LOCUS       NM_015893                264 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens prolactin releasing hormone (PRLH), mRNA.
ACCESSION   NM_015893
VERSION     NM_015893.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 264)
  AUTHORS   Xia,C., Qin,X., Zhou,L., Shi,X., Cai,T., Xie,Y., Li,W., Du,R.,
            OuYang,Y., Yin,Z. and Hu,G.
  TITLE     Reproductive Regulation of PrRPs in Teleost: The Link Between
            Feeding and Reproduction
  JOURNAL   Front Endocrinol (Lausanne) 12, 762826 (2021)
   PUBMED   34803923
  REMARK    GeneRIF: Reproductive Regulation of PrRPs in Teleost: The Link
            Between Feeding and Reproduction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 264)
  AUTHORS   Holubova,M., Hruba,L., Neprasova,B., Majercikova,Z., Lacinova,Z.,
            Kunes,J., Maletinska,L. and Zelezna,B.
  TITLE     Prolactin-releasing peptide improved leptin hypothalamic signaling
            in obese mice
  JOURNAL   J Mol Endocrinol 60 (2), 85-94 (2018)
   PUBMED   29233862
  REMARK    GeneRIF: This study demonstrates that palm(11)-PrRP31 positively
            affects feeding and leptin-related hypothalamic signaling.
REFERENCE   3  (bases 1 to 264)
  AUTHORS   Deluca,S.H., Rathmann,D., Beck-Sickinger,A.G. and Meiler,J.
  TITLE     The activity of prolactin releasing peptide correlates with its
            helicity
  JOURNAL   Biopolymers 99 (5), 314-325 (2013)
   PUBMED   23426574
  REMARK    GeneRIF: Data indicate that formation of a primarily alpha-helical
            C-terminal region of prolactin releasing peptide (PrRP) is critical
            for receptor activation.
REFERENCE   4  (bases 1 to 264)
  AUTHORS   Lagerstrom,M.C., Fredriksson,R., Bjarnadottir,T.K. and Schioth,H.B.
  TITLE     The ancestry of the prolactin-releasing hormone precursor
  JOURNAL   Ann N Y Acad Sci 1040, 368-370 (2005)
   PUBMED   15891064
  REMARK    GeneRIF: Review discusses the ancestral relationship between
            prolactin-releasing hormone and the C-terminal RF-motif amide
            precursor peptide (C-RF).
            Review article
REFERENCE   5  (bases 1 to 264)
  AUTHORS   Takahashi,K., Totsune,K., Murakami,O., Sone,M., Noshiro,T.,
            Hayashi,Y., Sasano,H. and Shibahara,S.
  TITLE     Expression of prolactin-releasing peptide and its receptor in the
            human adrenal glands and tumor tissues of adrenocortical tumors,
            pheochromocytomas and neuroblastomas
  JOURNAL   Peptides 23 (6), 1135-1140 (2002)
   PUBMED   12126742
  REMARK    GeneRIF: PrRP has a likely role in pheochromocytomas, based on its
            high expression in tumor tissue
REFERENCE   6  (bases 1 to 264)
  AUTHORS   Langmead,C.J., Szekeres,P.G., Chambers,J.K., Ratcliffe,S.J.,
            Jones,D.N., Hirst,W.D., Price,G.W. and Herdon,H.J.
  TITLE     Characterization of the binding of [(125)I]-human prolactin
            releasing peptide (PrRP) to GPR10, a novel G protein coupled
            receptor
  JOURNAL   Br J Pharmacol 131 (4), 683-688 (2000)
   PUBMED   11030716
REFERENCE   7  (bases 1 to 264)
  AUTHORS   Zhang,X., Danila,D.C., Katai,M., Swearingen,B. and Klibanski,A.
  TITLE     Expression of prolactin-releasing peptide and its receptor
            messenger ribonucleic acid in normal human pituitary and pituitary
            adenomas
  JOURNAL   J Clin Endocrinol Metab 84 (12), 4652-4655 (1999)
   PUBMED   10599733
REFERENCE   8  (bases 1 to 264)
  AUTHORS   Fujii,R., Fukusumi,S., Hosoya,M., Kawamata,Y., Habata,Y.,
            Hinuma,S., Sekiguchi,M., Kitada,C., Kurokawa,T., Nishimura,O.,
            Onda,H., Sumino,Y. and Fujino,M.
  TITLE     Tissue distribution of prolactin-releasing peptide (PrRP) and its
            receptor
  JOURNAL   Regul Pept 83 (1), 1-10 (1999)
   PUBMED   10498338
REFERENCE   9  (bases 1 to 264)
  AUTHORS   Hinuma,S., Onda,H. and Fujino,M.
  TITLE     The quest for novel bioactive peptides utilizing orphan
            seven-transmembrane-domain receptors
  JOURNAL   J Mol Med (Berl) 77 (6), 495-504 (1999)
   PUBMED   10475064
  REMARK    Review article
REFERENCE   10 (bases 1 to 264)
  AUTHORS   Hinuma,S., Habata,Y., Fujii,R., Kawamata,Y., Hosoya,M.,
            Fukusumi,S., Kitada,C., Masuo,Y., Asano,T., Matsumoto,H.,
            Sekiguchi,M., Kurokawa,T., Nishimura,O., Onda,H. and Fujino,M.
  TITLE     A prolactin-releasing peptide in the brain
  JOURNAL   Nature 393 (6682), 272-276 (1998)
   PUBMED   9607765
  REMARK    Erratum:[Nature 1998 Jul 16;394(6690):302]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB015419.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069081.1, AB015419.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2153980
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000165524.1/ ENSP00000165524.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..264
                     /gene="PRLH"
                     /gene_synonym="PRH; PRRP"
                     /note="prolactin releasing hormone"
                     /db_xref="GeneID:51052"
                     /db_xref="HGNC:HGNC:17945"
                     /db_xref="MIM:602663"
     CDS             1..264
                     /gene="PRLH"
                     /gene_synonym="PRH; PRRP"
                     /note="preproprolactin-releasing peptide;
                     prolactin-releasing peptide"
                     /codon_start=1
                     /product="prolactin-releasing peptide precursor"
                     /protein_id="NP_056977.1"
                     /db_xref="CCDS:CCDS2519.1"
                     /db_xref="GeneID:51052"
                     /db_xref="HGNC:HGNC:17945"
                     /db_xref="MIM:602663"
                     /translation="MKVLRAWLLCLLMLGLALRGAASRTHRHSMEIRTPDINPAWYAS
                     RGIRPVGRFGRRRATLGDVPKPGLRPRLTCFPLEGGAMSSQDG"
     exon            1..100
                     /gene="PRLH"
                     /gene_synonym="PRH; PRRP"
                     /inference="alignment:Splign:2.1.0"
     exon            101..264
                     /gene="PRLH"
                     /gene_synonym="PRH; PRRP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaggtgc tgagggcctg gctcctgtgc ctgctgatgc tgggcctggc cctgcgggga
       61 gctgcaagtc gtacccatcg gcactccatg gagatccgca cccctgacat caatcctgcc
      121 tggtacgcca gtcgcgggat caggcctgtg ggccgcttcg gtcggaggag ggcaaccctg
      181 ggggacgtcc ccaagcctgg cctgcgaccc cggctgacct gcttccccct ggaaggcggt
      241 gctatgtcgt cccaggatgg ctga
//
