LOCUS       NM_004248               5387 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens prolactin releasing hormone receptor (PRLHR), mRNA.
ACCESSION   NM_004248 NM_005287
VERSION     NM_004248.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5387)
  AUTHORS   Talbot,F., Feetham,C.H., Mokrosinski,J., Lawler,K., Keogh,J.M.,
            Henning,E., Mendes de Oliveira,E., Ayinampudi,V., Saeed,S.,
            Bonnefond,A., Arslan,M., Yeo,G.S.H., Froguel,P., Bechtold,D.A.,
            Adamson,A., Humphreys,N., Barroso,I., Luckman,S.M. and Farooqi,I.S.
  TITLE     A rare human variant that disrupts GPR10 signalling causes weight
            gain in mice
  JOURNAL   Nat Commun 14 (1), 1450 (2023)
   PUBMED   36922513
  REMARK    GeneRIF: A rare human variant that disrupts GPR10 signalling causes
            weight gain in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5387)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   3  (bases 1 to 5387)
  AUTHORS   Roumeas,L., Humbert,J.P., Schneider,S., Doebelin,C., Bertin,I.,
            Schmitt,M., Bourguignon,J.J., Simonin,F. and Bihel,F.
  TITLE     Effects of systematic N-terminus deletions and benzoylations of
            endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and
            GPR103
  JOURNAL   Peptides 71, 156-161 (2015)
   PUBMED   26211894
  REMARK    GeneRIF: Effects of systematic N-terminus deletions and
            benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R,
            GPR10, GPR54 and GPR103.
REFERENCE   4  (bases 1 to 5387)
  AUTHORS   Su,Q., Wang,Y., Zhao,J., Ma,C., Wu,T., Jin,T. and Xu,J.
  TITLE     Polymorphisms of PRLHR and HSPA12A and risk of gastric and
            colorectal cancer in the Chinese Han population
  JOURNAL   BMC Gastroenterol 15, 107 (2015)
   PUBMED   26302849
  REMARK    GeneRIF: The genotype 'A/T' of rs12413624 in PRLHR gene was
            associated with a decreased risk of colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5387)
  AUTHORS   Varghese,B.V., Koohestani,F., McWilliams,M., Colvin,A.,
            Gunewardena,S., Kinsey,W.H., Nowak,R.A., Nothnick,W.B. and
            Chennathukuzhi,V.M.
  TITLE     Loss of the repressor REST in uterine fibroids promotes aberrant G
            protein-coupled receptor 10 expression and activates mammalian
            target of rapamycin pathway
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), 2187-2192 (2013)
   PUBMED   23284171
  REMARK    GeneRIF: demonstrate previously unrecognized roles for GPR10 and
            its upstream regulator REST in the pathogenesis of uterine fibroids
REFERENCE   6  (bases 1 to 5387)
  AUTHORS   Langmead,C.J., Szekeres,P.G., Chambers,J.K., Ratcliffe,S.J.,
            Jones,D.N., Hirst,W.D., Price,G.W. and Herdon,H.J.
  TITLE     Characterization of the binding of [(125)I]-human prolactin
            releasing peptide (PrRP) to GPR10, a novel G protein coupled
            receptor
  JOURNAL   Br J Pharmacol 131 (4), 683-688 (2000)
   PUBMED   11030716
REFERENCE   7  (bases 1 to 5387)
  AUTHORS   Fujii,R., Fukusumi,S., Hosoya,M., Kawamata,Y., Habata,Y.,
            Hinuma,S., Sekiguchi,M., Kitada,C., Kurokawa,T., Nishimura,O.,
            Onda,H., Sumino,Y. and Fujino,M.
  TITLE     Tissue distribution of prolactin-releasing peptide (PrRP) and its
            receptor
  JOURNAL   Regul Pept 83 (1), 1-10 (1999)
   PUBMED   10498338
REFERENCE   8  (bases 1 to 5387)
  AUTHORS   Hinuma,S., Onda,H. and Fujino,M.
  TITLE     The quest for novel bioactive peptides utilizing orphan
            seven-transmembrane-domain receptors
  JOURNAL   J Mol Med (Berl) 77 (6), 495-504 (1999)
   PUBMED   10475064
  REMARK    Review article
REFERENCE   9  (bases 1 to 5387)
  AUTHORS   Hinuma,S., Habata,Y., Fujii,R., Kawamata,Y., Hosoya,M.,
            Fukusumi,S., Kitada,C., Masuo,Y., Asano,T., Matsumoto,H.,
            Sekiguchi,M., Kurokawa,T., Nishimura,O., Onda,H. and Fujino,M.
  TITLE     A prolactin-releasing peptide in the brain
  JOURNAL   Nature 393 (6682), 272-276 (1998)
   PUBMED   9607765
  REMARK    Erratum:[Nature 1998 Jul 16;394(6690):302]
REFERENCE   10 (bases 1 to 5387)
  AUTHORS   Marchese,A., Heiber,M., Nguyen,T., Heng,H.H., Saldivia,V.R.,
            Cheng,R., Murphy,P.M., Tsui,L.C., Shi,X., Gregor,P. et al.
  TITLE     Cloning and chromosomal mapping of three novel genes, GPR9, GPR10,
            and GPR14, encoding receptors related to interleukin 8,
            neuropeptide Y, and somatostatin receptors
  JOURNAL   Genomics 29 (2), 335-344 (1995)
   PUBMED   8666380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356865.19.
            
            On Nov 23, 2018 this sequence version replaced NM_004248.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290461.1, AK313269.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239032.4/ ENSP00000239032.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AL356865.19        79653-79785         c
            134-5387            AL356865.19        74134-79387         c
FEATURES             Location/Qualifiers
     source          1..5387
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.11"
     gene            1..5387
                     /gene="PRLHR"
                     /gene_synonym="GPR10; GR3; PrRPR"
                     /note="prolactin releasing hormone receptor"
                     /db_xref="GeneID:2834"
                     /db_xref="HGNC:HGNC:4464"
                     /db_xref="MIM:600895"
     exon            1..133
                     /gene="PRLHR"
                     /gene_synonym="GPR10; GR3; PrRPR"
                     /inference="alignment:Splign:2.1.0"
     exon            134..5387
                     /gene="PRLHR"
                     /gene_synonym="GPR10; GR3; PrRPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1252
                     /gene="PRLHR"
                     /gene_synonym="GPR10; GR3; PrRPR"
                     /note="hGR3; prRP receptor; G-protein coupled receptor 10"
                     /codon_start=1
                     /product="prolactin-releasing peptide receptor"
                     /protein_id="NP_004239.2"
                     /db_xref="CCDS:CCDS7606.1"
                     /db_xref="GeneID:2834"
                     /db_xref="HGNC:HGNC:4464"
                     /db_xref="MIM:600895"
                     /translation="MASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADA
                     PAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNL
                     ALSDVLMCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRY
                     VVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQ
                     ERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRT
                     FCLLVVIVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFI
                     YAWLHDSFREELRKLLVAWPRKIAPHGQNMTVSVVI"
     regulatory      1966..1971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRLHR"
                     /gene_synonym="GPR10; GR3; PrRPR"
                     /note="hexamer: AATAAA"
     polyA_site      1990
                     /gene="PRLHR"
                     /gene_synonym="GPR10; GR3; PrRPR"
                     /note="major polyA site"
     regulatory      2661..2666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRLHR"
                     /gene_synonym="GPR10; GR3; PrRPR"
                     /note="hexamer: ATTAAA"
     polyA_site      2684
                     /gene="PRLHR"
                     /gene_synonym="GPR10; GR3; PrRPR"
     regulatory      5369..5374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRLHR"
                     /gene_synonym="GPR10; GR3; PrRPR"
                     /note="hexamer: AATAAA"
     polyA_site      5387
                     /gene="PRLHR"
                     /gene_synonym="GPR10; GR3; PrRPR"
                     /note="major polyA site"
ORIGIN      
        1 atttggatcc gttcagctcc cgcggagaag cgagaccgga tcaccgacgt gggcagagga
       61 ctaccgaggg ccagcagaaa ttctgcccct tcttcccgcg agtgctttcc cgctctccaa
      121 accccactcc caggtggcca tggcctcatc gaccactcgg ggccccaggg tttctgactt
      181 attttctggg ctgccgccgg cggtcacaac tcccgccaac cagagcgcag aggcctcggc
      241 gggcaacggg tcggtggctg gcgcggacgc tccagccgtc acgcccttcc agagcctgca
      301 gctggtgcat cagctgaagg ggctgatcgt gctgctctac agcgtcgtgg tggtcgtggg
      361 gctggtgggc aactgcctgc tggtgctggt gatcgcgcgg gtgcgccggc tgcacaacgt
      421 gacgaacttc ctcatcggca acctggcctt gtccgacgtg ctcatgtgca ccgcctgcgt
      481 gccgctcacg ctggcctatg ccttcgagcc acgcggctgg gtgttcggcg gcggcctgtg
      541 ccacctggtc ttcttcctgc agccggtcac cgtctatgtg tcggtgttca cgctcaccac
      601 catcgcagtg gaccgctacg tcgtgctggt gcacccgctg aggcggcgca tctcgctgcg
      661 cctcagcgcc tacgctgtgc tggccatctg ggcgctgtcc gcggtgctgg cgctgcccgc
      721 cgccgtgcac acctatcacg tggagctcaa gccgcacgac gtgcgcctct gcgaggagtt
      781 ctggggctcc caggagcgcc agcgccagct ctacgcctgg gggctgctgc tggtcaccta
      841 cctgctccct ctgctggtca tcctcctgtc ttacgtccgg gtgtcagtga agctccgcaa
      901 ccgcgtggtg ccgggctgcg tgacccagag ccaggccgac tgggaccgcg ctcggcgccg
      961 gcgcaccttc tgcttgctgg tggtgatcgt ggtggtgttc gccgtctgct ggctgccgct
     1021 gcacgtcttc aacctgctgc gggacctcga cccccacgcc atcgaccctt acgcctttgg
     1081 gctggtgcag ctgctctgcc actggctcgc catgagttcg gcctgctaca accccttcat
     1141 ctacgcctgg ctgcacgaca gcttccgcga ggagctgcgc aaactgttgg tcgcttggcc
     1201 ccgcaagata gccccccatg gccagaatat gaccgtcagc gtggtcatct gatgccactt
     1261 agccaggcct tggtcaagga gctccacttc aactggcctc ctagggcacc actcgaggtc
     1321 aatctggtgc ttattctcag caccagagct agctaagcca acatagggca acatttccag
     1381 cccagccctc ttgtccggct gtctgtcttg tccttgtgtg tttgtaaaat gttaagcggg
     1441 ctttggtgag agtcttgctc tttgcttggg ggaggccaaa gagagggaag aggatttctt
     1501 atttcttctt tatgcccttg aaggacaaac aaaacttttt ctccacgttc agaaaagtat
     1561 ttcagaacca cgattgcctt cctggcgtcc cctcctcctg ctcgttggtg aaatgaacaa
     1621 tatgaatggg atttaaaagg aatgcattgg gcttggtaaa gattttcagt ttgcctttag
     1681 aaaaaggacc cagctgagag taccatgata ttgcttagtc catttgaacc cttgcattcc
     1741 tagaatttca ggtaaatatg tattaaaact ctacatctag gatttcagca tttcctgagt
     1801 aagaccttta tatgccaaaa gggtttcgtt ttaaaaccac ttgagtttat agtacaaaaa
     1861 cacctacaag ctccctttag aaaggtcttg ctattgtttc tcccctttcc tccccaacta
     1921 ctatttaaaa atgatgagac gaattagtca atgaagagat agataaataa agaggaaaag
     1981 gtccaattca cttaagaggt cattcaattg tacctaagga cagacatcct ctgtgtatgt
     2041 gtgtttgtgt atgtgtgtgt atgtgtgggt acacattcag tgtttgccac aaagtgggca
     2101 ctcaaatatt tggttttctg aatactcaat gtaaactgtg tagcgtggca ttctcctgca
     2161 gtctctaatt gctcacttgc aacagatcaa cagctgtcat ctgactgctc agcacctgct
     2221 ctgtagtgat tcttggaaca tgatcaaccc agaaatcaag gaccggcaga agtttactta
     2281 aggacagaac agaagaataa gctaccaccc acatgatgtg tagatcaaac actaattacc
     2341 tccagggtta agggaaaagg tgaagactgt ggagcatgat accaggctga taatcatcac
     2401 cttaacctcc tgtgagttct gtaaatgagg acaagtgcct tgggacaaag gtctccacac
     2461 tgttggaaaa gcaacttggg cagtgagggc aggagtcttg ggaaatgata cataatatcc
     2521 agctgtcaga tcagcctctg tgttcccagt aactcagtca ccatctgtag ggttcaacta
     2581 ctttcccagc tcactgaaca caagaatcac tgtttcacct cctcctgctt ctcttattca
     2641 gaaataagct caattcattc attaaaatgt gccctaaaag gaaaggaaag agggatgata
     2701 tgggaatgac aagggttcaa tcctattaca ttcatgtcaa caaccatggt gggagtggga
     2761 gtgatcacgg ttgggctggt tggcatagga atctttagta gttacagggc tagacttttt
     2821 gcacacagta aagggtagga aaggctggct tgggagaaag gaaaaggcag gcaaagatgg
     2881 gtatggaggt tacctctggc aatggtgcta aatgaacttg agcttcatcc gtggattgga
     2941 gaacaaagaa cctgtgtgct aatagtgcaa cccacccctg ccccagataa gctcatctcc
     3001 caggcatccc gaggactggc tcctgtgctt ccagcagcta tattacttgg gaggctcagg
     3061 gccagacatt tctcatttcc tcagagagtt cctttgatgg tcatgtgtgg agagtgtaga
     3121 tggtagaggg gaaggagagg gattatttgg ggagggatct gattcatcgt cggctctttg
     3181 ttggaaggtt tgaatcactg gttctcaacc ctggctgctc ctagaatcac ctggggaact
     3241 tttttttctt tttgtaattg atgtctgggc tctcctccca agagtctagt tgatttgaga
     3301 tggtgcctgg acactagcat tttccaaagc acttcagggg attttaatgt gcaaccaaga
     3361 ttaagcacct taagaattat cctttctagg gctgggcatg gtggcttaca cctgtaatcc
     3421 cagcattttg ggggaccgag gcaggcagat cacaaggtca ggagtttgag accagcctgg
     3481 ccaacgtgtt gaaaccctgt ctctacttaa aatacaaaaa ttagccaggc gtggtggcgc
     3541 acgcctgtaa tcccagctac tcgggaggct gaggcaggag aattgcttga acccagggag
     3601 gcagaggttg cagtgagctg agattgtgcc agtgtactcc aacctgggtg acagaacaag
     3661 actccatctc ggggtggggg gtgggggcgg gaatcctctt tctaatgaat ctcagaaaca
     3721 tccgaatgaa gctttagttg tacctgccaa aggtgttaat aatttggagc tgaatttgac
     3781 ggtgttacat gccatactta gagaatactc ttttagtctt caggcaatac cagctcaatc
     3841 acaaagaggc aaattattga aatcagaata tatagggatt cgttcaacag tttacttaca
     3901 tatttcttat gtatcagtcc aatcaattca gaaggaatat catcattcaa ccttaggtca
     3961 attgtattat aaagttacat accatggcca ggtaccatgg ctcacatcta taattccaaa
     4021 actttgggag accgaagagg gagaattgct tgagcccagg agttcaagac cagcctggga
     4081 aatatggcaa aactccatct ctacaaaaaa tagccggacg tggtggtgca cacctgtggt
     4141 cccagctact tgggacacaa aggcaggagg atcacttgag cctgggagga tcactgggct
     4201 gcagtgagct atcattacac cactgcactc cagtctcagt gacagagcaa aatctagtct
     4261 caaaaaaaca aaaaaaacaa aaacaacaaa aaacaacaaa aaacaaattt acataccatg
     4321 aattatttta aatcctggtt gtcagggtgt tagaaaaagt gctccttgat tagcttaagt
     4381 ttatatcaac tatgaaaaac aagcatctcc attaattact agaaaagctg ccactggttt
     4441 ctgtcatgcc tacaacttaa gtttgaaaca cttacatgga ctttataaag agcttaaaga
     4501 ggttggagaa ttagattgtg cttataaaca tctttacata ttatgaaaat cagcaacgga
     4561 acagcaatta attcttacaa catctgaaat gtgttgtgga ctagtttata aatcaaaccg
     4621 aatttcaaaa aaatcagagg tgagtcccag agagaactgc gtaggactgt aggtagaaaa
     4681 ttttatttaa taattcattt tggttaatat caagcatcta agatgtatac acagtcctct
     4741 tcctgcaagg agtaatacag gcagtcaggc tgggaactga gccaacttgg tacttggcag
     4801 cagcccttct caaggctgat gggaggttct gtaatcctct ttgcaagctt tgtcaccagg
     4861 tcacactttt ggcagccaat caatagattt atctcattaa actggcagaa gagtgtttca
     4921 atgcatgctc caacagctac ctggaaatag caattgtgag agatgctaag gtaaggatat
     4981 tccagttcct ataaccgtct gattttttgt ccttgtgaat tttcaatctg ctgttttact
     5041 gggatagcta agttccaggt ttattttctc aggtaggctc acccacgacc tctgtcctgt
     5101 ggtttgcatt cctgaacatc tgttagtctt tcaaatgcaa ggcacaaaac taacctcaag
     5161 agtgtggcta gatctgggag tgaacacagg gcctgtccct cacagacgag aggtcaggag
     5221 cacctttgtt tcccaaggca ggttcttgat tgatttacct tcatgcgttg atgtctttgc
     5281 tatgtgtgta aaatgcatgt gttgctgaat cacatgtgaa gctctacatg ctggggttta
     5341 tactgtgttt ggcatgttgt gggagctcaa taaatactaa atcagtt
//
