LOCUS       NM_024653               2159 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens PRKR interacting protein 1 (PRKRIP1), mRNA.
ACCESSION   NM_024653
VERSION     NM_024653.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2159)
  AUTHORS   Ozato,Y., Masuda,T., Kobayashi,Y., Takao,S., Hisamatu,Y.,
            Toshima,T., Yonemura,Y., Uemura,M., Eguchi,H., Doki,Y., Mori,M. and
            Mimori,K.
  TITLE     PRKRIP1, A Splicing Complex Factor, Is a Marker of Poor Prognosis
            in Colorectal Cancer
  JOURNAL   Anticancer Res 42 (10), 4701-4706 (2022)
   PUBMED   36192001
  REMARK    GeneRIF: PRKRIP1, A Splicing Complex Factor, Is a Marker of Poor
            Prognosis in Colorectal Cancer.
REFERENCE   2  (bases 1 to 2159)
  AUTHORS   Butte,A.J., Sigdel,T.K., Wadia,P.P., Miklos,D.B. and Sarwal,M.M.
  TITLE     Protein microarrays discover angiotensinogen and PRKRIP1 as novel
            targets for autoantibodies in chronic renal disease
  JOURNAL   Mol Cell Proteomics 10 (3), M110.000497 (2011)
   PUBMED   21183621
REFERENCE   3  (bases 1 to 2159)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 2159)
  AUTHORS   Yin,Z., Haynie,J., Williams,B.R. and Yang,Y.C.
  TITLE     C114 is a novel IL-11-inducible nuclear double-stranded RNA-binding
            protein that inhibits protein kinase R
  JOURNAL   J Biol Chem 278 (25), 22838-22845 (2003)
   PUBMED   12679338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073517.6.
            
            On Nov 23, 2018 this sequence version replaced NM_024653.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014298.2, AK023964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397912.3/ ENSP00000381010.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AC073517.6         35464-35638         c
            176-254             AC073517.6         34303-34381         c
            255-355             AC073517.6         32353-32453         c
            356-441             AC073517.6         27318-27403         c
            442-506             AC073517.6         24503-24567         c
            507-2159            AC073517.6         5335-6987           c
FEATURES             Location/Qualifiers
     source          1..2159
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2159
                     /gene="PRKRIP1"
                     /gene_synonym="C114; KRBOX3"
                     /note="PRKR interacting protein 1"
                     /db_xref="GeneID:79706"
                     /db_xref="HGNC:HGNC:21894"
                     /db_xref="MIM:617458"
     exon            1..175
                     /gene="PRKRIP1"
                     /gene_synonym="C114; KRBOX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..604
                     /gene="PRKRIP1"
                     /gene_synonym="C114; KRBOX3"
                     /note="likely ortholog of mouse C114 dsRNA-binding
                     protein; KRAB box domain containing 3; PRKR interacting
                     protein 1 (IL11 inducible)"
                     /codon_start=1
                     /product="PRKR-interacting protein 1"
                     /protein_id="NP_078929.1"
                     /db_xref="CCDS:CCDS34714.1"
                     /db_xref="GeneID:79706"
                     /db_xref="HGNC:HGNC:21894"
                     /db_xref="MIM:617458"
                     /translation="MASPAASSVRPPRPKKEPQTLVIPKNAAEEQKLKLERLMKNPDK
                     AVPIPEKMSEWAPRPPPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQDYMDAMAEK
                     QKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQEGPGQPKEQ
                     GSSSSAEASGTEEEEEVPSFTMGR"
     exon            176..254
                     /gene="PRKRIP1"
                     /gene_synonym="C114; KRBOX3"
                     /inference="alignment:Splign:2.1.0"
     exon            255..355
                     /gene="PRKRIP1"
                     /gene_synonym="C114; KRBOX3"
                     /inference="alignment:Splign:2.1.0"
     exon            356..441
                     /gene="PRKRIP1"
                     /gene_synonym="C114; KRBOX3"
                     /inference="alignment:Splign:2.1.0"
     exon            442..506
                     /gene="PRKRIP1"
                     /gene_synonym="C114; KRBOX3"
                     /inference="alignment:Splign:2.1.0"
     exon            507..2159
                     /gene="PRKRIP1"
                     /gene_synonym="C114; KRBOX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      921..926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKRIP1"
                     /gene_synonym="C114; KRBOX3"
                     /note="hexamer: AGTAAA"
     polyA_site      942
                     /gene="PRKRIP1"
                     /gene_synonym="C114; KRBOX3"
     regulatory      2133..2138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PRKRIP1"
                     /gene_synonym="C114; KRBOX3"
                     /note="hexamer: AATAAA"
     polyA_site      2159
                     /gene="PRKRIP1"
                     /gene_synonym="C114; KRBOX3"
                     /note="major polyA site"
ORIGIN      
        1 atacttgcgc gccgacgccg ccgctcgctt gtgaaactgg aaggctgcca tggctagccc
       61 agccgcctcc tcggtgcgac caccgaggcc caagaaagag ccgcagacgc tcgtcatccc
      121 caagaatgcg gcggaggagc agaagctcaa gctggagcgg ctcatgaaga acccggacaa
      181 agcagttcca attccagaga aaatgagtga atgggcacct cgacctcccc cagaatttgt
      241 ccgagatgtc atgggttcaa gtgctggggc cggcagtgga gagttccacg tgtacagaca
      301 tctgcgccgg agagaatatc agcgacagga ctacatggat gccatggctg agaagcaaaa
      361 attggatgca gagtttcaga aaagactgga aaagaataaa attgctgcag aggagcagac
      421 cgcaaagcgc cggaagaagc gccagaagtt aaaagagaag aaattactgg caaagaagat
      481 gaaacttgaa cagaagaaac aagaaggacc cggtcagccc aaggagcagg ggtccagcag
      541 ctctgcggag gcatctggaa cagaggagga ggaggaagtg cccagtttca ccatggggcg
      601 atgacaatgt ttgccacagc ctctgcctgg aacctggctc gtgctgtgac cagaagggaa
      661 aggcggctgt ttggctcttt ctcccccgca aggacccgct gacccgctgg atggagagca
      721 aaggagaccc ctcccgagcc gctcacagtc ctgtatttgg caggtttggg agcctgaggg
      781 gccatctccc tgacactcag aggcactgcc ttgcagacac catccgtgct cctggtaaag
      841 ggggacagag agcctcacct tgccacatat ttgaacagtg atgagtttgg ggctggtttc
      901 tgggaaggga acgtttattt agtaaagagc agaacaccct tgcgttttgt tgggacatgt
      961 ggaccgtgag tcgcaaacac tctggagaag gctgagatgc caccattccc acggggactg
     1021 aagacacatt acgtggacct ggtcccaggc tcagtgagga gatggcctca gctgtggggc
     1081 tggtccatgt tgcccactca ctccagtggg aagtggggac cacgccatag agggtctgct
     1141 cccactgcag ctcccggtgc tctcgtgttc tgggaaggcc tgggtgtgtg cacaaggagg
     1201 cccgggccag ggacttcacc aggggctggg tcacaagggc acagggtgtg tggaaagcgc
     1261 tgtgggggaa gagccggtca ccggagagtg agcaggcgga gactccaagc tgggctgagc
     1321 cagagcagaa ggcgagggat tcccagccgg acgggggttc tctcaccaac agctgtgatt
     1381 tcatcccgaa gtggaagggg gtctaaacag aacaggctga gagaggcggg actgggtcaa
     1441 gtgggtggag ctcctccttg catgactgca actgtcgggg ctttccgccg gctcacagca
     1501 gttggggcca gcggggagaa gagaggcgga actgctgtgt cctcatgtgg cgcagcctca
     1561 aactggcatc caggcactgg gcccatgcag agaaggcacc tgcagagagc agggcagccc
     1621 ggcgcagggg catgcgccta gaatcccagc tactcggaag gccaaggcag gaggaccgct
     1681 tgagtccagg gattcaaggc caacctgggc aatagagcga gaccctgtct cttaaaaaac
     1741 gatgatgatg aacacagagg acggggcact gtgctgggag ccagggggcc tgggaggagc
     1801 cgagaccagc cttttacctc ggggttttga ggccaacagg gacgacagag acagtttcta
     1861 gttagagcct tggctccatt tttggatgat ttagccccga gttcctgagt ctattttatg
     1921 ccccttacgt actttgatag aactaaggaa atagtggttt tgagtgaagg gaaaggaaac
     1981 ccagaaacat tttacgttgc ttttacttct gtagtgtaga ttgccccggc ccctctctga
     2041 gccctgtagc atctgtgata gcttctgtcc cttcatcggt tcatgtcaca gggattttct
     2101 ttcccaggaa gcggacacgg agagtcagcc ctaataaatg agcacatgcc ctggctgta
//
