaa acatagtatg atatgggaaa agtcagccat ttaccagaaa
     8941 ttatcttatt ttgattttaa aaactcattt ctatatgtag ttattgtaat gtctattttt
     9001 ttagacttaa agatttatag aagactatag ttatctgatt tgttattttg catttttcat
     9061 tctgtaaatc tttgcttatg gcacattgtg ctctctgttt tccatggttt tattcattta
     9121 tctcctccta ttttgagggg acaacatggg tagttaaatc tttgtcaata gtattggaga
     9181 taacactaac tgctattatc ataacatctt catttttact gcatgccaaa accaatgcct
     9241 gccaaacaaa atcttagaca tcccaatata atatgttagt tatatttcta ttcacatcat
     9301 tattgaaaat acccagctca gtgcctggct taataaatgt ttaattccct tacctactct
     9361 tgctctattt ttttatttga aatggagatg agcaaaataa cacattcatg gctgaagcaa
     9421 ttttttggac atttcttgtt accaaaagat ctataatcag gacattgttt atgtaagttg
     9481 gacaaaaaaa attcttcccc tttatgtcca cccttcctat gattgcaaga caaaatttcc
     9541 ctcctttacc tcatccctat aacatgggag gctgagaaaa atgaggggag atggaaccag
     9601 atacaaggag atccaataag agaagcttat ttaaatattg tgaaataaag gaagaaccaa
     9661 agcatttttt taagtgggga atccttttga acagttatta tttatccata ttattaacaa
     9721 catcttttct gacaaaatcc atcagatgaa gtgtaaatgg ataatctttt aatggatcta
     9781 aacctagaaa gtttcactta ctgttcatgt ccgtgttcca gaattgtgaa atggtgtgtg
     9841 gttttgcttt ccaagttctt ctctgcctcc tcttaattct ctaattccat gtcttacaga
     9901 agaatgagaa atttctttct tacttgagta tcatgctcta aaaaacttgg cttcagtcac
     9961 agaaacgctg gctctcctgt gcttatattg aagccaactg cctttaattc ttgggccctc
    10021 ttatattttt aaggtgcaaa atttgaagtc tcagtcacca gacacaggtt ctatacaatt
    10081 aatgatgagc tggagaagta atatgtagct aatttttcaa aagcattgaa tatactttcc
    10141 ggaaagaaaa cagaaattaa atattgccac atcttgccag aatcccatct gacaccttaa
    10201 ctttgtcagg tttcctacaa cttgctaatc aagttttata cattctaaat ctccccagtt
    10261 tctttggggc tggaagatgc aacttccatt taatagaaac tttgaaatct tggggtaagg
    10321 gagcagtggg gggactaggg agaaggataa gaaatagaat tattgaaaag cccccaccag
    10381 ggaccttcct ggccagaata tgcagagtaa ttcctgctgg cttcaccttt gaaagtccct
    10441 cgaaactatg cagatgaaac tgagtctgtt tttgatattg tcagatgtat tctaccttgg
    10501 aagtcccaac acctaaactg gaattcttgt atttacatct cctccactgt cccccacacc
    10561 acccctcaat tcctgctgcc cctgctaatg ttaagcattt ttctcttgtt atcatcaggt
    10621 tcacattaaa aacagatact tacaaactga cttgaagcac agatactttt acgaatgtga
    10681 taaaatattt tcttaagaaa aggaaagagg atgtgggtca aataaaacac cgcatggatg
    10741 ttgattggtg aatactggtg taagaaaagg gagctcagga atttttatta ctgtatttgt
    10801 aaatgagttt gaaggaattt gtaaatgcca ctggtacatt tttaaggtga cacatttgct
    10861 ccttataaag ttattaaaaa ttacagggta agcttaaatg acgtttgcca gtagttttac
    10921 tttatataat caatattgat attgttgctg aactatgtaa ctttatgatg catttttcag
    10981 tcccttttca gagcaaatgc ttttgcaatg gtagtaatgt ttagtttaaa ttgacttaat
    11041 aaattattac ctgagcaatg gttaaaaaa
//
