LOCUS       NM_005044               6102 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens protein kinase cAMP-dependent X-linked catalytic
            subunit (PRKX), mRNA.
ACCESSION   NM_005044
VERSION     NM_005044.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6102)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   2  (bases 1 to 6102)
  AUTHORS   DO Carmo,N.G., Sakamoto,L.H., Pogue,R., DO Couto Mascarenhas,C.,
            Passos,S.K., Felipe,M.S. and DE Andrade,R.V.
  TITLE     Altered Expression of PRKX, WNT3 and WNT16 in Human Nodular Basal
            Cell Carcinoma
  JOURNAL   Anticancer Res 36 (9), 4545-4551 (2016)
   PUBMED   27630294
  REMARK    GeneRIF: PRKX, WNT3 and WNT16 genes, belonging to the WNT signaling
            pathway, are involved in the tumorigenic process of nodular basal
            cell carcinoma
REFERENCE   3  (bases 1 to 6102)
  AUTHORS   Huang,S., Li,Q., Alberts,I. and Li,X.
  TITLE     PRKX, a Novel cAMP-Dependent Protein Kinase Member, Plays an
            Important Role in Development
  JOURNAL   J Cell Biochem 117 (3), 566-573 (2016)
   PUBMED   26252946
  REMARK    GeneRIF: The characteristics and developmental functions of PRKX.
            [review]
            Review article
REFERENCE   4  (bases 1 to 6102)
  AUTHORS   Taipale,M., Krykbaeva,I., Koeva,M., Kayatekin,C., Westover,K.D.,
            Karras,G.I. and Lindquist,S.
  TITLE     Quantitative analysis of HSP90-client interactions reveals
            principles of substrate recognition
  JOURNAL   Cell 150 (5), 987-1001 (2012)
   PUBMED   22939624
REFERENCE   5  (bases 1 to 6102)
  AUTHORS   Bender,C. and Ullrich,A.
  TITLE     PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in
            kidney carcinoma- and melanoma-cell lines
  JOURNAL   Int J Cancer 131 (2), E45-E55 (2012)
   PUBMED   22020623
  REMARK    GeneRIF: findings reveals a major role of PRKX, TTBK2 and RSK4 in
            triggering Sunitinib resistance formation; data suggest
            transcriptional regulation of these kinases together with other
            proteins might play an important role in formation of Sunitinib
            resistance by affecting transcription factors
REFERENCE   6  (bases 1 to 6102)
  AUTHORS   Zimmermann,B., Chiorini,J.A., Ma,Y., Kotin,R.M. and Herberg,F.W.
  TITLE     PrKX is a novel catalytic subunit of the cAMP-dependent protein
            kinase regulated by the regulatory subunit type I
  JOURNAL   J Biol Chem 274 (9), 5370-5378 (1999)
   PUBMED   10026146
REFERENCE   7  (bases 1 to 6102)
  AUTHORS   Semizarov,D., Glesne,D., Laouar,A., Schiebel,K. and Huberman,E.
  TITLE     A lineage-specific protein kinase crucial for myeloid maturation
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15412-15417 (1998)
   PUBMED   9860982
REFERENCE   8  (bases 1 to 6102)
  AUTHORS   Schiebel,K., Winkelmann,M., Mertz,A., Xu,X., Page,D.C., Weil,D.,
            Petit,C. and Rappold,G.A.
  TITLE     Abnormal XY interchange between a novel isolated protein kinase
            gene, PRKY, and its homologue, PRKX, accounts for one third of all
            (Y+)XX males and (Y-)XY females
  JOURNAL   Hum Mol Genet 6 (11), 1985-1989 (1997)
   PUBMED   9302280
REFERENCE   9  (bases 1 to 6102)
  AUTHORS   Schiebel,K., Mertz,A., Winkelmann,M., Glaser,B., Schempp,W. and
            Rappold,G.
  TITLE     FISH localization of the human Y-homolog of protein kinase PRKX
            (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13
  JOURNAL   Cytogenet Cell Genet 76 (1-2), 49-52 (1997)
   PUBMED   9154127
REFERENCE   10 (bases 1 to 6102)
  AUTHORS   Klink,A., Schiebel,K., Winkelmann,M., Rao,E., Horsthemke,B.,
            Ludecke,H.J., Claussen,U., Scherer,G. and Rappold,G.
  TITLE     The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp
            homology and is a site of chromosomal instability
  JOURNAL   Hum Mol Genet 4 (5), 869-878 (1995)
   PUBMED   7633447
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007685.2, DN997580.1,
            BE675757.1 and BC041073.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005044.4.
            
            Summary: This gene encodes a serine threonine protein kinase that
            has similarity to the catalytic subunit of cyclic AMP dependent
            protein kinases. The encoded protein is developmentally regulated
            and may be involved in renal epithelial morphogenesis. This protein
            may also be involved in macrophage and granulocyte maturation.
            Abnormal recombination between this gene and a related pseudogene
            on chromosome Y is a frequent cause of sex reversal disorder in XX
            males and XY females. Pseudogenes of this gene are found on
            chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X85545.1, SRR1660807.126259.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262848.6/ ENSP00000262848.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC007685.2         6808-6822
            16-572              DN997580.1         8-564
            573-731             BE675757.1         153-311
            732-1863            BC041073.1         520-1651
            1864-6102           AC007685.2         111879-116117
FEATURES             Location/Qualifiers
     source          1..6102
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.33"
     gene            1..6102
                     /gene="PRKX"
                     /gene_synonym="PKX1"
                     /note="protein kinase cAMP-dependent X-linked catalytic
                     subunit"
                     /db_xref="GeneID:5613"
                     /db_xref="HGNC:HGNC:9441"
                     /db_xref="MIM:300083"
     exon            1..562
                     /gene="PRKX"
                     /gene_synonym="PKX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             397..1473
                     /gene="PRKX"
                     /gene_synonym="PKX1"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase PRKX; protein
                     kinase PKX1; protein kinase X; protein kinase X-linked"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     PRKX"
                     /protein_id="NP_005035.1"
                     /db_xref="CCDS:CCDS14125.1"
                     /db_xref="GeneID:5613"
                     /db_xref="HGNC:HGNC:9441"
                     /db_xref="MIM:300083"
                     /translation="MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVY
                     SLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLK
                     EVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAI
                     EYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQS
                     KGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIK
                     KLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFE
                     TYPENDWDTAAPVPQKDLEIFKNF"
     exon            563..731
                     /gene="PRKX"
                     /gene_synonym="PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..995
                     /gene="PRKX"
                     /gene_synonym="PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1115
                     /gene="PRKX"
                     /gene_synonym="PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1211
                     /gene="PRKX"
                     /gene_synonym="PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1269
                     /gene="PRKX"
                     /gene_synonym="PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1347
                     /gene="PRKX"
                     /gene_synonym="PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1496
                     /gene="PRKX"
                     /gene_synonym="PKX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..6102
                     /gene="PRKX"
                     /gene_synonym="PKX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6048..6053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKX"
                     /gene_synonym="PKX1"
                     /note="hexamer: AATAAA"
     polyA_site      6072
                     /gene="PRKX"
                     /gene_synonym="PKX1"
                     /note="major polyA site"
     polyA_site      6102
                     /gene="PRKX"
                     /gene_synonym="PKX1"
ORIGIN      
        1 aggcggcttc cgcccgcccc aacagcgcgc acgcggctac cgagctggag gaggcggcgg
       61 gcgcgagacc cggaatgcgc agggcccccg cctcgccccc cccagcccgg gccgcggccc
      121 ccgccttccc cgcagtcgtc ccgcactcgg tgcccgcccc ccgaggccgg cggctgctcc
      181 cactcggggc cgttgctgct tgtgccgtga gcgccgccca gccattgtcc ccgtcgctcc
      241 gtcagccgcg ccggaccgcg caccaggagg cgagagcgcg catggggagc ctctgttgat
      301 gccgccgccg cgccgccctc cgaggctgcg tcccgggaag cccggctccc cgagcgctcc
      361 ggcctggccc ggtgccccgg acctgagtgc gtccccatgg aggcgcccgg gctggcccag
      421 gcggccgcgg cggagagcga ctcccgcaag gtggcggagg agacccccga cggggcgccc
      481 gcgctctgcc ccagccctga ggcgctgtcg ccggagccgc ctgtgtacag cctgcaggac
      541 tttgacacgc tggccaccgt gggcactggg acgttcgggc gggtgcacct ggtgaaggag
      601 aagacagcca agcatttctt cgccctcaag gtgatgagca ttcccgacgt catccgccta
      661 aagcaggagc aacacgtaca caatgagaag tctgtcctga aggaagtcag ccacccgttc
      721 ctcatcaggc tgttctggac gtggcatgac gagcgcttcc tctacatgct catggagtac
      781 gtgccgggcg gcgagctctt cagctacctg cgcaaccggg ggcgcttctc cagcaccacg
      841 gggctcttct actctgcaga gatcatctgt gccatcgagt acctgcactc caaagagatc
      901 gtctacaggg acttgaagcc agagaacatc ctgctggata gggatggcca cattaagctc
      961 acggactttg ggttcgccaa gaagctggta gacaggactt ggaccctctg tggaacaccc
     1021 gagtacctag cccccgaagt cattcagagc aagggccacg gaagggccgt ggactggtgg
     1081 gccctcggca tcctgatatt cgagatgctt tcggggtttc ctccgttttt tgatgacaac
     1141 ccgtttggca tttatcagaa aattcttgca ggcaaaatag atttccccag acatttggat
     1201 ttccatgtaa aagacctcat taagaaactg ctcgtggttg acagaacaag gcgattagga
     1261 aacatgaaga acggggcgaa tgatgtgaag catcatcggt ggttccgctc cgtggactgg
     1321 gaagctgttc cgcagagaaa actgaagcct cccatcgtgc ccaagatagc tggtgacggc
     1381 gacacttcca acttcgaaac ttaccctgag aatgactggg acacagccgc gcccgtgccg
     1441 cagaaggatt tagaaatctt caagaatttc tgaggacagg agctcacatc tggaagaaac
     1501 aggaagattg gaatctgcct ggaacaaaga actgcaccta agcagaccag aagcaaaatg
     1561 tcttcttcac ggcataagga catctccact tttctctgta cctgtgtgta tagaaataga
     1621 ttagagcaca gttgaaattc atggaactgg cattatttaa gcaactggaa ttccacactg
     1681 taggaaggtt ttgaaaattg tttggttgta gattttatct tatcctttag tgttgtgttc
     1741 ctactgtgat gtcttggttt ttgtcataga cttaagttta taagtttgaa ctggacttgt
     1801 tcgattataa ccacaaattg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1861 tgtatgcctg tgtgtatata tagaagtcat tatggcagat gcacagaaat tgtgcagtga
     1921 tgtaaatgtt catactttac agagcctata atttttattt ttcaatttgt tttttcaaaa
     1981 atctcttctc ggggacaaca tctgaagggt atgttgcatg cattaaaaaa aatcatctca
     2041 catgcatttt atagttttgg ggaagaaaat atcatgggga ggtctacctt cagtatcttt
     2101 agtgcttctt acctggtaac ttgagacttt aaaagaagaa acaaagaggg gaagatatgg
     2161 gagcgaattt attccaagaa tctacaatga cattgaagtt gttggaggaa tgtactgtat
     2221 ttaaaaaaac cttctgtgac acattcaaaa atttcatctg agctggatgc agtggcttgt
     2281 tcctatagtc ccagcacttt gggaggctga ggtgggtgga ttgcttgagc ccaggagttg
     2341 gagaccagtc tgggaaacgt ggtgagacct catctctaca aaatacaaaa aaattagccg
     2401 ggcatggtgg cacgtgagtg tagtctcagc tactcaggag gctgagatga gaggatcact
     2461 tgagcctggg gaggtccagg ccgcagtgat ccgagatcac accactgcat tccagcctgg
     2521 gtgacagagt gagaccctgt ccaaaaaaaa aaaaaaaaaa aaagaaggca atggctttgt
     2581 gcttttgaag atggattgaa gagaacgtcc accttaaggc tttaaaagac agtgaagctg
     2641 ggtgcggtgg tgcactcctg taaccctggg actttgggaa gctgaggcag gaagattgag
     2701 cctaggagtt cgagaccgac ctgggcagca tagcgagacc ccatctctat ataaaaaaaa
     2761 agatgttaaa acagtgaaat tacagaaaca gaacatagcc accctttttc atcagtgacc
     2821 ttttcttcac gtggaggtca actcagtagg tgagaataat tagtaggttc agcagaataa
     2881 actctttaca attaataact cagtggaaaa tgatgttcag atggtgaaat gtggaaatgt
     2941 tttagacaac tctattttca gcctgtgctt ctcactcacc atcctgttgg gattaacagt
     3001 tgagggccat cgctgcctaa acatttagcg tgcggtttcc catcagtttt accgtgaatg
     3061 tgaaaaggtg aaactggtgc tgacttcggc agcaggtata ctaaaattgg aatgacacag
     3121 aggagattag catggccccc tgcgcgagga agatctgcag attcatgcag cattccatat
     3181 ttttttaaga aaaggttaca ctgtgcaccg acatgtggag ctagaaggaa aagcttttaa
     3241 gtctcatgtt tgctgactat aaaaataaat catagtaata atattgaaca ttctacttta
     3301 aaaattatta ataaaaccat aaatgaaaca cttgagcaca ctttaaaaag tacataaatc
     3361 catgagtcca tatgcctatt tttaggttgt ctgttttatt atccaggatt tcatactcag
     3421 atgagaatta gcatcaggaa agcctgaaat gccttaattg tgaactgata tgcaggaaaa
     3481 tgaaatatgc aagcacattg gtgaccttgt tctttacaga cgtcgtgatc agcctccagc
     3541 catacagaac aaatgagaaa ttagaagcga ttccaagaac gtgtgatggt gtgaaaccca
     3601 ctttggacca tcacacacat ttcagcattt gaagtgacac aagctacctg gtaactgccc
     3661 atggcggggt catagtttaa atggcccaat gtcatgtaga ggttaattta atcaaaatga
     3721 gctataaaca tggagcaatc actgtataat tttaaaatag tttacctggc caggcatggt
     3781 ggctcacgcc tgtaatccca gcactttggg aggccgaggc aggtggatca cctgaggtca
     3841 ggagttcgag accagcctgg ccaacatggc aaaaccccca tctctactaa aatacaaaaa
     3901 ttaggtgtgg tggcgggcac ctgtaatcct ggctactcgg gaggctgagg caggagaatc
     3961 gcttgaaccc gggaggcaga ggctgcagta agccgagatc gtgccactgc actccagcct
     4021 gggccacaga gcaagactcc gtctcaaaac ataaaaataa aaaaaataca aatagctgac
     4081 ccgggtgggc attccaaaat gtccgcatgg acgatcacga aacaatcacg gtgcgaaatg
     4141 tccgcatgga tgatcacgaa acaatcacgg tgcagaatgt ccgtatggat gatcatgaca
     4201 aacaatcact gcgcaaaatg tggaggaaaa ttcattacca taatcacaac atttgtatca
     4261 gaaaaacatt acaaatttac tttgcttcat gtaattttac gagttggcaa tattttctta
     4321 aattggaata ctctaagaga ataggacatg gatatgttac aagaagaagt gtattggggc
     4381 aagtcttgtt tttctgaagg gaaatgccac cggcctgctt tcataggcat tgataaagcc
     4441 aggaaggaaa taaagtcaca accaaatagt atacactgtc tctactgaat tcttctaatt
     4501 ccttcgcaac agaagtctaa atcctgctta gcctaaacat atctatagcc agcgatgggc
     4561 aaattatatt tgctgtcagc atgatagaat aagaagcaga aaccccccag cagtggggta
     4621 agattgcgcg cttcatcccc tcaaaatgca gttcagcccc actccctctc catgcccatc
     4681 aaacaactgc acaatcactt gttactgaat ttcccattca gcgttttgtt tctttctgtc
     4741 catacttaaa gaccaaatca tttgtttgct ttgaagaaaa agcaaaaaca agaacaaaaa
     4801 caccaaatca tttgaaatca ctgtccatta aaaaaaatca ccagtggaac taaacagttg
     4861 agtggtttgg gatgtgttcg ccatttctgt gtttgaccta catggcctct aattctttgg
     4921 accattgtaa ctgtgaaact atggcttaat actgttaaag accccaaggc tccactctgt
     4981 agccaggtgc acctcaggct gcacaaatac cccaccagaa tgtcacaatc attcattgct
     5041 ccagctactg agtgaacagg gtgcaagaca gcactggctt gggttgtatt tttgcagcca
     5101 gttaactttg catcaggtct acacagtcct tgcagccttt gatttctcca gttgtagaga
     5161 tttgaaatgg ggtgcccggg ttcctctcgt ttttccttca atctacctag catgcatttt
     5221 acacacattg gaggagtcgt atgcactgtt tttctgttgc tgatggaggc aagcaggcct
     5281 tctaattagt ctaacttaaa cggatgggat tcacttaaca aaagcaagaa gaaaagcaca
     5341 cgaacaggtg tcttaatgca tttggatagt ttctttgcgg ggtgtgtgtg tgtgtgtgtg
     5401 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtc ttggtgaagg tgaggggctg tattttcacc
     5461 aagccttttc ataatcaagt ttgctttgca aaccttatgg ccttgcaccc cgcagaacag
     5521 tcccttccta atagcaggga tgctctgtca tggttttctg taaattatcg tgtgttggga
     5581 agttctgttg aggcttagtt tgatcttcca tggtggacac gtctgttctg tatgtaaaag
     5641 gcattacaat tgtgttttag cagatgagac ttgaagcctt tccacagtcc ttgtgctctg
     5701 agatggctgt tgagctctgc tcaactgtcg tagctgaatt ctttctttgc gctgaacact
     5761 gggcagcctc accatgttgc caacgtgctt ctggggcccc tgtcactgcc gccggatgcc
     5821 gcgcacacag gcagagtgcc ttggcaggtt tgtgcacccc ttggcgagcc agaactggga
     5881 accccgcggg gtgacccctt ctcatggggg gtcggggagg ggagtgccta tttttaatcc
     5941 tgtctgtttg ttgcacaatg gaaatcactg tgatttgtac atatgcccta ggaaaatttt
     6001 actgctgtct aatttatgta ataatactgt tgattccagg tttgtttaat aaaactttgt
     6061 atcttttcag aagtctgagt ttcatctgct tctgtctcca aa
//
